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JOURNAL ARTICLE
Ying Lu, Donghoon Lee, Yanan Zhu
We talk to co-first authors Donghoon Lee and Yanan Zhu and co-corresponding author Ying Lu about their paper "Molecular mechanism for activation of the 26S proteasome by ZFAND5" (this issue of Molecular Cell), the challenges of the project, their scientific pathways, and the late Dr. Alfred Goldberg.
August 17, 2023: Molecular Cell
#42
JOURNAL ARTICLE
Derwin King Chung Chan, Alfred Sing Yeung Lee, Tracy Chor Wai Tang, Kiko Leung, Joan Sau Kwan Chung, Martin S Hagger, Kyra Hamilton
Direct and moderation effects of swimming competence using an integrated model of self-determination theory (SDT) and theory of planned behaviour (TPB) were examined in two large-scale studies among young children. Specifically, we examined whether swimming competence had direct and moderation effects on social psychological variables of perceived need support, autonomous motivation, TPB social cognition constructs, and intention. In Study 1, using a cross-sectional survey of 4959 primary school children, swimming competence formed significant positive relationships with all model variables (β =...
July 27, 2023: Journal of Sports Sciences
#43
JOURNAL ARTICLE
Elisabeth R M van Haaren, Ingrid G M Poodt, Merel A Spiekerman van Weezelenburg, James van Bastelaar, Alfred Janssen, Bart de Vries, Marc B I Lobbes, Lee H Bouwman, Yvonne L J Vissers
PURPOSE: The outcome of the sentinel lymph node in breast cancer patients affects adjuvant treatment. Compared to conventional histopathology, analysis by one-step nucleic acid amplification (OSNA) harvests more micrometastasis, potentially inducing overtreatment. In this study we investigated the impact of OSNA analysis on adjuvant treatment, compared to histopathological analysis. METHODS: Data from T1-3 breast cancer patients with sentinel nodes analysed between January 2016 and December 2019 by OSNA (OSNA group, n = 1086) from Zuyderland Medical Centre, the Netherlands, were compared to concurrent data from the Netherlands Cancer Registry (NKR) where sentinel nodes were examined by histology (histology group, n = 35,143)...
November 2023: Breast Cancer Research and Treatment
#44
JOURNAL ARTICLE
Lindsay B Baker, Shelby Alfred, Khalil A Lee, Justina L Bonsignore, Kristin L Osterberg, Brandon Shepherd, Peter John D De Chavez, Kobi Bentkovski
Rehydration is important for athlete performance and recovery. However, it can be challenging to follow appropriate fluid replacement practices due in part to difficulties in tracking fluid intake in real time. The purpose of this study was to determine the accuracy of a smart bottle in measuring fluid intake during exercise. Thirty male American football athletes drank from bottles equipped with a smart cap during outdoor pre-season practices (110 ± 30 min; 29.3 ± 3...
