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JOURNAL ARTICLE
Lanbo Z Yang, Kavya G Sundar, Mary Catherine Cambou, Emma J Swayze, Eddy R Segura, Marineide Gonçalves de Melo, Breno Riegel Santos, Ivana Rosângela Dos Santos Varella, Karin Nielsen-Saines
BACKGROUND: Syphilis co-infection among pregnant people living with HIV (PLH) may worsen pregnancy outcomes. We evaluated the impact of syphilis co-infection on pregnancies in south Brazil. METHODS: Data was extracted from hospital records between 1/1/2008 -12/31/2018. Preterm birth (PTB), low birth weight (LBW < 2500 g), and a composite adverse infant outcome [AIO: HIV vertical transmission, loss to follow-up before HIV diagnosis (LTFU), stillbirth, congenital syphilis] were evaluated among pregnancies without HIV and syphilis (PWOH+S), PLH mono-infection, syphilis mono-infection (PLS), and PLH with syphilis (PLH + S)...
May 1, 2024: Sexually Transmitted Diseases
#2
JOURNAL ARTICLE
Robin P Goin-Kochel, Ivana Lozano, Gabrielle Duhon, Gabriela Marzano, Amy Daniels, J Kiely Law, Katharine Diehl, LeeAnne Green Snyder, Pamela Feliciano, Wendy K Chung
INTRODUCTION: Under enrollment of participants in clinical research is costly and delays study completion to impact public health. Given that research personnel make decisions about which strategies to pursue and participants are the recipients of these efforts, we surveyed research staff ( n = 52) and participants ( n = 4,144) affiliated with SPARK (Simons Foundation Powering Autism for Knowledge) - the largest study of autism in the U.S. - to understand their perceptions of effective recruitment strategies...
2024: Journal of Clinical and Translational Science
#3
EDITORIAL
Ivana Škrlec, Sergey N Kolomeichuk
Hypoxia-inducible factor 1 (HIF1) has a crucial function in the regulation of oxygen levels in mammalian cells, especially under hypoxic conditions. Its importance in cardiovascular diseases, particularly in cardiac ischemia, is because of its ability to alleviate cardiac dysfunction. The oxygen-responsive subunit, HIF1α, plays a crucial role in this process, as it has been shown to have cardioprotective effects in myocardial infarction through regulating the expression of genes affecting cellular survival, angiogenesis, and metabolism...
April 26, 2024: World Journal of Cardiology
#4
JOURNAL ARTICLE
Jacob M Keaton, Zoha Kamali, Tian Xie, Ahmad Vaez, Ariel Williams, Slavina B Goleva, Alireza Ani, Evangelos Evangelou, Jacklyn N Hellwege, Loic Yengo, William J Young, Matthew Traylor, Ayush Giri, Zhili Zheng, Jian Zeng, Daniel I Chasman, Andrew P Morris, Mark J Caulfield, Shih-Jen Hwang, Jaspal S Kooner, David Conen, John R Attia, Alanna C Morrison, Ruth J F Loos, Kati Kristiansson, Reinhold Schmidt, Andrew A Hicks, Peter P Pramstaller, Christopher P Nelson, Nilesh J Samani, Lorenz Risch, Ulf Gyllensten, Olle Melander, Harriette Riese, James F Wilson, Harry Campbell, Stephen S Rich, Bruce M Psaty, Yingchang Lu, Jerome I Rotter, Xiuqing Guo, Kenneth M Rice, Peter Vollenweider, Johan Sundström, Claudia Langenberg, Martin D Tobin, Vilmantas Giedraitis, Jian'an Luan, Jaakko Tuomilehto, Zoltan Kutalik, Samuli Ripatti, Veikko Salomaa, Giorgia Girotto, Stella Trompet, J Wouter Jukema, Pim van der Harst, Paul M Ridker, Franco Giulianini, Veronique Vitart, Anuj Goel, Hugh Watkins, Sarah E Harris, Ian J Deary, Peter J van der Most, Albertine J Oldehinkel, Bernard D Keavney, Caroline