keyword
https://read.qxmd.com/read/38537121/influence-of-low-level-tannin-supplementation-on-comparative-growth-performance-of-holstein-and-angus-x-holstein-cross-calf-fed-concentrate-based-finishing-diets-for-328-days
#1
JOURNAL ARTICLE
Pedro H V Carvalho, Brooke C Latack, Marcos V C Ferraz, Lester J R P Nolasco, Willi R Meireles, Heitor O M Oliveira, Richard A Zinn
The objective of the current study was to evaluate the effects of tannin and monensin supplementation in feedlot diets and breed (Holstein vs. Angus × Holstein) on growth performance, energetic efficiency, and carcass characteristics. Eighty purebred Holstein calves (HOL; initial body weight (BW) = 130 ± 5 kg) and eighty Angus × Holstein calves (AXH; initial BW = 129 ± 6 kg) were blocked by initial BW and randomly assigned to 40 pens. Dietary treatments consisted of a steam-flaked corn-based diet supplemented with 1) no feed additive (CON); 2) 30 mg of monensin/ kg of dry matter (DM) (MON; Rumensin 90, Elanco, Greenfield, IN); 3) 1...
March 27, 2024: Journal of Animal Science
https://read.qxmd.com/read/38537074/development-of-the-psu-child-pump
#2
JOURNAL ARTICLE
Christopher Scheib, Raymond Newswanger, Joshua Cysyk, Karl Bohnenberger, Branka Lukic, Lichong Xu, Eric Yeager, Kirby Bletcher, Patrick Leibich, Quandashia Jackson, Heidi Flory, Mindy Tillinger, William Weiss, Gerson Rosenberg, Choon-Sik Jhun
The Pennsylvania State University (PSU) Child Pump, a centrifugal continuous-flow ventricular assist device (cf-VAD), is being developed as a suitable long-term implantable device for pediatric heart failure patients between 10 and 35 kg, body surface area (BSA) of 0.5-1.2 m2, 1-11 years of age, and requiring a mean cardiac output of 1.0-3.5 L/min. In-vitro hydraulic and hemodynamic performances were evaluated on a custom mock circulatory loop with ovine blood. Normalized index of hemolysis (NIH) was evaluated under four conditions: 1) 8,300 rpm, 3...
March 28, 2024: ASAIO Journal: a Peer-reviewed Journal of the American Society for Artificial Internal Organs
https://read.qxmd.com/read/38536913/cardiac-tissue-model-of-immune-induced-dysfunction-reveals-the-role-of-free-mitochondrial-dna-and-the-therapeutic-effects-of-exosomes
#3
JOURNAL ARTICLE
Rick Xing Ze Lu, Naimeh Rafatian, Yimu Zhao, Karl T Wagner, Erika L Beroncal, Bo Li, Carol Lee, Jingan Chen, Eryn Churcher, Daniel Vosoughi, Chuan Liu, Ying Wang, Andrew Baker, Uriel Trahtemberg, Bowen Li, Agostino Pierro, Ana C Andreazza, Claudia C Dos Santos, Milica Radisic
Despite tremendous progress in the development of mature heart-on-a-chip models, human cell-based models of myocardial inflammation are lacking. Here, we bioengineered a vascularized heart-on-a-chip with circulating immune cells to model severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-induced acute myocarditis. We observed hallmarks of coronavirus disease (COVID-19)-induced myocardial inflammation, as the presence of immune cells augmented the secretion of proinflammatory cytokines, triggered progressive impairment of contractile function, and altered intracellular calcium transients...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536897/challenges-and-opportunities-in-valvular-heart-disease-from-molecular-mechanisms-to-the-community
#4
JOURNAL ARTICLE
Elena Aikawa, Mark C Blaser, Sasha A Singh, Robert A Levine, Magdi H Yacoub
No abstract text is available yet for this article.
