Christina B Karsten, Falk F R Buettner, Samanta Cajic, Inga Nehlmeier, Berit Roshani, Antonina Klippert, Ulrike Sauermann, Nicole Stolte-Leeb, Udo Reichl, Rita Gerardy-Schahn, Erdmann Rapp, Christiane Stahl-Hennig, Stefan Pöhlmann
The human immunodeficiency virus (HIV) envelope protein (Env) mediates viral entry into host cells and is the primary target for the humoral immune response. Env is extensively glycosylated, and these glycans shield underlying epitopes from neutralizing antibodies. The glycosylation of Env is influenced by the type of host cell in which the virus is produced. Thus, HIV is distinctly glycosylated by CD4+ T cells, the major target cells, and macrophages. However, the specific differences in glycosylation between viruses produced in these cell types have not been explored at the molecular level...
May 28, 2024: PLoS Pathogens