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JOURNAL ARTICLE
Rito L Mikhari, Susan Meiring, Linda de Gouveia, Wai Yin Chan, Keith A Jolley, Daria Van Tyne, Lee H Harrison, Henju Marjuki, Arshad Ismail, Vanessa Quan, Cheryl Cohen, Sibongile Walaza, Anne von Gottberg, Mignon du Plessis
BACKGROUND: Invasive meningococcal isolates in South Africa have in previous years (<2008) been characterized by serogroup B, C, W and Y lineages over time, with penicillin intermediate resistance (peni) at 6%. We describe the population structure and genomic markers of peni among invasive meningococcal isolates in South Africa, 2016-2021. METHODS: Meningococcal isolates were collected through national, laboratory-based invasive meningococcal disease (IMD) surveillance...
April 30, 2024: Journal of Infectious Diseases
#2
JOURNAL ARTICLE
Anahí Venzor Strader, Magda Sotz, Hannah N Gilbert, Ann C Miller, Anne Cc Lee, Peter Rohloff
INTRODUCTION: Neonatal mortality is a global public health challenge. Guatemala has the fifth highest neonatal mortality rate in Latin America, and Indigenous communities are particularly impacted. This study aims to understand factors driving neonatal mortality rates among Maya Kaqchikel communities. METHODS: We used sequential explanatory mixed methods. The quantitative phase was a secondary analysis of 2014-2016 data from the Global Maternal and Newborn Health Registry from Chimaltenango, Guatemala...
April 17, 2024: BMJ Global Health
#3
JOURNAL ARTICLE
Anne Cc Lee, Sara Cherkerzian, Fahmida Tofail, Lian V Folger, Salahuddin Ahmed, Sayedur Rahman, Nabid H Chowdhury, Rasheda Khanam, Ingrid Olson, Emily Oken, Raina Fichorova, Charles A Nelson, Abdullah H Baqui, Terrie Inder
BACKGROUND: There are limited data on the impact of perinatal inflammation on child neurodevelopment in low-middle income countries and among growth-restricted infants. METHODS: Population-based, prospective birth cohort study of 288 infants from July 2016-March 2017 in Sylhet, Bangladesh. Umbilical cord blood was analyzed for interleukin(IL)-1α, IL-1β, IL-6, IL-8, and C-reactive protein(CRP). Child neurodevelopment was assessed at 24 months with Bayley-III Scales of Infant Development...
April 8, 2024: Pediatric Research
#4
REVIEW
Jenny Koo, Po-Yin Cheung, Gerhard Pichler, Anne Lee Solevåg, Brenda Hiu Yan Law, Anup C Katheria, Georg M Schmölzer
Neonates requiring cardiopulmonary resuscitation (CPR) are at risk of mortality and neurodevelopmental injury. Poor outcomes following the need for chest compressions (CCs) in the delivery room prompt the critical need for improvements in resuscitation strategies. This article explores a technique of CPR which involves CCs with sustained inflation (CC+SI). Unique features of CC+SI include (1) improved tidal volume delivery, (2) passive ventilation during compressions, (3) uninterrupted compressions and (4) improved stability of cerebral blood flow during resuscitation...
March 7, 2024: Archives of Disease in Childhood. Fetal and Neonatal Edition
#5
JOURNAL ARTICLE
Krysten North, Katherine E A Semrau, Roopa M Bellad, Sangappa M Dhaded, Leena Das, Jnanindranath N Behera, Irving Hoffman, Tisungane Mvalo, Rodrick Kisenge, Christopher R Sudfeld, Sarah Somji, Rana R Mokhtar, Linda Vesel, Shivaprasad Goudar, Sunil S Vernekar, E S Siddhartha, Bipsa Singh, M B Koujalagi, Sanghamitra Panda, Eddah Kafansiyanji, Naomie Nyirenda, Melda Phiri, Friday Saidi, Nahya S Masoud, Robert Moshiro, Danielle E Tuller, Kiersten Israel-Ballard, Christopher P Duggan, Anne Cc Lee, Kimberly L Mansen, Melissa F Young, Karim Manji
OBJECTIVE: To assess the association between breastfeeding competency, as determined by Latch, Audible swallowing, Type of nipple, Comfort, and Hold (LATCH) and Preterm Infant Breastfeeding Behavior Scale (PIBBS) scores, and exclusive breastfeeding and growth among infants with low birth weight (LBW) in India, Malawi, and Tanzania. STUDY DESIGN: We conducted LATCH and PIBBS assessments among mother-infant dyads enrolled in the Low Birthweight Infant Feeding Exploration (LIFE) observational study of infants with moderately LBW (1500g-2499g) in India, Malawi, and Tanzania...