April 2024: Arteriosclerosis, Thrombosis, and Vascular Biology
https://read.qxmd.com/read/38536878/increased-risk-of-diabetes-mellitus-and-hyperlipidemia-in-patients-with-differentiated-thyroid-cancer
#5
JOURNAL ARTICLE
Hwa Young Ahn, Jooyoung Lee, Jinmo Kang, Eun Kyung Lee
OBJECTIVE: This study aimed to assess the risk of cardiometabolic disease (CMD) in patients with differentiated thyroid cancer (DTC) using a population-based nationwide cohort in Korea. DESIGN: This was a population-based cohort study. METHODS: We selected 2649 patients with DTC and 7947 matched controls. The primary outcome was the composite of CMD including diabetes mellitus (DM), hypertension, hyperlipidemia, cerebrovascular disease, and ischemic heart disease...
March 2, 2024: European Journal of Endocrinology
https://read.qxmd.com/read/38536806/lower-autonomic-arousal-as-a-risk-factor-for-criminal-offending-and-unintentional-injuries-among-female-conscripts
#6
JOURNAL ARTICLE
Sofi Oskarsson, Anneli Andersson, Bridget M Bertoldi, Antti Latvala, Ralf Kuja-Halkola, Brittany Evans, Adrian Raine, Christopher J Patrick, Henrik Larsson, Catherine Tuvblad
BACKGROUND: Lower autonomic arousal is a well-known correlate of criminal offending and other risk-taking behaviors in men, but few studies have investigated this association in women. AIM: To test associations between autonomic arousal and criminal offending as well as unintentional injuries among female conscripts. METHODS: All women born 1958-1994 in Sweden who participated in voluntary military conscription (n = 12,499) were identified by linking Swedish population-based registers...
2024: PloS One
https://read.qxmd.com/read/38536760/nonpharmacologic-rate-control-of-postoperative-atrial-fibrillation-in-the-canine-sterile-pericarditis-model
#7
JOURNAL ARTICLE
Seungyup Lee, Don Wallick, Celeen Khrestian, Dragan Juzbasich, Daniel Laurita, Gregory Rushing, Jayakumar Sahadevan
INTRODUCTION: Postoperative atrial fibrillation (POAF) is common following open heart surgery, and is associated with significant morbidity. Medications used for ventricular rate control of POAF may not be effective in controlling rapid ventricular rates during the postoperative period because of increased sympathetic tone. The purpose of this study was to develop nonpharmacologic rate control of POAF by atrioventricular node (AVN) fat pad stimulation using clinically available temporary pacing wires in the canine sterile pericarditis model...
March 27, 2024: Journal of Cardiovascular Electrophysiology
https://read.qxmd.com/read/38536670/tyrosinase-modified-uhmw-selp-polymers-as-wet-and-underwater-adhesives-to-achieve-multi-interface-adhesion
#8
JOURNAL ARTICLE
Wenxin Huang, Sijia Wang, Zhaoxuan Feng, Dasen Zhou, Wenqin Bai
The presence of a hydration layer in humid and underwater environments challenges adhesive-substrate interactions and prevents effective bonding, which has become a significant obstacle to the development of adhesives in the industrial and biomedical fields. In this study, ultrahigh-molecular-weight (UHMW) silk-elastin-like proteins (SELP) with 3,4-dihydroxyphenylalanine (DOPA) converted from tyrosine residues by tyrosinase exhibited excellent adhesive properties on different interfaces, such as glass, aluminum, wood, polypropylene sheets, and pigskin, under both dry and wet conditions...
March 27, 2024: ACS Synthetic Biology
https://read.qxmd.com/read/38536648/catheter-ablation-of-ventricular-tachycardia-in-ischemic-heart-disease-what-is-known-and-new-perspectives
#9
REVIEW
Pasquale Valerio Falzone, Sara Vazquez-Calvo, Ivo Roca-Luque
PURPOSE OF THE REVIEW: This review aims to evaluate current evidence regarding ventricular tachycardia ablation in patients with ischemic heart disease and explore novel approaches currently developing to improve procedural and long-term outcomes. RECENT FINDINGS: Recently published trials (PARTITA, PAUSE-SCD, and SURVIVE-VT) have demonstrated the prognostic benefit of prophylactic ventricular tachycardia ablation compared to current clinical practice. Advanced cardiac imaging provides a valuable pre-procedural evaluation of the arrhythmogenic substrate, identifying ablation targets non-invasively...
