Lei Chen, Xiuying Lin, Min Wei, Bo Zhang, Yani Sun, Xi Chen, Shitong Zhang, Hao Zhang, Jieyu Zhang, Xiaojiao Yu, Binghua Yao, Kang Zhao, Yufei Tang, Quanchang Tan, Zixiang Wu
Antibiotic-loaded calcium phosphate cement (CPC) has emerged as a promising biomaterial for drug delivery in orthopedics. However, there are problems such as the burst release of antibiotics, low cumulative release ratio, inappropriate release cycle, inferior mechanical strength, and poor anti-collapse properties. In this research, montmorillonite-gentamicin (MMT-GS) was fabricated by solution intercalation method and served as the drug release pathways in CPC to avoid burst release of GS, achieving promoted cumulative release ratios and a release cycle matched the time of inflammatory response...
April 21, 2024: Colloids and Surfaces. B, Biointerfaces