Michael J Balsan, Jeanne Burns, Fred Kimock, Emily Hirsch, Andrew Unger, Richard Telesco, Elisabeth Bloch-Salisbury
BACKGROUND: Loud noises in the neonatal intensive care unit (NICU) exacerbate patient cardiac and respiratory activity, disrupt sleep, and may contribute to hearing deficits, speech and language disorders, and neurodevelopmental delays among NICU graduates. AIMS: This study evaluated infant-patient tolerance and nurse ease of use of a novel frequency-selective hearing protection device, DREAMIES (NEATCap Medical, LLC). STUDY DESIGN AND SUBJECTS: Fifty neonates receiving care in a Level III NICU participated in a 2-phase prospective study...
March 26, 2021: Early Human Development
Marco Cason, Rudy Celeghin, Maria Bueno Marinas, Giorgia Beffagna, Mila DellaBarbera, Stefania Rizzo, Carol Ann Remme, Connie Bezzina, Natascia Tiso, Barbara Bauce, Gaetano Thiene, Cristina Basso, Kalliopi Pilichou
BACKGROUND: Arrhythmogenic cardiomyopathy (AC) is a myocardial disease due to desmosomal mutations, whose pathogenesis remains incompletely understood. OBJECTIVE: To identify molecular pathways underlying early AC by gene expression profiling in both humans and animal models. METHODS: RNA sequencing for differentially expressed genes (DEGs) was performed on the myocardium of transgenic mice over-expressing the Desmoglein2-N271S mutation before phenotype onset...
April 12, 2021: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Kamala P Tamirisa, Priscilla Hsue, Hiroko Beck, Nipavan Chiamvimonvat, Emily P Zeitler, Roopinder K Sandhu, Jodie L Hurwitz
No abstract text is available yet for this article.
April 12, 2021: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Louise Reilly, Lee Eckhardt
Potassium inward rectifier channel Kir2 is an important component of terminal cardiac repolarization and resting membrane stability. This functionality is part of balanced cardiac excitability and is a defining feature of excitable cardiac membranes. "Gain"- or "loss-of-function" mutations in KCNJ2, the gene encoding Kir2.1, cause genetic sudden cardiac death syndromes, and loss of Kir2 current, IK1 , is a major contributing factor to arrhythmogenesis in failing human hearts. Here we provide a contemporary review of the Kir2 channels' functional structure, physiology and pharmacology...
April 12, 2021: Heart Rhythm: the Official Journal of the Heart Rhythm Society
Maiara B Narde, Elisa L B C Domingues, Karolina R Gonçalves, Mirelle L Viana, Marcos S Zanini, Wanderson G de Lima, Maria T Bahia, Fabiane M Dos Santos
Chagas disease, caused by Trypanosoma cruzi, is a major neglected tropical disease that occurs mainly as chronic infection and systemic infection. Currently, there is no suitable and effective drug to treat this parasitic disease. Administration of nutrients with immunomodulatory properties, such as arginine and nitric oxide radicals, may be helpful as antiparasitic therapy. In this study, we evaluated the effects of arginine supplementation during the acute phase of infection under the development of chronic Chagas' heart disease in Swiss mice inoculated with the Berenice-78 strain of T...
April 12, 2021: Parasitology International
Jose F Huizar, Alex Y Tan, Karoly Kaszala, Kenneth A Ellenbogen
The medical community's understanding of the consequences of premature ventricular contractions (PVCs) and PVC-induced cardiomyopathy has been derived mostly from observational and large population-based studies. Due to the difficulty of predicting the development of PVC-cardiomyopathy, the acute and chronic cardiac effects of PVCs and the mechanism of PVC-cardiomyopathy have been derived from pre-clinical studies with large animal models. Recently, these studies have described myocardial substrates that could potentially increase morbidity and mortality in patients with frequent PVCs and PVC-cardiomyopathy...
April 12, 2021: Progress in Cardiovascular Diseases
Dominick Santoriello, Andrew S Bomback, Satoru Kudose, Ibrahim Batal, M Barry Stokes, Pietro Canetta, Jai Radhakrishnan, Gerald B Appel, Vivette D D'Agati, Glen S Markowitz
Hydralazine, a widely used therapy for hypertension and heart failure, can elicit autoimmune disease, including anti-neutrophil cytoplasmic antibody associated glomerulonephritis (ANCA-GN). We identified 80 cases of ANCA-GN complicating treatment with hydralazine, accounting for 4.3% (80/1858 biopsies) of ANCA-GN diagnosed between 2006 and 2019. Over three-fourths of patients were on hydralazine for at least one year, with mean daily dose of approximately 250 mg/day. ANCA testing revealed p-ANCA/myeloperoxidase-ANCA seropositivity in 98%, including 39% with dual p-ANCA/myeloperoxidase-ANCA and cANCA/anti-protinase 3-ANCA positivity, often accompanied by anti-nuclear antibody (89%), anti-histone antibody (98%), and hypocomplementemia (58%)...
