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JOURNAL ARTICLE
Matthéo Alcaraz, Sébastien Lyonnais, Chandramouli Ghosh, John Jairo Aguilera-Correa, Sébastien Richeter, Sébastien Ulrich, Laurent Kremer
Mycobacterium abscessus is increasingly recognized as an emerging opportunistic pathogen causing severe lung diseases and cutaneous infections. However, treatment of M. abscessus infections remains particularly challenging, largely due to intrinsic resistance to a wide panel of antimicrobial agents. New therapeutic alternatives are urgently needed. Herein, we show that, upon limited irradiation with a blue-light source, newly developed porphyrin-peptide cage-type photosensitizers exert a strong bactericidal activity against smooth and rough variants of M...
April 15, 2024: Microbiology Spectrum
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JOURNAL ARTICLE
Chandramouli Ghosh, Lamiaa M A Ali, Yannick Bessin, Sébastien Clément, Sébastien Richeter, Nadir Bettache, Sébastien Ulrich
The development of photodynamic therapy requires access to smart photosensitizers which combine appropriate photophysical and biological properties. Interestingly, supramolecular and dynamic covalent chemistries have recently shown their ability to produce novel architectures and responsive systems through simple self-assembly approaches. Herein, we report the straightforward formation of porphyrin-peptide conjugates and cage compounds which feature on their surface chemical groups promoting cell uptake and specific organelle targeting...
January 30, 2024: Organic & Biomolecular Chemistry
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JOURNAL ARTICLE
Emma Dutilloy, Anthony Arguëlles Arias, Nicolas Richet, Jean-François Guise, Matthieu Duban, Valérie Leclere, Sameh Selim, Philippe Jacques, Cédric Jacquard, Christophe Clément, Essaïd Ait Barka, Qassim Esmaeel
Wheat and barley rank among the main crops cultivated on a global scale, providing the essential nutritional foundation for both humans and animals. Nevertheless, these crops are vulnerable to several fungal diseases, such as Septoria tritici blotch and net blotch, which significantly reduce yields by adversely affecting leaves and grain quality. To mitigate the effect of these diseases, chemical fungicides have proven to be genuinely effective; however, they impose a serious environmental burden. Currently, biocontrol agents have attracted attention as a sustainable alternative to fungicides, offering an eco-friendly option...
December 2024: Applied Microbiology and Biotechnology
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JOURNAL ARTICLE
Quentin Landolff, Marine Quillot, Fabien Picard, Patrick Henry, Georgios Sideris, Olivier Bizeau, Christophe Piot, Bernard Jouve, Jérôme Rischner, Mourad Mejri, Claude Charmasson, Raphael Lasserre, Hervé Pouliquen, Thierry Joseph, Jacques Monsegu, Bernard Karsenty, Victoria Martin Yuste, Nicolas Richet, Guy Lapeyre, Fabrizio Beverelli, Farzin Beygui, René Koning
OBJECTIVES: The aim of this postmarket clinical study was to assess the safety and efficacy of the latest generation polymer-free sirolimus-eluting stents (PF-SES) in an all-comers population comparing outcomes in stable coronary artery disease (CAD) versus acute coronary syndrome (ACS) in France. BACKGROUND: The efficacy and safety of the first-generation PF-SES have already been demonstrated by randomized controlled trials and "all-comers" observational studies...
2023: Journal of Interventional Cardiology
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REVIEW
Amina Merabti, Sébastien Richeter, Claudiu T Supuran, Sébastien Clement, Jean-Yves Winum
INTRODUCTION: Photodynamic therapy (PDT) is a reactive oxygen species (ROS)-dependent treatment modality which has emerged as an alternative cancer therapy strategy. However, in solid tumors, the therapeutic efficacy of PDT is strongly reduced by hypoxia, a typical feature of many such tumors. The tumor-associated carbonic anhydrases IX (hCA IX) and XII (hCA XII), which are overexpressed under hypoxia are attractive, validated anticancer drug targets in solid tumors. Current challenges in therapeutic design of effective PDT systems aim to overcome the limitation of hypoxia by developing synergistic CA-targeted therapies combining photosensitizers and hCA IX/XII inhibitors...
