Amazing

Previous research has shown that languages from nearby families are easier to learn as second languages (L2) than languages from more distant families, attributing this difference to the presence of shared elements between the native language (L1) and L2. Building on this idea, we hypothesized that suffixes present in L1 might facilitate complex word acquisition in L2. To test this hypothesis, we recruited 76 late French-English bilinguals and tasked them with learning a set of 80 English derived-words containing suffixes that also exist in French (e...

Rationale: Systemic sclerosis (SSc) is a chronic and incurable autoimmune disease with high mortality rates, and skin fibrosis is one of distinguishing hallmarks in the pathogenesis. However, macrophage heterogeneity regulating skin fibrosis remain largely unknown. Methods: We established mouse disease model and performed single-cell RNA-sequencing (scRNA-seq) to resolve the dynamic and heterogenous characteristics of macrophages in skin fibrosis, and the role of TREM2-dependent macrophages in the pathological process was investigated using knockout mice and intraperitoneal transferring TREM2+ macrophages combining with functional assays...

Multi-principal element alloys (MPEAs) exhibit outstanding strength attributed to the complex dislocation dynamics as compared to conventional alloys. Here, we develop an atomic-lattice-distortion-dependent discrete dislocation dynamics framework consisted of random field theory and phenomenological dislocation model to investigate the fundamental deformation mechanism underlying massive dislocation motions in body-centered cubic MPEA. Amazingly, the turbulence of dislocation speed is identified in light of strong heterogeneous lattice strain field caused by short-range ordering...

INTRODUCTION: Parent child interaction (PCI) is positively associated with deaf children's language development. However, there are no known, deaf-specific tools to observe how a parent interacts with their deaf child aged 0-3 years. Without a framework for professionals to use with families, it is unknown how professionals assess PCI, what they assess, why they assess, and how the assessment results relate to case management. METHODS: Eighteen hearing and deaf professionals, who work with deaf and hard of hearing infants aged 0-3 years and their families, attended online focus groups...

Polycyclic aromatic hydrocarbons (PAHs), a group of seriously hazardous environmental contaminants, have attracted extensive attention due to their carcinogenicity, genotoxicity, mutagenicity, and ubiquity. In this work, the excellent hydrophobic trifluoromethyl-enriched covalent organic framework (CF3 -COF) was designed and synthesized as coating of solid-phase microextraction (SPME). The CF3 -COF offered a high adsorption selectivity for PAHs, which could be attributed to the multiple interactions between the CF3 -COF and PAHs, including hydrophobicity interaction, π-π and H bond interactions...

#PSMA is amazing new tech but is using it to expedite the call of disease progression helping #ProstateCancer patients?

The development of efficient defluorination technology is an important issue because the kind of emerging pollutant of hexafluoropropylene oxide dimer acid (GenX) as an alternative to perfluorooctanoic acid (PFOA) has the higher environmental risks. In the UV/bisulfite system, we first developed a hydrophobic confined α-Fe2 O3 nanoparticle layer rich in oxygen vacancies, which accelerated the enrichment of HSO3 - and GenX on the surface and pores through electrostatic attraction and hydrophobic interaction, retaining more hydrated electrons (eaq - ) and rapidly destroying GenX under UV excitation...

The ever-growing use of nature-derived materials creates exciting opportunities for novel development in various therapeutic biomedical applications. Living cells, serving as the foundation of nanoarchitectonics, exhibit remarkable capabilities that enable the development of bioinspired and biomimetic systems, which will be explored in this review. To understand the foundation of this development, we first revisited the anatomy of cells to explore the characteristics of the building blocks of life that is relevant...

Introduction: Connections among neurons form one of the most amazing and effective network in nature. At higher level, also the functional structures of the brain is organized as a network. It is therefore natural to use modern techniques of network analysis to describe the structures of networks in the brain. Many studies have been conducted in this area, showing that the structure of the neuronal network is complex, with a small-world topology, modularity and the presence of hubs. Other studies have been conducted to investigate the dynamical processes occurring in brain networks, analyzing local and large-scale network dynamics...

A complex electromagnetic environment is a formidable challenge in national defense areas. Microwave-absorbing materials are considered as a strategy to tackle this challenge. In this work, lightweight, flexible, and thermal insulating Carbon/SiO2 @CNTs (CSC) aerogel is successfully prepared coupled with outstanding microwave absorbing performance, through freeze-drying and high-temperature annealing techniques. The CSC aerogel shows a strong reflection loss (-55.16 dB) as well as wide effective absorbing bandwidth (8...