Hayward, Archie Campbell, Michael Boehnke, Laura J Scott, Thibaud Boutin, Chrysovalanto Mamasoula, Marjo-Riitta Järvelin, Annette Peters, Christian Gieger, Edward G Lakatta, Francesco Cucca, Jennie Hui, Paul Knekt, Stefan Enroth, Martin H De Borst, Ozren Polašek, Maria Pina Concas, Eulalia Catamo, Massimiliano Cocca, Ruifang Li-Gao, Edith Hofer, Helena Schmidt, Beatrice Spedicati, Melanie Waldenberger, David P Strachan, Maris Laan, Alexander Teumer, Marcus Dörr, Vilmundur Gudnason, James P Cook, Daniela Ruggiero, Ivana Kolcic, Eric Boerwinkle, Michela Traglia, Terho Lehtimäki, Olli T Raitakari, Andrew D Johnson, Christopher Newton-Cheh, Morris J Brown, Anna F Dominiczak, Peter J Sever, Neil Poulter, John C Chambers, Roberto Elosua, David Siscovick, Tõnu Esko, Andres Metspalu, Rona J Strawbridge, Markku Laakso, Anders Hamsten, Jouke-Jan Hottenga, Eco de Geus, Andrew D Morris, Colin N A Palmer, Ilja M Nolte, Yuri Milaneschi, Jonathan Marten, Alan Wright, Eleftheria Zeggini, Joanna M M Howson, Christopher J O'Donnell, Tim Spector, Mike A Nalls, Eleanor M Simonsick, Yongmei Liu, Cornelia M van Duijn, Adam S Butterworth, John N Danesh, Cristina Menni, Nicholas J Wareham, Kay-Tee Khaw, Yan V Sun, Peter W F Wilson, Kelly Cho, Peter M Visscher, Joshua C Denny, Daniel Levy, Todd L Edwards, Patricia B Munroe, Harold Snieder, Helen R Warren
Hypertension affects more than one billion people worldwide. Here we identify 113 novel loci, reporting a total of 2,103 independent genetic signals (P < 5 × 10-8 ) from the largest single-stage blood pressure (BP) genome-wide association study to date (n = 1,028,980 European individuals). These associations explain more than 60% of single nucleotide polymorphism-based BP heritability. Comparing top versus bottom deciles of polygenic risk scores (PRSs) reveals clinically meaningful differences in BP (16...
April 30, 2024: Nature Genetics
#5
JOURNAL ARTICLE
Marco Panizzolo, Francesco Barbero, Federica Ghelli, Giacomo Garzaro, Valeria Bellisario, Irina Guseva Canu, Ivana Fenoglio, Enrico Bergamaschi, Roberto Bono
The widespread and increasing use of nanomaterials has resulted in a higher likelihood of exposure by inhalation for nanotechnology workers. However, tracking the internal dose of nanoparticles deposited at the airways level, is still challenging. To assess the suitability of particle number concentration determination as biomarker of internal dose, we carried out a cross sectional investigation involving 80 workers handling nanomaterials. External exposure was characterized by portable counters of particles DISCminiTM (Testo, DE), allowing to categorize 51 workers as exposed and 29 as non-exposed (NE) to nanoparticles...
April 28, 2024: Chemosphere
#6
JOURNAL ARTICLE
Ivana Petrovic, Jonathan LoPresti, Shireen Fatemi, Andrew Gianoukakis, Kenneth Burman, Cristiane J Gomez-Lima, Caroline T Nguyen, Carole Ann Spencer
CONTEXT: Serum thyroglobulin (Tg) measured by Immunometric assays (IMA) is prone to underestimation due to Tg autoantibody (TgAb) interference, often prompting reflex Tg measurement by liquid chromatography/tandem mass spectrometry (MS) or radioimmunoassay (RIA). OBJECTIVE: IMA, MS and RIA methodologies were used to measure serum Tg in TgAb-negative (TgAb-) and TgAb-positive (TgAb+) patients with either distant metastatic thyroid cancer (DTC) or hyperthyroidism (HY) - patients in whom a detectable serum Tg would be expected...
