Haifa Lyster, Timothy Pitt, Olaf Maunz, Suzanne Diamond, Jason A Roberts, David Brown, Jeremy Mills, Darius Armstrong-James, Vicky Gerovasili, Martin Carby, John Dunning, Andre Simon, Anna Reed
Fungal infections are common and frequently associated with clinical failure in patients receiving extracorporeal membrane oxygenation (ECMO). Antifungal drugs have physicochemical characteristics associated with a higher likelihood of sequestration onto ECMO circuitry potentially leading to a subtherapeutic drug concentration. The percentage of sequestration of the antifungal drugs-caspofungin, posaconazole, and voriconazole-was determined using an ex vivo ECMO model. The circuits were primed with whole human blood, sodium chloride 0...
March 1, 2023: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs