Yan Tang, Junru Wu, Xuejing Sun, Shasha Tan, Wenbo Li, Siyu Yin, Lun Liu, Yuanyuan Chen, Yuanyuan Liu, Qian Tan, Youxiang Jiang, Wenjing Yang, Wei Huang, Chunyan Weng, Qing Wu, Yao Lu, Hong Yuan, Qingzhong Xiao, Alex F Chen, Qingbo Xu, Timothy R Billiar, Jingjing Cai
Cardiac dysfunction, an early complication of endotoxemia, is the major cause of death in intensive care units. No specific therapy is available at present for this cardiac dysfunction. Here, we show that the N-terminal gasdermin D (GSDMD-N) initiates mitochondrial apoptotic pore and cardiac dysfunction by directly interacting with cardiolipin oxidized by complex II-generated reactive oxygen species (ROS) during endotoxemia. Caspase-4/11 initiates GSDMD-N pores that are subsequently amplified by the upregulation and activation of NLRP3 inflammation through further generation of ROS...
May 15, 2024: Cell Reports
Daniele Masarone, Luigi Falco, Dario Catapano, Rita Gravino, Fabio Valente
No abstract text is available yet for this article.
May 16, 2024: Minerva cardiology and angiology
Charbel Gharios, Mandy M T van Leent, Helena L Chang, Shady Abohashem, David O'Connor, Michael T Osborne, Cheuk Y Tang, Audrey E Kaufman, Philip M Robson, Sarayu Ramachandran, Claudia Calcagno, Venkatesh Mani, Maria Giovanna Trivieri, Antonia V Seligowski, Sharon Dekel, Willem J M Mulder, James W Murrough, Lisa M Shin, Ahmed Tawakol, Zahi A Fayad
BACKGROUND AND AIMS: Chronic stress associates with cardiovascular disease, but mechanisms remain incompletely defined. Advanced imaging was used to identify stress-related neural imaging phenotypes associated with atherosclerosis. METHODS: Twenty-seven individuals with post-traumatic stress disorder (PTSD), 45 trauma-exposed controls without PTSD, and 22 healthy controls underwent 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI)...
May 16, 2024: European Heart Journal
Benjamin Ose, Zeeshan Sattar, Amulya Gupta, Christian Toquica, Chris Harvey, Amit Noheria
PURPOSE OF REVIEW: Artificial intelligence (AI) is transforming electrocardiography (ECG) interpretation. AI diagnostics can reach beyond human capabilities, facilitate automated access to nuanced ECG interpretation, and expand the scope of cardiovascular screening in the population. AI can be applied to the standard 12-lead resting ECG and single-lead ECGs in external monitors, implantable devices, and direct-to-consumer smart devices. We summarize the current state of the literature on AI-ECG...
May 16, 2024: Current Cardiology Reports
Jonathan A Pan, Amit R Patel
PURPOSE OF REVIEW: There has been increasing use of multimodality imaging in the evaluation of cardiomyopathies. RECENT FINDINGS: Echocardiography, cardiac magnetic resonance (CMR), cardiac nuclear imaging, and cardiac computed tomography (CCT) play an important role in the diagnosis, risk stratification, and management of patients with cardiomyopathies. Echocardiography is essential in the initial assessment of suspected cardiomyopathy, but a multimodality approach can improve diagnostics and management...
May 16, 2024: Current Cardiology Reports
Wei Cheng, Bo-Feng Zhang, Na Chen, Qun Liu, Xin Ma, Xiao Fu, Min Xu
Chronic heart failure (CHF) is a complex multifactorial clinical syndrome leading to abnormal cardiac structure and function. The severe form of this ailment is characterized by high disability, high mortality, and morbidity. Worldwide, 2-17% of patients die at first admission, of which 17-45% die within 1 year of admission and >50% within 5 years. Yangshen Maidong Decoction (YSMDD) is frequently used to treat the deficiency and pain of the heart. The specific mechanism of action of YSMDD in treating CHF, however, remains unclear...
May 16, 2024: Cell Biochemistry and Biophysics
Qingrui Cui, Wei Wang, Jiahui Shi, Fengqing Lai, Shan Luo, Yuhang Du, Xiaofei Wang, Yuke Xiang
BACKGROUND: Severe acute pancreatitis (SAP) is a potential fatal gastrointestinal disease that is usually complicated by myocardial injury and dysfunction. Due to the lack of understanding of the mechanism of SAP-associated cardiac injury (SACI), there is still no complete treatment. AIMS: To explore the alleviative effect and anti-ferroptosis mechanism against SACI of glycyrrhizin (GL), an inhibitor of oxidative stress. METHODS: The SAP model was established by perfusing 5% sodium taurocholate into biliopancreatic duct in rats...