April 30, 2024: Journal of Clinical Endocrinology and Metabolism
#7
JOURNAL ARTICLE
Iva Stojan, Danijela Šantić, Cristian Villena-Alemany, Željka Trumbić, Frano Matić, Ana Vrdoljak Tomaš, Ivana Lepen Pleić, Kasia Piwosz, Grozdan Kušpilić, Živana Ninčević Gladan, Stefanija Šestanović, Mladen Šolić
BACKGROUND: Aerobic anoxygenic phototrophs are metabolically highly active, diverse and widespread polyphyletic members of bacterioplankton whose photoheterotrophic capabilities shifted the paradigm about simplicity of the microbial food chain. Despite their considerable contribution to the transformation of organic matter in marine environments, relatively little is still known about their community structure and ecology at fine-scale taxonomic resolution. Up to date, there is no comprehensive (i...
April 29, 2024: Environmental microbiome
#8
REVIEW
Ivana Chim, Ragini Ghiya, Rodney D Sinclair, Samantha Eisman
INTRODUCTION: Alopecia areata (AA) is an immune-mediated disease that causes non-scarring hair loss. While acute, solitary patches often spontaneously remit, developing secondary patches or failure of the disease to resolve within 6-12 months predicts a poor prognosis, with an increased risk of alopecia totalis or universalis. Chronic AA increases the risk of depression and suicidality and reduces quality of life. Treatment options for chronic or acute diffuse AA were previously limited to corticosteroids and traditional immunomodulators...
April 29, 2024: Expert Opinion on Investigational Drugs
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JOURNAL ARTICLE
Ivana R Raslan, Thiago Yoshinaga Tonholo Silva, Fernando Kok, Marcelo M Rodrigues, Marcelo M Aragão, Ricardo S Pinho, Marcondes C França, Orlando G Barsottini, José Luiz Pedroso
BACKGROUND AND OBJECTIVES: Congenital ataxias are rare hereditary disorders characterized by hypotonia and developmental motor delay in the first few months of life, followed by cerebellar ataxia in early childhood. The course of the disease is predominantly nonprogressive, and many patients are incorrectly diagnosed with cerebral palsy. Despite significant advancements in next-generation sequencing in the past few decades, a specific genetic diagnosis is seldom obtained in cases of congenital ataxia...
June 2024: Neurology. Genetics
#10
JOURNAL ARTICLE
Ivana Generalić Mekinić, Olivera Politeo, Ivica Ljubenkov, Linda Mastelić, Marijana Popović, Maja Veršić Bratinčević, Vida Šimat, Sanja Radman, Danijela Skroza, Tonka Ninčević Runjić, Marko Runjić, Gvozden Dumičić, Branimir Urlić
Extreme environmental conditions affect the synthesis and accumulation of bioactive metabolites in halophytic plants. The aim of this study was to investigate the presence and quantity of key health-promoting phytochemicals in Croatian sea fennel, one of the most popular Mediterranean halophytes with a wide range of uses. The EOs were characterised by a high content of limonene (up to 93%), while the fatty acid profile shows a low content of oleic acid and the presence of valuable linoleic acid (ω-6) and linolenic acid (ω-3) in high percentages...
June 30, 2024: Food chemistry: X
#11
REVIEW
Felipe Alves De Lima, Fernando Liberalino Fernandes, Daria Raquel Queiroz De Almeida, Amanda Estevam Carvalho, Valéria Duarte Almeida, Gilson Aquino Cavalcante, Nickson Melo De Morais, Tayline Dantas Rodrigues, Ellany Gurgel Cosme Do Nascimento, Ivana Teixeira De Oliveira, Christiane Medeiros Bezerra, Jose Verissimo Fernandes, Thales Thales Allyrio Araujo De Medeiros Fernandes
BACKGROUND: Osteosarcoma is the most common primary malignant bone tumor, mainly affecting children, young adults, and the elderly. It is an aggressive cancer with a poor prognosis, exhibiting low survival rates even with standard treatment. Recently, circular RNA molecules capable of influencing gene expression through various functions, with their main role being acting as microRNA sponges and reducing their intracellular expression, have been identified. Recent studies have linked circular RNAs to osteosarcoma development and progression...
