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Journal of Translational Internal Medicine

Rebecca J Fisk, Disha Kumar, Daniel R Murphy, Monisha Arya
No abstract text is available yet for this article.
December 2018: Journal of Translational Internal Medicine
Sophie Samyn, Marielle Morissens, Ahmed Sanoussi, José Castro Rodriguez
Reinterventions for surgery complications in adult patients with complex congenital heart disease are often difficult and have a high operative risk. If anatomically possible, a percutaneous approach is an alternative to surgery. We report the case of a 36 year-old patient who underwent surgery for a double outlet right ventricle with transposition of the great arteries and pulmonary stenosis. On the days following the surgery, the patient was hemodynamically unstable due to a stenosis of the intraventricular Dacron conduit between the left ventricle and the aorta...
December 2018: Journal of Translational Internal Medicine
Xiangbo Xu, Zhaohui Bai, Qingchun Zhao, Hongyu Li, Qiang Shi, Jiao Deng, Jingqiao Zhang, Xiaozhong Guo, Xingshun Qi
Acute-on-chronic liver failure (ACLF) is a potentially lethal syndrome, which is characterized by an acute deterioration of liver function in patients with chronic liver diseases. The present paper reported that an alcoholic cirrhotic patient with ACLF developed septic shock, hydrothorax, ascites, hepatic encephalopathy, acute kidney injury, and acute upper gastrointestinal bleeding at the same hospitalization and was successfully rescued by pharmacotherapy alone without any invasive intervention.
December 2018: Journal of Translational Internal Medicine
Tuba Tülay Koca
Background and Objective: Bilirubin (Bb) is the product of the intravascular compartment of catabolic pathway. In a small number of clinical trials, it has been shown that Bb molecules are associated with cardiovascular diseases, diabetes, cancer, autoimmune (lupus, rheumatoid arthritis) diseases and schizophrenia. Behçet's disease is a chronic, multisystemic, inflammatory vasculitis that was first described by Hulusi Behçet in 1937, which affects almost all organs and systems without any known aetiology...
December 2018: Journal of Translational Internal Medicine
Jawaid Iqbal, Muhammad Ali Khalid, Farina M Hanif, Rajesh Mandhwani, Syed Mudassir Laeeq, Zain Majid, Nasir Hassan Luck
Background: Renal dysfunction is one of the dreaded complications of cirrhosis. MELD is a validated chronic liver disease (CLD) severity scoring system. Urinary (U) Na/K ratio closely correlates with renal dysfunction in terms of low GFR in cirrhotic patients. Patients and Methods: All consecutive patients with decompensated cirrhosis between the age of 18 to 70 years, of either gender, presenting in the outpatients' department of Sindh Institute of Urology and Transplantation, Karachi, from June 2015 to June 2017 were included...
December 2018: Journal of Translational Internal Medicine
Dimitrios Velissaris, Nikolaos-Dimitrios Pantzaris, Anastasia Skroumpelou, Panagiotis Polychronopoulos, Vasilios Karamouzos, Charalampos Pierrakos, Charalampos Gogos, Menelaos Karanikolas
Objective: To evaluate the electroencephalographic (EEG) findings and correlate EEG findings with inflammatory biomarkers and the sepsis prognostic scores SOFA, SAPS II and APACHE II in patients who present in the Emergency Department with sepsis without clinical central nervous system involvement. Methods: The study included seventeen patients (< 70 years old) with sepsis without central nervous system involvement presenting in the Emergency Department of the University Hospital of Patras, Greece...
December 2018: Journal of Translational Internal Medicine
Sankalp Yadav, Gautam Rawal
The waterpipe tobacco smoking is an ancient form of smoking that is present in the society since centuries. The majority of consumers of this exotic activity are still unaware of the serious consequences that this type of smoking has on the health of the smoker. The paucity of data related to the prevalence and extent of this habit in the society is still not available. In this present short review, the authors try to highlight this serious health issue and suggest preventive measures.
December 2018: Journal of Translational Internal Medicine
Weili Men, Haijuan Xiao, Zhiping Yang, Daiming Fan
By retrieving the 1900-2016 medical education-related essays from the web of science database, UCINET software was used to build the national cooperation network and its nested visualization software, and NetDraw was used to visualize the country cooperation networks in different time windows. We found that international medical education papers began to show exponential growth until 1945 and international cooperation did not begin to become dense until 1961. With the increasing number of participating countries in international medical education, the cooperation factions formed more complicated...
December 2018: Journal of Translational Internal Medicine
Ningning Zhu, Dijiong Wu, Baodong Ye
Aplastic anemia (AA) is a common hematologic disease that is characterized by hematopoietic failure of the bone marrow and pancytopenia of the peripheral blood, which can be divided into severe and non-severe aplastic ane-mia, or acute and chronic aplastic anemia according to the severity of the disease and the progress of the clinical course. During the past years, the advantages of Traditional Chinese Medicine (TCM) on the treatment of AA have been well clarified and its theory system has been improved as well...
December 2018: Journal of Translational Internal Medicine
David De Bels, Charalampos Pierrakos, Herbert D Spapen, Patrick M Honore
No abstract text is available yet for this article.
