Ricardo de Souza Tesch, Esther Rieko Takamori, Karla Menezes, Rosana Bizon Vieira Carias, Carmen Lucia Kuniyoshi Rebelatto, Alexandra Cristina Senegaglia, Debora Regina Daga, Leticia Fracaro, Anny Waloski Robert, Carlos Bruno Reis Pinheiro, Marcelo de Freitas Aguiar, Pablo Javier Blanco, Eduardo Guerreiro Zilves, Paulo Roberto Slud Brofman, Radovan Borojevic
Condylar resorption is an aggressive and disability form of temporomandibular joint (TMJ) degenerative disease, usually non-respondent to conservative or minimally invasive therapies and often leading to surgical intervention and prostheses implantation. This condition is also one of the most dreaded postoperative complications of orthognathic surgery, with severe cartilage erosion and loss of subchondral bone volume and mineral density, associated with a painful or not inflammatory processes. Because regenerative medicine has emerged as an alternative for orthopedic cases with advanced degenerative joint disease, we conducted a phase I/IIa clinical trial (U1111-1194-6997) to evaluate the safety and efficacy of autologous nasal septal chondroprogenitor cells...
April 12, 2024: Stem Cells Translational Medicine