Emmi K Saarinen, Tomi Kuusimäki, Kari Lindholm, Kalle Niemi, Emma A Honkanen, Tommi Noponen, Marko Seppänen, Toni Ihalainen, Kirsi Murtomäki, Tuomas Mertsalmi, Elina Jaakkola, Elina Myller, Mikael Eklund, Simo Nuuttila, Reeta Levo, Kallol Ray Chaudhuri, Angelo Antonini, Tero Vahlberg, Marko Lehtonen, Juho Joutsa, Filip Scheperjans, Valtteri Kaasinen
OBJECTIVE: This study was undertaken to investigate the effects of dietary caffeine intake on striatal dopamine function and clinical symptoms in Parkinson disease in a cross-sectional and longitudinal setting. METHODS: One hundred sixty-three early Parkinson disease patients and 40 healthy controls were investigated with [123 I]FP-CIT single photon emission computed tomography, and striatal dopamine transporter binding was evaluated in association with the level of daily coffee consumption and clinical measures...
May 20, 2024: Annals of Neurology