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JOURNAL ARTICLE
Niki A Konstantinides, Sean M Murphy, Bridget M Whelan, Kimberly G Harmon, Sourav K Poddar, Theresa D Hernández, Rachel K Rowe
BACKGROUND: Sport-related concussion (SRC) is a heterogenous injury that often presents with varied symptoms and impairment. Recently, research has focused on identifying subtypes, or clinical profiles of concussion to be used in assessing and treating athletes with SRC. The purpose of this study was to investigate sex differences in clinical profiles, recovery duration, and initial symptom severity after SRC in a cohort of collegiate athletes in the Pacific-12 Conference (Pac-12). METHODS: This prospective cohort study examined post-SRC symptoms, recovery, and return-to-play times using data from the Pac-12 CARE Affiliated Program and Pac-12 Health Analytics Program...
April 2, 2024: Sports Medicine—Open
#2
JOURNAL ARTICLE
Lee Hulbert-Williams, Nicholas J Hulbert-Williams, Ana Martins, Lesley Storey, Jennie Bradley, Hatty O'Sullivan, Lorna A Fern, Maria Lawal, Rachael Windsor, Craig Gerrand, Jeremy S Whelan, Lindsey Bennister, Mary Wells, Rachel M Taylor
The Sarcoma Assessment Measure (SAM) was developed as a sarcoma-specific patient-reported outcome measure to be used in clinical practice. We have reported in detail how SAM has been developed in collaboration with patients and healthcare professionals. The aim of this paper is to report the preliminary validation of SAM. The 22-item SAM was administered alongside a validated quality of life questionnaire and measure of activities of daily living. Linear modelling was used to build a measure, which had predictive validity in comparison to more established outcome measures...
March 8, 2024: Cancers
#3
JOURNAL ARTICLE
Rachel M Taylor, Jeremy S Whelan, Julie A Barber, Javier Alvarez-Galvez, Richard G Feltbower, Faith Gibson, Dan P Stark, Lorna A Fern
Purpose: In England, health care policy promotes specialized age-appropriate cancer services for teenagers and young adults (TYA), for those aged 13-24 years at diagnosis. Specialist Principal Treatment Centers (PTCs) provide enhanced age-specific care for TYA, although many still receive all or some of their care in adult or children's cancer services. Our aim was to determine the patient-reported outcomes associated with TYA-PTC based care. Methods: We conducted a multicenter cohort study, recruiting 1114 TYA aged 13-24 years at diagnosis...
January 30, 2024: Journal of Adolescent and Young Adult Oncology
#4
REVIEW
Steven Joffe, Rena M Conti, Jorge L Contreras, Emily A Largent, Holly Fernandez Lynch, David Mitchell, Rachel E Sachs, Allison M Whelan, Matthew S McCoy
No abstract text is available yet for this article.
November 8, 2023: Gene Therapy
#5
JOURNAL ARTICLE
Luke Hughes, Lorna A Fern, Jeremy S Whelan, Rachel M Taylor, Brightlight Study Group
OBJECTIVES: The BRIGHTLIGHT cohort study was the national evaluation of cancer services for teenager and young adults (TYA). This was analysis of free-text survey data to better understand their experiences of cancer care. DESIGN: Cohort study SETTING: National Health Service hospitals delivering cancer care in England PARTICIPANTS: 830 young people newly diagnosed with cancer. INTERVENTIONS: Exposure to specialist care in the first 6 months after diagnosis defined as care in a TYA Principal Treatment Centre (PTC)...
September 20, 2023: BMJ Open
#6
JOURNAL ARTICLE
Sam Martin, Sigrún Eyrúnardóttir Clark, Craig Gerrand, Katie Gilchrist, Maria Lawal, Laura Maio, Ana Martins, Lesley Storey, Rachel M Taylor, Mary Wells, Jeremy S Whelan, Rachael Windsor, Julie Woodford, Cecilia Vindrola-Padros, Lorna A Fern
UNLABELLED: Patients with sarcoma often report prolonged time to diagnosis, which is attributed to the rarity of sarcoma and the low awareness of pre-diagnostic signs and symptoms. AIMS: To describe patients' experiences of pre-diagnostic signs/symptoms and pathways to diagnosis, including where help was sought, and the processes involved. METHODS: Mixed methods involving quantitative, qualitative and inductive thematic analyses using novel process mapping of patient journey data, as reported by the patients...
