Jordan Janowski, Van A B Pham, Simon Vecchioni, Karol Woloszyn, Brandon Lu, Yijia Zou, Betel Erkalo, Lara Perren, Joe Rueb, Jesse Madnick, Chengde Mao, Masahico Saito, Yoel P Ohayon, Nataša Jonoska, Ruojie Sha
Tertiary chirality describes the handedness of supramolecular assemblies and relies not only on the primary and secondary structures of the building blocks but also on topological driving forces that have been sparsely characterized. Helical biopolymers, especially DNA, have been extensively investigated as they possess intrinsic chirality that determines the optical, mechanical, and physical properties of the ensuing material. Here, we employ the DNA tensegrity triangle as a model system to locate the tipping points in chirality inversion at the tertiary level by X-ray diffraction...
May 7, 2024: Proceedings of the National Academy of Sciences of the United States of America