Josephin Wagner, Lauren M Park, Partha Mukhopadhyay, Csaba Matyas, Eszter Trojnar, Ruslan Damadzic, Jeesun Jung, Andrew S Bell, Lucas A Mavromatis, Ali M Hamandi, Daniel B Rosoff, Leandro F Vendruscolo, George F Koob, Pal Pacher, Falk W Lohoff
Alcohol Use Disorder (AUD) is a persistent condition linked to neuroinflammation, neuronal oxidative stress, and neurodegenerative processes. While the inhibition of proprotein convertase subtilisin/kexin type 9 (PCSK9) has demonstrated effectiveness in reducing liver inflammation associated with alcohol, its impact on the brain remains largely unexplored. This study aimed to assess the effects of alirocumab, a monoclonal antibody targeting PCSK9 to lower systemic low-density lipoprotein cholesterol (LDL-C), on central nervous system (CNS) pathology in a rat model of chronic alcohol exposure...
April 22, 2024: Brain, Behavior, and Immunity