Jerónimo Aragón-Vela, Rafael A Casuso, Ana Sagrera Aparisi, Julio Plaza-Díaz, Ascensión Rueda-Robles, Agustín Hidalgo-Gutiérrez, Luis Carlos López, Andrea Rodríguez-Carrillo, José Antonio Enriquez, Sara Cogliati, Jesús R Huertas
In eukaryotic cells, aerobic energy is produced by mitochondria through oxygen uptake. However, little is known about the early mitochondrial responses to moderate hypobaric hypoxia (MHH) in highly metabolic active tissues. Here, we describe the mitochondrial responses to acute MHH in the heart and skeletal muscle. Rats were randomly allocated into a normoxia control group (n = 10) and a hypoxia group (n = 30), divided into three groups (0, 6, and 24 h post-MHH). The normoxia situation was recapitulated at the University of Granada, at 662 m above sea level...
April 17, 2024: Journal of Physiology
Jen-Hung Huang, Yung-Kuo Lin, Ming-Hsiung Hsieh, Shih-Ann Chen, Yi-Jen Chen
BACKGROUND: Atrial fibrillation (AF) is the most common sustained atrial arrhythmia. Accurate detection of the timing and possibility of AF termination is vital for optimizing rhythm and rate control strategies. The present study evaluated whether the ventricular response (VR) in AF offers a distinctive electrocardiographic indicator for predicting AF termination. METHODS: Patients experiencing sustained paroxysmal AF for more than 3 h were observed using 24-h ambulatory Holter monitoring...
April 17, 2024: Pacing and Clinical Electrophysiology: PACE
Henri Gruwez, Daniel Ezzat, Tim Van Puyvelde, Sebastiaan Dhont, Evelyne Meekers, Liesbeth Bruckers, Femke Wouters, Michiel Kellens, Hugo Van Herendael, Maximo Rivero-Ayerza, Dieter Nuyens, Peter Haemers, Laurent Pison
AIMS: Photoplethysmography- (PPG) based smartphone applications facilitate heart rate and rhythm monitoring in patients with paroxysmal and persistent atrial fibrillation (AF). Despite an endorsement from the European Heart Rhythm Association, validation studies in this setting are lacking. Therefore, we evaluated the accuracy of PPG-derived heart rate and rhythm classification in subjects with an established diagnosis of AF in unsupervised real-world conditions. METHODS AND RESULTS: Fifty consecutive patients were enrolled, 4 weeks before undergoing AF ablation...
March 30, 2024: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
Michael A Borger, Victoria Delgado
No abstract text is available yet for this article.
April 17, 2024: European Heart Journal
Luigi Tassetti, Carlotta Rellini, Gianluca Pontone
No abstract text is available yet for this article.
April 17, 2024: European Heart Journal Cardiovascular Imaging
David Adlam, Fleur S van Dijk, Bart Loeys
No abstract text is available yet for this article.
April 17, 2024: European Heart Journal
Jason D Roh, Claire Castro, Andy Yu, Sarosh Rana, Sajid Shahul, Kathryn J Gray, Michael C Honigberg, Melanie Ricke-Hoch, Yoshiko Iwamoto, Ashish Yeri, Robert Kitchen, Justin Baldovino Guerra, Ryan Hobson, Vinita Chaudhari, Bliss Chang, Amy Sarma, Carolin Lerchenmüller, Zeina R Al Sayed, Carmen Diaz Verdugo, Peng Xia, Niv Skarbianskis, Amit Zeisel, Johann Bauersachs, James L Kirkland, S Ananth Karumanchi, John Gorcsan, Masataka Sugahara, Julie Damp, Karen Hanley-Yanez, Patrick T Ellinor, Zoltan Arany, Dennis M McNamara, Denise Hilfiker-Kleiner, Anthony Rosenzweig
Peripartum cardiomyopathy (PPCM) is an idiopathic form of pregnancy-induced heart failure associated with preeclampsia. Circulating factors in late pregnancy are thought to contribute to both diseases, suggesting a common underlying pathophysiological process. However, what drives this process remains unclear. Using serum proteomics, we identified the senescence-associated secretory phenotype (SASP), a marker of cellular senescence associated with biological aging, as the most highly up-regulated pathway in young women with PPCM or preeclampsia...
April 17, 2024: Science Translational Medicine
David J Durgan, Jasenka Zubcevic, Matam Vijay-Kumar, Tao Yang, Ishan Manandhar, Sachin Aryal, Rikeish R Muralitharan, Hong-Bao Li, Ying Li, Justine M Abais-Battad, Jennifer L Pluznick, Dominik N Muller, Francine Z Marques, Bina Joe
No abstract text is available yet for this article.
May 2024: Hypertension
Aaron M Eisen, Gregory N Bratman, Hector A Olvera-Alvarez
BACKGROUND: Emerging epidemiological evidence indicates nature exposure could be associated with greater health benefits among groups in lower versus higher socioeconomic positions. One possible mechanism underpinning this evidence is described by our framework: (susceptibility) adults in low socioeconomic positions face higher exposure to persistent psychosocial stressors in early life, inducing a pro-inflammatory phenotype as a lifelong susceptibility to stress; (differential susceptibility) susceptible adults are more sensitive to the health risks of adverse (stress-promoting) environments, but also to the health benefits of protective (stress-buffering) environments...
2024: PloS One
(no author information available yet)
No abstract text is available yet for this article.
April 17, 2024: European Heart Journal
Remo Poto, Gianni Marone, Stephen J Galli, Gilda Varricchi
Mast cells are tissue-resident immune cells strategically located in different compartments of the normal human heart (the myocardium, pericardium, aortic valve and close to nerves) as well as in atherosclerotic plaques. Cardiac mast cells produce a broad spectrum of vasoactive and proinflammatory mediators, which have potential roles in inflammation, angiogenesis, lymphangiogenesis, tissue remodeling and fibrosis. Mast cells release preformed mediators (e.g., histamine, tryptase, chymase) and de novo synthesized mediators [e...
April 17, 2024: Cardiovascular Research
Chayakrit Krittanawong, Neelkumar Patel, Dhrubajyoti Bandyopadhyay, Neil Sagar Maitra, Muzamil Khawaja, Zhen Wang, Mahboob Alam, Jacob Shani, Robert Frankel, Samin Sharma, Hani Jneid
No abstract text is available yet for this article.
April 17, 2024: European Heart Journal. Acute Cardiovascular Care
Alec Rhodes, Stephanie Moulton, Cäzilia Loibl, Donald Haurin, Joshua Joseph
OBJECTIVE: The medical diagnosis of a disease is common in older age and can carry significant financial costs. For many older adults, equity in a home is their primary component of wealth; however, housing wealth is illiquid. We analyze the relationship between the liquidation of housing wealth through mortgage borrowing on older homeowners' ability to successfully control a disease. METHODS: We use data on homeowners age 65 and older from the 1998-2016 waves of the Health and Retirement Study (N=3,457)...
April 17, 2024: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
Adrian Ryser, Christof Baeriswyl, Michel Moser, Jurgen Burger, Tobias Reichlin, Thomas Niederhauser, Andreas Haeberlin
The first commercial dual-chamber leadless pacemaker (LLPM) was introduced recently. The system combines two separate implants situated in the right atrium and the right ventricle of the heart. Implant synchronization is accomplished with conductive intracardiac communication (CIC) using the myocardium and blood as transmission channel. Successful implant synchronization of this dual-chamber LLPM has been demonstrated. However, the continuously active synchronization transceivers, consuming about 800 nA, cause a 25-45% reduction in the projected device longevity...
April 17, 2024: IEEE Transactions on Biomedical Circuits and Systems
Zihao Li, Dan Liu, Zhao Li
No abstract text is available yet for this article.
