Florian Heinen, Petr Kaňovský, A Sebastian Schroeder, Henry G Chambers, Edward Dabrowski, Thorin L Geister, Angelika Hanschmann, Francisco J Martinez-Torres, Irena Pulte, Marta Banach, Deborah Gaebler-Spira
PURPOSE: Investigate the efficacy and safety of multipattern incobotulinumtoxinA injections in children/adolescents with lower-limb cerebral palsy (CP)-related spasticity. METHODS: Phase 3 double-blind study in children/adolescents (Gross Motor Function Classification System - Expanded and Revised I-V) with unilateral or bilateral spastic CP and Ashworth Scale (AS) plantar flexor (PF) scores ⩾ 2 randomized (1:1:2) to incobotulinumtoxinA (4, 12, 16 U/kg, maximum 100, 300, 400 U, respectively) for two 12- to 36-week injection cycles...
June 5, 2021: Journal of Pediatric Rehabilitation Medicine