May 16, 2024: Digestive Diseases and Sciences
Mario Masarone, Benedetta Maria Motta, Pietro Torre, Marco Aquino, Federica Belladonna, Martina Lombardi, Jacopo Troisi, Marcello Persico
Metabolic associated steatotic liver disease (MASLD) is the most common liver condition. It is associated with increased liver-related morbidity and mortality, and also with high risk of cardiovascular events (CVD), representing itself an independent risk factor for it. This makes MASLD a presentation of high interest for internal medicine, also because of its association with metabolic syndrome (MetS). It is crucial to assess its risks in a noninvasive way. With the aim of finding specific risk profiles for CVD development in MASLD by performing a noninvasive assessment of: (1) preclinical signs of endothelial dysfunction (ED); (2) clinical assessment of CVD risk by Framingham Heart Risk Score (FHRs); (3) genomic characterization of MASLD associated polymorphisms; (4) specific untargeted metabolomic profiles, we enrolled 466 MASLD patients non-invasively classified in 4 group of liver fibrosis severity (group-A: low-fibrosis risk, group-B: high-fibrosis risk, group-C: MASLD-cirrhosis, group-D: MASLD-HCC) and 73 healthy controls...
May 16, 2024: Internal and Emergency Medicine
Gian Luca Forni, Antonis Kattamis, Kevin H M Kuo, Aurelio Maggio, Sujit Sheth, Ali T Taher, Vip Viprakasit
In this review, we provide a summary of evidence on iron overload in young children with transfusion-dependent β-thalassemia (TDT) and explore the ideal timing for intervention. Key data from clinical trials and observational studies of the three available iron chelators deferoxamine, deferiprone, and deferasirox are also evaluated for inclusion of subsets of young children, especially those less than 6 years of age. Evidence on the efficacy and safety of iron chelation therapy for children ≥2 years of age with transfusional iron overload is widely available...
May 16, 2024: Pediatric Blood & Cancer
Dawei Lin, Peng Zhang, Yongchao Zhao, Wanjiao Chen, Dandan Chen, Xiaochun Zhang, Daxin Zhou, Junbo Ge
Functional tricuspid regurgitation (FTR) is the most common TR, although experimental models to effectively study it are scarce; therefore, this study aimed to establish a robust experimental swine model. A swine FTR model was developed using radiofrequency ablation, atrial septostomy, and right atrial volume overload. The baseline and follow-up echocardiography was performed to evaluate the progression FTR and changes in the heart. Autopsy was employed to verify the anatomy of tricuspid valve. One-month post intervention, among the subjects, one (8...
May 16, 2024: Journal of Cardiovascular Translational Research
Amanda D McCormick, Kriti Puri, S Yukiko Asaki, Shahnawaz Amdani, Devyani Chowdhury, Julie S Glickstein, Seda Tierney, Patricia Ibeziako, Melissa K Cousino, Christina Ronai
Mental health conditions are a common comorbidity among children living with heart disease. Children with congenital heart disease are more likely to have a mental health condition than their unaffected peers or peers with other chronic illnesses, and mental health risk persists across their lifetime. While poorer mental health in adults with congenital heart disease is associated with worse overall health outcomes, the association between mental health and cardiac outcomes for children with heart disease remains unknown...
May 16, 2024: Pediatric Cardiology
Jan Gröschel, Leonhard Grassow, Edyta Blaszczyk, Kerstin Lommel, Georgios Kokolakis, Robert Sabat, Jeanette Schulz-Menger
BACKGROUND: Psoriasis vulgaris (PV) is a chronic inflammatory disorder frequently associated with cardiovascular disease (CVD). This study aims to provide a prospective tissue characterization in patients with PV without major CVD using cardiovascular magnetic resonance (CMR). METHODS: Patients with PV underwent laboratory assessment, a 12-lead and 24-h ECG, and a CMR exam at a 1.5-T scanner. Scan protocol included assessment of left (LV) and right (RV) ventricular function and strain analysis, native and post-contrast T1 mapping, T2 mapping and late gadolinium enhancement (LGE)...