March 27, 2024: Current Heart Failure Reports
https://read.qxmd.com/read/38536640/genetically-predicted-apolipoprotein-e-levels-with-the-risk-of-panvascular-diseases-a-mendelian-randomization-study
#10
JOURNAL ARTICLE
Yi-Ming Shi, Dian Ou, Jia-Ting Li, Le Bao, Xiao-Dan Liu, Wei Zhang, Huang Ding
The aim of this study was to comprehensively assess the causal relationship between the overall genetic effect of circulating ApoE levels and panvascular lesions using newer genome-wide association data and two-sample bidirectional Mendelian randomization (MR) analysis. Two-way MR using single-nucleotide polymorphisms of circulating ApoE as instrumental variables was performed using the highest-priority Genome-wide association study (GWAS) data, with factor-adjusted and data-corrected statistics, to estimate causal associations between circulating ApoE levels and 10 pan-vascular diseases in > 500,000 UK Biobank participants, > 400,000 participants of Finnish ancestry, and numerous participants in a consortium of predominantly European ancestry...
March 27, 2024: Cardiovascular Toxicology
https://read.qxmd.com/read/38536566/quality-assurance-of-3d-printed-patient-specific-anatomical-models-a-systematic-review
#11
JOURNAL ARTICLE
Martin Schulze, Lukas Juergensen, Robert Rischen, Max Toennemann, Gregor Reischle, Jan Puetzler, Georg Gosheger, Julian Hasselmann
BACKGROUND: The responsible use of 3D-printing in medicine includes a context-based quality assurance. Considerable literature has been published in this field, yet the quality of assessment varies widely. The limited discriminatory power of some assessment methods challenges the comparison of results. The total error for patient specific anatomical models comprises relevant partial errors of the production process: segmentation error (SegE), digital editing error (DEE), printing error (PrE)...
March 27, 2024: 3D Printing in Medicine
https://read.qxmd.com/read/38536532/association-between-the-american-heart-association-s-new-life-s-essential-8-metrics-and-kidney-stone
#12
JOURNAL ARTICLE
Xingmo Dong, Lihua Liao, Yani Wang, Xueqin Lin, Weihua Chen, Huaijing Luo, Yi Yi, Dewen Zhong, Haifeng Wang, Zecong Ma, Yongfei Liu, Ying Liao
PURPOSE: The incidence of kidney stone disease has increased worldwide, resulting in high medical costs and social burden. Kidney stone disease shares some common features with the risk factors of cardiovascular diseases (CVDs). We investigated the association between cardiovascular health (CVH) based on the Life's Essential 8 (LE8) score developed by the American Heart Association and the incidence of kidney stone disease. METHODS: We analyzed the data of 29,469 US adults aged 20 years or above from the National Health and Nutrition Examination Survey, 2007-2018...
March 27, 2024: World Journal of Urology
https://read.qxmd.com/read/38536517/development-and-validation-of-a-risk-prediction-model-for-valve-regurgitation-in-beh%C3%A3-et-s-disease
#13
JOURNAL ARTICLE
Zixian Deng, Benhui Liang, Tangzhiming Li, Qiyun Liu, Xiaoyu Wang, Xin Sun, Ziwei Ou, Lin Zhao, Cong Xu, Huadong Liu, Jianghua Li
BACKGROUND: In Behçet's disease (BD), mild-to-severe valvular regurgitation (VR) poses a serious complication that contributes significantly to heart failure and eventually death. The accurate prediction of VR is crucial in the early stages of BD subjects for improved prognosis. Accordingly, this study aimed to develop a nomogram that can detect VR early in the course of BD. METHODS: One hundred seventy-two patients diagnosed with Behçet's disease (BD) were conducted to assess cardiac valve regurgitation as the primary outcome...