March 4, 2024: Journal of Pediatrics
#6
JOURNAL ARTICLE
Ann M Chan, Tove Olafsen, Jessica Tsui, Felix B Salazar, Brian Aguirre, Kirstin A Zettlitz, Michael Condro, Anna M Wu, Jonathan Braun, Lynn K Gordon, Negin Ashki, Julian Whitelegge, Shili Xu, Oluwatayo Ikotun, Jason Thanh Lee, Madhuri Wadehra
Epithelial membrane protein-2 (EMP2) is upregulated in a number of tumors and therefore remains a promising target for monoclonal antibody (mAb)-based therapy. In the current study, image guided therapy for an anti-EMP2 mAb was evaluated by positron emission tomography (PET) in both syngeneic and immunodeficient cancer models expressing different levels of EMP2 in order to enable a better understanding of its tumor uptake and off target accumulation and clearance. The therapeutic efficacy of the anti-EMP2 mAb was initially evaluated in high- and low-expressing tumors, and the mAb reduced tumor load for the high EMP2 expressing 4T1 and HEC-1-A tumors...
February 28, 2024: Molecular Cancer Therapeutics
#7
JOURNAL ARTICLE
Diksha Puri, Raj Kumar, Sushil Kumar, M S Thakur, Gusztáv Fekete, Daeho Lee, Tej Singh
Dissolved oxygen (DO) is an important parameter in assessing water quality. The reduction in DO concentration is the result of eutrophication, which degrades the quality of water. Aeration is the best way to enhance the DO concentration. In the current study, the aeration efficiency (E20 ) of various numbers of circular jets in an open channel was experimentally investigated for different channel angle of inclination (θ), discharge (Q), number of jets (Jn ), Froude number (Fr), and hydraulic radius of each jet (HRJn )...
February 7, 2024: Scientific Reports
#8
JOURNAL ARTICLE
Georg M Schmölzer, Gerhard Pichler, Anne Lee Solevåg, Brenda Hiu Yan Law, Souvik Mitra, Michael Wagner, Daniel Pfurtscheller, Maryna Yaskina, Po-Yin Cheung
OBJECTIVE: In newborn infants requiring chest compression (CC) in the delivery room (DR) does continuous CC superimposed by a sustained inflation (CC+SI) compared with a 3:1 compression:ventilation (3:1 C:V) ratio decreases time to return of spontaneous circulation (ROSC). DESIGN: International, multicenter, prospective, cluster cross-over randomised trial. SETTING: DR in four hospitals in Canada and Austria, PARTICIPANTS: Newborn infants >28 weeks' gestation who required CC...
January 11, 2024: Archives of Disease in Childhood. Fetal and Neonatal Edition
#9
JOURNAL ARTICLE
Agata M P Atayde, Neena R Kapoor, Sara Cherkerzian, Ingrid Olson, Chloe Andrews, Anne C C Lee, Sarbattama Sen, Lars Bode, Kaitlin George, Katherine Bell, Terrie Inder, Mandy B Belfort
BACKGROUND: Lactoferrin is an immuno-modulatory nutrient in human milk that may be neuroprotective. METHODS: In 36 infants born <32 weeks' gestation, we sampled human milk at 14 and 28 days of chronologic age and measured lactoferrin by electrochemiluminescence multiplex immunoassay. Using 3T quantitative brain magnetic resonance imaging scans obtained at term equivalent, we estimated total and regional brain volumes. We compared outcomes between infants exposed to low (bottom tertile, range 0...
