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JOURNAL ARTICLE
Maximiliano Barbosa, Leandro Pralon, Antonio L L Ramos, José Antonio Apolinário
The prevalence of Low Probability of Interception (LPI) and Low Probability of Exploitation (LPE) radars in contemporary Electronic Warfare (EW) presents an ongoing challenge to defense mechanisms, compelling constant advances in protective strategies. Noise radars are examples of LPI and LPE systems that gained substantial prominence in the past decade despite exhibiting a common drawback of limited Doppler tolerance. The Advanced Pulse Compression Noise (APCN) waveform is a stochastic radar signal proposed to amalgamate the LPI and LPE attributes of a random waveform with the Doppler tolerance feature inherent to a linear frequency modulation...
April 15, 2024: Sensors
#2
JOURNAL ARTICLE
Loraine Ledón-Llanes, Irazú Contreras-Yáñez, Guillermo Arturo Guaracha-Basáñez, Salvador Saúl Valverde-Hernández, Maximiliano Cuevas-Montoya, Ana Belén Ortiz-Haro, Virginia Pascual-Ramos
BACKGROUND: Rheumatoid arthritis (RA) is one of the most prevalent rheumatic diseases that harms all aspects of patients' lives, including sexual and reproductive health (SRH), often neglected in patients' care. The study aimed to explore the sexual and reproductive experiences of Mexican outpatients with RA from a narrative perspective. PATIENTS AND METHODS: From July 2020 to October 2021, 30 adult patients with RA from the Department of Immunology and Rheumatology outpatient clinic of a national referral center for rheumatic diseases had in-depth interviews audiotaped, transcribed, and analyzed using a thematic analysis approach...
2024: PloS One
#3
JOURNAL ARTICLE
Demian Bellido, Emanuel R Gumina, Gonzalo J Rodríguez Senes, Franco M Chiariotti, Maximiliano Audrito, Pedro M Sueldo, Gustavo M Sueldo, Andrés Wigdorovitz
Bovine respiratory disease (BRD) is a serious health and economic problem in the beef industry, which is often associated with transportation and caused by different pathogens. In this study, we evaluated the effect of a novel subunit targeted vaccine against bovine viral diarrhea virus (BVDV) in feedlot cattle, a major viral agent of BRD. The core of this novel vaccine is the fusion of the BVDV structural glycoprotein, E2, to a single-chain antibody, APCH, together termed, APCH-E2. The APCH antibody targets the E2 antigen to the major histocompatibility type II molecule (MHC-II) present in antigen-presenting cells...
2024: Translational Animal Science
#4
REVIEW
Nikolaos G Papadopoulos, Adnan Custovic, Antoine Deschildre, James E Gern, Antonio Nieto Garcia, Michael Miligkos, Wanda Phipatanakul, Gary Wong, Paraskevi Xepapadaki, Ioana Agache, Stefania Arasi, Zeinab Awad El-Sayed, Leonard B Bacharier, Matteo Bonini, Fulvio Braido, Davide Caimmi, Jose A Castro-Rodriguez, Zhimin Chen, Michael Clausen, Timothy Craig, Zuzana Diamant, Francine M Ducharme, Motohiro Ebisawa, Philippe Eigenmann, Wojciech Feleszko, Vincezo Fierro, Alessandro Fiocchi, Luis Garcia-Marcos, Anne Goh, René Maximiliano Gómez, Maia Gotua, Eckard Hamelmann, Gunilla Hedlin, Elham M Hossny, Zhanat Ispayeva, Daniel J Jackson, Tuomas Jartti, Miloš Jeseňák, Omer Kalayci, Alan Kaplan, Jon R Konradsen, Piotr Kuna, Susanne Lau, Peter Le Souef, Robert F Lemanske, Michael Levin, Mika J Makela, Alexander G Mathioudakis, Oleksandr Mazulov, Mário Morais-Almeida, Clare Murray, Karthik Nagaraju, Zoltan Novak, Ruby Pawankar, Marielle W Pijnenburg, Helena Pite, Paulo M Pitrez, Petr Pohunek, David Price, Alfred Priftanji, Valeria Ramiconi, Daniela Rivero Yeverino, Graham Roberts, Aziz Sheikh, Kun-Ling Shen, Zsolt Szepfalusi, Ioanna Tsiligianni, Mirjana Turkalj, Steve Turner, Tetiana Umanets, Arunas Valiulis, Susanne Vijveberg, Jiu-Yao Wang, Tonya Winders, Dong Keon Yon, Osman M Yusuf, Heather J Zar
Monitoring is a major component of asthma management in children. Regular monitoring allows for diagnosis confirmation, treatment optimization, and natural history review. Numerous factors that may affect disease activity and patient well-being need to be monitored: response and adherence to treatment, disease control, disease progression, comorbidities, quality of life, medication side-effects, allergen and irritant exposures, diet and more. However, the prioritization of such factors and the selection of relevant assessment tools is an unmet need...
