Konstantin Kahnert, Luca Soattin, Robert W Mills, Claire Wilson, Svetlana Maurya, Andrea Sorrentino, Sami Al-Othman, Roman Tikhomirov, Yordi J van de Vegte, Finn B Hansen, Jonathan Achter, Wei Hu, Min Zi, Matthew Smith, Pim van der Harst, Morten S Olesen, Kristine Boisen Olsen, Jytte Banner, Thomas H L Jensen, Henggui Zhang, Mark R Boyett, Alicia D'Souza, Alicia Lundby
AIMS: In patients with heart failure (HF), concomitant sinus node dysfunction (SND) is an important predictor of mortality, yet its molecular underpinnings are poorly understood. Using proteomics, this study aimed to dissect the protein and phosphorylation remodelling within the sinus node in an animal model of HF with concurrent SND. METHODS AND RESULTS: We acquired deep sinus node proteomes and phosphoproteomes in mice with heart failure and SND and report extensive remodelling...
April 25, 2024: Cardiovascular Research