Alison Moe, Aditya Rayasam, Garrett Sauber, Ravi K Shah, Ashley Doherty, Cheng-Yin Yuan, Aniko Szabo, Bob M Moore Ii, Marco Colonna, Weiguo Cui, Julian Romero, Anthony E Zamora, Cecilia J Hillard, William R Drobyski
Neuroinflammation is a recognized complication of immunotherapeutic approaches such as immune checkpoint inhibitor treatment, chimeric antigen receptor therapy, and graft versus host disease (GVHD) occurring after allogeneic hematopoietic stem cell transplantation. While T cells and inflammatory cytokines play a role in this process, the precise interplay between the adaptive and innate arms of the immune system that propagates inflammation in the central nervous system remains incompletely understood. Using a murine model of GVHD, we demonstrate that type 2 cannabinoid receptor (CB2R) signaling plays a critical role in the pathophysiology of neuroinflammation...
April 25, 2024: Journal of Clinical Investigation