April 2024: Pediatric Allergy and Immunology
#5
JOURNAL ARTICLE
Sanchali Nanda, Tatyana Shutova, Maximiliano Cainzos, Pushan Bag, Stefan Jansson, Alfred R Holzwarth
Chlorophyll fluorescence is a ubiquitous tool in basic and applied plant science research. Various standard commercial instruments are available for characterization of photosynthetic material like leaves or microalgae, most of which integrate the overall fluorescence signals above a certain cut-off wavelength. However, wavelength-resolved (fluorescence signals appearing at different wavelengths having different time dependent decay) signals contain vast information required to decompose complex signals and processes into their underlying components that can untangle the photo-physiological process of photosynthesis...
2024: Physiologia Plantarum
#6
Daniella M Hernandez, Melissa Marzouk, Madeline Cole, Marla C Fortoul, Saipranavi Reddy Kethireddy, Rehan Contractor, Habibul Islam, Trent Moulder, Ariane R Kalifa, Estefania Marin Meneses, Maximiliano Barbosa Mendoza, Ruth Thomas, Saad Masud, Sheena Pubien, Patricia Milanes, Gabriela Diaz-Tang, Allison J Lopatkin, Robert P Smith
The inoculum effect has been observed for nearly all antibiotics and bacterial species. However, explanations accounting for its occurrence and strength are lacking. We previously found that growth productivity, which captures the relationship between [ATP] and growth, can account for the strength of the inoculum effect for bactericidal antibiotics. However, the molecular pathway(s) underlying this relationship, and therefore determining the inoculum effect, remain undiscovered. We show that nucleotide synthesis can determine the relationship between [ATP] and growth, and thus the strength of inoculum effect in an antibiotic class-dependent manner...
April 9, 2024: bioRxiv
#7
JOURNAL ARTICLE
Erik Justin Courcelles, Kasper Kjelsberg, Laura Convertino, Rajeevkumar Raveendran Nair, Menno P Witter, Maximiliano José Nigro
GABAergic neurons represent 10-15% of the neuronal population of the cortex but exert a powerful control over information flow in cortical circuits. The largest GABAergic class in the neocortex is represented by the parvalbumin-expressing fast-spiking neurons, which provide powerful somatic inhibition to their postsynaptic targets. Recently, the density of parvalbumin interneurons has been shown to be lower in associative areas of the mouse cortex as compared with sensory and motor areas. Modelling work based on these quantifications linked the low-density of parvalbumin interneurons with specific computations of associative cortices...
