Maja Repajić, Ena Cegledi, Zoran Zorić, Sandra Pedisić, Ivona Elez Garofulić, Sanja Radman, Igor Palčić, Verica Dragović-Uzelac
This study evaluated the presence of bioactives in wild nettle leaves and stalks during the phenological stage and in the context of natural habitat diversity. Thus, wild nettle samples collected before flowering, during flowering and after flowering from 14 habitats situated in three different regions (continental, mountain and seaside) were analyzed for low molecular weight polyphenols, carotenoids and chlorophylls using UPLC-MS/MS and HPLC analysis, while the ORAC method was performed for the antioxidant capacity measurement...
January 18, 2021: Foods (Basel, Switzerland)
Lavinia Mareri, Gea Guerriero, Jean-Francois Hausman, Giampiero Cai
Sucrose synthase is a key enzyme in sucrose metabolism as it saves an important part of sucrose energy in the uridine-5'-diphosphate glucose (UDP-glucose) molecule. As such it is also involved in the synthesis of fundamental molecules such as callose and cellulose , the latter being present in all cell walls of plant cells and therefore also in the gelatinous cell walls of sclerenchyma cells such as bast fibers. Given the importance of these cells in plants of economic interest such as hemp, flax and nettle, in this work we have studied the occurrence of Sucrose synthase in nettle stems by analyzing its distribution between the cytosol, membranes and cell wall...
January 16, 2021: International Journal of Molecular Sciences
Nabila Brahmi-Chendouh, Simona Piccolella, Ersilia Nigro, Sabrina Hamri-Zeghichi, Khodir Madani, Aurora Daniele, Severina Pacifico
The metabolite profiling of plant extracts always represents an exciting challenge, as the chemical diversity of natural products is still far beyond the researchers' imagination, even focusing on a plant that is thought to have already been broadly investigated. Herein UHPLC-HRMS/MS techniques were applied to an alcoholic crude extract from nettle leaves and proved to be a precious tool for the disclosure of secondary metabolites never found before. Hydroxycinnamic acid derivatives were the most representative constituents, with a 2-caffeoilisocitric acid cyclodimer described for the first time, besides four C-glycosylated flavones, bearing a 3-hydroxy-3-methylglutaryl function...
January 6, 2021: Journal of Pharmaceutical and Biomedical Analysis
Ali H Abu Almaaty, Rehab M Mosaad, Mohamed K Hassan, Elham H A Ali, Ghada A Mahmoud, Hassan Ahmed, Nahla Anber, Saad Alkahtani, Mohamed M Abdel-Daim, Lotfi Aleya, Seddik Hammad
Alzheimer's disease (AD) is characterized by alterations in monoamines, oxidative stress, and metabolic dysfunctions. We aim to assess the therapeutic impacts of roots or leaf extract from Urtica dioica (UD; stinging nettle) against scopolamine (SCOP)-induced memory dysfunction, amnesia, and oxidative stress in rats. Spatial memory was assessed by Y maze test. Tissue analyses of norepinephrine (NE), dopamine (DA), serotonin (5-HT), malondialdehyde (MDA), nitric oxide (NO), glutathione (GSH, GSSG), AMP, ADP, and ATP were assessed by HPLC...
January 6, 2021: Environmental Science and Pollution Research International
Shobha Upreti, Jyoti Sankar Prusty, Satish Chandra Pandey, Awanish Kumar, Mukesh Samant
The pandemic outbreak of coronavirus (SARS-CoV-2) is rapidly spreading across the globe, so the development of anti-SARS-CoV-2 agents is urgently needed. Angiotensin-converting enzyme 2 (ACE-2), a human receptor that facilitates entry of SARS-CoV-2, serves as a prominent target for drug discovery. In the present study, we have applied the bioinformatics approach for screening of a series of bioactive chemical compounds from Himalayan stinging nettle (Urtica dioica) as potent inhibitors of ACE-2 receptor (PDB ID: 1R4L)...
January 4, 2021: Molecular Diversity
Evelien Vanderlinden, Nathalie Van Winkel, Lieve Naesens, Els J M Van Damme, Leentje Persoons, Dominique Schols
Here, we report on the anti-influenza virus activity of the mannose-binding agents, Hippeastrum hybrid agglutinin (HHA) and Galanthus nivalis agglutinin (GNA), and the ( N -acetylglucosamine)n -specific Urtica dioica agglutinin (UDA). These carbohydrate-binding agents (CBA) strongly inhibited various influenza A(H1N1), A(H3N2) and B viruses in vitro , with EC50 values ranging from 0.016 to 83 nM, generating selectivity indexes up to 125,000. Somewhat less activity was observed against the A/PR/8/34 and an A(H1N1)pdm09 strain...