September 5, 2023: Expert Opinion on Therapeutic Targets
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JOURNAL ARTICLE
Yuang Wu, Yue Sun, Evelyne Richet, Zhifu Han, Jijie Chai
Proteins from the signal transduction ATPases with numerous domains (STAND) family are known to play an important role in innate immunity. However, it remains less well understood how they function in transcriptional regulation. MalT is a bacterial STAND that controls the Escherichia coli maltose system. Inactive MalT is sequestered by different inhibitory proteins such as MalY. Here, we show that MalY interacts with one oligomerization interface of MalT to form a 2:2 complex. MalY represses MalT activity by blocking its oligomerization and strengthening ADP-mediated MalT autoinhibition...
August 15, 2023: Nature Communications
#7
JOURNAL ARTICLE
Francis Matthews, Gert Verstraeten, Pasquale Borrelli, Matthias Vanmaercke, Jean Poesen, An Steegen, Aurore Degré, Belén Cárceles Rodríguez, Charles Bielders, Christine Franke, Claire Alary, David Zumr, Edouard Patault, Estela Nadal-Romero, Ewa Smolska, Feliciana Licciardello, Gilles Swerts, Hans Thodsen, Javier Casalí, Javier Eslava, Jean-Baptiste Richet, Jean-François Ouvry, Joaquim Farguell, Jolanta Święchowicz, João Pedro Nunes, Lai Ting Pak, Leonidas Liakos, Miguel A Campo-Bescós, Mirosław Żelazny, Morgan Delaporte, Nathalie Pineux, Nathan Henin, Nejc Bezak, Noemí Lana-Renault, Ourania Tzoraki, Rafael Giménez, Tailin Li, Víctor Hugo Durán Zuazo, Vincenzo Bagarello, Vincenzo Pampalone, Vito Ferro, Xavier Úbeda, Panos Panagos
As a network of researchers we release an open-access database (EUSEDcollab) of water discharge and suspended sediment yield time series records collected in small to medium sized catchments in Europe. EUSEDcollab is compiled to overcome the scarcity of open-access data at relevant spatial scales for studies on runoff, soil loss by water erosion and sediment delivery. Multi-source measurement data from numerous researchers and institutions were harmonised into a common time series and metadata structure. Data reuse is facilitated through accompanying metadata descriptors providing background technical information for each monitoring station setup...
August 4, 2023: Scientific Data
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JOURNAL ARTICLE
Julián D Restrepo-Leal, Marie Belair, Jochen Fischer, Nicolas Richet, Florence Fontaine, Caroline Rémond, Olivier Fernandez, Ludovic Besaury
Neofusicoccum parvum is one of the most aggressive Botryosphaeriaceae species associated with grapevine trunk diseases. This species may secrete enzymes capable of overcoming the plant barriers, leading to wood colonization. In addition to their roles in pathogenicity, there is an interest in taking advantage of N. parvum carbohydrate-active enzymes (CAZymes), related to plant cell wall degradation, for lignocellulose biorefining. Furthermore, N. parvum produces toxic secondary metabolites that may contribute to its virulence...
2023: Mycologia
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JOURNAL ARTICLE
Pedro Henrique Costa de Resende, Alexander Moreira-Almeida, Humberto Schubert Coelho
The Society for Psychical Research (SPR) of London was founded in 1882 with the purpose of investigating psychical phenomena, especially the theme of survival, with scientific rigour. Despite the recognized importance of the SPR for dynamic psychiatry in the nineteenth and twentieth centuries, there are few studies of its epistemological contributions to the theme of survival and its implications to science. In order to fill this gap, we have consulted the main journals of the SPR in its golden period, and highlight the epistemologies of Sidgwick, Myers, James, Podmore, Schiller, Lodge and Richet...
June 5, 2023: History of Psychiatry
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JOURNAL ARTICLE
Maxime Roger, Yann Bretonnière, Yann Trolez, Antoine Vacher, Imane Arbouch, Jérôme Cornil, Gautier Félix, Julien De Winter, Sébastien Richeter, Sébastien Clément, Philippe Gerbier
Three new tetraphenylethene (TPE) push-pull chromophores exhibiting strong intramolecular charge transfer (ICT) are described. They were obtained via [2 + 2] cycloaddition-retroelectrocyclization (CA-RE) click reactions on an electron-rich alkyne-tetrafunctionalized TPE (TPE-alkyne) using both 1,1,2,2-tetracyanoethene (TCNE), 7,7,8,8-tetracyanoquinodimethane (TCNQ) and 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4 -TCNQ) as electron-deficient alkenes. Only the starting TPE-alkyne displayed significant AIE behavior, whereas for TPE-TCNE, a faint effect was observed, and for TPE-TCNQ and TPE-F4 -TCNQ, no fluorescence was observed in any conditions...
