Xiaowei Xu, Qianjun Jia, Haiyun Yuan, Hailong Qiu, Yuhao Dong, Wen Xie, Zeyang Yao, Jiawei Zhang, Zhiqaing Nie, Xiaomeng Li, Yiyu Shi, James Y Zou, Meiping Huang, Jian Zhuang
Congenital heart disease (CHD) is the most common type of birth defect. Without timely detection and treatment, approximately one-third of children with CHD would die in the infant period. However, due to the complicated heart structures, early diagnosis of CHD and its types is quite challenging, even for experienced radiologists. Here, we present an artificial intelligence (AI) system that achieves a comparable performance of human experts in the critical task of classifying 17 categories of CHD types. We collected the first-large CT dataset from three different CT machines, including more than 3750 CHD patients over 14 years...
September 6, 2023: Medical Image Analysis
Kirby L Wycoff, Jabina G Coleman, Christine M Santoro, Leah L Zullig, Niesha Darden, Porsche M Holland, Jane F Cruice, Shukriyyah Mitchell, Michelle Smith, Saleemah J McNeil, Sharon J Herring
OBJECTIVE: To explore how patients, community-based perinatal support professionals, and health system clinicians and staff perceived facilitators and barriers to implementation of a randomized clinical trial (RCT) designed to optimize Black maternal heart health. METHODS: This article describes the formative work that we believed needed to occur before the start of the Change of H.E.A.R.T (Here for Equity, Advocacy, Reflection and Transformation) RCT. We used a qualitative, descriptive design and community-based, participatory approach, the latter of which allowed our team to intentionally focus on avoiding harm and equalizing power dynamics throughout the research process...
October 1, 2023: Obstetrics and Gynecology
Kwannapas Saengsin, Francesca Sperotto, Minmin Lu, Julia Garcia Mancebo, Elizabeth Sacco, Manasee Godsay, James A DiNardo, John N Kheir
BACKGROUND: Phosphodiesterase inhibitors are known to relieve symptoms in the setting of heart failure, although their effects in restrictive ventricular physiology have been poorly characterized. We explored the association between the use of milrinone and volume administration during the first 72 hours following surgical repair of tetralogy of Fallot (TOF). METHODS: We reviewed all cases of primary surgical repair of TOF with pulmonary stenosis or atresia at Boston Children's Hospital between 2011 and 2020...
September 21, 2023: Anesthesia and Analgesia
Jordan G Tropf, Benjamin W Hoyt, Sarah A Walsh, Jeffery A Gibson, Elizabeth M Polfer, Jason M Souza, Benjamin K Potter
BACKGROUND: There are little long-term health data, particularly in terms of body composition and development of metabolic syndromes, to help surgeons to guide the decision between limb salvage and amputation in patients with limb-threatening trauma. The purpose of this study was to compare long-term health outcomes after high-energy lower-extremity trauma between patients who underwent attempted flap-based limb salvage or amputation. METHODS: We performed a retrospective review of servicemembers with a minimum 10-year follow-up who underwent flap-based limb salvage followed by unilateral amputation or continued limb salvage after combat-related, lower-extremity trauma between 2005 and 2011...
September 21, 2023: Journal of Bone and Joint Surgery. American Volume
Patrick Mordel, Fanny Fontaine, Quentin Dupas, Michael Joubert, Stéphane Allouche
AIMS: Glycemic variability has been suggested as a risk factor for diabetes complications but the precise deleterious mechanisms remain poorly understood. Since mitochondria are the main source of energy in heart and cardiovascular diseases remain the first cause of death in patients with diabetes, the aim of the study was to evaluate the impact of glucose swings on mitochondrial functions in the cardiomyocyte cell line HL-1. METHODS: HL-1 cells were exposed to low (LG, 2...
2023: PloS One
Anne Garnier, Jérôme Leroy, Claudine Deloménie, Philippe Mateo, Benoit Viollet, Vladimir Veksler, Mathias Mericskay, Renée Ventura-Clapier, Jérôme Piquereau
The beta-adrenergic system is a potent stimulus for enhancing cardiac output that may become deleterious when energy metabolism is compromised as in heart failure. We thus examined whether the AMP-activated protein kinase (AMPK) that is activated in response to energy depletion may control the beta-adrenergic pathway. We studied the cardiac response to beta-adrenergic stimulation of AMPKα2-/- mice or to pharmacological AMPK activation on contractile function, calcium current, cAMP content and expression of adenylyl cyclase 5 (AC5), a rate limiting step of the beta-adrenergic pathway...