April 21, 2024: European Journal of Neuroscience
#8
JOURNAL ARTICLE
Gabriela Manco Machado, Ana Clara Falabello Luca, Renata Paz Leal Pereira, Ana Yne Fernandez, Lucas Gabriel Santini Rodrigues, Isabella Petroline Leite, Maximiliano Sergio Cenci, Tatiana Pereira Cenci, Ana Paula Pires Santos, Branca Heloisa Oliveira, Paulo Nadanovsky, Marina Deus Moura Lima, Marcoeli Silva Moura, Edson Hilan Gomes Lucena, Tathiane Larissa Lenzi, Ana Carla Crispim, Fernanda Campos Almeida Carrer, Mariana Gabriel, Claudia Cazal Lira, Carla Vecchione Gurgel, Helder Henrique Costa Pinheiro, Gilberto Alfredo Pucca, Fábio Carneiro Martins, Paola Gondim Calvasina, Maria Fernanda Montezuma Tricoli, Camila Menezes Costa Castelo Branco, Raiza Dias Freitas, José Carlos Pettorossi Imparato, Daniela Prócida Raggio, Tamara Kerber Tedesco, Fausto Medeiros Mendes, Mariana Minatel Braga
BACKGROUND: Important evidence has been constantly produced and needs to be converted into practice. Professional consumption of such evidence may be a barrier to its implementation. Then, effective implementation of evidence-based interventions in clinical practice leans on the understanding of how professionals value attributes when choosing between options for dental care, permitting to guide this implementation process by maximizing strengthens and minimizing barriers related to that...
April 19, 2024: BMC Oral Health
#9
JOURNAL ARTICLE
Álvaro Huerta Ojeda, Emilio Jofré-Saldía, Jimena Arriagada Molina, Patricia Rojas Quinchavil, María Paz Parada Toledo, Sergio Galdames Maliqueo, María-Mercedes Yeomans-Cabrera, Carlos Jorquera-Aguilera, Frano Giakoni-Ramirez, Maximiliano Bravo
Functional autonomy (FA) is a critical factor in determining the quality of life of older adults (OA), especially in the case of older women (OW), as they face a decline in FA in their later years of life. FA should be assessed early, using valid, reliable, and low-cost tests. This study evaluated the test-retest reliability of GDLAM and GDLAM autonomy index (GI) in OW. Thirty-nine OW (71.2 ± 6.50 years) participated in the study. A repeated measures design was used to compare the interday test-retest reliability of the five GDLAM tests (seconds) and the GI (points)...
2024: PloS One
#10
JOURNAL ARTICLE
Francisco Caiza-Zambrano, Martín Gómez Lastra, Silvia Garbugino, Fabio Maximiliano Gonzalez, Julio Galarza Menoscal, Mauricio Benetti, Yemina Neme Segura, Luis Ariel Miquelini, Claudia Uribe-Roca, Manuel Fernández-Pardal, Luciana León-Cejas, Ricardo Reisin, Pablo Bonardo
The three classic symptoms of carotid cavernous fistula (CCF) are pulsating exophthalmos, bruit and conjunctival chemosis. Here, we present a clinical case of isolated abducens nerve palsy due to a high-flow CCF in an 84-year-old woman, without the typical congestive orbito-ocular features. It was a diagnostic challenge because, for patients older than 50 years with cardiovascular risk factors, ischaemic mononeuropathy is the most frequent aetiology. This case illustrates the least common type of CCF that can be easily misdiagnosed...
April 18, 2024: Journal of the Royal College of Physicians of Edinburgh
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JOURNAL ARTICLE
Nazli Kubra Okumus, Emily P Zeitler, Abdelmoniem Moustafa, Maximiliano Iglesias, Rahul Khanna, Yiran Rong, Saima Karim
BACKGROUND: Sinus node dysfunction (SND) is commonly seen in patients with atrial fibrillation (AF). The purpose of this study was to compare the incidence of pacemaker implantation among patients with SND and AF treated with catheter ablation (CA) versus anti-arrhythmic drugs (AADs). METHODS: The 2013-2022 Optum Clinformatics database, an administrative claims database for commercially insured individuals in the United States (US), was used for this study. Patients with AF and SND and a history of at least one AAD prescription were identified and classified into CA or AAD cohorts based on subsequent treatment received...
