Jordan Canning, Stefan Siebert, Bhautesh D Jani, Louisa Harding-Edgar, Isla Kempe, Frances S Mair, Barbara I Nicholl
OBJECTIVE: Multimorbidity (the co-existence of two or more long-term conditions (LTCs)) is highly prevalent in people with rheumatoid arthritis (RA). This work systematically reviewed the literature to determine the effect of multimorbidity on all-cause mortality, functional status and quality of life in RA. METHODS: Six electronic databases were searched: CINAHL, Cochrane Library, Embase, Medline, PsycINFO and Scopus. Full-text longitudinal observational studies in English were selected...
March 1, 2021: Arthritis Care & Research
Anindit Chhibber, Savannah Hansen, Joseph Biskupiak
BACKGROUND: Patients with rheumatoid arthritis (RA) have higher rates of mortality attributed to the inflammatory nature and the associated burden of cardiovascular complications. Previous research indicates that treatment with statin therapy may play a role in reducing the mortality rate of RA patients, but similar evidence in U.S. patients is lacking. OBJECTIVE: To assess the association between statin use and overall mortality among RA patients in the United States. METHODS: A population-based study of RA patients with incident statin use was conducted...
March 2021: Journal of Managed Care & Specialty Pharmacy
Frederik Kyhl, Rasmus Vedby Rasmussen, Jesper Lindhardsen, Morten Smerup, Emil L Fosbøl
Background: Rheumatoid arthritis (RA) may involve the cardiovascular system and can cause significant structural cardiac disease. RA mimicking infective endocarditis (IE) is rarely reported. Case summary: A 46-year-old man with a medical history of seropositive RA attended a planned outpatient visit for infliximab treatment. The pre-infusion examination revealed a pulse of 41 b.p.m. and the following electrocardiogram showed 3rd degree atrioventricular block. A temporary pacemaker was inserted, and subsequent transthoracic and transoesophageal echocardiograms showed severe aortic valve regurgitation with thickened cusps and thus raised suspicion of infective aortic endocarditis with root abscess...
January 2021: European Heart Journal. Case Reports
Mir Sohail Fazeli, Vadim Khaychuk, Keith Wittstock, Xue Han, Grace Crocket, Margaret Lin, Sarah L Hill, Leticia Ferri
OBJECTIVES: To summarise the epidemiology, risk and prognostic factors, and treatment landscape of rheumatoid arthritis-associated interstitial lung disease (RA-ILD). METHODS: Targeted and systematic literature reviews were conducted to characterise the epidemiology and treatment landscape associated with RA-ILD, respectively. MEDLINE®, Embase, and CENTRAL were searched via OvidSP in March 2019 and December 2018. The results were narratively summarised. RESULTS: A total of 24 and 20 publications were captured through targeted and systematic literature review, respectively...
February 26, 2021: Clinical and Experimental Rheumatology
Gregory C McDermott, Tracy J Doyle, Jeffrey A Sparks
PURPOSE OF REVIEW: To summarize the current understanding of rheumatoid arthritis-associated interstitial lung disease (RA-ILD) throughout the rheumatoid arthritis (RA) disease course from preclinical to established disease. RECENT FINDINGS: ILD is a serious extra-articular manifestation of RA. Multiple studies have demonstrated a high prevalence of both subclinical and clinical ILD throughout the RA disease course. Investigations of patients without RA have demonstrated an association between RA-related autoantibodies like anticitrullinated protein antibodies (ACPA) and interstitial abnormalities on lung imaging...
February 22, 2021: Current Opinion in Rheumatology
Kristin M D'Silva, Zachary S Wallace
PURPOSE OF REVIEW: The coronavirus disease 2019 (COVID-19) pandemic has caused significant morbidity and mortality worldwide. Patients with rheumatoid arthritis (RA) face unique challenges during the pandemic, including concerns regarding infection risk, drug shortages, limited access to care, social isolation, and mental health. This review will examine the multifaceted impacts of the COVID-19 pandemic on patients living with RA. RECENT FINDINGS: In patients with RA, risk factors for severe COVID-19 outcomes include older age and comorbidities, similar to those in the general population...
February 22, 2021: Current Opinion in Rheumatology
Hannah Bower, Thomas Frisell, Daniela Di Giuseppe, Bénédicte Delcoigne, Gerd-Marie Ahlenius, Eva Baecklund, Katerina Chatzidionysiou, Nils Feltelius, Helena Forsblad-d'Elia, Alf Kastbom, Lars Klareskog, Elisabet Lindqvist, Ulf Lindström, Carl Turesson, Christopher Sjöwall, Johan Askling
OBJECTIVES: To estimate absolute and relative risks for all-cause mortality and for severe COVID-19 in inflammatory joint diseases (IJDs) and with antirheumatic therapies. METHODS: Through Swedish nationwide multiregister linkages, we selected all adult patients with rheumatoid arthritis (RA, n=53 455 in March 2020), other IJDs (here: spondyloarthropathies, psoriatic arthritis and juvenile idiopathic arthritis, n=57 112), their antirheumatic drug use, and individually matched population referents...
