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JOURNAL ARTICLE
Justyne E Ross, Shruthi Mohan, Jing Zhang, Mia J Sullivan, Loredana Bury, Kristy Lee, Isabella Futchi, Annabelle Frantz, Dara McDougal, Juliana Perez Botero, Marco Cattaneo, Nichola Cooper, Kate Downes, Paolo Gresele, Catriona Keenan, Alfred Lee, Karyn Megy, Pierre-Emmanuel Morange, Neil V Morgan, Harald Schulze, Karen Zimowski, Kathleen Freson, Michele P Lambert
BACKGROUND: Inherited bleeding, thrombotic, and platelet disorders (BTPDs) are a heterogeneous set of diseases, many of which are globally very rare. Over the past five decades, the genetic basis of some of these disorders has been identified, and recently, high-throughput sequencing has become the primary means of identifying disease-causing genetic variants. OBJECTIVES: Knowledge of the clinical validity of a gene-disease relationship is essential to both providing an accurate diagnosis based on results of diagnostic gene panel tests and informing the construction of such panels...
November 26, 2023: Journal of Thrombosis and Haemostasis: JTH
#22
JOURNAL ARTICLE
Jieling Xiao, Rebecca Wenling Zeng, Wen Hui Lim, Darren Jun Hao Tan, Jie Ning Yong, Clarissa Elysia Fu, Phoebe Tay, Nicholas Syn, Christen En Ya Ong, Elden Yen Hng Ong, Charlotte Hui Chung, Shi Yan Lee, Jia Hong Koh, Margaret Teng, Sameer Prakash, Eunice Xx Tan, Karn Wijarnpreecha, Anand V Kulkarni, Ken Liu, Pojsakorn Danpanichkul, Daniel Q Huang, Mohammad Shadab Siddiqui, Cheng Han Ng, Alfred Wei Chieh Kow, Mark D Muthiah
The scarcity of liver grafts has prompted developments in living donor liver transplantations (LDLT), with previous literature illustrating similar outcomes in recipients compared to deceased donor transplants. However, significant concerns regarding living donor morbidity and mortality have yet to be examined comprehensively. This study aims to provide estimates of the incidence of various outcomes in living liver donors. In this meta-analysis, Medline and Embase were searched from inception to July 2022 for articles assessing the incidence of outcomes in LDLT donors...
November 29, 2023: Liver Transplantation
#23
JOURNAL ARTICLE
Alfred W Bronkhorst, Chop Y Lee, Martin M Möckel, Sabine Ruegenberg, Antonio M de Jesus Domingues, Shéraz Sadouki, Rossana Piccinno, Tetsutaro Sumiyoshi, Mikiko C Siomi, Lukas Stelzl, Katja Luck, René F Ketting
Piwi-interacting RNAs (piRNAs) direct PIWI proteins to transposons to silence them, thereby preserving genome integrity and fertility. The piRNA population can be expanded in the ping-pong amplification loop. Within this process, piRNA-associated PIWI proteins (piRISC) enter a membraneless organelle called nuage to cleave their target RNA, which is stimulated by Gtsf proteins. The resulting cleavage product gets loaded into an empty PIWI protein to form a new piRISC complex. However, for piRNA amplification to occur, the new RNA substrates, Gtsf-piRISC, and empty PIWI proteins have to be in physical proximity...
November 20, 2023: EMBO Journal
#24
JOURNAL ARTICLE
Dzmitry Firaha, Yifei Michelle Liu, Jacco van de Streek, Kiran Sasikumar, Hanno Dietrich, Julian Helfferich, Luc Aerts, Doris E Braun, Anders Broo, Antonio G DiPasquale, Alfred Y Lee, Sarah Le Meur, Sten O Nilsson Lill, Walter J Lunsmann, Alessandra Mattei, Pierandrea Muglia, Okky Dwichandra Putra, Mohamed Raoui, Susan M Reutzel-Edens, Sandrine Rome, Ahmad Y Sheikh, Alexandre Tkatchenko, Grahame R Woollam, Marcus A Neumann
The physicochemical properties of molecular crystals, such as solubility, stability, compactability, melting behaviour and bioavailability, depend on their crystal form1 . In silico crystal form selection has recently come much closer to realization because of the development of accurate and affordable free-energy calculations2-4 . Here we redefine the state of the art, primarily by improving the accuracy of free-energy calculations, constructing a reliable experimental benchmark for solid-solid free-energy differences, quantifying statistical errors for the computed free energies and placing both hydrate crystal structures of different stoichiometries and anhydrate crystal structures on the same energy landscape, with defined error bars, as a function of temperature and relative humidity...
