Yossi Rosman, Shaul Ravfogel, Arthur Shiyovich, Shai Shrot, Nadav Milk, Nimrod Ophir, Michael Aviram, Ishai Nir, Michael Kassirer, Arik Eisenkraft
BACKGROUND: Paraoxonase-1, an organophosphorous-hydrolyzing enzyme, was shown to provide protection against organophosphates poisoning in vivo. In vitro findings suggest that the phytoalexin resveratrol can elevate paraoxonase-1 levels and thus may provide protection against organophosphate poisoning. This study was conducted to evaluate the effect of prolonged resveratrol intake on paraoxonase-1 levels in rats, and its role as a potential prophylactic treatment in organophosphate poisoning...
2016: Disaster and Military Medicine