August 3, 2023: Cancers
#7
JOURNAL ARTICLE
Eirini Dimidi, Alastair James McArthur, Rachel White, Kevin Whelan, Miranda C E Lomer
BACKGROUND: A diet low in fermentable oligo-saccharides, di-saccharides, mono-saccharides and polyols (low FODMAP diet) is complex and clinical effectiveness is achieved with dietitian-led education, although dietitian availability in clinical practice varies. This study aimed to assess the feasibility of undertaking a trial to investigate the clinical and cost-effectiveness of different education delivery methods of the low FODMAP diet in patients with disorders of gut-brain interaction (DGBI)...
July 21, 2023: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
#8
JOURNAL ARTICLE
Georgia Rogerson, Yifan Xu, Megan Whelan, Rachel Gibson
BACKGROUND: There are no beverage measurement tools evaluated for use in UK working-age adults. This study aimed to develop and evaluate a novel beverage intake questionnaire. METHODS: A 57-item online tool (Workplace Beverage Intake Questionnaire [WBIQ]) was developed through stakeholder consensus. Relative validity was measured against 7-day food records, and reliability was tested across three time points. Evaluation outcomes of interest were total beverage intake and beverage intake during working hours, intake from seven beverage categories (plain water, sugar sweetened, low/zero calorie, tea, coffee, milk based and 100% fruit based) and energy, caffeine and free sugar intake from beverages...
July 17, 2023: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
#9
JOURNAL ARTICLE
Wafaa B Alsoussi, Sameer Kumar Malladi, Julian Q Zhou, Zhuoming Liu, Baoling Ying, Wooseob Kim, Aaron J Schmitz, Tingting Lei, Stephen C Horvath, Alexandria J Sturtz, Katherine M McIntire, Birk Evavold, Fangjie Han, Suzanne M Scheaffer, Isabella F Fox, Senaa F Mirza, Luis Parra-Rodriguez, Raffael Nachbagauer, Biliana Nestorova, Spyros Chalkias, Christopher W Farnsworth, Michael K Klebert, Iskra Pusic, Benjamin S Strnad, William D Middleton, Sharlene A Teefey, Sean P J Whelan, Michael S Diamond, Robert Paris, Jane A O'Halloran, Rachel M Presti, Jackson S Turner, Ali H Ellebedy
The primary two-dose SARS-CoV-2 mRNA vaccine series are strongly immunogenic in humans, but the emergence of highly infectious variants necessitated additional doses and the development of new variant-derived vaccines1-4 . SARS-CoV-2 booster immunizations in humans primarily recruit pre-existing memory B cells (MBCs)5-9 . It remains unclear, however, whether the additional doses induce germinal centre (GC) reactions where reengaged B cells can further mature and whether variant-derived vaccines can elicit responses to variant-specific epitopes...
April 3, 2023: Nature
#10
JOURNAL ARTICLE
Sarah E Greene, Yuefang Huang, Wooseob Kim, Mariel J Liebeskind, Vinay Chandrasekaran, Zhuoming Liu, Parakkal Deepak, Michael A Paley, Daphne Lew, Monica Yang, Mehrdad Matloubian, Lianne S Gensler, Mary C Nakamura, Jane A O'Hallaran, Rachel M Presti, Sean P J Whelan, William J Buchser, Alfred H J Kim, Gary J Weil
OBJECTIVE: Lateral flow assays (LFA) are sensitive for detecting antibodies to SARS-CoV-2 proteins within weeks after infection. This study tested samples from immunocompetent adults, and those receiving treatments for chronic inflammatory diseases (CID), before and after mRNA SARS-CoV-2 vaccination. METHODS: We compared results obtained with the COVIBLOCK Covid-19 LFA to those obtained by anti-spike (S) ELISA. RESULTS: The LFA detected anti-S antibodies in 29 of 29 (100%) of the immunocompetent and 110 of 126 (87...
January 11, 2023: J Clin Virol Plus
#11
REVIEW
Georgia Rogerson, Megan Whelan, Rachel Gibson
BACKGROUND: Beverage intake in employees is important to quantify due to the potential of dehydration to increase the risk of errors and reduced work performance. This systematic review aimed to 1) characterise existing fluid intake measurement tools used in the workplace setting or amongst free-living, healthy adults of working age and 2) report the current validation status of available assessment tools for use in a UK setting. METHODS: Three electronic databases were searched for publications measuring beverage intake using a defined tool or method...