November 2023: Nature
#25
Alex Pines, Diana Llerena Schiffmacher, Shun-Hsiao Lee, Katarzyna Kliza, Arjan Theil, Masaki Akita, Angela Helfricht, Karel Bezstarosti, Camila Gonzalo-Hansen, Haico van Attikum, Matty Verlaan-de Vries, Alfred Vertegaal, Jan Hoeijmakers, Jurgen Marteijn, Hannes Lans, Jeroen Demmers, Michiel Vermeulen, Titia Sixma, Tomoo Ogi, Wim Vermeulen
Transcription-blocking DNA lesions are specifically targeted by transcription-coupled nucleotide excision repair (TC-NER), which removes a broad spectrum of DNA lesions to preserve transcriptional output and thereby cellular homeostasis to counteract aging. TC-NER is initiated by the stalling of RNA polymerase II at DNA lesions, which triggers the assembly of the TC-NER-specific proteins CSA, CSB and UVSSA. CSA, a WD40-repeat containing protein, is the substrate receptor subunit of a cullin-RING ubiquitin ligase complex composed of DDB1, CUL4A/B and RBX1 (CRL4 CSA )...
October 12, 2023: Research Square
#26
JOURNAL ARTICLE
Stephen P Bergin, Roy F Chemaly, Sanjeet S Dadwal, Joshua A Hill, Yeon Joo Lee, Ghady Haidar, Alfred Luk, Alexander Drelick, Peter V Chin-Hong, Esther Benamu, Fareed Khawaja, Deepa Nanayakkara, Genovefa A Papanicolaou, Catherine Butkus Small, Monica Fung, Michelle A Barron, Thomas Davis, Micah T McClain, Eileen K Maziarz, Deng B Madut, Armando D Bedoya, Daniel L Gilstrap, Jamie L Todd, Christina E Barkauskas, Robert Bigelow, Jeffrey D Leimberger, Ephraim L Tsalik, Olivia Wolf, Mona Mughar, Desiree Hollemon, Radha Duttagupta, Daniel S Lupu, Sivan Bercovici, Bradley A Perkins, Timothy A Blauwkamp, Vance G Fowler, Thomas L Holland
BACKGROUND: Pneumonia is a common cause of morbidity and mortality, yet a causative pathogen is identified in a minority of cases. Plasma microbial cell-free DNA sequencing may improve diagnostic yield in immunocompromised patients with pneumonia. METHODS: In this prospective, multicenter, observational study of immunocompromised adults undergoing bronchoscopy to establish a pneumonia etiology, plasma microbial cell-free DNA sequencing was compared to standardized usual care testing...
October 10, 2023: Clinical Infectious Diseases
#27
JOURNAL ARTICLE
Iris Lee, Andrea Ramirez Gomez, Alfred H J Kim, Dean W Coble, Brigid Marshall, Aaditya Shah, Seth Eisen, Rajendra S Apte, Tingting Li
OBJECTIVE: To determine the association between disease activity and choroidal thickness in patients with systemic lupus erythematosus (SLE). METHODS: We conducted a cohort study of 24 SLE patients and 13 healthy controls recruited at Washington University School of Medicine between June 2019 and November 2021. SLE disease activity was assessed using the SLE Disease Activity Index-2000 Responder Index-50 (S2K RI-50). Patients were divided into four groups: high disease activity/no lupus nephritis (HDA/no LN; S2K RI-50 > 4), HDA/active LN (HDA/active LN; S2K RI-50 > 4), low disease activity/inactive LN (LDA/inactive LN; S2K RI-50 ≤ 4), and LDA/no LN (LDA/no LN; S2K RI-50 ≤ 4)...
