Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#61
REVIEW
Jason A Roberts, Rinaldo Bellomo, Menino O Cotta, Birgit C P Koch, Haifa Lyster, Marlies Ostermann, Claire Roger, Kiran Shekar, Kevin Watt, Mohd H Abdul-Aziz
Intensive care unit (ICU) patients with end-organ failure will require specialised machines or extracorporeal therapies to support the failing organs that would otherwise lead to death. ICU patients with severe acute kidney injury may require renal replacement therapy (RRT) to remove fluid and wastes from the body, and patients with severe cardiorespiratory failure will require extracorporeal membrane oxygenation (ECMO) to maintain adequate oxygen delivery whilst the underlying pathology is evaluated and managed...
October 2022: Intensive Care Medicine
#62
JOURNAL ARTICLE
Carrigan Belcher, Vivek Kataria, Klayton M Ryman, Xuan Wang, Joon Yong Moon, Ariel Modrykamien, Adan Mora
Purpose: To evaluate unfractionated heparin (UFH) dosing guided by antifactor Xa levels during targeted temperature management (TTM) post-cardiac arrest. Methods: Single-center, retrospective, observational study between January 1, 2014 and September 1, 2020. Patients initiated on TTM post-cardiac arrest and UFH were evaluated for inclusion. Patients included were ≥18 years of age and received weight-based UFH for ≥6 hours with 2 antifactor Xa levels drawn at target temperature...
August 2022: Hospital Pharmacy
#63
JOURNAL ARTICLE
Pinyo Rattanaumpawan, Supunnee Jirajariyavej, Kanokorn Lerdlamyong, Nattawan Palavutitotai, Jatuporn Saiyarin
Favipiravir is a broad-spectrum oral antiviral agent that shows in vitro activity against SARS-CoV-2. Presently, data on the real-world effectiveness and optimal dosage of favipiravir for treating COVID-19 are limited. We conducted a retrospective observational study of hospitalized adult patients with COVID-19 at five tertiary care hospitals in Thailand. We reviewed patient charts to obtain all necessary data. Among 247 COVID-19 patients, 63 (23.0%) received ≥1 dose of favipiravir. Of these 63 patients, 61...
June 15, 2022: Antibiotics
#64
JOURNAL ARTICLE
Lisa Kriegl, Stefan Hatzl, Christoph Zurl, Alexander Christian Reisinger, Gernot Schilcher, Philipp Eller, Yvonne Gringschl, Tina Muhr, Andreas Meinitzer, Juergen Prattes, Martin Hoenigl, Robert Krause
BACKGROUND: Isavuconazole is an antifungal drug used for treatment of invasive fungal infections. Critically ill COVID-19 and influenza patients require extracorporeal membrane oxygenation (ECMO) in cases with severe acute respiratory distress syndrome and have risk factors for invasive pulmonary aspergillosis. Little is known about isavuconazole plasma concentrations during ECMO. OBJECTIVES: To determine isavuconazole plasma concentrations in seven patients treated with intravenous isavuconazole under ECMO and the influence of the ECMO circuit immediately after the first isavuconazole dose...
August 25, 2022: Journal of Antimicrobial Chemotherapy
#65
Danyang Peng, Fan Zhang, Pin Lv, Yinyin Chen, Jianxu Yang, Wenliang Zhu, Shichao Zhu, Huanzhang Shao
Background: Polymyxins antibiotics have become the first-line clinical drugs in the treatment of refractory gram-negative bacterial infections. Currently, there is a lack of clinical studies on the effect of extracorporeal membrane oxygenation (ECMO) combined with continuous renal replacement therapy (CRRT) on polymyxin concentrations. The purpose of this report was to investigate the changes in the plasma concentrations of Colistin sulfate during ECMO and CRRT and to provide drug administration programs for critically ill patients receiving ECMO and CRRT...
May 2022: Annals of Translational Medicine
#66
JOURNAL ARTICLE
Comparison of Standard-Dose Versus High-Dose Dexmedetomidine in Extracorporeal Membrane Oxygenation.