April 18, 2024: Journal of Interventional Cardiac Electrophysiology: An International Journal of Arrhythmias and Pacing
#12
JOURNAL ARTICLE
Julia Martin, Julieta L De Battista, Nicolás A Maugeri, Maximiliano Azcona
Introducción: Esta investigación parte de algunos obstáculos en la implementación de la Ley Nacional de Salud Mental, especialmente en el primer nivel de atención y en lo relativo al manejo de urgencias, con o sin riesgo cierto e inminente. La escasez de protocolos de intervención en salud mental y la percepción de que podrían limitar la lectura singular de cada situación crítica son desafíos identificados en la práctica. No obstante, los protocolos pueden ser herramientas organizativas valoradas en circunstancias complejas...
April 10, 2024: Vertex: Revista Argentina de Psiquiatriá
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JOURNAL ARTICLE
Leydi M Moreno, Jairo Quiroga, Rodrigo Abonia, María Del P Crespo, Carlos Aranaga, Luis Martínez-Martínez, Maximiliano Sortino, Mauricio Barreto, María E Burbano, Braulio Insuasty
This study presents the synthesis of four series of novel hybrid chalcones ( 20,21 ) a - g and ( 23,24 ) a - g and six series of 1,3,5-triazine-based pyrimido[4,5- b ][1,4]diazepines ( 28 - 33 ) a - g and the evaluation of their anticancer, antibacterial, antifungal, and cytotoxic properties. Chalcones 20b , d , 21a,b , d , 23a , d - g , 24a - g and the pyrimido[4,5- b ][1,4]diazepines 29e , g , 30g , 31a , b , e - g , 33a , b , e - g exhibited outstanding anticancer activity against a panel of 60 cancer cell lines with GI50 values between 0...
March 23, 2024: International Journal of Molecular Sciences
#14
JOURNAL ARTICLE
Maximiliano Ortiz
No abstract text is available yet for this article.
April 12, 2024: Nature Communications
#15
JOURNAL ARTICLE
Riccardo Levi, Maximiliano Mollura, Giovanni Savini, Federico Garoli, Massimiliano Battaglia, Angela Ammirabile, Luca A Cappellini, Simona Superbi, Marco Grimaldi, Riccardo Barbieri, Letterio S Politi
Radiomics features (RFs) studies have showed limitations in the reproducibility of RFs in different acquisition settings. To date, reproducibility studies using CT images mainly rely on phantoms, due to the harness of patient exposure to X-rays. The provided CadAIver dataset has the aims of evaluating how CT scanner parameters effect radiomics features on cadaveric donor. The dataset comprises 112 unique CT acquisitions of a cadaveric truck acquired on 3 different CT scanners varying KV, mA, field-of-view, and reconstruction kernel settings...
April 11, 2024: Scientific Data
#16
JOURNAL ARTICLE
Maximiliano Klug, Chad D Strange, Mylene T Truong, Zehavit Kirshenboim, Efrat Ofek, Eli Konen, Edith Michelle Marom
Thymic imaging is challenging because the imaging appearance of a variety of benign and malignant thymic conditions are similar. CT is the most commonly used modality for mediastinal imaging, while MRI and fluorine 18 fluorodeoxyglucose (FDG) PET/CT are helpful when they are tailored to the correct indication. Each of these imaging modalities has limitations and technical pitfalls that may lead to an incorrect diagnosis and mismanagement. CT may not be sufficient for the characterization of cystic thymic processes and differentiation between thymic hyperplasia and thymic tumors...