October 12, 2023: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
#28
JOURNAL ARTICLE
Kaitlin Conway-Moore, Cécile Knai, Diane Finegood, Lee Johnston, Hannah Brinsden, Anaely Aguiar, Birgit Kopainsky, Furkan Önal, Arnfinn Helleve, Knut-Inge Klepp, Nanna Lien, Aleksandra Luszczynska, Ana Isabel Rito, Alfred Mestad Rønnestad, Madeleine Ulstein, Laurence Blanchard, Natalie Savona, Harry Rutter
Despite growing recognition of the importance of applying a systems lens to action on obesity, there has only been limited analysis of the extent to which this lens has actually been applied. The CO-CREATE project used a youth-led participatory action research approach to generate policy ideas towards the reduction of adolescent overweight and obesity across Europe. In order to assess the extent to which these youth-generated policy ideas take a systems approach, we analyzed them using the Intervention Level Framework (ILF)...
September 2023: Obesity Reviews
#29
Nick Shrine, Abril G Izquierdo, Jing Chen, Richard Packer, Robert J Hall, Anna L Guyatt, Chiara Batini, Rebecca J Thompson, Chandan Pavuluri, Vidhi Malik, Brian D Hobbs, Matthew Moll, Wonji Kim, Ruth Tal-Singer, Per Bakke, Katherine A Fawcett, Catherine John, Kayesha Coley, Noemi Nicole Piga, Alfred Pozarickij, Kuang Lin, Iona Y Millwood, Zhengming Chen, Liming Li, Sara R A Wijnant, Lies Lahousse, Guy Brusselle, Andre G Uitterlinden, Ani Manichaikul, Elizabeth C Oelsner, Stephen S Rich, R Graham Barr, Shona M Kerr, Veronique Vitart, Michael R Brown, Matthias Wielscher, Medea Imboden, Ayoung Jeong, Traci M Bartz, Sina A Gharib, Claudia Flexeder, Stefan Karrasch, Christian Gieger, Annette Peters, Beate Stubbe, Xiaowei Hu, Victor E Ortega, Deborah A Meyers, Eugene R Bleecker, Stacey B Gabriel, Namrata Gupta, Albert Vernon Smith, Jian'an Luan, Jing-Hua Zhao, Ailin F Hansen, Arnulf Langhammer, Cristen Willer, Laxmi Bhatta, David Porteous, Blair H Smith, Archie Campbell, Tamar Sofer, Jiwon Lee, Martha L Daviglus, Bing Yu, Elise Lim, Hanfei Xu, George T O'Connor, Gaurav Thareja, Omar M E Albagha, Karsten Suhre, Raquel Granell, Tariq O Faquih, Pieter S Hiemstra, Annelies M Slats, Benjamin H Mullin, Jennie Hui, Alan James, John Beilby, Karina Patasova, Pirro Hysi, Jukka T Koskela, Annah B Wyss, Jianping Jin, Sinjini Sikdar, Mikyeong Lee, Sebastian May-Wilson, Nicola Pirastu, Katherine A Kentistou, Peter K Joshi, Paul R H J Timmers, Alexander T Williams, Robert C Free, Xueyang Wang, John L Morrison, Frank D Gilliland, Zhanghua Chen, Carol A Wang, Rachel E Foong, Sarah E Harris, Adele Taylor, Paul Redmond, James P Cook, Anubha Mahajan, Lars Lind, Teemu Palviainen, Terho Lehtimäki, Olli T Raitakari, Jaakko Kaprio, Taina Rantanen, Kirsi H Pietiläinen, Simon R Cox, Craig E Pennell, Graham L Hall, W James Gauderman, Chris Brightling, James F Wilson, Tuula Vasankari, Tarja Laitinen, Veikko Salomaa, Dennis O Mook-Kanamori, Nicholas J Timpson, Eleftheria Zeggini, Josée Dupuis, Caroline Hayward, Ben Brumpton, Claudia Langenberg, Stefan Weiss, Georg Homuth, Carsten Oliver Schmidt, Nicole Probst-Hensch, Marjo-Riitta Jarvelin, Alanna C Morrison, Ozren Polasek, Igor Rudan, Joo-Hyeon Lee, Ian Sayers, Emma L Rawlins, Frank Dudbridge, Edwin K Silverman, David P Strachan, Robin G Walters, Andrew P Morris, Stephanie J London, Michael H Cho, Louise V Wain, Ian P Hall, Martin D Tobin
No abstract text is available yet for this article.