March 27, 2024: Clinical Rheumatology
https://read.qxmd.com/read/38536509/mid-and-long-term-results-of-open-repair-for-chronic-type-b-aortic-dissection-in-endovascular-era
#14
JOURNAL ARTICLE
Akitoshi Takazawa, Toshihisa Asakura, Osamu Kinoshita, Hiroyuki Nakajima, Akihiro Yoshitake
Medical management is the standard treatment of chronic type B aortic dissection (CTBAD). However, the roles of open surgical repair (OSR) and thoracic endovascular repair (TEVAR) in patients with CTBAD remain controversial. Thus, this study aimed to assess and compare the mid- and long-term clinical outcomes of OSR via left thoracotomy with that of TEVAR for CTBAD. The data of 85 consecutive patients who underwent surgery for CTBAD from April 2007 to May 2021 were retrospectively reviewed. The patients were divided into two groups: Group G, which included patients who underwent OSR, and Group E, which included patients who underwent TEVAR...
March 27, 2024: Heart and Vessels
https://read.qxmd.com/read/38536505/metabolic-changes-contribute-to-maladaptive-right-ventricular-hypertrophy-in-pulmonary-hypertension-beyond-pressure-overload-an-integrative-imaging-and-omics-investigation
#15
JOURNAL ARTICLE
Inés García-Lunar, Inmaculada Jorge, Jorge Sáiz, Núria Solanes, Ana Paula Dantas, Juan José Rodríguez-Arias, María Ascaso, Carlos Galán-Arriola, Francisco Rafael Jiménez, Elena Sandoval, Jorge Nuche, Maria Moran-Garrido, Emilio Camafeita, Montserrat Rigol, Javier Sánchez-Gonzalez, Valentín Fuster, Jesús Vázquez, Coral Barbas, Borja Ibáñez, Daniel Pereda, Ana García-Álvarez
Right ventricular (RV) failure remains the strongest determinant of survival in pulmonary hypertension (PH). We aimed to identify relevant mechanisms, beyond pressure overload, associated with maladaptive RV hypertrophy in PH. To separate the effect of pressure overload from other potential mechanisms, we developed in pigs two experimental models of PH (M1, by pulmonary vein banding and M2, by aorto-pulmonary shunting) and compared them with a model of pure pressure overload (M3, pulmonary artery banding) and a sham-operated group...
March 27, 2024: Basic Research in Cardiology
https://read.qxmd.com/read/38536440/circulating-catecholamines-endothelin-1-and-nitric-oxide-releases-do-not-explain-the-preserved-fmd-following-acute-resistance-exercise-in-strength-trained-men
#16
JOURNAL ARTICLE
Takuma Morishima, Nobukazu Kasai
PURPOSE: Acute resistance exercise decreases endothelial function in sedentary individuals but not in strength-trained (ST) individuals. However, the underlying mechanism(s) of vascular protection in ST individuals remains unclear. Herein, we compared catecholamines, endothelin-1 (ET-1), and nitric oxide (NOx) releases after acute resistance exercise between sedentary and ST individuals. METHODS: The untrained (UT) group comprised 12 male individuals with no regular training, while the ST group comprised 12 male individuals...