May 2024: Radiographics: a Review Publication of the Radiological Society of North America, Inc
#17
JOURNAL ARTICLE
Ilakya Selvarajan, Miika Kiema, Ru-Ting Huang, Jin Li, Jiayu Zhu, Petri Pölönen, Tiit Örd, Kadri Õunap, Mehvash Godiwala, Anna Kathryn Golebiewski, Aarthi Ravindran, Kiira Mäklin, Anu Toropainen, Lindsey K Stolze, Maximiliano Arce, Peetra U Magnusson, Stephen White, Casey E Romanoski, Merja Heinäniemi, Johanna P Laakkonen, Yun Fang, Minna Kaikkonen-Määttä
BACKGROUND: CALCRL (calcitonin receptor-like) protein is an important mediator of the endothelial fluid shear stress response, which is associated with the genetic risk of coronary artery disease. In this study, we functionally characterized the noncoding regulatory elements carrying coronary artery disease that risks single-nucleotide polymorphisms and studied their role in the regulation of CALCRL expression in endothelial cells. METHODS: To functionally characterize the coronary artery disease single-nucleotide polymorphisms harbored around the gene CALCRL , we applied an integrative approach encompassing statistical, transcriptional (RNA-seq), and epigenetic (ATAC-seq, chromatin immunoprecipitation assay-quantitative polymerase chain reaction, and electromobility shift assay) analyses, alongside luciferase reporter assays, and targeted gene and enhancer perturbations (siRNA and clustered regularly interspaced short palindromic repeats/clustered regularly interspaced short palindromic repeat-associated 9) in human aortic endothelial cells...
April 11, 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
#18
JOURNAL ARTICLE
Virginia Pascual-Ramos, Irazú Contreras-Yáñez, Maximiliano Cuevas-Montoya, Guillermo Arturo Guaracha-Basañez, Mario García-Alanis, Oscar Rodríguez-Mayoral, Harvey Max Chochinov
BACKGROUND: The loss of perceived dignity is an existential source of human suffering, described in patients with cancer and chronic diseases and hospitalized patients but rarely explored among patients with rheumatic diseases (RMDs). We recently observed that distress related to perceived dignity (DPD) was present in 26.9% of Mexican patients with different RMDs. The study aimed to investigate the factors associated with DPD. METHODS: This cross-sectional study was performed between February and September 2022...
April 10, 2024: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
#19
JOURNAL ARTICLE
Facundo Villamil, Guido Caffaratti, Mauro Ruella, Lucila Domecq Laplace, Ismael Calandri, Maximiliano Darakdjian, Maximiliano Nuñez, Ruben Mormandi, Andrés Cervio
OBJECTIVE: The V3 segment of the vertebral artery (V3-VA) is at risk during diverse approaches to the craniovertebral junction. Our objective is to present a system of anatomic and topographic landmarks to identify the V3-VA during the paramedian suboccipital approach (PMSOA) with the help of minimal or basic tools. MATERIAL AND METHODS: The first was a retrospective analysis of the angiotomography (CTA) of 50 patients over 18-years old, and 9 anatomical dissections...
May 2024: Clinical Neurology and Neurosurgery
#20
JOURNAL ARTICLE
Claudio Parra, Patricio Muñoz-Torres, Hugo Escobar, Mario J Simirgiotis, Gabriela Contreras-Contreras, Álvaro Ruiz-Fernández, Cristian Maulen, Maximiliano Martínez-Cifuentes, María Salomé Mariotti-Celis
The species Senecio nutans Sch. Bip., commonly called "chachacoma", is widely used as a medicinal plant by the Andean communities of Northern Chile. Ethanolic extracts of S. nutans and the main compound, 4-hydroxy-3-(3-methyl-2-butenyl) acetophenone, have shown interesting biological activity. However, due to the high-altitude areas where this species is found, access to S. nutans is very limited. Due to the latter, in this work, we carried out micropropagation in vitro and ex vitro adaptation techniques as an alternative for the massive multiplication, conservation, and in vitro production of high-value metabolites from this plant...
March 7, 2024: Plants (Basel, Switzerland)
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