July 14, 2023: Scientific Reports
#45
JOURNAL ARTICLE
N J Abdulameer, U Acharya, A Adare, C Aidala, N N Ajitanand, Y Akiba, R Akimoto, M Alfred, N Apadula, Y Aramaki, H Asano, E T Atomssa, T C Awes, B Azmoun, V Babintsev, M Bai, N S Bandara, B Bannier, K N Barish, S Bathe, A Bazilevsky, M Beaumier, S Beckman, R Belmont, A Berdnikov, Y Berdnikov, L Bichon, D Black, B Blankenship, J S Bok, V Borisov, K Boyle, M L Brooks, J Bryslawskyj, H Buesching, V Bumazhnov, S Campbell, V Canoa Roman, C-H Chen, M Chiu, C Y Chi, I J Choi, J B Choi, T Chujo, Z Citron, M Connors, R Corliss, Y Corrales Morales, M Csanád, T Csörgő, A Datta, M S Daugherity, G David, C T Dean, K DeBlasio, K Dehmelt, A Denisov, A Deshpande, E J Desmond, L Ding, A Dion, V Doomra, J H Do, A Drees, K A Drees, J M Durham, A Durum, H En'yo, A Enokizono, R Esha, B Fadem, W Fan, N Feege, D E Fields, M Finger, M Finger, D Firak, D Fitzgerald, S L Fokin, J E Frantz, A Franz, A D Frawley, P Gallus, C Gal, P Garg, H Ge, M Giles, F Giordano, A Glenn, Y Goto, N Grau, S V Greene, M Grosse Perdekamp, T Gunji, H Guragain, Y Gu, T Hachiya, J S Haggerty, K I Hahn, H Hamagaki, J Hanks, S Y Han, M Harvey, S Hasegawa, T K Hemmick, X He, J C Hill, A Hodges, R S Hollis, K Homma, B Hong, T Hoshino, J Huang, Y Ikeda, K Imai, Y Imazu, M Inaba, A Iordanova, D Isenhower, D Ivanishchev, B V Jacak, S J Jeon, M Jezghani, X Jiang, Z Ji, B M Johnson, E Joo, K S Joo, D Jouan, D S Jumper, J H Kang, J S Kang, D Kawall, A V Kazantsev, J A Key, V Khachatryan, A Khanzadeev, A Khatiwada, K Kihara, C Kim, D H Kim, D J Kim, E-J Kim, H-J Kim, M Kim, T Kim, Y K Kim, D Kincses, A Kingan, E Kistenev, J Klatsky, D Kleinjan, P Kline, T Koblesky, M Kofarago, J Koster, D Kotov, L Kovacs, B Kurgyis, K Kurita, M Kurosawa, Y Kwon, J G Lajoie, D Larionova, A Lebedev, K B Lee, S H Lee, M J Leitch, M Leitgab, N A Lewis, S H Lim, M X Liu, X Li, D A Loomis, D Lynch, S Lökös, T Majoros, Y I Makdisi, M Makek, A Manion, V I Manko, E Mannel, M McCumber, P L McGaughey, D McGlinchey, C McKinney, A Meles, M Mendoza, B Meredith, Y Miake, A C Mignerey, A J Miller, A Milov, D K Mishra, J T Mitchell, M Mitrankova, Iu Mitrankov, S Miyasaka, S Mizuno, M M Mondal, P Montuenga, T Moon, D P Morrison, T V Moukhanova, A Muhammad, B Mulilo, T Murakami, J Murata, A Mwai, S Nagamiya, J L Nagle, M I Nagy, I Nakagawa, H Nakagomi, K Nakano, C Nattrass, S Nelson, P K Netrakanti, M Nihashi, T Niida, R Nouicer, N Novitzky, G Nukazuka, A S Nyanin, E O'Brien, C A Ogilvie, J Oh, J D Orjuela Koop, M Orosz, J D Osborn, A Oskarsson, K Ozawa, R Pak, V Pantuev, V Papavassiliou, J S Park, S Park, L Patel, M Patel, S F Pate, J-C Peng, W Peng, D V Perepelitsa, G D N Perera, D Yu Peressounko, C E PerezLara, J Perry, R Petti, C Pinkenburg, R Pinson, R P Pisani, M Potekhin, A Pun, M L Purschke, P V Radzevich, J Rak, N Ramasubramanian, I Ravinovich, K F Read, D Reynolds, V Riabov, Y Riabov, D Richford, N Riveli, D Roach, S D Rolnick, M Rosati, Z Rowan, J G Rubin, J Runchey, N Saito, T Sakaguchi, H Sako, V Samsonov, M Sarsour, S Sato, S Sawada, B Schaefer, B K Schmoll, K Sedgwick, J Seele, R Seidl, A Sen, R Seto, P Sett, A Sexton, D Sharma, I Shein, M Shibata, T-A Shibata, K Shigaki, M Shimomura, Z Shi, P Shukla, A Sickles, C L Silva, D Silvermyr, B K Singh, C P Singh, V Singh, M Slunečka, K L Smith, R A Soltz, W E Sondheim, S P Sorensen, I V Sourikova, P W Stankus, M Stepanov, S P Stoll, T Sugitate, A Sukhanov, T Sumita, J Sun, Z Sun, J Sziklai, R Takahama, A Takahara, A Taketani, K Tanida, M J Tannenbaum, S Tarafdar, A Taranenko, A Timilsina, T Todoroki, M Tomášek, H Torii, M Towell, R Towell, R S Towell, I Tserruya, Y Ueda, B Ujvari, H W van Hecke, M Vargyas, J Velkovska, M Virius, V Vrba, E Vznuzdaev, X R Wang, Z Wang, D Watanabe, Y Watanabe, Y S Watanabe, F Wei, S Whitaker, S Wolin, C P Wong, C L Woody, M Wysocki, B Xia, L Xue, S Yalcin, Y L Yamaguchi, A Yanovich, I Yoon, I Younus, I E Yushmanov, W A Zajc, A Zelenski, L Zou