Erika L Zarfoss, Jeffrey Garavaglia, J W Awori Hayanga, Galen Kabulski
BACKGROUND: Dexmedetomidine is commonly used to achieve light sedation in patients on extracorporeal membrane oxygenation (ECMO) despite minimal evidence. In vivo studies have shown dexmedetomidine sequestration in ECMO circuits, and higher doses may be used to overcome sequestration. OBJECTIVE: The purpose of this study was to compare safety and efficacy of dexmedetomidine at standard versus high doses in ECMO. METHODS: A retrospective analysis of adult ECMO patients was performed...
June 9, 2022: Annals of Pharmacotherapy
#67
JOURNAL ARTICLE
Mickaël Lescroart, Claire Pressiat, Benjamin Péquignot, N'Guyen Tran, Jean-Louis Hébert, Nassib Alsagheer, Nicolas Gambier, Bijan Ghaleh, Julien Scala-Bertola, Bruno Levy
BACKGROUND: Adjusting drug therapy under veno-venous extracorporeal membrane oxygenation (VV ECMO) is challenging. Although impaired pharmacokinetics (PK) under VV ECMO have been reported for sedative drugs and antibiotics, data about amiodarone are lacking. We evaluated the pharmacokinetics of amiodarone under VV ECMO both in vitro and in vivo. METHODS: In vitro: Amiodarone concentration decays were compared between closed-loop ECMO and control stirring containers over a 24 h period...
April 30, 2022: Pharmaceutics
#68
JOURNAL ARTICLE
Dzenefa Alihodzic, Sebastian G Wicha, Otto R Frey, Christina König, Michael Baehr, Dominik Jarczak, Stefan Kluge, Claudia Langebrake
Extracorporeal membrane oxygenation (ECMO) is utilized to temporarily sustain respiratory and/or cardiac function in critically ill patients. Ciprofloxacin is used to treat nosocomial infections, but data describing the effect of ECMO on its pharmacokinetics is lacking. Therefore, a prospective, observational trial including critically ill adults ( n = 17), treated with ciprofloxacin (400 mg 8-12 hourly) during ECMO, was performed. Serial blood samples were collected to determine ciprofloxacin concentrations to assess their pharmacokinetics...
April 29, 2022: Pharmaceutics
#69
JOURNAL ARTICLE
Truong Vu, Joel Feih, Janelle Juul
BACKGROUND: Patients requiring extracorporeal membrane oxygenation (ECMO) demonstrate complex drug pharmacokinetics due to alterations in clearance and volume of distribution, necessitating close therapeutic drug monitoring. CASE REPORT: A 19-year-old Caucasian female with no past medical history was transferred from an outside hospital and admitted to the intensive care unit for acute respiratory distress syndrome secondary to a fresh water drowning event . The patient decompensated, requiring veno-arterial ECMO, which was subsequently changed to veno-venous ECMO...
May 25, 2022: Journal of Pharmacy Practice
#70
JOURNAL ARTICLE
Abigail K Kois, Jason A Gluck, David P Nicolau, Joseph L Kuti
This study determined the pharmacokinetics of cefepime in patients requiring extracorporeal membrane oxygenation (ECMO) support to guide dosage selection. Cefepime population pharmacokinetics where characterized in Pmetrics for R for six critically ill patients receiving ECMO. Simulation was employed to determine the fT>MIC and total trough concentration of varying regimens in each patient to evaluate ability to achieve optimal pharmacodynamic exposure and thresholds for cefepime-associated neurotoxicity...
July 2022: International Journal of Antimicrobial Agents
#71
JOURNAL ARTICLE
Vesa Cheng, Mohd H Abdul-Aziz, Fay Burrows, Hergen Buscher, Amanda Corley, Arne Diehl, Bianca J Levkovich, Vincent Pellegrino, Claire Reynolds, Sam Rudham, Steven C Wallis, Susan A Welch, Jason A Roberts, Kiran Shekar, John F Fraser
INTRODUCTION: This study aimed to describe the pharmacokinetics (PK) of ciprofloxacin in critically ill patients receiving ECMO and recommend a dosing regimen that provides adequate drug exposure. METHODS: Serial blood samples were taken from ECMO patients receiving ciprofloxacin. Total ciprofloxacin concentrations were measured by chromatographic assay and analysed using a population PK approach with Pmetrics®. Dosing simulations were performed to ascertain the probability of target attainment (PTA) represented by the area under the curve to minimum inhibitory concentration ratio (AUC0-24 /MIC) ≥ 125...
April 23, 2022: Anaesthesia, Critical Care & Pain Medicine
#72
JOURNAL ARTICLE
Michelle Miller, Geena Kludjian, Kerry Mohrien, Kazumi Morita
PURPOSE: We present the case of a 56-year-old man with stage IV sarcoidosis on veno-venous extracorporeal membrane oxygenation (VV-ECMO) support for the management of respiratory failure receiving treatment with isavuconazole for invasive aspergillosis. SUMMARY: VV-ECMO is an increasingly utilized life support therapy for patients with cardiac and/or respiratory failure, but its impact on medication dosing is poorly understood. In our patient with invasive Aspergillus infection receiving VV-ECMO, because of difficulty achieving therapeutic serum concentrations of voriconazole, we administered isavuconazole 372 mg intravenously (IV) every 8 hours for 6 doses followed by 372 mg IV once daily...
July 22, 2022: American Journal of Health-system Pharmacy: AJHP
#73
JOURNAL ARTICLE
Adham Mohamed, Timothy P Berry, Julie A Welge, Elizabeth L Thomas, Larisa Zhurav, Jonathan Kozinn, Michelle M Haines
OBJECTIVES: To describe angiotensin II (ANGII) use in patients on mechanical circulatory support (MCS). To evaluate the efficacy and safety of ANGII in patients with shock on MCS. DESIGN: Retrospective cohort study. SETTING: A single-center, quaternary care academic medical center. PARTICIPANTS: The study comprised critically ill patients on MCS. INTERVENTIONS: None. MEASUREMENTS AND MAIN RESULTS: Fourteen patients were included in this retrospective analysis...
January 7, 2022: Journal of Cardiothoracic and Vascular Anesthesia
#74
REVIEW
Heather Torbic, Benjamin Hohlfelder, Sudhir Krishnan, Adriano R Tonelli
BACKGROUND: Little data is published describing the use of medications prescribed for pulmonary arterial hypertension (PAH) in patients receiving extracorporeal membrane oxygenation (ECMO). Even though many patients with PAH may require ECMO as a bridge to transplant or recovery, little is reported regarding the use of PAH medications in this setting. METHODS: This retrospective case series summarizes the clinical experience of 8 patients with PAH receiving ECMO and reviews medication management in the setting of ECMO...
2022: Journal of Cardiovascular Pharmacology and Therapeutics
#75
Crystal Ives Tallman, Yu Zhang, Nicholas Black, Kara Lynch, Mohamed Fayed, Patil Armenian
Metformin overdose may result in vasodilatory shock, lactic acidosis and death. Hemodialysis is an effective means of extracorporeal elimination, but may be insufficient in the shock setting. We present a case of a 39 yo male who presented with hypotension, coma, hypoglycemia, and lactate of 6.5 mmol/L after ingesting an unknown medication. Metformin overdose was suspected, and he was started on hemodialysis. He developed profound vasoplegia refractory to high doses of norepinephrine, vasopressin, epinephrine and phenylephrine...
2022: Toxicology Reports
#76
JOURNAL ARTICLE
Cierra A Frazier, Brittany M Scott, Peter N Johnson, Joseph M LaRochelle
OBJECTIVE: The purpose was to characterize antimicrobial and anticoagulation therapies used in health systems with children receiving extracorporeal membrane oxygenation (ECMO). METHODS: An anonymous electronic survey assessing health system demographics and antimicrobial and anticoagulation therapies during ECMO was distributed to the American College of Clinical Pharmacy Pediatric Practice and Research Network and the Pediatric Pharmacy Association Critical Care Special Interest Group...
2022: Journal of Pediatric Pharmacology and Therapeutics: JPPT: the Official Journal of PPAG
#77
JOURNAL ARTICLE
Xiao-Bin Lin, Xiao-Guang Hu, Yan-Zhe Xia, Xiao-Man Liu, Tao Liang, Xiao Chen, Chang-Jie Cai
The pharmacokinetics (PK) of several drugs including antimicrobials might be highly altered during extracorporeal membrane oxygenation (ECMO) therapy. We present the change of voriconazole (VRC) PK during ECMO in a critically ill patient who received intravenous VRC at a maintenance dose of 200 mg every 12 h for empirical antifungal therapy. Two PK profiles were drawn before and after the initiation of ECMO therapy. Though the trough levels (both C 0 and C 12 ) with ECMO were slightly lower than that without ECMO (12...
July 2022: Journal of Chemotherapy
#78
JOURNAL ARTICLE
Dongngan T Truong, Audrey Dionne, Juan Carlos Muniz, Kimberly E McHugh, Michael A Portman, Linda M Lambert, Deepika Thacker, Matthew D Elias, Jennifer S Li, Olga H Toro-Salazar, Brett R Anderson, Andrew M Atz, C Monique Bohun, M Jay Campbell, Maryanne Chrisant, Laura D'Addese, Kirsten B Dummer, Daniel Forsha, Lowell H Frank, Olivia H Frosch, Sarah K Gelehrter, Therese M Giglia, Camden Hebson, Supriya S Jain, Pace Johnston, Anita Krishnan, Kristin C Lombardi, Brian W McCrindle, Elizabeth C Mitchell, Koichi Miyata, Trent Mizzi, Robert M Parker, Jyoti K Patel, Christina Ronai, Arash A Sabati, Jenna Schauer, S Kristen Sexson Tejtel, J Ryan Shea, Lara S Shekerdemian, Shubhika Srivastava, Jodie K Votava-Smith, Sarah White, Jane W Newburger
BACKGROUND: Understanding the clinical course and short-term outcomes of suspected myocarditis after the coronavirus disease 2019 (COVID-19) vaccination has important public health implications in the decision to vaccinate youth. METHODS: We retrospectively collected data on patients <21 years old presenting before July 4, 2021, with suspected myocarditis within 30 days of COVID-19 vaccination. Lake Louise criteria were used for cardiac MRI findings. Myocarditis cases were classified as confirmed or probable on the basis of the Centers for Disease Control and Prevention definitions...
February 2022: Circulation
#79
JOURNAL ARTICLE
Amandine Polain, Julie Gorham, Immacolata Romeo, Mirko Belliato, Lorenzo Peluso, Francesco Partipilo, Hassane Njimi, Alexandre Brasseur, Frederique Jacobs, Jacques Creteur, Maya Hites, Fabio Silvio Taccone
BACKGROUND: The aim of this study was to identify predictors of insufficient beta-lactam concentrations in patients undergoing extracorporeal membrane oxygenation (ECMO). METHODS: Retrospective analysis of all patients receiving ECMO support and treated with ceftazidime or cefepime (CEF), piperacillin/tazobactam (TZP), or meropenem (MEM). Trough drug concentrations (Cmin ) were measured before the subsequent dose, according to the decision of the attending physician...
October 25, 2021: Microorganisms
#80
JOURNAL ARTICLE
Dong-Hwan Lee, Hyoung-Soo Kim, Sunghoon Park, Hwan-Il Kim, Sun-Hee Lee, Yong-Kyun Kim
Limited studies have investigated population pharmacokinetic (PK) models and optimal dosage regimens of meropenem for critically ill adult patients using the probability of target attainment, including patients receiving extracorporeal membrane oxygenation (ECMO). A population PK analysis was conducted using non-linear mixed-effect modeling. Monte Carlo simulation was used to determine for how long the free drug concentration was above the minimum inhibitory concentration (MIC) at steady state conditions in patients with various degrees of renal function...
November 4, 2021: Pharmaceutics
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