February 23, 2021: Annals of the Rheumatic Diseases
Toru Takematsu, Keisuke Kosumi, Takuya Tajiri, Kosuke Kanemitsu, Kosuke Mima, Mitsuhiro Inoue, Takao Mizumoto, Tatsuo Kubota, Nobutomo Miyanari, Hideo Baba
BACKGROUND: Visceral artery aneurysms are rare, but they may cause heavy bleeding and high mortality. In addition, aneurysms originating from the superior mesenteric artery (SMA) account for only 1% of visceral artery aneurysms. We report the rare case of a ruptured transverse pancreatic artery aneurysm originating from the SMA that required urgent surgical treatment. CASE PRESENTATION: A 66-year-old woman presented with acute back pain after lunch, and she was transported by ambulance...
February 22, 2021: Surgical Case Reports
Fabiana Assunta Figus, Matteo Piga, Irene Azzolin, Rebecca McConnell, Annamaria Iagnocco
Although synovitis is the pathological hallmark of rheumatoid arthritis (RA), many extra-articular manifestations (EMs) and comorbidities likely occur due to the complex, chronic, inflammatory, and autoimmune features of RA. Cardiovascular (CV) disease is the most common cause of death in patients with RA. Compared to the general population, patients with RA have twice the risk of myocardial infarction and up to 50% increased CV mortality risk. Severe and prolonged disease activity, genetics, and inflammation (e...
February 17, 2021: Autoimmunity Reviews
David R Hallan
Background Obesity has been shown to have a positive mortality benefit in patients undergoing percutaneous coronary intervention, dialysis, those with rheumatoid arthritis, chronic obstructive pulmonary disease, and various wasting diseases. Studies for this mortality benefit in ischemic stroke patients are conflicting, and it has not been well studied in mechanical thrombectomy patients. We sought to determine the impact of obesity on outcomes of mechanical thrombectomy patients. Methodology We used a large global health research network to gather clinical data extracted from the electronic medical records of ischemic stroke patients who underwent mechanical thrombectomy, and then stratified these patients into obese and non-obese cohorts...
January 13, 2021: Curēus
Laura L Miller, Daniel Prieto-Alhambra, Lea Trela-Larsen, J Mark Wilkinson, Emma M Clark, Ashley W Blom, Alexander J MacGregor
AIM: To assess revision rates and postoperative mortality in patients undergoing hip arthroplasty (HA) for inflammatory arthritis compared to hip osteoarthritis (OA). METHODS: The analysis was conducted among cases of HA that were recorded in the National Joint Registry for England and Wales (NJR) between April 2003 and December 2012 and linked to Office for National Statistics mortality records. Procedures were identified where the indication for surgery was listed as seropositive rheumatoid arthritis (RA), ankylosing spondylitis (AS), other inflammatory arthritis (otherIA), or OA...
February 18, 2021: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
Regina M Taylor-Gjevre, Bindu V Nair, Shan Jin, Jacqueline Quail
OBJECTIVES: To estimate provincial all-cause mortality rates of Saskatchewan people with rheumatoid arthritis (RA) for comparison with the general population over time and between different geographic regions. METHODS: Saskatchewan provincial administrative health databases (2001-2019) were utilized as data sources. Two RA case definitions were employed: (1) ≥ 3 physician billing diagnoses, at least 1 from a specialist (rheumatologist, general internist or orthopaedic surgeon) within 2 years; (2) ≥ 1 hospitalization diagnosis (ICD-9 code 714, and ICD-10-CA codes M05, M06)...
February 17, 2021: Canadian Journal of Public Health. Revue Canadienne de Santé Publique
Juopperi Samuli, Sund Reijo, Rikkonen Toni, Kröger Heikki, Sirola Joonas
BACKGROUND: Good physical capability is an important part of healthy biological ageing. Several factors influencing physical capability have previously been reported. Long-term reports on physical capability and the onset of clinical disorders and chronic diseases are lacking. Decrease in physical capacity has been shown to increase mortality. This study focuses on the prevalence of chronic diseases. The primary objective of the study was to reveal the association between physical capability and morbidity...
