Lijuan Lv, Qiurong Li, Kexin Wang, Jianping Zhao, Kejun Deng, Ran Zhang, Zhong Chen, Ikhlas A Khan, Chunshan Gui, Suxiang Feng, Shilin Yang, Yanli Liu, Qiongming Xu
Anemoside B4 (AB4), a triterpenoidal saponin from Pulsatilla chinensis , shows significant anti-inflammatory activity, and may be used for treating inflammatory bowel disease (IBD). Nevertheless, its application is limited due to its high molecular weight and pronounced water solubility. To discover new effective agents for treating IBD, we synthesized 28 AB4 derivatives and evaluated their cytotoxic and anti-inflammatory activities in vitro . Among them, A3-6 exhibited significantly superior anti-inflammatory activity compared to AB4...
April 30, 2024: Journal of Medicinal Chemistry