Luca Canciani, Cristina Giaroni, Elena Zanetti, Daniela Giuliani, Rossana Pisani, Elisabetta Moro, Marco Trinchera, Francesca Crema, Sergio Lecchini, Gianmario Frigo
The existence of a functional interplay between alpha(2)-adrenoceptor and opioid receptor inhibitory pathways modulating neurotransmitter release has been demonstrated in the enteric nervous system by development of sensitivity changes to alpha(2)-adrenoceptor, mu- and kappa-opioid receptor agents on enteric cholinergic neurons after chronic sympathetic denervation. In the present study, to further examine this hypothesis we evaluated whether manipulation of alpha(2)-adrenoceptor pathways by chronic treatment with the antidepressant drug, desipramine (10 mg/kg i...
December 28, 2006: European Journal of Pharmacology