Neveen Madbouly, Adham Ooda, Ahmed Nabil, Areej Nasser, Esraa Ahmed, Fatma Ali, Fatma Mohamed, Habiba Faried, Mai Badran, Mariam Ahmed, Mariam Ibrahim, Mariam Rasmy, Martina Saleeb, Vereena Riad, Yousr Ibrahim, Alyaa Farid
The development of nanoparticles (NPs) with active components with upgraded stability, and prolonged release helps in enhanced tissue regeneration. In addition, NPs are feasible strategy to boost antibiotic effectiveness and reduce drug side effects. Our study focuses on the use of amikacin (AMK) and gamma amino butyric acid (GABA) unloaded combinations or loaded on chitosan nanoparticles (CSNPs) for kidney protection. The AMK-GABA-CSNPs were prepared with the ionic gelation method, the morphology was studied using transmission electron microscopy (TEM), zetasizer and the Fourier transform-infrared spectroscopy (FT-IR) spectrum of the synthesized NPs was observed...
April 25, 2024: Inflammopharmacology