December 2018: Journal of Translational Internal Medicine
Ilaria Botta, Jacques Devriendt, Jose Castro Rodriguez, Marielle Morissens, Andrew Carling, Leonel Barreto Gutierrez, Thierry Preseau, David De Bels, Patrick M Honore, Sebastien Redant
We present a case of a 21-year-old Caucasian woman at 27 weeks of pregnancy who was admitted to the obstetric department for pre-term labor. She received 10 mg of nifedipine 4 times in 1 h, according to the internal protocol. Shortly after, she brutally deteriorated with pulmonary edema and hypoxemia requiring transfer to the intensive care unit (ICU) for mechanical ventilation. She finally improved and was successfully extubated after undergoing a percutaneous valvuloplasty of the mitral valve. This case illustrates a severe cardiogenic shock after administration of nifedipine for premature labor in a context of unknown rheumatic mitral stenosis...
September 2018: Journal of Translational Internal Medicine
Herbert Djiambou-Nganjeu
Background and Objectives: Hepatic encephalopathy (HE) research has long been impeded by the vague definition of this disabling complication of liver failure. This article provides an overview of the etiology and impact of HE on neuromuscular functions as well as its role in the development of infections and anemia. Materials and Methods: This was a descriptive study conducted in 36 patients with HE. Close monitoring of these patients was done by checking on several parameters...
September 2018: Journal of Translational Internal Medicine
Gianluca Rigatelli, Marco Zuin, Fabio Dell'Avvocata, Aravinda Nanjundappa, Ramesh Daggubati, Thach Nguyen
Objectives: To non-invasively evaluate by computational fluid dynamic (CFD) analysis the physiology and rheology of aortoiliac bifurcation disease at different angles and different stent configurations. Material and methods: For the analysis, we considered a physiologic model of abdominal aorta with an iliac bifurcation set at 30°, 45° and 70° without stenosis. Subsequently, a bilateral ostial common iliac stenosis of 80% was considered for each type of bifurcation...
September 2018: Journal of Translational Internal Medicine
Chunyan Liu, Zonghong Shao
Aplastic anemia (AA) is a hematologic disease characterized by pancytopenia. Up to now, severe aplastic anemia (SAA) has been recognized by international and domestic scholars as an autoimmune disease with bone marrow (BM) failure mediated by the hyperfunctional T lymphocytes. The incidence of AA is more in China compared with other countries. In the recent years, both the pathogenesis and treatment of AA have made a great progress in our country. Thus, the therapeutic effect of AA was much better than before...
September 2018: Journal of Translational Internal Medicine
Justin S Michael, Bong-Seop Lee, Miqin Zhang, John S Yu
Glioblastoma multiforme (GBM), a grade IV astrocytoma as defined by the World Health Organization (WHO) criteria, is the most common primary central nervous system tumor in adults. After treatment with the current standard of care consisting of surgical resection, concurrent temozolomide (TMZ), and radiation, the median survival is only 15 months. The limited and less-effective treatment options for these highly aggressive GBMs call for the development of new techniques and the improvement of existing technologies...
September 2018: Journal of Translational Internal Medicine
Patrick M Honore, David De Bels, Thierry Preseau, Sebastien Redant, Herbert D Spapen
In most of the case, regional citrate anticoagulation is using diluted citrate around 1% depending on the types used in clinical practice. Diluted citrate is much more safer when compared to highly concentrated citrate around 4% or even more. In clinical practice, trisodium citrate is used in high concentration (around 30%) as a bactericidal agent with anticoagulant properties for locking deep venous catheters used in hemodialysis (HD; close to 25-30% of citrate). In this review article, buffer and anticoagulant potential of citrate are discussed during renal replacement therapy in critically ill patients with particular focus on the practical approach at the bedside...
September 2018: Journal of Translational Internal Medicine
J David Spence
There have been recent advances in stroke prevention in nutrition, blood pressure control, antiplatelet therapy, anticoagulation, identification of high-risk asymptomatic carotid stenosis, and percutaneous closure of patent foramen ovale. There is evidence that the Mediterranean diet significantly reduces the risk of stroke and that B vitamins lower homocysteine, thus preventing stroke. The benefit of B vitamins to lower homocysteine was masked by harm from cyanocobalamin among study participants with impaired renal function; we should be using methylcobalamin instead of cyanocobalamin...
September 2018: Journal of Translational Internal Medicine
Faisal Khan, Homoyon Mehrzad, Dhiraj Tripathi
Budd-Chiari syndrome (BCS) is a rare but fatal disease caused by the obstruction in hepatic venous outflow tract (usually by thrombosis) and is further classified into two subtypes depending on the level of obstruction. Patients with BCS often have a combination of prothrombotic risk factors. Clinical presentation is diverse. Stepwise management strategy has been suggested with excellent 5-year survival rate. It includes anticoagulation, treatment of identified prothrombotic risk factor, percutaneous recanalization, and transjugular intrahepatic portosystemic shunt (TIPS) to reestablish hepatic venous outflow and liver transplantation in unresponsive patients...
September 2018: Journal of Translational Internal Medicine
Hisashi Sawada, Jeff Z Chen, Bradley C Wright, Mary B Sheppard, Hong S Lu, Alan Daugherty
No abstract text is available yet for this article.
September 2018: Journal of Translational Internal Medicine
Tingxue Song, Zhe Jia, Xiaozhong Guo, Haitao Zhao, Wenchun Bao, Dan Han, Xinmiao Zhou, Xingshun Qi
No abstract text is available yet for this article.
June 2018: Journal of Translational Internal Medicine
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