October 2023: Nature Genetics
#30
JOURNAL ARTICLE
Seul A Lee, Fang Liu, Christopher Yuwono, Monique Phan, Sarah Chong, Joanna Biazik, Alfred Chin Yen Tay, Michael Janitz, Stephen M Riordan, Ruiting Lan, Michael C Wehrhahn, Li Zhang
Aeromonas species are emerging human enteric pathogens. This study examines the isolation of Aeromonas and other enteric bacterial pathogens from patients with and without inflammatory bowel disease (IBD). This study also investigates the intestinal epithelial pathogenic mechanisms of Aeromonas veronii . The isolation rates of seven enteric bacterial pathogens from 2,279 patients with IBD and 373,276 non-IBD patients were compared. An A. veronii strain (AS1) isolated from intestinal biopsies of a patient with IBD was used for pathogenic mechanism investigation, and Escherichia coli K12 was used as a bacterial control...
September 21, 2023: Microbiology Spectrum
#31
JOURNAL ARTICLE
Alfred S Y Lee, Patrick Shu-Hang Yung, Michael Tim-Yun Ong, Chris Lonsdale, Thomson W L Wong, Parco M Siu, Martin S Hagger, Derwin K C Chan
RATIONALE: Patients with anterior cruciate ligament (ACL) reconstruction often have poor adherence to post-surgery rehabilitation. OBJECTIVE: This study applied the integrated model of self-determination theory and the theory of planned behavior to examine the effects of a smartphone-delivered intervention on the recovery outcomes of patients with an ACL rupture during post-surgery rehabilitation period. Additionally, we explored the effects of the intervention on participants with different beliefs toward rehabilitation at baseline...
September 9, 2023: Social Science & Medicine
#32
JOURNAL ARTICLE
Andie S Lee, Leanne Dolan, Frances Jenkins, Bernadette Crawford, Sebastiaan J van Hal
BACKGROUND: Whole-genome sequencing (WGS) is increasingly used to characterize hospital outbreaks of carbapenemase-producing Enterobacterales (CPE). However, access to WGS is variable and testing is often centralized, leading to delays in reporting of results. OBJECTIVE: We describe the utility of a local sequencing service to promptly respond to facility needs over an 8-year period. METHODS: The study was conducted at Royal Prince Alfred Hospital in Sydney, Australia...
