Brad Kline, Surekha Yadav, Youngho Seo, Robin Cumming Ippisch, Jessa Castillo, Rahul R Aggarwal, Robin Kate Kelley, Spencer C Behr, Robert R Flavell, Courtney Lawhn-Heath, Michelle Melisko, Hope S Rugo, Victoria Wang, Sue S Yom, Patrick Ha, Fei Jiang, Thomas A Hope
Fibroblast activation protein (FAP), expressed in the tumor microenvironment of a variety of cancers, has become a target of novel PET tracers. The purpose of this report is to evaluate the imaging characteristics of 68 Ga-FAP-2286, present the first-to our knowledge-dosimetry analysis to date, and compare the agent with 18 F-FDG and FAPI compounds. Methods: Patients were administered 219 ± 43 MBq of 68 Ga-FAP-2286 and scanned after 60 min. Uptake was measured in up to 5 lesions per patient and within the kidneys, spleen, liver, and mediastinum (blood pool)...
May 2, 2024: Journal of Nuclear Medicine