We present measurements of the cross section and double-helicity asymmetry A_{LL} of direct-photon production in p[over →]+p[over →] collisions at sqrt[s]=510 GeV. The measurements have been performed at midrapidity (|η|<0.25) with the PHENIX detector at the Relativistic Heavy Ion Collider. At relativistic energies, direct photons are dominantly produced from the initial quark-gluon hard scattering and do not interact via the strong force at leading order. Therefore, at sqrt[s]=510 GeV, where leading-order-effects dominate, these measurements provide clean and direct access to the gluon helicity in the polarized proton in the gluon-momentum-fraction range 0...
June 23, 2023: Physical Review Letters
#46
JOURNAL ARTICLE
Kevin Kien Hoa Chung, Chun Bun Lam, Kevin Shing-Chi Chan, Alfred S Y Lee, Catrina Liu, Li-Chih Wang
This study investigated the cross-sectional relationships between reading-related affective and cognitive factors and reading skills among adolescents with and without dyslexia. Participants included 120 Chinese-speaking eighth graders, including 60 adolescents with dyslexia and 60 typically developing adolescents from Hong Kong, China. Adolescents completed questionnaires on general anxiety, reading anxiety, and reading self-concept. They were also assessed on measures of rapid digit naming, verbal working memory, word reading, reading fluency, and reading comprehension...
July 7, 2023: Journal of Learning Disabilities
#47
Mengying Zhou, Rui Fang, Louis Colson, Katherine A Donovan, Moritz Hunkeler, Yuyu Song, Can Zhang, Siyi Chen, Dong-Hoon Lee, Gary A Bradshaw, Robyn Eisert, Yihong Ye, Marian Kalocsay, Alfred Goldberg, Eric S Fischer, Ying Lu
Selective breakdown of proteins and aggregates is crucial for maintaining normal cellular activities and is involved in the pathogenesis of diverse diseases. How the cell recognizes and tags these targets in different structural states for degradation by the proteasome and autophagy pathways has not been well understood. Here, we discovered that a HECT-family ubiquitin ligase HUWE1 is broadly required for the efficient degradation of soluble factors and for the clearance of protein aggregates/condensates. Underlying this capacity of HUWE1 is a novel Ubiquitin-Directed ubiquitin Ligase (UDL) activity which recognizes both soluble substrates and aggregates that carry a high density of ubiquitin chains and rapidly expand the ubiquitin modifications on these targets...
May 30, 2023: bioRxiv
#48
JOURNAL ARTICLE
Ari S Mushin, Janine M Trevillyan, Sue J Lee, Anna C Hearps, Jennifer F Hoy
BACKGROUND: People living with HIV (PLHIV) are at increased risk for coronary artery disease (CAD). This study aimed to describe the features associated with CAD in PLHIV. METHODS: A case ([n=160] PLHIV with CAD) control ([n=317] PLHIV matched by age and sex without CAD) study was performed at the Alfred Hospital, Melbourne, Australia (January 1996 and December 2018). Data collected included CAD risk factors, duration of HIV infection, nadir and at-event CD4+ T-cell counts, CD4:CD8 ratio, HIV viral load, and antiretroviral therapy exposure...