April 17, 2024: European Heart Journal Cardiovascular Imaging
Štěpán Strnad, Vladimír Vrkoslav, Anna Mengr, Ondřej Fabián, Jiří Rybáček, Miloš Kubánek, Vojtěch Melenovský, Lenka Maletínská, Josef Cvačka
Cholesterol plays an important biological role in the body, and its disruption in homeostasis and synthesis has been implicated in several diseases. Mapping the locations of cholesterol is crucial for gaining a better understanding of these conditions. Silver deposition has proven to be an effective method for analyzing cholesterol using mass spectrometry imaging (MSI). We optimized and evaluated thermal evaporation as an alternative deposition technique to sputtering for silver deposition in MSI of cholesterol...
April 17, 2024: Analyst
Ravi B Patel, Frank E Silvestry, Jan Komtebedde, Scott D Solomon, Gerd Hasenfuß, Sheldon E Litwin, Barry A Borlaug, Matthew J Price, Rami Kawash, Scott L Hummel, Donald E Cutlip, Martin B Leon, Dirk J van Veldhuisen, Andreas J Rieth, Scott McKenzie, Heiko Bugger, Jeremy A Mazurek, Samir R Kapadia, Marc Vanderheyden, Bonnie Ky, Sanjiv J Shah
IMPORTANCE: Although the results of A Study to Evaluate the Corvia Medical Inc IASD System II to Reduce Elevated Left Atrial Pressure in Patients with Heart Failure (REDUCE LAP-HF II) trial were neutral overall, atrial shunt therapy demonstrated potential efficacy in responders (no latent pulmonary vascular disease and no cardiac rhythm management device). Post hoc analyses were conducted to evaluate the effect of shunt vs sham stratified by responder status. OBJECTIVE: To evaluate the effect of atrial shunt vs sham control on cardiac structure/function in the overall study and stratified by responder status...
April 17, 2024: JAMA Cardiology
Dániel Kucsera, Mihály Ruppert, Nabil V Sayour, Viktória E Tóth, Tamás Kovács, Zsombor I Hegedűs, Zsófia Onódi, Alexandra Fábián, Attila Kovács, Tamás Radovits, Béla Merkely, Pál Pacher, Péter Ferdinandy, Zoltán V Varga
Both heart failure with preserved ejection fraction (HFpEF) and non-alcoholic fatty liver disease (NAFLD) develop due to metabolic dysregulation, has similar risk factors (e.g., insulin resistance, systemic inflammation) and are unresolved clinical challenges. Therefore, the potential link between the two disease is important to study. We aimed to evaluate whether NASH is an independent factor of cardiac dysfunction and to investigate the age dependent effects of NASH on cardiac function. C57Bl/6 J middle aged (10 months old) and aged mice (24 months old) were fed either control or choline deficient (CDAA) diet for 8 weeks...
April 17, 2024: GeroScience
Mohamed Hamed, Sheref Mohamed, Mohamed Mahmoud, Jonathan Kahan, Amr Mohsen, Faisal Rahman, Waleed Kayani, Fernando Alfonso, Emmanuel S Brilakis, Islam Y Elgendy, Mamas A Mamas, Ayman Elbadawi
INTRODUCTION: Trials evaluating the role of intravascular imaging in percutaneous coronary intervention (PCI) for complex coronary artery disease have yielded mixed results. This study aimed to compare the outcomes of intravascular imaging specifically intravascular ultrasound (IVUS) with those from conventional coronary angiography in complex PCI. METHODS: Comprehensive electronic search of MEDLINE, EMBASE, and Cochrane databases was performed until March 2023 for randomized clinical trials (RCTs) comparing intravascular imaging with coronary angiography in patients undergoing complex PCI...
April 17, 2024: Cardiology and Therapy
Bryan Gervais de Liyis, Gusti Ngurah Prana Jagannatha, Anastasya Maria Kosasih, I Kadek Susila Surya Darma, I Made Junior Rina Artha
BACKGROUND: The impacts of single high-dose statin preloading in patients undergoing percutaneous coronary intervention (PCI) have not been fully examined. This study aims to evaluate post-procedure impacts of single high-dose statin pretreatment with acute coronary syndrome (ACS). METHODS: The meta-analysis reviewed Cochrane, PubMed, and Medline databases for studies comparing single high-dose atorvastatin or rosuvastatin to placebo in ACS patients undergoing PCI...
April 17, 2024: Egyptian Heart Journal: EHJ
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