journal
https://read.qxmd.com/read/37770501/hepatitis-a-virus-infection
#1
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
September 28, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37770459/hepatitis-a-virus-infection
#2
REVIEW
Pierre Van Damme, Rosa M Pintó, Zongdi Feng, Fuqiang Cui, Angela Gentile, Daniel Shouval
Hepatitis A is a vaccine-preventable infection caused by the hepatitis A virus (HAV). Over 150 million new infections of hepatitis A occur annually. HAV causes an acute inflammatory reaction in the liver that usually resolves spontaneously without chronic sequelae. However, up to 20% of patients experience a prolonged or relapsed course and <1% experience acute liver failure. Host factors, such as immunological status, age, pregnancy and underlying hepatic diseases, can affect the severity of disease. Anti-HAV IgG antibodies produced in response to HAV infection persist for life and protect against re-infection; vaccine-induced antibodies against hepatitis A confer long-term protection...
September 28, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37709866/male-infertility
#3
REVIEW
Michael L Eisenberg, