Johannes Schetelig, Henning Baldauf, Falk Heidenreich, Jorinde D Hoogenboom, Stephen R Spellman, Alexander Kulagin, Thomas Schroeder, Henrik Sengeloev, Peter Dreger, Edouard Forcade, Jan Vydra, Eva Maria Wagner-Drouet, Goda Choi, Shankara Paneesha, Nuno A A Miranda, Alina Tanase, Liesbeth C de Wreede, Vinzenz Lange, Alexander H Schmidt, Jürgen Sauter, Joshua A Fein, Yung-Tsi Bolon, Meilun He, Steven G E Marsh, Shahinaz M Gadalla, Sophie Paczesny, Annalisa Ruggeri, Christian Chabannon, Katharina Fleischhauer
Optimizing natural killer (NK) cell alloreactivity could further improve outcome after allogeneic hematopoietic cell transplantation (alloHCT). The donor's Killer-cell Immunoglobulin-like Receptor (KIR) genotype may provide important information in this regard. In the past decade, different models have been proposed aiming at maximizing NK cell activation by activating KIR-ligand interactions or minimizing inhibitory KIR-ligand interactions. Alternative classifications intended predicting outcome after alloHCT by donor KIR-haplotypes...
2024: Frontiers in Immunology