January 8, 2024: Pediatric Research
#10
JOURNAL ARTICLE
Linda Vesel, Emily Benotti, Sarah Somji, Roopa M Bellad, Umesh Charantimath, Sangappa M Dhaded, Shivaprasad S Goudar, Chandrashekhar Karadiguddi, Geetanjali Mungarwadi, Sunil S Vernekar, Rodrick Kisenge, Karim Manji, Nahya Salim, Abraham Samma, Christopher R Sudfeld, Irving F Hoffman, Tisungane Mvalo, Melda Phiri, Friday Saidi, Jennifer Tseka, Mercy Tsidya, Bethany A Caruso, Christopher P Duggan, Kiersten Israel-Ballard, Anne Cc Lee, Kimberly L Mansen, Stephanie L Martin, Krysten North, Melissa F Young, Eliza Fishman, Katelyn Fleming, Katherine Ea Semrau, Lauren Spigel, Danielle E Tuller, Natalie Henrich
BACKGROUND: Low birthweight (LBW) infants are at increased risk of morbidity and mortality. Exclusive breastfeeding up to six months is recommended to help them thrive through infection prevention, growth improvements, and enhancements in neurodevelopment. However, limited data exist on the feeding experiences of LBW infants, their caregivers and key community influencers. The qualitative component of the Low Birthweight Infant Feeding Exploration (LIFE) study aimed to understand practices, facilitators, and barriers to optimal feeding options in the first six months for LBW infants in low-resource settings...
November 8, 2023: International Breastfeeding Journal
#11
JOURNAL ARTICLE
Fisseha Shiferie, Firehiwot Workneh Abate, Tigest Shifraw, Michelle Eglovitch, Hanna Amanuel, Grace J Chan, Sheila Isanaka, Amare Worku Tadesse, Alemayehu Worku, Anne Cc Lee, Yemane Berhane
INTRODUCTION: in Ethiopia, increasing access to basic antenatal and neonatal health services may improve maternal and newborn survival. This study examined perceptions regarding antenatal health seeking behaviors from pregnant women, their families, community members, and health care providers in rural Amhara, Ethiopia. METHODS: the study was conducted in four rural districts of the Amhara region of Ethiopia. A total of forty participants who were living and working within the catchment areas of the selected health centres were interviewed from October 3rd through October 14th , 2018...
2023: Pan African Medical Journal
#12
JOURNAL ARTICLE
Diksha Puri, Raj Kumar, Parveen Sihag, Mohindra Singh Thakur, Kahkashan Perveen, Faisal M Alfaisal, Daeho Lee
Jet aeration is a commonly used technique for introducing air into water during wastewater treatment. In this investigation, the efficacy of different soft computing models, namely, Random Forest, Reduced Error Pruning Tree, Artificial Neural Network (ANN), Gaussian Process, and Support Vector Machine, was examined in predicting the aeration efficiency (E20 ) of circular and square jet configurations in an open channel flow. A total of 126 experimental data points were utilized to develop and validate these models...
September 5, 2023: ACS Omega
#13
JOURNAL ARTICLE
Jae Woong Kim, Doeun Rim, Chang Hyeok Ann, Sug Hyung Lee
The butyrophilin family genes are immunoregulatory genes with either immune stimulatory or inhibitory functions. In the present study, we analyzed three butyrophilin genes, BTN2A1 (immune-stimulatory), BTN2A2 (inhibitory), and BTNL3 (stimulatory) genes in sporadic colon cancers (CCs). By the mutation analysis, we identified the frameshift mutations of BTN2A1, BTN2A2, and BTNL3 genes in 2, 4, and 8 CCs in microsatellite instability-high (MSI-H) CCs (2.1-8.4% of MSI-H), respectively, but not the microsatellite stable (MSS) CCs...
August 23, 2023: Pathology, Research and Practice
#14
JOURNAL ARTICLE
Ajay Niranjan, Andrew Faramand, Sudesh S Raju, Cheng-Chia Lee, Huai-Che Yang, Ahmed M Nabeel, Sameh R Tawadros, Amr M N El-Shehaby, Khaled Abdelkarim, Reem M Emad, Wael A Reda, Roberto Martínez Álvarez, Nuria E Martínez Moreno, Roman Liscak, Jaromir May, David Mathieu, Anne-Marie Langlois, M Harrison Snyder, Matthew J Shepard, Jason Sheehan, Baha'eddin A Muhsen, Hamid Borghei-Razavi, Gene Barnett, Douglas Kondziolka, John G Golfinos, Luca Attuati, Piero Picozzi, James McInerney, Lekhaj Chand Daggubati, Ronald E Warnick, Caleb E Feliciano, Eric Carro, David McCarthy, Robert M Starke, Howard J Landy, Christopher P Cifarelli, John A Vargo, John Flickinger, L Dade Lunsford
BACKGROUND AND OBJECTIVES: An international, multicenter, retrospective study was conducted to evaluate the long-term clinical outcomes and tumor control rates after stereotactic radiosurgery (SRS) for trigeminal schwannoma. METHODS: Patient data (N = 309) were collected from 14 international radiosurgery centers. The median patient age was 50 years (range 11-87 years). Sixty patients (19%) had prior resections. Abnormal facial sensation was the commonest complaint (49%)...