September 13, 2023: Infection Control and Hospital Epidemiology
#33
REVIEW
Edward C Kuan, Eric W Wang, Nithin D Adappa, Daniel M Beswick, Nyall R London, Shirley Y Su, Marilene B Wang, Waleed M Abuzeid, Borislav Alexiev, Jeremiah A Alt, Paolo Antognoni, Michelle Alonso-Basanta, Pete S Batra, Mihir Bhayani, Diana Bell, Manuel Bernal-Sprekelsen, Christian S Betz, Jean-Yves Blay, Benjamin S Bleier, Juliana Bonilla-Velez, Claudio Callejas, Ricardo L Carrau, Roy R Casiano, Paolo Castelnuovo, Rakesh K Chandra, Vasileios Chatzinakis, Simon B Chen, Alexander G Chiu, Garret Choby, Naweed I Chowdhury, Martin J Citardi, Marc A Cohen, Roi Dagan, Gianluca Dalfino, Iacopo Dallan, Camila Soares Dassi, John de Almeida, Angelo P Dei Tos, John M DelGaudio, Charles S Ebert, Ivan H El-Sayed, Jean Anderson Eloy, James J Evans, Christina H Fang, Nyssa F Farrell, Marco Ferrari, Nancy Fischbein, Adam Folbe, Wytske J Fokkens, Meha G Fox, Valerie J Lund, Gary L Gallia, Paul A Gardner, Mathew Geltzeiler, Christos Georgalas, Anne E Getz, Satish Govindaraj, Stacey T Gray, Jessica W Grayson, Bradley A Gross, Jordon G Grube, Ruifeng Guo, Patrick K Ha, Ashleigh A Halderman, Ehab Y Hanna, Richard J Harvey, Stephen C Hernandez, Adam L Holtzman, Claire Hopkins, Zhigang Huang, Zhenxiao Huang, Ian M Humphreys, Peter H Hwang, Alfred M Iloreta, Masaru Ishii, Michael E Ivan, Aria Jafari, David W Kennedy, Mohemmed Khan, Adam J Kimple, Todd T Kingdom, Anna Knisely, Ying-Ju Kuo, Devyani Lal, Eric D Lamarre, Ming-Ying Lan, Hien Le, Matt Lechner, Nancy Y Lee, Jivianne K Lee, Victor H Lee, Corinna G Levine, Jin-Ching Lin, Derrick T Lin, Brian C Lobo, Tran Locke, Amber U Luong, Kelly R Magliocca, Svetomir N Markovic, Gesa Matnjani, Erin L McKean, Cem Meço, William M Mendenhall, Loren Michel, Shorook Na'ara, Piero Nicolai, Daniel W Nuss, Gurston G Nyquist, Gretchen M Oakley, Kazuhiro Omura, Richard R Orlandi, Nobuyoshi Otori, Peter Papagiannopoulos, Zara M Patel, David G Pfister, Jack Phan, Alkis J Psaltis, Mindy R Rabinowitz, Murugappan Ramanathan, Ryan Rimmer, Marc R Rosen, Olabisi Sanusi, Zoukaa B Sargi, Philippe Schafhausen, Rodney J Schlosser, Ahmad R Sedaghat, Brent A Senior, Raj Shrivastava, Raj Sindwani, Timothy L Smith, Kristine A Smith, Carl H Snyderman, C Arturo Solares, Satyan B Sreenath, Aldo Stamm, Katharina Stölzel, Baran Sumer, Pavol Surda, Bobby A Tajudeen, Lester D R Thompson, Brian D Thorp, Charles C L Tong, Raymond K Tsang, Justin H Turner, Mario Turri-Zanoni, Aaron M Udager, Thibaut van Zele, Kyle VanKoevering, Kevin C Welch, Sarah K Wise, Ian J Witterick, Tae-Bin Won, Stephanie N Wong, Bradford A Woodworth, Peter-John Wormald, William C Yao, Chien-Fu Yeh, Bing Zhou, James N Palmer
BACKGROUND: Sinonasal neoplasms, whether benign and malignant, pose a significant challenge to clinicians and represent a model area for multidisciplinary collaboration in order to optimize patient care. The International Consensus Statement on Allergy and Rhinology: Sinonasal Tumors (ICSNT) aims to summarize the best available evidence and presents 48 thematic and histopathology-based topics spanning the field. METHODS: In accordance with prior International Consensus Statement on Allergy and Rhinology documents, ICSNT assigned each topic as an Evidence-Based Review with Recommendations, Evidence-Based Review, and Literature Review based on the level of evidence...
February 2024: International Forum of Allergy & Rhinology
#34
JOURNAL ARTICLE
Ngai Sze Wong, Bonnie Chun-Kwan Wong, Man-Po Lee, Owen Tak-Yin Tsang, Danny King Fai Cheung, Alfred Yao-Wai Sit, Samuel Yeung-Shan Wong, Shui-Shan Lee
Following the post-COVID-19 reopening of the society with enhanced traveling between countries, people at risk of mpox infection, notably men who have sex with men (MSM) and people living with HIV, are facing increasing threat of virus exposure. Mpox vaccination is an important public health strategy which is provided free in Hong Kong to people at higher risk of infection. Between October 2022 and January 2023, 326 and 184 MSM vaccinees from vaccination sites and HIV specialist clinics in Hong Kong, respectively, were recruited for assessing their infection risks...