May 13, 2023: International Journal of Molecular Sciences
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JOURNAL ARTICLE
Denis Monneret, Amélie Moreau, Carole Chirica, Dorra Guergour, Caroline Richet, Laurent Desmurs, Sylvie Colognac, Audrey Frugier, Marc Chévrier, Oriane Marmontel, Dominique Bonnefont-Rousselot, Philippe Gonzalo, Claire Rodriguez-Lafrasse, Régine Cartier
OBJECTIVES: Non-linearity in lipase assays and the ensuing gaps in results distribution have been described on Roche analysers, but have yet to be studied on other analysers. DESIGN & METHODS: Eighteen lithium-heparinized plasma pools of lipase activities decreasing from 1700 to <4 U/L were prepared for multicentric evaluation on several analysers. Non-linearity was modelled as the difference between the polynomial regression of lipase activities depending on relative dilutions over the primary measuring range, and the linear regression of the same variables above the manufacturer's limit of linearity (MLL)...
February 9, 2023: Clinical Biochemistry
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JOURNAL ARTICLE
Maxime Durand, Alicia Chateau, Justine Jubréaux, Jérôme Devy, Héna Paquot, Gautier Laurent, Rana Bazzi, Stéphane Roux, Nicolas Richet, Aurélie Reinhard-Ruch, Pascal Chastagner, Sophie Pinel
PURPOSE: This study aimed to evaluate the radiosensitizing potential of Au@DTDTPA(Gd) nanoparticles when combined with conventional external X-ray irradiation (RT) to treat GBM. METHODS: Complementary biological models based on U87 spheroids including conventional 3D invasion assay, organotypic brain slice cultures, chronic cranial window model were implemented to investigate the impact of RT treatments (10 Gy single dose; 5×2 Gy or 2×5 Gy) combined with Au@DTDTPA(Gd) nanoparticles on tumor progression...
2023: International Journal of Nanomedicine
#13
JOURNAL ARTICLE
Gabriella M Cerna, Laurel E K Serieys, Seth P D Riley, Cécile Richet, Simona Kraberger, Arvind Varsani
Viruses in the family Circoviridae have small circular single-stranded DNA (ssDNA) genomes. Circoviruses are known to infect a wide variety of animals, with notable disease pathology in psittacine (psittacine beak and feather disease) and porcine (postweaning multisystemic wasting syndrome) species. There is still a dearth of research investigating circoviruses associated with felid species. In six fecal samples collected from bobcats (Lynx rufus) in California from 2010 to 2011, we identified six viruses belonging to the genera Circovirus (n = 1) and Cyclovirus (n = 5), using a high-throughput-sequencing-based approach...
January 3, 2023: Archives of Virology
#14
JOURNAL ARTICLE
Catarina Leal, David Gramaje, Florence Fontaine, Nicolas Richet, Patricia Trotel-Aziz, Josep Armengol
BACKGROUND: Grapevine trunk diseases (GTDs) are a complex group of diseases, that lead to major economic losses in all wine producing countries. The investigation of biocontrol agents (BCAs) capable to forestall or at least minimize the development of GTDs has, recently, become a priority. Nursery experiments were set up to (i) assess the biocontrol effect of Trichoderma atroviride SC1 and Bacillus subtilis PTA-271, alone and in simultaneous application, against Botryosphaeria dieback (BOT) and black foot (BF) associated pathogens during the grapevine propagation process, and (ii) evaluate the success of the BCA inoculation during the grapevine propagation process, using qRT-PCR techniques...
December 27, 2022: Pest Management Science
#15
JOURNAL ARTICLE
Eva Richet, Laurie Ferret, Louise Gaboriau, Pascal Charpentier, Laure Dujardin, Julie Fulcrand, Amélie Boursier
Introduction Dronabinol is a drug composed of synthetic delta-9-tetrahydrocannabinol. In France dronabinol requires a named Temporary Utilisation Authorisation (TUA), for the treatment of refractory neuropathic pain. Few data currently exist concerning its efficacy and tolerance. We present our feedback on its use for chronic pain patients, the multidisciplinary supervision and the monitoring set up by the clinical pharmacist. Method This retrospective monocentric study presents Patients Global Impression of Change and tolerance data from patients treated with dronabinol in a pain center between October 2020 and July 2021...