April 12, 2021: Kidney International
Ashim K Bagchi, Akshi Malik, Gauri Akolkar, Alexsandra Zimmer, Adriane Belló-Klein, Katia De Angelis, Davinder S Jassal, Mehdi A Fini, Kurt R Stenmark, Pawan K Singal
Although a high cumulative dose of Doxorubicin (Dox) is known to cause cardiotoxicity, there is still a lack of understanding of the subcellular basis of this drug-induced cardiomyopathy. Differential effects of Dox on mitochondria and endoplasmic reticulum (ER) were examined in cardiomyocytes, tumor cells, implanted tumors and hearts of normal as well as tumor-bearing animals. Dox increased mitochondrial (Mito) Bax activation at 3h in the cardiomyocyte without change in the DNA damage inducible transcriptor-3 (DDIT3) expression in the ER...
April 12, 2021: Biochimica et Biophysica Acta. Molecular Cell Research
Stephanie M Toth-Manikowski, Wei Yang, Lawrence Appel, Jing Chen, Rajat Deo, Anne Frydrych, Marie Krousel-Wood, Mahboob Rahman, Sylvia E Rosas, Daohang Sha, Jackson Wright, Martha L Daviglus, Alan S Go, James P Lash, Ana C Ricardo
RATIONALE & OBJECTIVE: Cardiovascular events are less common in women than men in general populations; however, studies in chronic kidney disease (CKD) are less conclusive. We evaluated sex-related differences in cardiovascular events and death in adults with CKD. STUDY DESIGN: Prospective cohort study. SETTING & PARTICIPANTS: 1778 women and 2161 men enrolled in the Chronic Renal Insufficiency Cohort (CRIC). EXPOSURE: Sex (women vs...
April 12, 2021: American Journal of Kidney Diseases
Hazaim Alwair, Katherine Whitehouse, Mark S Slaughter, Jaimin R Trivedi
BACKGROUND: Use of continuous flow left ventricular assist devices (CFVAD) has previously increased over the years as bridge to transplant (BTT). The Heartware HVAD and HeartMate III (HM3) are currently approved centrifugal flow devices used for BTT. We sought to evaluate outcomes of the patients listed and transplanted after receiving these two devices. METHODS: The United Network of Organ Sharing (UNOS) thoracic transplant database was queried after August 23, 2017 till December 2018 to identify patients aged > 18 years listed for HTx and supported by either HVAD or HM3...
April 12, 2021: Annals of Thoracic Surgery
Suguru Ohira, Ramin Malekan, Masashi Kai, Joshua B Goldberg, Philip J Spencer, Steven L Lansman, David Spielvogel
BACKGROUND: This study reviews the outcomes of our reoperative total arch repair (TAR) technique using a trifurcated graft and selective antegrade cerebral perfusion (SACP). METHODS: Fifty patients underwent reoperative TAR from January 2005 to September 2020, with either a one-stage (N=9), or two-stage repair (N=41). The two-stage technique includes minimal dissection of the mediastinal structures, an arch-first technique using a trifurcated graft, and construction of a classical elephant trunk via a partial transverse incision distally in the old-graft or in the aorta just distal to the old graft...
April 12, 2021: Annals of Thoracic Surgery
Shanna Hamilton, Radmila Terentyeva, Richard T Clements, Andriy E Belevych, Dmitry Terentyev
Sudden cardiac death due to ventricular tachyarrhythmias remains the major cause of mortality in the world. Heart failure, diabetic cardiomyopathy, old age-related cardiac dysfunction and inherited disorders are associated with enhanced propensity to malignant cardiac arrhythmias. Both defective mitochondrial function and abnormal intracellular Ca2+ homeostasis have been established as the key contributing factors in the pathophysiology and arrhythmogenesis in these conditions. This article reviews current advances in understanding of bidirectional control of ryanodine receptor-mediated sarcoplasmic reticulum Ca2+ release and mitochondrial function, and how defects in crosstalk between these two organelles increase arrhythmic risk in cardiac disease...
April 12, 2021: Journal of Molecular and Cellular Cardiology
Ayele Taddese Tsedeke, Srinivas Allanki, Alessandra Gentile, Vanesa Jimenez-Amilburu, Seyed Javad Rasouli, Stefan Guenther, Shih-Lei Lai, Didier Y R Stainier, Rubén Marín-Juez
Contrary to adult mammals, zebrafish are able to regenerate their heart after cardiac injury. This regenerative response relies, in part, on the endogenous ability of cardiomyocytes (CMs) to dedifferentiate and proliferate to replenish the lost muscle. However, CM heterogeneity and population dynamics during development and regeneration require further investigation. Through comparative transcriptomic analyses of the developing and adult zebrafish heart, we identified tnnc2 and tnni4b.3 expression as markers for CMs at early and late developmental stages, respectively...