2023: PloS One
Aaron P Pearston, Amanda I Ingemi, Zachary A Shaeffer, Chad M Cameron, Katharine T Biagi, Myra Gobble, Amin Yehya, David A Baran
BACKGROUND: Cardiac transplantation requires lifelong immunosuppressant medications to prevent rejection. However, some patients may not tolerate multiple immunosuppressants due to adverse effects. At our institution, patients may be converted to monotherapy with tacrolimus if unable to tolerate a combination regimen. This study evaluated the outcomes among patients converted to tacrolimus monotherapy compared with those maintained on combination immunosuppression. METHODS: This single-center, retrospective cohort study included patients who received heart transplants at Sentara Norfolk General Hospital between January 2015 and July 2021...
September 21, 2023: Clinical Transplantation
Paola Nicolini, Tiziano Lucchi, Marco Vicenzi
No abstract text is available yet for this article.
September 20, 2023: Aging
Yingyu Yang, Ziwei Hao, Ning An, Yuting Han, Weilan Miao, Kenneth B Storey, Etienne Lefai, Xiaoxuan Liu, Junshu Wang, Shuo Liu, Manjiang Xie, Hui Chang
Hibernating mammals are natural models of resistance to ischemia, hypoxia-reperfusion injury, and hypothermia. Daurian ground squirrels (spermophilus dauricus) can adapt to endure multiple torpor-arousal cycles without sustaining cardiac damage. However, the molecular regulatory mechanisms that underlie this adaptive response are not yet fully understood. This study investigates morphological, functional, genetic, and metabolic changes that occur in the heart of ground squirrels in three groups: summer active (SA), late torpor (LT), and interbout arousal (IBA)...
September 21, 2023: Journal of Cellular Physiology
Monalisa Sahoo, Rajendra Singh, Pawan Kumar, Asok Kumar Mariappan, Palanivelu Munnuswamy, Karampal Singh, Mani Saminathan, Kuldeep Dhama, Ganesh Kondabattula, Tareni Das, Jigarji Chaturji Thakor, Gayatri Kashyap, Nihar Ranjan Sahoo
The Foot-and-Mouth disease is highly contagious acute viral disease of livestock inflicting huge economic loss to the farmers. The limited knowledge regarding the pathological lesions vis-a-vis distribution of the FMDV in in lesser explored endocrine glands and important vital organs other than the target organs of infected calves prompted us to take the present investigation to have detailed insight into the pathogenesis. The systematic necropsy of 37 dead calves (cattle-28 and buffalo-9) was conducted, and thin representative tissue pieces from the affected organs were collected in 10% neutral buffered formalin (NBF) for pathological and immunohistochemical investigations...
September 21, 2023: Veterinary Quarterly
Ciro Cococcetta, Thomas Coutant, Albert Phouratsamay, Graham Zoller, Sophie Bagur, Minh Huynh
Manual handling of chickens is required for many veterinary, research, and breeding procedures. This study aimed to assess the changes in physiological parameters over time during manual restraint of chickens, as well as the effect of hooding on these parameters. Heart rate, heart rate variability, respiratory rate, and body temperature were measured every 3 minutes for 15 minutes during manual restraint in 13 adult laying hens ( Gallus gallus domesticus ). Heart rate variability was significantly higher in hooded hens than in nonhooded hens ( P = 0...
September 2023: Journal of Avian Medicine and Surgery
Thomas Coutant, Ciro Cococcetta, Albert Phouratsamay, Chloé Touzet, Graham Zoller, Minh Huynh
Backyard poultry hens are becoming very popular as pets, and thus the demand for treating the individual chicken is increasing. Few basic diagnostic techniques commonly used in small animal practice have been evaluated in this species. At the moment, there is no study in backyard hens describing radiographic measurements of internal organs contrary to psittacine birds or birds of prey. Moreover, the effect of egg laying on these measurements has not been studied in avian species even though it could affect radiographic measurements depending on the stage of egg formation...
September 2023: Journal of Avian Medicine and Surgery
Ciro Cococcetta, Thomas Coutant, Sophie Bagur, Morena Bernadette Wernick, Minh Huynh
The high cardiac contractility of birds poses a challenge to traditional cardiac auscultation, particularly for the accurate determination of heart rate (HR). The objectives of this study were to 1) evaluate the feasibility of using phonocardiograms of adequate length and quality to assess HR in different avian species with a commercially available digital stethoscope, 2) compare 5 counting methods, including 2 direct reading methods (manual counting and using a semiautomatic computerized algorithm as a reference method) and 3 listening methods (progressive mental counting, counting by 10s, and counting with a smartphone application tap counter), and 3) obtain the HR in selected birds and identify a correlation between body weight and HR in different avian species...
September 2023: Journal of Avian Medicine and Surgery
Xinyue Wang, Hongjian Huang, Renfeng Xu, Yan Fang, Yunxiang Weng, Zhengchao Wang, Xiaopeng Xiong, Haiqing Liu
Adhesives with robust but readily detachable wet tissue adhesion are of great significance for wound closure. Polyelectrolyte complex adhesive (PECA) is an important wet tissue adhesive. However, its relatively weak cohesive and adhesive strength cannot satisfy clinical applications. Herein, modified tannic acid (mTA) with a catechol group, a long alkyl hydrophobic chain, and a phenyl group was prepared first, and then, it was mixed with acrylic acid (AA) and polyethylenimine (PEI), followed by UV photopolymerization to make a wet tissue adhesive hydrogel with tough cohesion and adhesion strength...
