Hazem Elkady, Hazem A Mahdy, Mohammed S Taghour, Mohammed A Dahab, Alaa Elwan, Mohamed Hagras, Mona H Hussein, Ibrahim M Ibrahim, Dalal Z Husein, Eslam B Elkaeed, Aisha A Alsfouk, Ahmed Metwaly, Ibrahim Eissa
BACKGROUND: VEGFR-2 has emerged as a prominent positive regulator of cancer progression. AIM: Discovery of new anticancer agents and apoptotic inducers targeting VEGFR-2. METHODS: Design and synthesis of new thiazolidine-2,4-diones followed by extensive in vitro studies, including VEGFR-2 inhibition assay, MTT assay, apoptosis analysis, and cell migration assay. In silico investigations including docking, MD simulations, ADMET, toxicity, and DFT studies were performed...
March 21, 2024: Biochimica et Biophysica Acta. General Subjects