March 27, 2024: European Journal of Applied Physiology
https://read.qxmd.com/read/38536171/a-revised-definition-of-left-bundle-branch-block-using-time-to-notch-in-lead-i
#17
JOURNAL ARTICLE
Jeremy S Treger, Ahmad B Allaw, Pouyan Razminia, Dipayon Roy, Amulya Gampa, Swati Rao, Andrew D Beaser, Srinath Yeshwant, Zaid Aziz, Cevher Ozcan, Gaurav A Upadhyay
IMPORTANCE: Current left bundle branch block (LBBB) criteria are based on animal experiments or mathematical models of cardiac tissue conduction and may misclassify patients. Improved criteria would impact referral decisions and device type for cardiac resynchronization therapy. OBJECTIVE: To develop a simple new criterion for LBBB based on electrophysiological studies of human patients, and then to validate this criterion in an independent population. DESIGN, SETTING, AND PARTICIPANTS: In this diagnostic study, the derivation cohort was from a single-center, prospective study of patients undergoing electrophysiological study from March 2016 through November 2019...
March 27, 2024: JAMA Cardiology
https://read.qxmd.com/read/38536153/prognostic-models-for-mortality-and-morbidity-in-heart-failure-with-preserved-ejection-fraction
#18
JOURNAL ARTICLE
Kirsty McDowell, Toru Kondo, Atefeh Talebi, Ken Teh, Erasmus Bachus, Rudolf A de Boer, Ross T Campbell, Brian Claggett, Ashkay S Desai, Kieran F Docherty, Adrian F Hernandez, Silvio E Inzucchi, Mikhail N Kosiborod, Carolyn S P Lam, Felipe Martinez, Joanne Simpson, Muthiah Vaduganathan, Pardeep S Jhund, Scott D Solomon, John J V McMurray
IMPORTANCE: Accurate risk prediction of morbidity and mortality in patients with heart failure with preserved ejection fraction (HFpEF) may help clinicians risk stratify and inform care decisions. OBJECTIVE: To develop and validate a novel prediction model for clinical outcomes in patients with HFpEF using routinely collected variables and to compare it with a biomarker-driven approach. DESIGN, SETTING, AND PARTICIPANTS: Data were used from the Dapagliflozin Evaluation to Improve the Lives of Patients With Preserved Ejection Fraction Heart Failure (DELIVER) trial to derive the prediction model, and data from the Angiotensin Receptor Neprilysin Inhibition in Heart Failure With Preserved Ejection Fraction (PARAGON-HF) and the Irbesartan in Heart Failure With Preserved Ejection Fraction Study (I-PRESERVE) trials were used to validate it...
March 27, 2024: JAMA Cardiology
https://read.qxmd.com/read/38536038/impaired-muscle-oxygenation-despite-normal-pulmonary-function-in-uncomplicated-type-2-diabetes
#19
JOURNAL ARTICLE
Islem Jlali, Imen Touil, Hassen Ibn Hadj Amor, Mohamed Amine Bouzid, Omar Hammouda, Elsa Heyman, Pierre Fontaine, Hamdi Chtourou, Remi Rabasa-Lhoret, Georges Baquet, Semah Tagougui
Long-term hyperglycemia in individuals with type 2 diabetes can detrimentally impact pulmonary function and muscle oxygenation. As a result, these factors can impede the body's adaptation to physical exertion. We aimed to evaluate the oxygen pathway during maximal exercise among overweight/obese individuals with uncomplicated type 2 diabetes, in comparison with a group of matched overweight/obese individuals without diabetes, specifically concentrating on the effects on pulmonary function and muscle oxygenation...
March 27, 2024: American Journal of Physiology. Endocrinology and Metabolism
https://read.qxmd.com/read/38536007/acute-myocarditis-an-overview-of-pathogenesis-diagnosis-and-management
#20
JOURNAL ARTICLE
Marina Zafeiri, Kristopher Knott, Temi Lampejo
Acute myocarditis encompasses a diverse presentation of inflammatory cardiomyopathies with infectious and non-infectious triggers. The clinical presentation is heterogeneous, from subtle symptoms like mild chest pain to life-threatening fulminant heart failure requiring urgent advanced hemodynamic support. This review provides a comprehensive overview of the current state of knowledge regarding the pathogenesis, diagnostic approach, management strategies, and directions for future research in acute myocarditis...
March 27, 2024: Panminerva Medica
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