December 13, 2022: Journal of Human Nutrition and Dietetics: the Official Journal of the British Dietetic Association
#12
JOURNAL ARTICLE
Ana Martins, Lindsey Bennister, Lorna A Fern, Craig Gerrand, Maria Onasanya, Lesley Storey, Mary Wells, Jeremy S Whelan, Rachael Windsor, Julie Woodford, Rachel M Taylor
BACKGROUND: Treatment of soft tissue sarcoma frequently involves extensive surgery, loss of mobility, and complex rehabilitation programs. Poorer patient-reported outcomes are reported in comparison to those from patients with other cancer types. Understanding patient experience is therefore important to support patients and improve care. OBJECTIVE: The aim of this study was an in-depth exploration of patients' experience of being diagnosed with soft tissue sarcoma...
March 2024: Cancer Nursing
#13
Wafaa B Alsoussi, Sameer K Malladi, Julian Q Zhou, Zhuoming Liu, Baoling Ying, Wooseob Kim, Aaron J Schmitz, Tingting Lei, Stephen C Horvath, Alexandria J Sturtz, Katherine M McIntire, Birk Evavold, Fangjie Han, Suzanne M Scheaffer, Isabella F Fox, Luis Parra-Rodriguez, Raffael Nachbagauer, Biliana Nestorova, Spyros Chalkias, Christopher W Farnsworth, Michael K Klebert, Iskra Pusic, Benjamin S Strnad, William D Middleton, Sharlene A Teefey, Sean P J Whelan, Michael S Diamond, Robert Paris, Jane A O'Halloran, Rachel M Presti, Jackson S Turner, Ali H Ellebedy
The primary two-dose SARS-CoV-2 mRNA vaccine series are strongly immunogenic in humans, but the emergence of highly infectious variants necessitated additional doses of these vaccines and the development of new variant-derived ones 1-4 . SARS-CoV-2 booster immunizations in humans primarily recruit pre-existing memory B cells (MBCs) 5-9 . It remains unclear, however, whether the additional doses induce germinal centre (GC) reactions where reengaged B cells can further mature and whether variant-derived vaccines can elicit responses to novel epitopes specific to such variants...
September 22, 2022: bioRxiv
#14
JOURNAL ARTICLE
Rachel Whelan, Lauren Schaeffer, Ingrid Olson, Lian V Folger, Saima Alam, Nayab Ajaz, Karima Ladhani, Bernard Rosner, Blair J Wylie, Anne C C Lee
In low- and middle-income countries (LMIC), measurement of symphysis fundal height (SFH) is often the only available method of estimating gestational age (GA) in pregnancy. This systematic review aims to summarize methods of SFH measurement and assess the accuracy of SFH for the purpose of GA estimation. We searched PubMed, EMBASE, Cochrane, Web of Science, POPLINE, and WHO Global Health Libraries from January 1980 through November 2021. For SFH accuracy, we pooled the variance of the mean difference between GA confirmed by ultrasound versus SFH...
2022: PloS One
#15
JOURNAL ARTICLE
Krysten North, Rachel Whelan, Lian V Folger, Harriet Lawford, Ingrid Olson, Sophie Driker, Michelle B Bass, Karen Edmond, Anne C C Lee
BACKGROUND AND OBJECTIVES: Preterm and low birth weight (LBW) infants are often separated from parents during hospitalization. Our objective was to assess effects of interventions to increase family involvement in the routine newborn care of preterm or LBW infants compared with standard NICU care on infant and parental outcomes. METHODS: Data sources include Medline, Embase, CINAHL, and World Health Organization Global Index Medicus to August 2021. The study selection included randomized controlled trials (RCTs) of family involvement intervention packages...
August 1, 2022: Pediatrics
#16
REVIEW
Sally Whelan, Arlene Mannion, Azeem Madden, Fine Berger, Rachel Costello, Saeid Ghadiri, Geraldine Leader
Over forty percent of autistic children experience poor sleep quality, and social interaction difficulties are a core characteristic of autism. However, the relationship between sleep quality and social functioning and behavior remains poorly understood. This systematic review examined the evidence concerning the impact of sleep quality on the social functioning and behavior problems in autistic children and adolescents. It also identified key related factors and evaluated how this issue has been researched to date...
