Debora Rondinella, Gianluca Quaranta, Tommaso Rozera, Pasquale Dargenio, Giovanni Fancello, Irene Venturini, Alessandra Guarnaccia, Serena Porcari, Stefano Bibbò, Maurizio Sanguinetti, Antonio Gasbarrini, Luca Masucci, Giovanni Cammarota, Gianluca Ianiro
Fecal microbiota transplantation (FMT) is effective against recurrent Clostridioides difficile infection (rCDI), but its safety is jeopardized by the potential transmission of pathogens, so international guidelines recommend either a quarantine or a direct stool testing. Whereas reports of the quarantine-based approach are emerging, data on the direct testing-based approach are not available. Our aim is to report outcomes of a donor screening framework for FMT including direct stool testing. In this prospective cohort study, all donor candidates recruited at our FMT centre underwent a four-step screening process to be enrolled as actual donors...
April 26, 2024: Microbes and Infection