February 16, 2021: BMC Musculoskeletal Disorders
Elena Myasoedova, John M Davis, Veronique L Roger, Sara J Achenbach, Cynthia S Crowson
OBJECTIVE: To assess trends in incidence of cardiovascular disease (CVD) and mortality following incident CVD events in patients with rheumatoid arthritis (RA) onset in 1980- 2009 versus non-RA subjects. METHODS: We studied Olmsted County, Minnesota residents with incident RA (age ≥ 18 years, 1987 ACR criteria met in 1980-2009) and non-RA subjects from the same source population with similar age, sex and calendar year of index. All subjects were followed until death, migration, or 12/31/2016...
February 15, 2021: Journal of Rheumatology
Lyn D Ferguson, Naveed Sattar, Iain B McInnes
Individuals with rheumatoid arthritis, systemic lupus erythematosus, or gout have increased risk of cardiovascular disease (CVD) compared with the general population. This risk relates to a combination of traditional cardiovascular risk factors and disease-specific factors. Screening for CVD is important because CVD contributes to significant morbidity and mortality. Management includes tight control of disease activity to reduce inflammation, but with care to minimize use of nonsteroidal anti-inflammatory drugs and prolonged courses of high-dose corticosteroids...
March 2021: Medical Clinics of North America
Julie Beyrer, Janna Manjelievskaia, Machaon Bonafede, Gregory Lenhart, Sandra Nolot, Diane Haldane, Joseph Johnston
PURPOSE: An International Classification of Disease (ICD-10) Charlson Comorbidity Index (CCI) adaptation had not been previously developed and validated for United States (US) healthcare claims data. Many researchers use the Canadian adaption by Quan et al. (2005), not validated in US data. We sought to evaluate the predictive validity of a US ICD-10 CCI adaptation in US claims and compare it with the Canadian standard. METHODS: Diverse patient cohorts (rheumatoid arthritis, hip/knee replacement, lumbar spine surgery, acute myocardial infarction [AMI], stroke, pneumonia) in the IBM® MarketScan® Research Databases were linked with the IBM MarketScan Mortality file...
February 12, 2021: Pharmacoepidemiology and Drug Safety
Rohit Gaurav, Ted R Mikuls, Geoffrey M Thiele, Amy J Nelson, Meng Niu, Chittibabu Guda, James D Eudy, Austin E Barry, Todd A Wyatt, Debra J Romberger, Michael J Duryee, Bryant R England, Jill A Poole
Rheumatoid arthritis (RA)-associated lung disease is a leading cause of mortality in RA, yet the mechanisms linking lung disease and RA remain unknown. Using an established murine model of RA-associated lung disease combining collagen-induced arthritis (CIA) with organic dust extract (ODE)-induced airway inflammation, differences among lung immune cell populations were analyzed by single cell RNA-sequencing. Additionally, four lung myeloid-derived immune cell populations including macrophages, monocytes/macrophages, monocytes, and neutrophils were isolated by fluorescence cell sorting and gene expression was determined by NanoString analysis...
2021: PloS One
Alfonso J Cruz-Jentoft, Susana Romero-Yuste, Eugenio Chamizo Carmona, Joan M Nolla
INTRODUCTION: Sarcopenia is defined by a loss of muscle mass and function associated with mortality, decreased physical performance, falls, and disability. Since chronic inflammation and decreased physical activity are risk factors for developing sarcopenia, it is critical to assess the role of sarcopenia in immune-mediated rheumatic diseases (IMRDs). Moreover, nutritional interventions are emerging as key modifiable and affordable options to improve physical performance in sarcopenia...
February 10, 2021: Aging Clinical and Experimental Research
Meredith A Jones, William M MacCuaig, Alex N Frickenstein, Seda Camalan, Metin N Gurcan, Jennifer Holter-Chakrabarty, Katherine T Morris, Molly W McNally, Kristina K Booth, Steven Carter, William E Grizzle, Lacey R McNally
Inflammatory diseases include a wide variety of highly prevalent conditions with high mortality rates in severe cases ranging from cardiovascular disease, to rheumatoid arthritis, to chronic obstructive pulmonary disease, to graft vs. host disease, to a number of gastrointestinal disorders. Many diseases that are not considered inflammatory per se are associated with varying levels of inflammation. Imaging of the immune system and inflammatory response is of interest as it can give insight into disease progression and severity...
February 4, 2021: Biomedicines
Joshua Bell, Sean Sequeira, Pramod Kamalapathy, Varun Puvanesarajah, Hamid Hassanzadeh
BACKGROUND CONTEXT: RA is a systemic disease state with prominent musculoskeletal manifestations associated with increased morbidity and mortality in patients undergoing cervical spine surgery; however, few studies have specifically examined postoperative outcomes in RA patients following lumbar surgery. OBJECTIVE: The aim of the study is to evaluate if Rheumatoid arthritis (RA) patients undergoing PLF have increased postoperative complications and economic burden compared to those without...
February 3, 2021: World Neurosurgery
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