July 31, 2023: Neurosurgery
#15
JOURNAL ARTICLE
Jae Woong Kim, Ha Yoon Mo, Hyun Ji Son, Nam Jin Yoo, Chang Hyeok Ann, Sug Hyung Lee
Cancer genes are largely categorized into tumor suppressor gene (TSG) and proto-oncogene, but many have dual activities depending on the cellular context. In the present study, we analyzed DYRK1B, ESRP1, MTSS1, ADAMTS1, and INPP5F genes known to possess the dual activities in sporadic colon cancers (CCs). By the mutation analysis, we identified DYRK1B, ESRP1, MTSS1, ADAMTS1, and INPP5F frameshift mutations in 2, 2, 3, 3, and 1 CCs in instability-high (MSI-H) cases (1.1-3.2% of MSI-H CCs), respectively, but not microsatellite stable (MSS) cases...
June 30, 2023: Pathology, Research and Practice
#16
JOURNAL ARTICLE
Firehiwot Workneh, Sitota Tsegaye, Hanna Amanuel, Michelle Eglovitch, Tigest Shifraw, Fisseha Shiferie, Amare W Tadesse, Alemayehu Worku, Sheila Isanaka, Anne Cc Lee, Yemane Berhane
BACKGROUND: Nutrition during pregnancy has lifelong impacts on the mother and fetus. In Ethiopia, nearly a third of pregnant women experience undernutrition. When designing nutrition interventions during pregnancy, it is important to understand existing dietary perspectives and practices in local communities. OBJECTIVES: To explore the processes that shape dietary perspectives and practices during pregnancy in rural West Gojjam and South Gondar Zones of the Amhara region in Ethiopia...
June 2023: Current Developments in Nutrition
#17
JOURNAL ARTICLE
S Anne Kavitha, R Krishna Priya, Krishna Prakash Arunachalam, Siva Avudaiappan, Nelson Maureira-Carsalade, Ángel Roco-Videla
Today, new materials based on natural fibres have been emerging day by day to completely eradicate plastics to favour our environmental nature. In this view, the present work is based on the extraction and characterisation of the novel root fibres of the Zea mays (Zm) plant, grown by the hydroponic method. Both the dried untreated and alkali treated root fibres are investigated using a variety of structural, morphological, thermal, elemental and mechanical tests by subjecting both the samples to p-XRD, FT-IR, SEM-EDAX, TGA-DTA, CHNS and tensile strength analyses...
April 6, 2023: Polymers
#18
JOURNAL ARTICLE
Anna K Radin, Jenny Shaw, Siobhan P Brown, Jessica Torres, Maggie Harper, Hilary Flint, Tara Fouts, Elizabeth McCue, Anton Skeie, Cecelia Peña, Jonathan Youell, Amelia Doty-Jones, Jacob Wilson, Lee Flinn, George Austin, Kwun C G Chan, Zihan Zheng, Martina Fruhbauerova, Michael Walton, Amanda Kerbrat, Katherine Anne Comtois
BACKGROUND: Caring Contacts can effectively reduce suicide ideation, attempts, and death. In published clinical trials, Caring Contacts were sent by someone who knew the recipient. At scale, Caring Contacts programs rarely introduce the recipient and sender. It is not known whether receiving Caring Contacts from someone unknown is as effective as messages from someone the recipient has met. METHODS: Pragmatic randomized controlled trial comparing Caring Contacts with (CC+) versus without an introductory phone call (CC)...