2022: Nature and Science of Sleep
#17
JOURNAL ARTICLE
Rachel M Brouwer, Marieke Klein, Katrina L Grasby, Hugo G Schnack, Neda Jahanshad, Jalmar Teeuw, Sophia I Thomopoulos, Emma Sprooten, Carol E Franz, Nitin Gogtay, William S Kremen, Matthew S Panizzon, Loes M Olde Loohuis, Christopher D Whelan, Moji Aghajani, Clara Alloza, Dag Alnæs, Eric Artiges, Rosa Ayesa-Arriola, Gareth J Barker, Mark E Bastin, Elisabet Blok, Erlend Bøen, Isabella A Breukelaar, Joanna K Bright, Elizabeth E L Buimer, Robin Bülow, Dara M Cannon, Simone Ciufolini, Nicolas A Crossley, Christienne G Damatac, Paola Dazzan, Casper L de Mol, Sonja M C de Zwarte, Sylvane Desrivières, Covadonga M Díaz-Caneja, Nhat Trung Doan, Katharina Dohm, Juliane H Fröhner, Janik Goltermann, Antoine Grigis, Dominik Grotegerd, Laura K M Han, Mathew A Harris, Catharina A Hartman, Sarah J Heany, Walter Heindel, Dirk J Heslenfeld, Sarah Hohmann, Bernd Ittermann, Philip R Jansen, Joost Janssen, Tianye Jia, Jiyang Jiang, Christiane Jockwitz, Temmuz Karali, Daniel Keeser, Martijn G J C Koevoets, Rhoshel K Lenroot, Berend Malchow, René C W Mandl, Vicente Medel, Susanne Meinert, Catherine A Morgan, Thomas W Mühleisen, Leila Nabulsi, Nils Opel, Víctor Ortiz-García de la Foz, Bronwyn J Overs, Marie-Laure Paillère Martinot, Ronny Redlich, Tiago Reis Marques, Jonathan Repple, Gloria Roberts, Gennady V Roshchupkin, Nikita Setiaman, Elena Shumskaya, Frederike Stein, Gustavo Sudre, Shun Takahashi, Anbupalam Thalamuthu, Diana Tordesillas-Gutiérrez, Aad van der Lugt, Neeltje E M van Haren, Joanna M Wardlaw, Wei Wen, Henk-Jan Westeneng, Katharina Wittfeld, Alyssa H Zhu, Andre Zugman, Nicola J Armstrong, Gaia Bonfiglio, Janita Bralten, Shareefa Dalvie, Gail Davies, Marta Di Forti, Linda Ding, Gary Donohoe, Andreas J Forstner, Javier Gonzalez-Peñas, Joao P O F T Guimaraes, Georg Homuth, Jouke-Jan Hottenga, Maria J Knol, John B J Kwok, Stephanie Le Hellard, Karen A Mather, Yuri Milaneschi, Derek W Morris, Markus M Nöthen, Sergi Papiol, Marcella Rietschel, Marcos L Santoro, Vidar M Steen, Jason L Stein, Fabian Streit, Rick M Tankard, Alexander Teumer, Dennis van 't Ent, Dennis van der Meer, Kristel R van Eijk, Evangelos Vassos, Javier Vázquez-Bourgon, Stephanie H Witt, Hieab H H Adams, Ingrid Agartz, David Ames, Katrin Amunts, Ole A Andreassen, Celso Arango, Tobias Banaschewski, Bernhard T Baune, Sintia I Belangero, Arun L W Bokde, Dorret I Boomsma, Rodrigo A Bressan, Henry Brodaty, Jan K Buitelaar, Wiepke Cahn, Svenja Caspers, Sven Cichon, Benedicto Crespo-Facorro, Simon R Cox, Udo Dannlowski, Torbjørn Elvsåshagen, Thomas Espeseth, Peter G Falkai, Simon E Fisher, Herta Flor, Janice M Fullerton, Hugh Garavan, Penny A Gowland, Hans J Grabe, Tim Hahn, Andreas Heinz, Manon Hillegers, Jacqueline Hoare, Pieter J Hoekstra, Mohammad A Ikram, Andrea P Jackowski, Andreas Jansen, Erik G Jönsson, Rene S Kahn, Tilo Kircher, Mayuresh S Korgaonkar, Axel Krug, Herve Lemaitre, Ulrik F Malt, Jean-Luc Martinot, Colm McDonald, Philip B Mitchell, Ryan L Muetzel, Robin M Murray, Frauke Nees, Igor Nenadić, Jaap Oosterlaan, Roel A Ophoff, Pedro M Pan, Brenda W J H Penninx, Luise Poustka, Perminder S Sachdev, Giovanni A Salum, Peter R Schofield, Gunter Schumann, Philip Shaw, Kang Sim, Michael N Smolka, Dan J Stein, Julian N Trollor, Leonard H van den Berg, Jan H Veldink, Henrik Walter, Lars T Westlye, Robert Whelan, Tonya White, Margaret J Wright, Sarah E Medland, Barbara Franke, Paul M Thompson, Hilleke E Hulshoff Pol
Human brain structure changes throughout the lifespan. Altered brain growth or rates of decline are implicated in a vast range of psychiatric, developmental and neurodegenerative diseases. In this study, we identified common genetic variants that affect rates of brain growth or atrophy in what is, to our knowledge, the first genome-wide association meta-analysis of changes in brain morphology across the lifespan. Longitudinal magnetic resonance imaging data from 15,640 individuals were used to compute rates of change for 15 brain structures...