December 7, 2020: Antimicrobial Agents and Chemotherapy
Miriam Saponaro, Isabella Giacomini, Giulia Morandin, Veronica Cocetta, Eugenio Ragazzi, Genny Orso, Ilaria Carnevali, Massimiliano Berretta, Mariangela Mancini, Francesco Pagano, Monica Montopoli
Benign prostatic hyperplasia (BPH) is an age-related chronic disorder, characterized by the hyperproliferation of prostatic epithelial and stromal cells, which drives prostate enlargement. Since BPH aetiology and progression have been associated with the persistence of an inflammatory stimulus, induced both by Nuclear Factor-kappa B (NF-κB) activation and reactive oxygen species (ROS) production, the inhibition of these pathways could result in a good tool for its clinical treatment. This study aimed to evaluate the antioxidant and anti-inflammatory activity of a combined formulation of Serenoa repens and Urtica dioica (SR/UD) in an in vitro human model of BPH...
December 2, 2020: International Journal of Molecular Sciences
Joshua Petelka, Barbara Plagg, Ina Säumel, Stefan Zerbe
BACKGROUND: Worldwide mountain regions are recognized as hotspots of ethnopharmacologically relevant species diversity. In South Tyrol (Southern Alps, Italy), and due to the region's high plant diversity and isolated population, a unique traditional botanical knowledge of medicinal plants has flourished, which traces its history back to prehistoric times. However, changes in rural life and culture may threaten this unique biodiversity and cultural heritage. Our study aims to collect and analyze information on native plants used in traditional folk medicine, focusing on the preservation of botanical and cultural diversity...
November 26, 2020: Journal of Ethnobiology and Ethnomedicine
Ceren Kazancı, Soner Oruç, Marine Mosulishvili
BACKGROUND: The Mountains of the Western Lesser Caucasus with its rich plant diversity, multicultural and multilingual nature host diverse ethnobotanical knowledge related to medicinal plants. However, cross-cultural medicinal ethnobotany and patterns of plant knowledge have not yet been investigated in the region. Doing so could highlight the salient medicinal plant species and show the variations between communities. This study aimed to determine and discuss the similarities and differences of medicinal ethnobotany among people living in highland pastures on both sides of the Georgia-Turkey border...
November 23, 2020: Journal of Ethnobiology and Ethnomedicine
Kanokon Nuilek, Winadda Wongwiriyapan, Vichuda Sattayarut, Andrea Simon, Daniel Koncz-Horváth, Tibor Ferenczi, Ferenc Kristály, Peter Baumli
Carbon nanosheets (CNs) were successfully synthesized from nettle stem (NS) which is an inexpensive material with a high carbon content that is abundantly available in nature. CNs were produced using chemical (potassium hydroxide activation and acid exfoliation) and thermal treatments. Sulfuric (H2 SO4 ), phosphoric (H3 PO4 ) and nitric (HNO3 ) acid solutions were used for exfoliation. CNs exfoliated by H3 PO4 have higher specific surface area (789 m2  g-1 ) compared to CNs exfoliated by H2 SO4 (705 m2  g-1 ) and HNO3 (106 m2  g-1 )...
October 14, 2020: Scientific Reports
Ali Akbar Karami, Mahsa Sheikhsoleimani, Mohammad Reza Memarzadeh, Elnaz Haddadi, Mohammad Bakhshpour, Navid Mohammadi, Seyyed Mehdi Mirhashemi
BACKGROUND AND OBJECTIVES: Benign Prostatic Hyperplasia (BPH) is a common urological disorder as men get older. BPH can cause uncomfortable urinary tract symptoms. Given the high incidence of the disease, further research is an undeniable necessity for its better management. In this research, the efficacy of Urtica Dioica root extract (UDE) on clinical and biochemical parameters were evaluated in this type of patients. MATERIALS AND METHODS: Participants were 60 men with BPH that randomly allocated to two equal groups (Intervention = 30 and Comparison = 30)...
January 2020: Pakistan Journal of Biological Sciences: PJBS
Nicola Mori, Elena Cargnus, Marta Martini, Francesco Pavan
Hyalesthes obsoletus is the vector of " Candidatus Phytoplasma ( Ca . P.) solani," the causal agent of grapevine yellows Bois noir (BN). The relationships among the planthopper, its main herbaceous hosts as phytoplasma reservoirs ( Convolvolus arvensis and Urtica dioica ) and BN spreading were studied in northern Italy. In two areas the relationship between host plants and the phenology and survival of planthopper adults was investigated in potted plants and in field conditions. Moreover, H. obsoletus ecology, newly symptomatic grapevine occurrence and " Ca ...
September 7, 2020: Insects
Mohammad Hassan Hodroj, Nour Al Hoda Al Bast, Robin I Taleb, Jamilah Borjac, Sandra Rizk
Urtica dioica (UD), commonly known as "stinging nettle", is a herbaceous flowering plant that is a widely used agent in traditional medicine worldwide. Several formulations of UD leaf extract have been reported to exhibit anti-inflammatory and antioxidant properties, with anticancer potential. The current study investigated the possible anticancer properties of nettle tea, prepared from Urtica dioica leaves, on acute myeloid leukemia (AML) cell lines, and deciphered the underlying molecular mechanisms...