May 16, 2024: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
Tsung-Ying Tsai, Ali Aldujeli, Ayman Haq, Aurimas Knokneris, Kasparas Briedis, Diarmaid Hughes, Ramunas Unikas, Mick Renkens, Pruthvi C Revaiah, Akihiro Tobe, Kotaro Miyashita, Faisal Sharif, Scot Garg, Yoshinobu Onuma, Patrick W Serruys
BACKGROUND: Microvascular resistance reserve (MRR) can characterize coronary microvascular dysfunction (CMD); however, its prognostic impact in ST-segment elevation myocardial infarction (STEMI) patients remains undefined. OBJECTIVES: This study sought to investigate the prevalence of CMD in STEMI patients and to elucidate the prognostic performance of MRR. METHODS: This prospective cohort study enrolled 210 STEMI patients with multivessel disease who underwent successful revascularization and returned at 3 months for coronary physiology assessments with bolus thermodilution...
April 23, 2024: JACC. Cardiovascular Interventions
Ambarish Pandey, Kershaw V Patel, Matthew W Segar, Michael D Shapiro, Christie M Ballantyne, Salim S Virani, Vijay Nambi, Erin D Michos, Michael J Blaha, Khurram Nasir, Miguel Cainzos-Achirica, Colby R Ayers, B Daan Westenbrink, Jose L Flores-Guerrero, Stephan J L Bakker, Margery A Connelly, Robin P F Dullaart, Anand Rohatgi
BACKGROUND: High-density lipoprotein (HDL) is commonly characterized by its cholesterol concentration (HDL-C) and inverse association with atherosclerotic cardiovascular disease. OBJECTIVES: The authors sought to evaluate the association of HDL particle concentration (HDL-P), HDL particle size (HDL-size), HDL-C, and cholesterol content per particle (HDL-C/HDL-P) with risk of overall heart failure (HF) and subtypes. METHODS: Participants from the Atherosclerosis Risk In Communities Study, Dallas Heart Study, Multi-Ethnic Study of Atherosclerosis, and Prevention of Renal and Vascular End-stage Disease studies without HF history were included...
April 30, 2024: JACC. Heart Failure
Sonya Vijayvargiya, Wissam Mekary, Vardhmaan Jain, Birju R Rao, Rand Ibrahim, Anshul M Patel, Anand D Shah, David B DeLurgio, Stacy Westerman, Michael S Lloyd, Neal Bhatia, Faisal M Merchant, Mikhael F El-Chami
BACKGROUND: Because of differences in chest wall anatomy, female patients may have higher rates of subcutaneous implantable cardioverter-defibrillator (S-ICD) pocket-related complications. OBJECTIVE: We sought to evaluate sex-based outcomes after S-ICD implantation. METHODS: Patients implanted with an S-ICD at Emory Healthcare between 2010 and 2023 were included in the analysis. Patients' clinical characteristics and post-S-ICD implantation complications were collected...
May 5, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Michael I Gurin, Gregory E Supple, Matthew C Hyman, David J Callans, Francis E Marchlinski, Timothy M Markman
No abstract text is available yet for this article.
April 1, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
John Silberbauer, Justo Juliá
No abstract text is available yet for this article.
April 17, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Connor P Oates, Binaya Basyal, William Whang, Vivek Y Reddy, Jacob S Koruth
BACKGROUND: Rapid technologic development and expansion of procedural expertise have led to widespread proliferation of catheter-based electrophysiology procedures. It is unclear whether these advances come at cost to patient safety. OBJECTIVE: This meta-analysis aimed to assess complication rates after modern electrophysiology procedures during the lifetime of the procedures. METHODS: A comprehensive search was performed to identify relevant data published before May 30, 2023...
April 16, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Martha G Ferrara, Lyle W Larson
No abstract text is available yet for this article.
April 7, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Sana M Al-Khatib, Jagmeet P Singh, Hamid Ghanbari, David D McManus, Thomas F Deering, Jennifer N Avari Silva, Suneet Mittal, Andrew Krahn, Jodie L Hurwitz
The field of electrophysiology (EP) has benefited from numerous seminal innovations and discoveries that have enabled clinicians to deliver therapies and interventions that save lives and promote quality of life. The rapid pace of innovation in EP may be hindered by several challenges including the aging population with increasing morbidity, the availability of multiple costly therapies that, in many instances, confer minor incremental benefit, the limitations of healthcare reimbursement, the lack of response to therapies by some patients, and the complications of the invasive procedures performed...
May 5, 2024: Heart Rhythm: the Official Journal of the Heart Rhythm Society
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