July 3, 2023: Sexual Health
#49
REVIEW
Bo Peng, Kara K L Reeves, Shara W Y Lee, Tina H Y Chung, Heidi W L Hui, Alfred H L Leung, Johnson C Y Pang
INTRODUCTION: The COVID-19 pandemic has impacted children and adolescents' physical activity (PA), sleeping patterns, and psychological and behavioral health. Yet, little is known about the differences between those in countries with various economic statuses. METHODS: Articles published from database inception through 16 March 2022 were retrieved using CINAHL Complete, Cochrane Library, EMBASE, Medline, PubMed, and PsycINFO. High-quality studies that reported the number of participants with parameters associated with PA, sleeping patterns, and psychological and behavioral problems in young people aged under 18 years during the pandemic were included...
2023: Frontiers in Pediatrics
#50
JOURNAL ARTICLE
Sarah Xinhui Tan, Yoanna Pumpalova, Alexandra M Rogers, Kishan Bhatt, Candice-Lee Herbst, Paul Ruff, Alfred I Neugut, Chin Hur
BACKGROUND: Colon cancer incidence is rising in low- and middle-income countries (LMICs), where resource limitations and cost often dictate treatment decisions. In this study, we evaluate the cost-effectiveness of adjuvant chemotherapy for high-risk stage II and stage III colon cancer treatment in South Africa (ZA) and illustrate how such analyses can inform cancer treatment recommendations in a LMIC. METHODS: We created a decision-analytic Markov model to compare lifetime costs and outcomes for patients with high-risk stage II and stage III colon cancer treated with three adjuvant chemotherapy regimens in a public hospital in ZA: capecitabine and oxaliplatin (CAPOX) for 3 and 6 months, and capecitabine for 6 months, compared to no adjuvant treatment...
June 15, 2023: Cancer Medicine
#51
JOURNAL ARTICLE
Elayne M Thomas, Matthew K McBride, Owen A Lee, Ryan C Hayward, Alfred J Crosby
Electroadhesion is the modulation of adhesive forces through electrostatic interactions and has potential applications in a number of next-generation technologies. Recent efforts have focused on using electroadhesion in soft robotics, haptics, and biointerfaces that often involve compliant materials and nonplanar geometries. Current models for electroadhesion provide limited insight on other contributions that are known to influence adhesion performance, such as geometry and material properties. This study presents a fracture mechanics framework for understanding electroadhesion that incorporates geometric and electrostatic contributions for soft electroadhesives...
June 14, 2023: ACS Applied Materials & Interfaces
#52
REVIEW
Alfred Mays, Angela Byars-Winston, Antentor Hinton, Andrea G Marshall, Annet Kirabo, Avery August, Bianca J Marlin, Blake Riggs, Blanton Tolbert, Celestine Wanjalla, Chad Womack, Chantell S Evans, Christopher Barnes, Chrystal Starbird, Clintoria Williams, Corey Reynolds, Cornelius Taabazuing, Craig E Cameron, Debra D Murray, Derek Applewhite, Derrick J Morton, Dexter Lee, Dionna W Williams, Donald Lynch, Donita Brady, Erin Lynch, Florentine U N Rutaganira, Gustavo M Silva, Haysetta Shuler, Ishmail Abdus Saboor, Jamaine Davis, Kafui Dzirasa, Latanya Hammonds-Odie, Loretta Reyes, Mariya T Sweetwyne, Melanie R McReynolds, Michael D L Johnson, Nathan A Smith, Nikea Pittman, Olujimi A Ajijola, Quinton Smith, Renã A S Robinson, Samantha C Lewis, Sandra A Murray, Sherilynn Black, Sonya E Neal, Stanley Andrisse, Steven Townsend, Steven M Damo, Theanne N Griffith, W Marcus Lambert, William M Clemons
We are 52 Black scientists. Here, we establish the context of Juneteenth in STEMM and discuss the barriers Black scientists face, the struggles they endure, and the lack of recognition they receive. We review racism's history in science and provide institutional-level solutions to reduce the burdens on Black scientists.