August 28, 2020: Nutrients
Nirmala Joshi, Abdolbaset Ghorbani, Mohan Siwakoti, Katja Kehlenbeck
ETHNOPHARMACOLOGICAL RELEVANCE: In Nepal, wild plant resources play an important role in local communities' health care. However, this role and its patterns are poorly studied in many regions of the country. This study aimed at documenting the indigenous knowledge on the use patterns of medicinal plants of three ethnic groups from Makawanpur district, Central Nepal. MATERIALS AND METHODS: Ethnobotanical information was collected through interviews with 165 respondents from the Bankaria, Newah and Tamang ethnic groups across five locations of different altitude levels...
August 6, 2020: Journal of Ethnopharmacology
Jelena S Matejić, Nikola Stefanović, Milan Ivković, Nemanja Živanović, Petar D Marin, Ana M Džamić
ETHNOPHARMACOLOGICAL RELEVANCE: River and mountain regions in Eastern and South-Eastern Serbia are geographically interesting and, historically they represent an important resource of plants used as food, spices and as remedies for treating many diseases. Different cultures have lived in these regions for ages. They have used wild plants and the methods of their preparation and application, which has remained throughout the history and now is passed on from generation to generation. The aim of the study is a survey of herbal drug uses for the specific ailment categories and their comparison between the two research regions...
July 27, 2020: Journal of Ethnopharmacology
Dhandevi Pem, Rajesh Jeewon, Faruk Selcuk, Merve Ulukapi, Jayarama Bhat, Mingkwan Doilom, Saisamorn Lumyong, Kevin D Hyde
During an ongoing investigation of Ascomycetes from plant substrates, three saprobic species were found from plant substrates. Two new species, Leptosphaeria regiae and Neomicrosphaeropsis juglandis were isolated from dead branches of Juglans regia from Turkey. Another species is introduced herein as Subplenodomus urticae sp. nov within the family Leptosphaeriaceae found on Urtica dioica in Italy. Multigene phylogenies based on combined LSU, ITS, SSU, and β-tubulin DNA sequence data generated from maximum likelihood and MrBayes analyses indicate that Leptosphaeria regiae is related to L...
2020: Frontiers in Microbiology
Gözde Kutlu, Fatih Bozkurt, Fatih Tornuk
Nettle seed gum (NSG) which is a novel potential source of hydrocolloid was characterized in terms of yield, physicochemical, rheological, functional and thermal properties. According to Response Surface Methodology, the maximum extraction yield was determined as 6.17% on dry basis. In order to clarify the structural information of the gum, the FT-IR analysis and monosaccharide composition determination were also performed. In the results, the NSG had 8.48% moisture, 10.81% total ash, 2.89% total protein, 1...
June 20, 2020: International Journal of Biological Macromolecules
Saeed Hajihashemi, Mahboubeh Ahmadi, Ali Chehrei, Fatemeh Ghanbari
Objective: Effects of cotreatment with Urtica dioica (UD) methanolic leaf extract on gentamicin (GM)-induced acute kidney injury were evaluated in rats. Materials and Methods: Male Wistar rats (n=32) were separated into four groups. Gentamicin (100 mg/kg/day, IP) was injected for eight days with or without UD methanolic extract (200 mg/kg/day, gavage).  The renal blood flow (RBF) and systolic blood pressure of rats were recorded. Concentration of creatinine, blood urea nitrogen (BUN), sodium, and potassium and osmolarity were measured in the urine and plasma samples...
May 2020: Avicenna Journal of Phytomedicine
Gea Guerriero, Emilie Piasecki, Roberto Berni, Xuan Xu, Sylvain Legay, Jean-Francois Hausman
Callose is an important biopolymer of β-1,3-linked glucose units involved in different phases of plant development, reproduction and response to external stimuli. It is synthesized by glycosyltransferases (GTs) known as callose synthases (CalS) belonging to family 48 in the Carbohydrate-Active enZymes (CAZymes) database. These GTs are anchored to the plasma membrane via transmembrane domains. Several genes encoding CalS have been characterized in higher plants with 12 reported in the model organism Arabidopsis thaliana ...
May 28, 2020: International Journal of Molecular Sciences
Meta Sterniša, Franz Bucar, Olaf Kunert, Sonja Smole Možina
To control Pseudomonas and Shewanella as important psychrotrophic spoilage bacteria in fish meat, we used ethanolic extracts of oregano (Origanum vulgare subsp. vulgare) and nettle (Urtica dioica), with phytochemical characterisation of the extracts and their bioactive compounds. Liquid chromatography coupled with photodiode array detection and electrospray ionisation-mass spectrometry was used for qualitative compositional determination of the extracts. Four main compounds were identified in the oregano extract, with rosmarinic acid the most abundant, followed by three glycosylated phenolics, one of which is reported for the first time in O...
May 18, 2020: International Journal of Food Microbiology
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