Journals American Journal of Ophthalmol...

American Journal of Ophthalmology Case Reports
Matteo Menean, Alessandro Marchese, Giulio Modorati, Rosa Favale, Francesco Boscia, Francesco Bandello, Elisabetta Miserocchi
PURPOSE: To describe a case of bilateral panuveitis in a patient with Stimulator of Interferon Genes (STING)-Associated Vasculitis with Onset in Infancy (SAVI). OBSERVATIONS: A 45-year-old patient diagnosed with SAVI presented bilateral panuveitis and uncontrolled secondary intraocular hypertension due to structural complications from uveitis. Multimodal imaging revealed the presence of intraretinal fluid and bilateral vasculitis. The patient was started with systemic methotrexate...
June 2024: American Journal of Ophthalmology Case Reports
Takahiro Kogo, Yuki Muraoka, Masaharu Ishikura, Naomi Nishigori, Yuki Akiyama, Masayuki Hata, Akitaka Tsujikawa
PURPOSE: We report a case of laser-induced retinopathy that posed diagnostic challenges with conventional spectral domain optical coherence tomography (SD-OCT), but was successfully diagnosed using adaptive optics-optical coherence tomography (AO-OCT). OBSERVATIONS: A 27-year-old man with a history of occupational laser device use presented with central scotoma and visual disturbances in the right eye. Conventional SD-OCT only revealed decreased reflectivity in parts of the foveal ellipsoidal zone band...
June 2024: American Journal of Ophthalmology Case Reports
Liam D Redden, Douglas S M Iaboni, Sarah van der Ende, Mathew Nightingale, Daniel Gaston, Christopher R McMaster, Johane M Robitaille, R Rishi Gupta
PURPOSE: To report a rare clinical finding of preretinal granules associated with atypical familial exudative vitreoretinopathy (FEVR) and perform a review of the literature. OBSERVATIONS: An asymptomatic 18-year-old male was referred for unilateral peripheral avascular retina evaluation in association with presumed FEVR. He was first noted to have white preretinal granules on fundus examination at five years of age. The lesions remained unchanged over the subsequent years...
June 2024: American Journal of Ophthalmology Case Reports
Samantha Madala, Yicheng K Bao, Jun Hui Lee, Jeffrey Gluckstein, Jessica Chang, Sandy Zhang-Nunes
PURPOSE: To report a case of retrograde embolism of cosmetic injection of platelet-rich plasma (PRP) to the ophthalmic artery, resulting in orbital ischemia, blindness, and eventual phthisis bulbi. OBSERVATIONS: A 37-year-old woman presented with two days of vision loss OS beginning seconds after undergoing cosmetic PRP filler injections to the face at an outside clinic. Immediately after injection to the left medial forehead, the patient reported bleeding, transient loss of consciousness, and complete vision loss OS...
June 2024: American Journal of Ophthalmology Case Reports
Emily White, Nicholas Fazio, Konstantinos Tourmouzis, Samuel Ryu, Paul T Finger, Jodi Sassoon, Roger Keresztes, Timothy Chou, Kevin Kaplowitz, Robert Honkanen
PURPOSE: We describe a case of Classic Kaposi's sarcoma in a functionally monocular patient following a COVID19 vaccine booster and provide compelling evidence that suggests the booster was a relevant co-factor in the initiation of the disease process. OBSERVATIONS: The patient presented with red, irritated conjunctival area described as "bubbling" in her right eye. While her past medical history includes hypercholesterolemia and hypertension, she had no history of a compromised immune system...
June 2024: American Journal of Ophthalmology Case Reports
Davoud Amirkashani, Saeid Talebi, Mohammad Vafaei Shahi, Ali Zekri, Parisa Abdi, Mahdokht Mehramiz
PURPOSE: To report a 15 year old girl with citrullinemia type 1 and 2 accompanied by neurologic signs and symptoms and a novel ocular complaint in cornea like tyrosinemia type 2. OBSERVATIONS: A 15 year old female was admitted with decreased consciousness and neurologic signs and symptoms. Citrulinemia was discovered through metabolic testing. Later genetic studies revealed mutations in both ASS1 and SLC25A13 genes. Two years after the first presentation, the patient was re-admitted with complaints of bilateral photophobia and tearing...
June 2024: American Journal of Ophthalmology Case Reports
Mizuho Mitamura, Satoru Kase, Yuka Suimon, Hiromi Kanno-Okada, Susumu Ishida
PURPOSE: Choroidal melanocytoma is a rare benign melanocytic tumor. We report a case of choroidal melanocytoma that was definitively diagnosed by histopathological findings after local resection. OBSERVATION: A 71-year-old female complained of blurred vision in her left eye. Her best-corrected visual acuity (BCVA) was 1.0. A dark-brown elevated lesion, measuring 5 papilla-diameter was found in the periphery of the fundus in her left eye. The mass showed hyperfluorescence on fluorescein angiography, early hypofluorescence and late hyperfluorescence on indocyanine green angiography...