June 8, 2023: Cell
#53
JOURNAL ARTICLE
Diana L Y Su, Alfred S Y Lee, Joan S K Chung, Tracy C W Tang, Catherine M Capio, Lei Zhang, Derwin K C Chan
This two-wave prospective study applied the Social Influence in Sport Model to investigate whether the social influences of parents, physical education (PE) teachers, and peers were predictive of students' intention to engage in leisure-time physical activity (PA). Participants were 2,484 secondary school students (11-18 years old) who completed a questionnaire assessing positive influence, punishment, and dysfunction from the three social agents (parents, PE teachers, and peers) at baseline, and PA intention at a 1-month follow-up...
July 2023: Journal of Exercise Science and Fitness
#54
JOURNAL ARTICLE
Yuriy A Abramov, Luca Iuzzolino, Yingdi Jin, Gregory York, Chien-Hung Chen, C Scott Shultz, Zhuocen Yang, Chao Chang, Baimei Shi, Tian Zhou, Chandler Greenwell, Sivakumar Sekharan, Alfred Y Lee
Crystal structure prediction (CSP) is an invaluable tool in the pharmaceutical industry because it allows to predict all the possible crystalline solid forms of small-molecule active pharmaceutical ingredients. We have used a CSP-based cocrystal prediction method to rank ten potential cocrystal coformers by the energy of the cocrystallization reaction with an antiviral drug candidate, MK-8876, and a triol process intermediate, 2-ethynylglyclerol. For MK-8876, the CSP-based cocrystal prediction was performed retrospectively and successfully predicted the maleic acid cocrystal as the most likely cocrystal to be observed...
June 6, 2023: Molecular Pharmaceutics
#55
Donghoon Lee, Yanan Zhu, Louis Colson, Xiaorong Wang, Siyi Chen, Emre Tkacik, Lan Huang, Qi Ouyang, Alfred L Goldberg, Ying Lu
Various hormones, kinases, and stressors (fasting, heat shock) stimulate 26S proteasome activity. To understand how its capacity to degrade ubiquitylated protein can increase, we studied ZFAND5, which promotes protein degradation during muscle atrophy. Cryo-electron microscopy showed that ZFAND5 induces large conformational changes in the 19S regulatory particle. ZFAND5's AN1 Zn finger interacts with the Rpt5 ATPase and its C-terminus with Rpt1 ATPase and Rpn1, a ubiquitin-binding subunit. Surprisingly, these C-terminal interactions are sufficient to activate proteolysis...
May 10, 2023: bioRxiv
#56
JOURNAL ARTICLE
Marta Masó-Martínez, Benjamin Fryer, Dimitri Aubert, Benjamin Peacock, Rebecca Lees, Graham A Rance, Michael W Fay, Paul D Topham, Alfred Fernández-Castané
Magnetosomes are biologically-derived magnetic nanoparticles (MNPs) naturally produced by magnetotactic bacteria (MTB). Due to their distinctive characteristics, such as narrow size distribution and high biocompatibility, magnetosomes represent an attractive alternative to existing commercially-available chemically-synthesized MNPs. However, to extract magnetosomes from the bacteria, a cell disruption step is required. In this study, a systematic comparison between three disruption techniques (enzymatic treatment, probe sonication and high-pressure homogenization) was carried out to study their effect on the chain length, integrity and aggregation state of magnetosomes isolated from Magnetospirillum gryphiswaldense MSR-1 cells...