August 1, 2023: Human Vaccines & Immunotherapeutics
#35
JOURNAL ARTICLE
Medha Barbhaiya, Stephane Zuily, Ray Naden, Alison Hendry, Florian Manneville, Mary-Carmen Amigo, Zahir Amoura, Danieli Andrade, Laura Andreoli, Bahar Artim-Esen, Tatsuya Atsumi, Tadej Avcin, H Michael Belmont, Maria Laura Bertolaccini, D Ware Branch, Graziela Carvalheiras, Alessandro Casini, Ricard Cervera, Hannah Cohen, Nathalie Costedoat-Chalumeau, Mark Crowther, Guilherme de Jesús, Aurelien Delluc, Sheetal Desai, Maria De Sancho, Katrien M Devreese, Reyhan Diz-Kucukkaya, Ali Duarte-García, Camille Frances, David Garcia, Jean-Christophe Gris, Natasha Jordan, Rebecca K Leaf, Nina Kello, Jason S Knight, Carl Laskin, Alfred I Lee, Kimberly Legault, Steve R Levine, Roger A Levy, Maarten Limper, Michael D Lockshin, Karoline Mayer-Pickel, Jack Musial, Pier Luigi Meroni, Giovanni Orsolini, Thomas L Ortel, Vittorio Pengo, Michelle Petri, Guillermo Pons-Estel, Jose A Gomez-Puerta, Quentin Raimboug, Robert Roubey, Giovanni Sanna, Surya V Seshan, Savino Sciascia, Maria G Tektonidou, Angela Tincani, Denis Wahl, Rohan Willis, Cécile Yelnik, Catherine Zuily, Francis Guillemin, Karen Costenbader, Doruk Erkan
OBJECTIVE: To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) and EULAR. METHODS: This international multidisciplinary initiative included four phases: (1) Phase I, criteria generation by surveys and literature review; (2) Phase II, criteria reduction by modified Delphi and nominal group technique exercises; (3) Phase III, criteria definition, further reduction with the guidance of real-world patient scenarios, and weighting via consensus-based multicriteria decision analysis, and threshold identification; and (4) Phase IV, validation using independent adjudicators' consensus as the gold standard...
October 2023: Annals of the Rheumatic Diseases
#36
JOURNAL ARTICLE
Medha Barbhaiya, Stephane Zuily, Ray Naden, Alison Hendry, Florian Manneville, Mary-Carmen Amigo, Zahir Amoura, Danieli Andrade, Laura Andreoli, Bahar Artim-Esen, Tatsuya Atsumi, Tadej Avcin, H Michael Belmont, Maria Laura Bertolaccini, D Ware Branch, Graziela Carvalheiras, Alessandro Casini, Ricard Cervera, Hannah Cohen, Nathalie Costedoat-Chalumeau, Mark Crowther, Guilherme de Jesus, Aurelien Delluc, Sheetal Desai, Maria De Sancho, Katrien M Devreese, Reyhan Diz-Kucukkaya, Ali Duarte-Garcia, Camille Frances, David Garcia, Jean-Christophe Gris, Natasha Jordan, Rebecca K Leaf, Nina Kello, Jason S Knight, Carl Laskin, Alfred I Lee, Kimberly Legault, Steve R Levine, Roger A Levy, Maarten Limper, Michael D Lockshin, Karoline Mayer-Pickel, Jack Musial, Pier Luigi Meroni, Giovanni Orsolini, Thomas L Ortel, Vittorio Pengo, Michelle Petri, Guillermo Pons-Estel, Jose A Gomez-Puerta, Quentin Raimboug, Robert Roubey, Giovanni Sanna, Surya V Seshan, Savino Sciascia, Maria G Tektonidou, Angela Tincani, Denis Wahl, Rohan Willis, Cecile Yelnik, Catherine Zuily, Francis Guillemin, Karen Costenbader, Doruk Erkan
OBJECTIVE: To develop new antiphospholipid syndrome (APS) classification criteria with high specificity for use in observational studies and trials, jointly supported by the American College of Rheumatology (ACR) and EULAR. METHODS: This international multidisciplinary initiative included 4 phases: 1) Phase I, criteria generation by surveys and literature review; 2) Phase II, criteria reduction by modified Delphi and nominal group technique exercises; 3) Phase III, criteria definition, further reduction with the guidance of real-world patient scenarios, and weighting via consensus-based multicriteria decision analysis, and threshold identification; and 4) Phase IV, validation using independent adjudicators' consensus as the gold standard...