April 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
#12
JOURNAL ARTICLE
Alma Lucia Villela Zumaya, Vladimíra Svobodová Pavlíčková, Silvie Rimpelová, Markéta Štějdířová, Michal Fulem, Ivana Křížová, Pavel Ulbrich, Pavel Řezanka, Fatima Hassouna
Improving the anticancer efficacy of chemotherapeutic drugs and photosensitizers requires innovative multifunctional nanoplatforms. This study introduces a chemo- and phototherapeutic drug delivery system (DDS) based on poly(lactide-co-glycolide) (PLGA) nanoparticles (NPs), both PEGylated and non-PEGylated, with a mean size of 200 ± 75nm. Colchicine (Colch) and purpurin18 (P18) were co-encapsulated into these NPs, and their in vitro drug release profiles were investigated. The anticancer potential of these systems was evaluated across various cell lines (i...
April 26, 2024: International Journal of Pharmaceutics
#13
JOURNAL ARTICLE
Jan Miroslav Hartinger, Martin Šíma, Zdenka Hrušková, Alena Pilková, Vojtěch Krátký, Romana Ryšavá, Eva Jančová, Daniel Bobek, Jiří Douša, Ivana Francová, Vladimír Tesař, Ondřej Slanař
OBJECTIVES: Rituximab is being increasingly prescribed for the treatment of autoimmune glomerular diseases. While it is highly effective for some diseases, the response is less predictable for others, which may be due to differing requirements in terms of the dosing according to the disease type and variations concerning exposure to the drug. METHODS: We compiled novel rituximab dosing schedules according to pharmacokinetic analysis of data gathered from rituximab treated patients in a tertiary referral nephrology centre between May 2020 and June 2023...
April 27, 2024: Biomedicine & Pharmacotherapy
#14
JOURNAL ARTICLE
Astrid Marchal, Elizabeth T Cirulli, Iva Neveux, Evangelos Bellos, Ryan S Thwaites, Kelly M Schiabor Barrett, Yu Zhang, Ivana Nemes-Bokun, Mariya Kalinova, Andrew Catchpole, Stuart G Tangye, András N Spaan, Justin B Lack, Jade Ghosn, Charles Burdet, Guy Gorochov, Florence Tubach, Pierre Hausfater, Clifton L Dalgard, Shen-Ying Zhang, Qian Zhang, Christopher Chiu, Jacques Fellay, Joseph J Grzymski, Vanessa Sancho-Shimizu, Laurent Abel, Jean-Laurent Casanova, Aurélie Cobat, Alexandre Bolze
Human genetic studies of critical COVID-19 pneumonia have revealed the essential role of type I interferon-dependent innate immunity to SARS-CoV-2 infection. Conversely, an association between the HLA-B*15:01 allele and asymptomatic SARS-CoV-2 infection in unvaccinated individuals was recently reported, suggesting a contribution of pre-existing T cell-dependent adaptive immunity. We report a lack of association of classical HLA alleles, including HLA-B*15:01, with pre-omicron asymptomatic SARS-CoV-2 infection in unvaccinated participants in a prospective population-based study in the US (191 asymptomatic vs...
April 26, 2024: HGG advances
#15
Silvia Farkašová Iannaccone, Ivana Kholová, Alžbeta Ginelliová, Lucia Fröhlichová, Daniel Farkaš
We report an unexpected death of a 22-year-old primigravida who was admitted to the hospital with sudden abdominal pain two days before a scheduled delivery. During an emergency caesarean section due to intrauterine asphyxia, intraabdominal bleeding was observed with no apparent source of bleeding. Newly formed blood clots in the subdiaphragmatic space and arterial bleeding near the splenic hilum required a surgery on the next day. Hemorrhagic shock led to multiple organ failure on the fourth day of admission...
