Jun Ki Hong, DO Yeon Kim, Jae-Sik Shin, Yea Seong Ryu, Jai-Hee Moon, Dong-In Koh, Seul Lee, Jinwoo Lee, Won Jun Lee, Eun Young Lee, Soo-A Jung, Seung Chan Kim, Ha Na Yu, Mi Jin Kim, Seung-Woo Hong, Sang Soo Park, Joonyee Jung, Seung Mi Kim, Eun Ho Kim, Hong-Rae Jeong, Ji Hee Gong, Jieun Kim, Tae Won Kim, Dong-Hoon Jin
BACKGROUND/AIM: Colorectal cancer is reported to have the highest mortality rate among human malignancies. Although many research results for the treatment of colorectal cancer have been reported, there is no suitable treatment when resistance has developed. Therefore, it is necessary to develop new therapeutic agents. Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling plays an essential role in cell differentiation, proliferation, and survival. Abnormal activation of the JAK/STAT signaling pathway, by gene mutation or amplification, may induce cancer development, and sustained JAK/STAT activation is involved in chemoresistance...
April 2022: Anticancer Research