April 2022: Nature Neuroscience
#18
RANDOMIZED CONTROLLED TRIAL
Martin J Wildman, Alicia O'Cathain, Chin Maguire, Madelynne A Arden, Marlene Hutchings, Judy Bradley, Stephen J Walters, Pauline Whelan, John Ainsworth, Iain Buchan, Laura Mandefield, Laura Sutton, Paul Tappenden, Rachel A Elliott, Zhe Hui Hoo, Sarah J Drabble, Daniel Beever
INTRODUCTION: Recurrent pulmonary exacerbations lead to progressive lung damage in cystic fibrosis (CF). Inhaled medications (mucoactive agents and antibiotics) help prevent exacerbations, but objectively measured adherence is low. We investigated whether a multi-component (complex) self-management intervention to support adherence would reduce exacerbation rates over 12 months. METHODS: Between October 2017 and May 2018, adults with CF (aged ≥16 years; 19 UK centres) were randomised to the intervention (data-logging nebulisers, a digital platform and behavioural change sessions with trained clinical interventionists) or usual care (data-logging nebulisers)...
May 2022: Thorax
#19
JOURNAL ARTICLE
George A O'Toole, Aurélie Crabbé, Rolf Kümmerli, John J LiPuma, Jennifer M Bomberger, Jane C Davies, Dominique Limoli, Vanessa V Phelan, James B Bliska, William H DePas, Lars E Dietrich, Thomas H Hampton, Ryan Hunter, Cezar M Khursigara, Alexa Price-Whelan, Alix Ashare, Robert A Cramer, Joanna B Goldberg, Freya Harrison, Deborah A Hogan, Michael A Henson, Dean R Madden, Jared R Mayers, Carey Nadell, Dianne Newman, Alice Prince, Damian W Rivett, Joseph D Schwartzman, Daniel Schultz, Donald C Sheppard, Alan R Smyth, Melanie A Spero, Bruce A Stanton, Paul E Turner, Chris van der Gast, Fiona J Whelan, Rachel Whitaker, Katrine Whiteson
A recent workshop titled "Developing Models to Study Polymicrobial Infections," sponsored by the Dartmouth Cystic Fibrosis Center (DartCF), explored the development of new models to study the polymicrobial infections associated with the airways of persons with cystic fibrosis (CF). The workshop gathered 35+ investigators over two virtual sessions. Here, we present the findings of this workshop, summarize some of the challenges involved with developing such models, and suggest three frameworks to tackle this complex problem...
October 26, 2021: MBio
#20
JOURNAL ARTICLE
Aaron J Schmitz, Jackson S Turner, Zhuoming Liu, Julian Q Zhou, Ishmael D Aziati, Rita E Chen, Astha Joshi, Traci L Bricker, Tamarand L Darling, Daniel C Adelsberg, Clara G Altomare, Wafaa B Alsoussi, James Brett Case, Laura A VanBlargan, Tingting Lei, Mahima Thapa, Fatima Amanat, Trushar Jeevan, Thomas Fabrizio, Jane A O'Halloran, Pei-Yong Shi, Rachel M Presti, Richard J Webby, Florian Krammer, Sean P J Whelan, Goran Bajic, Michael S Diamond, Adrianus C M Boon, Ali H Ellebedy
The emergence of SARS-CoV-2 antigenic variants with increased transmissibility is a public health threat. Some variants show substantial resistance to neutralization by SARS-CoV-2 infection- or vaccination-induced antibodies. Here, we analyzed receptor binding domain-binding monoclonal antibodies derived from SARS-CoV-2 mRNA vaccine-elicited germinal center B cells for neutralizing activity against the WA1/2020 D614G SARS-CoV-2 strain and variants of concern. Of five monoclonal antibodies that potently neutralized the WA1/2020 D614G strain, all retained neutralizing capacity against the B...
September 14, 2021: Immunity
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