April 25, 2024: Cardiovascular Pathology: the Official Journal of the Society for Cardiovascular Pathology
#16
JOURNAL ARTICLE
Hifa Salah Adeen Embirsh, Marija M Vuksanović, Ivana O Mladenović, Nataša Knežević, Milena Milošević, Slavko Mijatov, Radmila Jančić Heinemann, Aleksandar Marinković
Materials from green resources boast a low carbon footprint, forming the foundation of the circular economy approach in materials science. Thus, in this study, waste poly(ethylene terephthalate) (PET) was subjected to depolymerization using propylene glycol (PG), and subsequent polycondensation with bio-based maleic anhydride (MA) produced unsaturated polyester resin (b-UPR). Bio-derived acryloyl-modified Kraft lignin (Kf L-A) served as a vinyl reactive filler in the b-UPR matrix to create b-UPR/Kf L-A composites...
April 25, 2024: Chemosphere
#17
JOURNAL ARTICLE
Ivana Adamov, Gordana Stanojević, Stefan M Pavlović, Djordje Medarević, Branka Ivković, David Kočović, Svetlana Ibrić
Laser sintering, known as powder bed fusion-laser beam (PBF-LB), offers promising potential for the fabrication of patient-specific drugs. The aim of this study was to provide an insight into the PBF-LB process with regard to the process parameters, in particular the laser hatching distance, and its influence on the properties of zolpidem tartrate (ZT) tablets. PHARMACOAT® 603 was used as the polymer, while Candurin® Gold Sheen and AEROSIL® 200 were added to facilitate 3D printing. The particle size distribution of the powder blend showed that the layer height should be set to 100 µm, while the laser hatching distance was varied in five different steps (50, 100, 150, 200 and 250 µm), keeping the temperature and laser scanning speed constant...
April 25, 2024: International Journal of Pharmaceutics
#18
JOURNAL ARTICLE
Bernhard Blank-Landeshammer, Bettina Schwarzinger, Verena Arnaut, Theresa Gramatte, Ivana Drotarova, Michaela Feichtinger, Clemens Röhrl, Julian Weghuber
Plant extracts rich in phytochemicals are known for their health benefits. Plant extract library from edible plants obtained from the region of Upper Austria was prepared. Food grade extraction procedures were applied, and relevant physico-chemical parameters measured. A focus on polyphenolic compounds revealed a significant correlation between the total phenolic content (measured by a colorimetric assay) and the cumulated concentration of main individual polyphenols (measured by HPLC-DAD), demonstrating the comparability of these parameters...
April 23, 2024: Food Chemistry
#19
JOURNAL ARTICLE
Kristina Pavić, Goran Poje, Lais Pessanha de Carvalho, Tana Tandarić, Marina Marinović, Diana Fontinha, Jana Held, Miguel Prudêncio, Ivo Piantanida, Robert Vianello, Ivona Krošl Knežević, Ivana Perković, Zrinka Rajić
Although cancer and malaria are not etiologically nor pathophysiologically connected, due to their similarities successful repurposing of antimalarial drugs for cancer and vice-versa is known and used in clinical settings and drug research and discovery. With the growing resistance of cancer cells and Plasmodium to the known drugs, there is an urgent need to discover new chemotypes and enrich anticancer and antimalarial drug portfolios. In this paper, we present the design and synthesis of harmiprims, hybrids composed of harmine, an alkaloid of the β-carboline type bearing anticancer and antiplasmodial activities, and primaquine, 8-aminoquinoline antimalarial drug with low antiproliferative activity, covalently bound via triazole or urea...
April 23, 2024: Bioorganic & Medicinal Chemistry
#20
JOURNAL ARTICLE
Ivana Liric Rajlic, Beatriz Guglieri-Lopez, Nabeel Rangoonwala, Vijay Ivaturi, Linh Van, Simone Mori, Brian Wipke, Douglas Burdette, Husain Attarwala
Regulatory T cells (Tregs ) are essential for maintaining immune homeostasis by serving as negative regulators of adaptive immune system effector cell responses. Reduced production or function of Tregs has been implicated in several human autoimmune diseases. The cytokine interleukin 2 plays a central role in promoting Treg differentiation, survival, and function in vivo and may therefore have therapeutic benefits for autoimmune diseases. mRNA-6231 is an investigational, lipid nanoparticle-encapsulated, mRNA-based therapy that encodes a modified human interleukin 2 mutein fused to human serum albumin (HSA-IL2m)...
April 26, 2024: CPT: Pharmacometrics & Systems Pharmacology
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