2023: Frontiers in Bioengineering and Biotechnology
#57
JOURNAL ARTICLE
Jonathan M Philpott, Alfred M Freeberg, Jiyoung Park, Kwangjun Lee, Clarisse G Ricci, Sabrina R Hunt, Rajesh Narasimamurthy, David H Segal, Rafael Robles, Yao Cai, Sarvind Tripathi, J Andrew McCammon, David M Virshup, Joanna C Chiu, Choogon Lee, Carrie L Partch
PERIOD (PER) and Casein Kinase 1δ regulate circadian rhythms through a phosphoswitch that controls PER stability and repressive activity in the molecular clock. CK1δ phosphorylation of the familial advanced sleep phase (FASP) serine cluster embedded within the Casein Kinase 1 binding domain (CK1BD) of mammalian PER1/2 inhibits its activity on phosphodegrons to stabilize PER and extend circadian period. Here, we show that the phosphorylated FASP region (pFASP) of PER2 directly interacts with and inhibits CK1δ...
May 18, 2023: Molecular Cell
#58
JOURNAL ARTICLE
Juliet Chepngeno, Joshua O Amimo, Husheem Michael, Sergei A Raev, Kwonil Jung, Marcia V Lee, Debasu Damtie, Alfred Omwando, Anastasia N Vlasova, Linda J Saif
Rotavirus A (RVA) causes ~200,000 diarrheal deaths annually in children <5yrs, mostly in low- and middle-income countries. Risk factors include nutritional status, social factors, breastfeeding status, and immunodeficiency. We evaluated the effects of vitamin A (VA) deficiency/VA supplementation and RVA exposure (anamnestic) on innate and T cell immune responses in RVA seropositive pregnant and lactating sows and passive protection of their piglets post-RVA challenge. Sows were fed VA deficient (VAD) or sufficient (VAS) diets starting at gestation day (GD)30...
2023: Frontiers in Immunology
#59
JOURNAL ARTICLE
Ah-Jung Jeon, Chukwuemeka George Anene-Nzelu, Yue-Yang Teo, Shay Lee Chong, Karthik Sekar, Lingyan Wu, Sin-Chi Chew, Jianbin Chen, Raden Indah Kendarsari, Hannah Lai, Wen Huan Ling, Neslihan Arife Kaya, Jia Qi Lim, Alexander Yaw Fui Chung, Peng-Chung Cheow, Juinn Huar Kam, Krishnakumar Madhavan, Alfred Kow, Iyer Shridhar Ganpathi, Tony Kiat Hon Lim, Wei-Qiang Leow, Shihleone Loong, Tracy Jiezhen Loh, Wei Keat Wan, Gwyneth Shook Ting Soon, Yin Huei Pang, Boon Koon Yoong, Diana Bee-Lan Ong, Jasmine Lim, Vanessa H de Villa, Rouchelle D Dela Cruz, Rawisak Chanwat, Jidapa Thammasiri, Glenn K Bonney, Brian K P Goh, Roger Sik Yin Foo, Pierce Kah-Hoe Chow
BACKGROUND & AIMS: Lifestyle and environmental-related exposures are important risk factors for hepatocellular carcinoma (HCC), suggesting that epigenetic dysregulation significantly underpins HCC. We profiled 30 surgically resected tumours and the matched adjacent normal tissues to understand the aberrant epigenetic events associated with HCC. METHODS: We identified tumour differential enhancers and the associated genes by analysing H3K27 acetylation (H3K27ac) chromatin immunoprecipitation sequencing (ChIP-seq) and Hi-C/HiChIP data from the resected tumour samples of 30 patients with early-stage HCC...
June 2023: JHEP reports: innovation in hepatology
#60
Cecily Allen, Samir Gautam, Wei Cheng, Alexander B Pine, Nikolai A Podoltsev, Amer M Zeidan, Alfred I Lee, Rory M Shallis
Patients with acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) often receive antibacterial prophylaxis. Antibacterial agents can cause elevations in the prothrombin time and international normalized ratio (INR). The impact of prophylactic antibacterials on the coagulation profiles and bleeding risk in patients with AML/MDS is unknown. We evaluated patients with AML or MDS who were being admitted to the hospital. The cohort was divided into two groups of patients: (1) those receiving and (2) those not receiving prophylactic antibacterials, at the time of admission...
2023: Acta Haematologica
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