June 2024: American Journal of Ophthalmology Case Reports
Debora H Lee, Melody Ziari, Ruchi D Shah, Gioconda Mojica, Asadolah Movahedan
PURPOSE: To report the clinical course of an aphakic patient who developed positional secondary angle closure glaucoma following pars plana vitrectomy (PPV) with perfluoropropane (C3F8) gas tamponade. OBSERVATIONS: A 23-year-old male presented due to a two-year history of vision loss in the left eye. Best-corrected visual acuity (BCVA) was 20/200 and intraocular pressure (IOP) was 12 mm Hg OS. Exam revealed iridodonesis and aphakia of both eyes, and a total RRD in the left eye...
June 2024: American Journal of Ophthalmology Case Reports
Antoine G Sassine, Yavuz Cakir, Lyndsey Della Vecchia, Justis P Ehlers
PURPOSE: This report aims to highlight the wide spectrum of ophthalmic adverse events associated with erdafitinib, a fibroblast growth factor inhibitor that blocks activation of the mitogen-activated protein kinase kinase (MAPK/MEK) cascade. The purpose of this report is to describe a case of erdafitinib-associated bilateral outer retinal alterations in the MEK-associated retinopathy spectrum and rapid onset bilateral total cataracts following a 20-month course of erdafitinib therapy...
June 2024: American Journal of Ophthalmology Case Reports
Arieke I Jadnanansing, Jose P Martinez Ciriano, Jan van Droogenbroeck, Leigh Spielberg, Eva Vanhonsebrouck
PURPOSE: To report a case of a perifoveal exudative vascular anomalous complex (PEVAC) resembling lesion in a patient with multiple myeloma. OBSERVATIONS: A 56-year-old male with multiple myeloma presented with sudden moderate vision loss in the right eye. Best-corrected visual acuity was 20/25 in his right eye. Fundus examination showed a vascular irregularity in the perifoveal region. Fluorescein angiography (FA) revealed an isolated perifoveal aneurysmal lesion with minimal leakage...
June 2024: American Journal of Ophthalmology Case Reports
Priya R Chandrasekaran, Hiok Hong Chan, Tien-En Tan, Farah N I Ibrahim, Jinzhi Zhao, Kelvin Y C Teo
PURPOSE: To report a case of secondary Multiple Evanescent White Dot Syndrome in a patient with preexisting wet age-related macular degeneration. OBSERVATION: A 75-year-old male on treat and extend regimen for wet age-related macular degeneration (AMD) presented with a sudden loss of vision and saw central dark shadow in the right eye (RE) for a duration of 1 week. There was no significant history preceding the visual loss. Examination showed a visual acuity (VA) of counting fingers at 1 meter in the right eye and 20/25 in the left eye...
June 2024: American Journal of Ophthalmology Case Reports
Yuzen Kashima, Kumiko Kato, Maki Takeuchi, Yuka Yonekawa, Yuko Takashima, Koji Hirano, Mineo Kondo
PURPOSE: To determine the characteristics of an eye that developed acute hydrops while being treated for infectious keratitis. OBSERVATION: A 35-year-old man presented with pain and blurred vision in his left eye. He had undergone cataract surgery seven years earlier and was being treated for poorly controlled atopic dermatitis. The decimal best-corrected visual acuity (BCVA) of the left eye was 0.01. Slit-lamp microscopy showed conjunctival injection, corneal opacification, and a corneal ulcer...
June 2024: American Journal of Ophthalmology Case Reports
Ayushi Agarwal, Milind Naik, Mohammad Javed Ali, Nandini Bothra
PURPOSE: To study cases of hardware-associated secondary acquired lacrimal duct obstructions (SALDO) and the role of computed tomography dacryocystography (CT-DCG) scans in its diagnosis and management. OBSERVATIONS: Retrospective, interventional case review of four patients diagnosed as Hardware-associated SALDO, with primary maxillofacial repair performed elsewhere, were analyzed. The mean age was 36.5 years (range: 22-74 years), three of them being males. Left and right lacrimal systems were equally involved...