September 21, 2023: ACS Applied Materials & Interfaces
Joana E Andoh, Tahreem A Mir, Christopher C Teng, Emily A Wang, Kristen Nwanyanwu
The purpose of this study was to investigate the prevalence of and factors associated with visual impairment among adults with a history of criminal justice involvement (CJI). This retrospective, cross-sectional study reviewed adult respondents from the 2015-2018 National Survey on Drug Use and Health. We analyzed sociodemographic and health characteristics to determine factors associated with visual impairment among adults with and without a history of CJI. In this national, population-based study, we found similar rates of visual impairment among adults with and without CJI (5...
September 21, 2023: Journal of Correctional Health Care
Drusus A Johnson, Mark P Funnell, Liam M Heaney, Thomas G Cable, Patrick C Wheeler, Stephen J Bailey, Tom Clifford, Lewis J James
Introduction: Cannabidiol (CBD) is a nonintoxicating phytocannabinoid used in clinical treatments and sold widely in consumer products. CBD products may be designed for sublingual or oral delivery, but it is unclear whether either is advantageous for CBD absorption. This study compared CBD pharmacokinetics after providing CBD oil as sublingual drops and within orally ingested gelatin capsules, at a dose relevant to consumer products. Materials and Methods: Eight males completed three conditions in a participant-blinded, randomized crossover design...
September 22, 2023: Cannabis and Cannabinoid Research
Stefano Fumagalli, Giulia Ricciardi, Claudia Di Serio, Giancarlo La Marca, Giuseppe Pieraccini, Riccardo Franci Montorzi, Emanuele Santamaria, Giulia Spanalatte, Francesca Marchetti, Ginevra Corti, Laura Pinton, Niccolò Marchionni
BACKGROUND: Atrial fibrillation (AF) is associated with chronic inflammation, a hallmark of ageing process. The aim of this study was to determine interleukin-6 (IL-6)-associated variables, also exploring acylcarnitines, expression of mitochondrial abnormalities. METHODS: We evaluated 22 controls and 50 patients with persistent AF. IL-6 and acylcarnitines were measured with ELISA kits and mass spectrometry techniques. RESULTS: IL-6 concentration (mean: 3...
September 21, 2023: Aging Clinical and Experimental Research
Yihang Wu, Pengchao Tian, Lin Liang, Yuyi Chen, Jiayu Feng, Boping Huang, Liyan Huang, Xuemei Zhao, Jing Wang, Jingyuan Guan, Xinqing Li, Jian Zhang, Yuhui Zhang
BACKGROUND: Estimated plasma volume status (ePVS) is a marker of intravascular congestion and has prognostic value in patients with heart failure (HF). The elevation of intracardiac filling pressures is defined as hemodynamic congestion and is also associated with poor prognosis. However, the relationship between intravascular congestion and hemodynamic congestion remains unclear. This study sought to explore the correlation between ePVS and hemodynamic parameters and determine the association between ePVS and clinical outcomes in patients with advanced HF...
September 21, 2023: Internal and Emergency Medicine
Kelli Blackwell, Michele Blackwell, Thomas Blackwell
PURPOSE OF REVIEW: The purpose of this review is to analyze the link between testosterone replacement therapy (TRT) and adverse cardiovascular (CV) events. RECENT FINDINGS: A few published studies suggest a link between TRT and CV events. These studies contained flaws, and many other studies reveal a reduction in CV events. Hypogonadism is associated with increased mortality in men with CVD. TRT in hypogonadal men can improve many CVD risk factors, reduce QT interval prolongation, lead to better outcomes in heart failure patients, and slow the progression of atherosclerosis...
September 21, 2023: Current Cardiology Reports
Gbolahan Olatunji, Emmanuel Kokori, Ismaila Yusuf, Emmanuel Ayanleke, Olakanmi Damilare, Samson Afolabi, Busayo Adetunji, Saad Mohammed, Olumide Akinmoju, Gbolahan Aboderin, Nicholas Aderinto
Heart failure (HF) is a prevalent and debilitating global cardiovascular condition affecting around 64 million individuals, placing significant strain on healthcare systems and diminishing patients' quality of life. The escalating prevalence of HF underscores the urgent need for innovative therapeutic approaches that target the root causes and aim to restore normal cardiac function. Stem cell-based therapies have emerged as promising candidates, representing a fundamental departure from conventional treatments focused primarily on symptom management...
September 21, 2023: Heart Failure Reviews
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