October 2023: Arthritis & Rheumatology
#37
JOURNAL ARTICLE
Donghoon Lee, Yanan Zhu, Louis Colson, Xiaorong Wang, Siyi Chen, Emre Tkacik, Lan Huang, Qi Ouyang, Alfred L Goldberg, Ying Lu
Various hormones, kinases, and stressors (fasting, heat shock) stimulate 26S proteasome activity. To understand how its capacity to degrade ubiquitylated proteins can increase, we studied mouse ZFAND5, which promotes protein degradation during muscle atrophy. Cryo-electron microscopy showed that ZFAND5 induces large conformational changes in the 19S regulatory particle. ZFAND5's AN1 Zn-finger domain interacts with the Rpt5 ATPase and its C terminus with Rpt1 ATPase and Rpn1, a ubiquitin-binding subunit. Upon proteasome binding, ZFAND5 widens the entrance of the substrate translocation channel, yet it associates only transiently with the proteasome...
August 17, 2023: Molecular Cell
#38
JOURNAL ARTICLE
Ying Lu, Donghoon Lee, Yanan Zhu
We talk to co-first authors Donghoon Lee and Yanan Zhu and co-corresponding author Ying Lu about their paper "Molecular mechanism for activation of the 26S proteasome by ZFAND5" (this issue of Molecular Cell), the challenges of the project, their scientific pathways, and the late Dr. Alfred Goldberg.
August 17, 2023: Molecular Cell
#39
JOURNAL ARTICLE
Derwin King Chung Chan, Alfred Sing Yeung Lee, Tracy Chor Wai Tang, Kiko Leung, Joan Sau Kwan Chung, Martin S Hagger, Kyra Hamilton
Direct and moderation effects of swimming competence using an integrated model of self-determination theory (SDT) and theory of planned behaviour (TPB) were examined in two large-scale studies among young children. Specifically, we examined whether swimming competence had direct and moderation effects on social psychological variables of perceived need support, autonomous motivation, TPB social cognition constructs, and intention. In Study 1, using a cross-sectional survey of 4959 primary school children, swimming competence formed significant positive relationships with all model variables (β =...
July 27, 2023: Journal of Sports Sciences
#40
JOURNAL ARTICLE
Elisabeth R M van Haaren, Ingrid G M Poodt, Merel A Spiekerman van Weezelenburg, James van Bastelaar, Alfred Janssen, Bart de Vries, Marc B I Lobbes, Lee H Bouwman, Yvonne L J Vissers
PURPOSE: The outcome of the sentinel lymph node in breast cancer patients affects adjuvant treatment. Compared to conventional histopathology, analysis by one-step nucleic acid amplification (OSNA) harvests more micrometastasis, potentially inducing overtreatment. In this study we investigated the impact of OSNA analysis on adjuvant treatment, compared to histopathological analysis. METHODS: Data from T1-3 breast cancer patients with sentinel nodes analysed between January 2016 and December 2019 by OSNA (OSNA group, n = 1086) from Zuyderland Medical Centre, the Netherlands, were compared to concurrent data from the Netherlands Cancer Registry (NKR) where sentinel nodes were examined by histology (histology group, n = 35,143)...
November 2023: Breast Cancer Research and Treatment
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