December 10, 2022: Annales Pharmaceutiques Françaises
#16
JOURNAL ARTICLE
Ludivine Poyac, Stefano Scoditti, Xavier Dumail, Michel Granier, Sébastien Clément, Rafael Gramage-Doria, Charles H Devillers, Sébastien Richeter
Electronic and steric properties of NHC ligands functionalized with porphyrins were investigated. When porphyrins are used as NHC-wingtips, nickel(II) in the macrocyle significantly improves the catalytic activity of the neighbouring NHC-Rh(I) complex in the conjugate addition of phenylboronic acid to cyclohexen-2-one.
November 14, 2022: Chemical Communications: Chem Comm
#17
JOURNAL ARTICLE
Clément Kotras, Maxime Leclercq, Maxime Roger, Camille Bouillon, Antonio Recupido, Aurélien Lebrun, Yannick Bessin, Philippe Gerbier, Sébastien Richeter, Sébastien Ulrich, Sébastien Clément, Mathieu Surin
Dynamic covalent polymers (DCPs) offer opportunities as adaptive materials of particular interest for targeting, sensing and delivery of biological molecules. In this view, combining cationic units and fluorescent units along DCP chains is attractive for achieving optical probes for the recognition and delivery of nucleic acids. Here, we report on the design of acylhydrazone-based DCPs combining cationic arginine units with π-conjugated fluorescent moieties based on thiophene-ethynyl-fluorene cores. Two types of fluorescent building blocks bearing neutral or cationic side groups on the fluorene moiety are considered in order to assess the role of the number of cationic units on complexation with DNA...
October 6, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
#18
JOURNAL ARTICLE
Krzysztof Szpila, Nikolas P Johnston, Kamran Akbarzadeh, Rene Richet, Adam Tofilski
The flesh flies are a group of insects well known for their forensic importance. Reliable identification of these flies relies on the use of either molecular markers or the morphology of the male genital apparatus. Identification of female flesh flies is more time consuming and less reliable than their male counterparts. This is particularly problematic for forensic entomology practitioners, because female flesh flies are more abundant than males in carrion arthropod assemblages. As such, it is critical that alternative methods for flesh fly identification are established that are equally effective for both sexes...
September 13, 2022: Forensic Science International
#19
JOURNAL ARTICLE
Lamiaa M A Ali, Kazuya Miyagawa, Norihito Fukui, Mélanie Onofre, Khaled El Cheikh, Alain Morère, Sébastien Clément, Magali Gary-Bobo, Sébastien Richeter, Hiroshi Shinokubo
5,15-Diazaporphyrin appended with D-mannose moieties was prepared through Suzuki-Miyaura cross-coupling reaction and SN 2 alkylation. The resultant diazaporphyrin was hydrophilic enough to exhibit sufficient solubility in aqueous media. Because of the photosensitizing ability of diazaporphyrins, the in vitro activity of the D-mannose-appended diazaporphyrin in photodynamic therapy (PDT) was investigated. The specific internalization of the functionalized diazaporphyrin into human breast adenocarcinoma (MDA-MB-231) cells through mannose receptors was confirmed by confocal microscopy imaging...
August 31, 2022: Organic & Biomolecular Chemistry
#20
JOURNAL ARTICLE
Stefano Scoditti, Francesco Chiodo, Gloria Mazzone, Sébastien Richeter, Emilia Sicilia
The photophysical properties of two classes of porphyrins and metalloporphyrins linked to N-heterocyclic carbene (NHC) Au(I) complexes have been investigated by means of density functional theory and its time-dependent extension for their potential application in photodynamic therapy. For this purpose, the absorption spectra, the singlet-triplet energy gaps, and the spin-orbit coupling (SOC) constants have been determined. The obtained results show that all the studied compounds possess the appropriate properties to generate cytotoxic singlet molecular oxygen, and consequently, they can be employed as photosensitizers in photodynamic therapy...
June 23, 2022: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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