The presence of halogen bonds (R-X···B; R = substituent group, X = halogen, and B = Lewis base) provides quite amazing molecular systems for electronic structure investigations, presenting unique characteristics of fundamental relevance to supramolecular chemistry among other areas. Here, we use a double-hybrid approach from Density Functional Theory and triple-ζ basis sets augmented with diffuse functions (B2PLYP/def2-TZVPD) to deal with a large group of simple molecular systems containing halogen bonds (XBs), focusing on geometrical structures, binding energies, harmonic vibrational frequencies, and fundamental infrared intensities...

Energy has always been the most concerned topic worldwide due to its large consumption. Among various types of energies, light has amazing characteristics and have interesting effects on living organisms. Interest is increasing in the use of laser kernel treatment as an environment friendly physical technique for better results in agronomic crops, but the work is still in progress. The present study was conducted with the aim to examine the application of range of Neodymium-doped Yttrium Aluminum Garnet (Nd:YAG) pulsed laser exposures (200, 400, 600, 800, 1000, 1200, 1400 J/cm2 ) as pre-sowing kernel treatment on seedling survival rate, leaf photosynthetic activity in relation with photosynthetic pigments and visual morphological effects at seedling to maturity stage...

The ketogenic diet was an amazing approach to treating epilepsy from its beginning. The body undergoes a change in obtaining energy, going from depending on carbohydrates to depending on fats, and then a whole series of biochemical routes are launched that, independently but also complementary, give rise to a set of effects that benefit the patient. This search for its mechanism of action, of devising how to improve compliance and take advantage of it for other diseases has marked its trajectory. This article briefly reviews these aspects, emphasizing the importance of continuing to carry out basic and clinical research so that this treatment can be applied with solid scientific bases...

Our editor discusses our editorial board members, who come from eight countries on four continents, and wider issues of the peer review system.

In amniote limbs, Fibroblast Growth Factor 10 (FGF10) is essential for limb development, but whether this function is broadly conserved in tetrapods and/or involved in adult limb regeneration remains unknown. To tackle this question, we established Fgf10 mutant lines in the newt Pleurodeles waltl which has amazing regenerative ability. While Fgf10 mutant forelimbs develop normally, the hindlimbs fail to develop and downregulate FGF target genes. Despite these developmental defects, Fgf10 mutants were able to regenerate normal hindlimbs rather than recapitulating the embryonic phenotype...

BACKGROUND: Left ventricular thrombus (LVT) is a source of cardiogenic embolic stroke. Conflicting data exist in the literature regarding the utilization of intravenous thrombolysis (IVT) at the acute phase of stroke in presence of LVT. We sought to assess the efficacy and safety of reperfusion therapies (IVT and/or thrombectomy) in patients with LVT. METHODS: We retrospectively analyzed patients with acute ischemic stroke and proven LVT and divided them in two groups: an intervention group with patients treated by reperfusion therapies and a control group with untreated patients...

BACKGROUND: Asthma remission is a potential treatment goal. RESEARCH QUESTION: Does adding azithromycin to standard therapy in patients with persistent uncontrolled asthma induce remission compared to placebo? STUDY DESIGN AND METHODS: This secondary analysis used data from the AMAZES clinical trial - a double-blind placebo-controlled trial that evaluated the safety and efficacy of azithromycin on asthma exacerbations. The primary remission definition (referred to as clinical remission) was zero exacerbations and zero oral corticosteroids (OCS) during the previous six months evaluated at 12 months and Asthma Control Questionnaire (ACQ-5) ≤1 at 12 months...

Nuclear energy continues to be an important supplier of electricity, but it has problems with waste management and the possibility to leak radioactive material. Iodine, a potentially harmful byproduct of uranium fission, is hazardous to both the environment and human health. Therefore, developing safe, effective, and affordable storage facilities for iodine waste is crucial. Owing to their well-controlled pore structure and substantial certain surface area, covalent organic frameworks (COFs) show promise for the adsorption of radioactive iodine...

BACKGROUND: Low rates of participation and quality of life (QoL) and high rates of psychological distress are common in spinal cord injury (SCI) population. Research has supported the mediating role of self-efficacy and functionality in improving psychosocial outcomes. Furthermore, evidence supports the impact of physical activity (PA) on psychosocial variables, but little is known about the types and intensities of PA. The objective of this study was to determine whether functionality and/or general self-efficacy (GSE) mediate the relationships between the various types of PA: (1) lifestyle and (2) leisure-time physical activity (LTPA); and various intensities of PA: (1) mild, (2) moderate, and (3) heavy PA with participation, psychological distress, and perception of QoL...

Biological materials, although composed of meager minerals and biopolymers, often exhibit amazing mechanical properties far beyond their components due to hierarchically ordered structures. Understanding their structure-properties relationships and replicating them into artificial materials would boost the development of bulk structural nanocomposites. Layered microstructure widely exists in biological materials, serving as the fundamental structure in nanosheet-based nacres and nanofiber-based Bouligand tissues, and implying superior mechanical properties...