April 12, 2021: Developmental Biology
Claude J Rogers, Espoir M Kyubwa, Agnes I Lukaszewicz, Jason Yamada-Hanff, Mark A Starbird, Thomas A Miller, Asa A Phelps, Seth Wallack, Saikanth Mahendra, Karla Thrall, Naresh Menon
Thoracic exposure to ionizing radiation can lead to delayed injuries to the heart and lung that are serious and even life-threatening. These injuries are difficult to predict since they manifest over many weeks and months. To identify non-invasive, tissue-specific biomarkers for the early detection of late radiation injury, circulating microRNA (miRNA) levels were measured in non-human primates (NHP, Macaca mulatta) that received a single exposure of whole-thorax lung irradiation (WTLI) at a dose likely to result in 20% or 75% mortality within 180 days (9...
April 15, 2021: Radiation Research
Cristobal Rodero, Marina Strocchi, Maciej Marciniak, Stefano Longobardi, John Whitaker, Mark D O'Neill, Karli Gillette, Christoph Augustin, Gernot Plank, Edward J Vigmond, Pablo Lamata, Steven A Niederer
Cardiac anatomy plays a crucial role in determining cardiac function. However, there is a poor understanding of how specific and localised anatomical changes affect different cardiac functional outputs. In this work, we test the hypothesis that in a statistical shape model (SSM), the modes that are most relevant for describing anatomy are also most important for determining the output of cardiac electromechanics simulations. We made patient-specific four-chamber heart meshes (n = 20) from cardiac CT images in asymptomatic subjects and created a SSM from 19 cases...
April 2021: PLoS Computational Biology
Yan Liang, Robert C Lyon, Jason Pellman, William H Bradford, Stephan Lange, Julius Bogomolovas, Nancy D Dalton, Yusu Gu, Marcus Bobar, Mong-Hong Lee, Tomoo Iwakuma, Vishal Nigam, Angeliki Asimaki, Melvin Scheinman, Kirk L Peterson, Farah Sheikh
Dysregulated protein degradative pathways are increasingly recognized as mediators of human disease. This mechanism may have particular relevance to desmosomal proteins that play critical structural roles in both tissue architecture and cell-cell communication as destabilization/breakdown of the desmosomal proteome is a hallmark of genetic-based desmosomal-targeted diseases, such as the cardiac disease, arrhythmogenic right ventricular dysplasia/cardiomyopathy (ARVD/C). However, no information exists on whether there are resident proteins that regulate desmosomal proteome homeostasis...
April 15, 2021: Journal of Clinical Investigation
Fernando Barber, Peter Langfield, Miguel Lozano, Ignacio Garcia-Fernandez, Josselin Duchateau, Melze Hocini, Michel Haissaguerre, Edward Vigmond, Rafael Sebastian
The Purkinje system is a heart structure responsible for transmitting electrical impulses through the ventricles in a fast and coordinated way to trigger mechanical contraction. Estimating a patient-specific compatible Purkinje Network from an electro-anatomical map is a challenging task, that could help to improve models for electrophysiology simulations or provide aid in therapy planning, such as radiofrequency ablation. In this study, we present a methodology to inversely estimate a Purkinje network from a patient's electro-anatomical map...
April 15, 2021: IEEE Transactions on Medical Imaging
Mina K Chung, David A Zidar, Michael R Bristow, Scott J Cameron, Timothy Chan, Clifford V Harding, Deborah H Kwon, Tamanna Singh, John C Tilton, Emily J Tsai, Nathan R Tucker, John Barnard, Joseph Loscalzo
A pandemic of historic impact, coronavirus disease 2019 (COVID-19) has potential consequences on the cardiovascular health of millions of people who survive infection worldwide. Severe acute respiratory syndrome-coronavirus 2 (SARS-CoV-2), the etiologic agent of COVID-19, can infect the heart, vascular tissues, and circulating cells through ACE2 (angiotensin-converting enzyme 2), the host cell receptor for the viral spike protein. Acute cardiac injury is a common extrapulmonary manifestation of COVID-19 with potential chronic consequences...
April 16, 2021: Circulation Research
Joanne F Garbincius, John W Elrod
No abstract text is available yet for this article.
April 16, 2021: Circulation Research
Peter Nymberg, Ashfaque A Memon, Jan Sundquist, Kristina Sundquist, Bengt Zöller
Venous thromboembolism (VTE) is the third most common cardiovascular disease. Low amount of mitochondrial DNA copy number (mtDNA-CN) has been associated with arterial cardiovascular disease (CVD) and reflects mitochondrial dysfunctions. However, whether mtDNA-CN is associated with VTE has not been determined. To examine the association between mtDNA-CN and incident VTE among middle-aged women. 6917 women aged 50-64 years, followed for 20 years in the Women's Health In the Lund Area (WHILA) study. DNA samples for mtDNA quantification were available from 2521 women...
April 15, 2021: Journal of Thrombosis and Thrombolysis
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