June 2024: American Journal of Ophthalmology Case Reports
Stephanie Rico, Ifat Sher, Fabio Lavinksy, Daniel Lavinksy, Ygal Rotenstreich
PURPOSE: The purpose of this case report is to outline the management of a 41-year-old female with pathological myopia and type II choroidal neovascularization (CNV) diagnosed by optical coherence tomography angiography (OCT-A) angio-B mode. OBSERVATIONS: The early detection of CNV with OCT-A angio-B mode and treatment with intra-vitreous injections of Bevacizumab contributed to the amelioration of her vision to 20/20, a better visual acuity than she had prior to treatment...
June 2024: American Journal of Ophthalmology Case Reports
Yuezhu Lu, Yang Jiang, Zaowen Wang
PURPOSE: To report the application of a refined total capsular bag suspension technique for lens subluxation from Cystathionine beta-synthase (CBS) deficiency. OBSERVATIONS: A 15-year-old CBS deficiency male patient with a history of intracranial venous thrombosis presented to our clinic due to bilateral vision loss. The patient was treated with lens aspiration, intraocular lens (IOL) implantation, and total capsular bag suspension in both eyes respectively. During the six months postoperative follow-up, the patient exhibited improved visual acuity and minor refractive error...
June 2024: American Journal of Ophthalmology Case Reports
Emily S Levine, Nikhil N Batra
PURPOSE: To report the findings supported by multimodal imaging in a case of secondary vitreoretinal lymphoma presenting with inner retina and optic nerve head infiltration. OBSERVATIONS: A 64-year-old man with systemic diffuse large B-cell lymphoma presented with reduced visual acuity. Moderate anterior chamber and vitreous cell were present. Fundus exam showed bilateral disc edema and diffuse opaque macular infiltrates with a pseudo cherry-red spot in the left eye...
June 2024: American Journal of Ophthalmology Case Reports
Mona Bhargava, Varsha Bhambhani, Ahana Sen, Aditi Johri
PURPOSE: To report a case of metallic corneal foreign-body (CFB) penetrating the Laser in situ keratomileusis (LASIK) flap and its successful outcome. To highlight usefulness of Anterior Segment Optical Coherence Tomography (ASOCT) in diagnosis and management of post-LASIK CFB. To enumerate other similar cases published in literature. METHOD: A 30-year-old male presented to the emergency department of a tertiary eye care centre with a metallic CFB. He had undergone uneventful LASIK elsewhere 4-years back...
June 2024: American Journal of Ophthalmology Case Reports
Samuel Sigurdsson, Elin Bohman, Frank Träisk, Urszula Arnljots
PURPOSE: Superior ophthalmic vein thrombosis (SOVT) is a rare clinical entity, which can have a septic and an aseptic cause. Aseptic SOVT is typically treated with anticoagulation. Glucocorticoids are reserved for cases with concurrent orbital inflammation.We present three cases of SOVT due to carotid cavernous fistula not responding to standard treatment, subsequently successfully treated with glucocorticoids. OBSERVATIONS: Three patients with various degrees of proptosis, ophthalmoplegia, orbital stasis and reduced vision are presented...
June 2024: American Journal of Ophthalmology Case Reports
Karen E Lee, Tobin B T Thuma, Mirataollah Salabati, Meera D Sivalingam, Jose S Pulido, Kammi B Gunton
PURPOSE: We report a patient with pseudoxanthoma elasticum (PXE) with angioid streaks near a scleral buckle site. OBSERVATIONS: A 46-year-old male with PXE presented for evaluation of blurry vision and was found to have classic PXE findings in both eyes and angioid streaks adjacent to the site of a scleral buckle in his left eye. He underwent multimodal imaging, genetic testing, and intravitreal aflibercept in the right eye. CONCLUSIONS AND IMPORTANCE: Bruch's membrane is known to be fragile in PXE, and patients are often counseled about the heightened risk of playing contact sports...
June 2024: American Journal of Ophthalmology Case Reports
Tianxiang Huang, Takenori Inomata, Jaemyoung Sung, Naoko Yoshida, Gaku Ishida, Hitomi Ohara, Masahiro Yamaguchi, Yasutsugu Akasaki, Yuichi Okumura, Ken Nagino, Kunihiko Hirosawa, Toshihiro Mita, Shintaro Nakao, Nobuo Ishida
PURPOSE: We report the clinical findings and molecular identification of ocular Thelazia callipaeda from Niigata Prefecture in the Hokuriku area of Japan during winter. OBSERVATIONS: A 77-year-old male visited an ophthalmology clinic in Niigata Prefecture in January 2022 after a 2-week-duration of a conjunctival injection in the left eye and foreign body sensation. Slit-lamp microscopy revealed 11 active nematodes in the left conjunctival sac. Morphological characteristics included longer female body length than male, buccal cavity lacking teeth and lips, and serrated striations along the body surface...
June 2024: American Journal of Ophthalmology Case Reports
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