March 22, 2023: Journal of Affective Disorders
#19
JOURNAL ARTICLE
Alison D Gernand, Kelly Gallagher, Nita Bhandari, Patrick Kolsteren, Anne Cc Lee, Yasir Shafiq, Sunita Taneja, James M Tielsch, Firehiwot Workneh Abate, Estifanos Baye, Yemane Berhane, Ranadip Chowdhury, Trenton Dailey-Chwalibóg, Brenda de Kok, Neeta Dhabhai, Fyezah Jehan, Yunhee Kang, Joanne Katz, Subarna Khatry, Carl Lachat, Sarmila Mazumder, Ameer Muhammad, Muhammad Imran Nisar, Sitanshi Sharma, Leigh A Martin, Ravi Prakash Upadhyay, Parul Christian
BACKGROUND: Public health and clinical recommendations are established from systematic reviews and retrospective meta-analyses combining effect sizes, traditionally, from aggregate data and more recently, using individual participant data (IPD) of published studies. However, trials often have outcomes and other meta-data that are not defined and collected in a standardized way, making meta-analysis problematic. IPD meta-analysis can only partially fix the limitations of traditional, retrospective, aggregate meta-analysis; prospective meta-analysis further reduces the problems...
February 11, 2023: BMC Pregnancy and Childbirth
#20
JOURNAL ARTICLE
Bernhard Mlecnik, Alessandro Lugli, Gabriela Bindea, Florence Marliot, Carlo Bifulco, Jiun-Kae Jack Lee, Inti Zlobec, Tilman T Rau, Martin D Berger, Iris D Nagtegaal, Elisa Vink-Börger, Arndt Hartmann, Carol I Geppert, Julie Kolwelter, Susanne Merkel, Robert Grützmann, Marc Van den Eynde, Anne Jouret-Mourin, Alex Kartheuser, Daniel Léonard, Christophe Remue, Julia Wang, Prashant Bavi, Michael H A Roehrl, Pamela S Ohashi, Linh T Nguyen, SeongJun Han, Heather L MacGregor, Sara Hafezi-Bakhtiari, Bradly G Wouters, Giuseppe V Masucci, Emilia K Andersson, Eva Zavadova, Michal Vocka, Jan Spacek, Lubos Petruzelka, Bohuslav Konopasek, Pavel Dundr, Helena Skalova, Kristyna Nemejcova, Gerardo Botti, Fabiana Tatangelo, Paolo Delrio, Gennaro Ciliberto, Michele Maio, Luigi Laghi, Fabio Grizzi, Tessa Fredriksen, Bénédicte Buttard, Lucie Lafontaine, Pauline Maby, Amine Majdi, Assia Hijazi, Carine El Sissy, Amos Kirilovsky, Anne Berger, Christine Lagorce, Christopher Paustian, Carmen Ballesteros-Merino, Jeroen Dijkstra, Carlijn van de Water, Shannon van Lent-van Vliet, Nikki Knijn, Ana-Maria Mușină, Dragos-Viorel Scripcariu, Boryana Popivanova, Mingli Xu, Tomonobu Fujita, Shoichi Hazama, Nobuaki Suzuki, Hiroaki Nagano, Kiyotaka Okuno, Toshihiko Torigoe, Noriyuki Sato, Tomohisa Furuhata, Ichiro Takemasa, Prabhu Patel, Hemangini H Vora, Birva Shah, Jayendrakumar B Patel, Kruti N Rajvik, Shashank J Pandya, Shilin N Shukla, Yili Wang, Guanjun Zhang, Yutaka Kawakami, Francesco M Marincola, Paolo A Ascierto, Bernard A Fox, Franck Pagès, Jérôme Galon
BACKGROUND: The prognostic value of Immunoscore was evaluated in Stage II/III colon cancer (CC) patients, but it remains unclear in Stage I/II, and in early-stage subgroups at risk. An international Society for Immunotherapy of Cancer (SITC) study evaluated the pre-defined consensus Immunoscore in tumors from 1885 AJCC/UICC-TNM Stage I/II CC patients from Canada/USA (Cohort 1) and Europe/Asia (Cohort 2). METHODS: Digital-pathology is used to quantify the densities of CD3+ and CD8+ T-lymphocyte in the center of tumor (CT) and the invasive margin (IM)...
January 8, 2023: Cancers
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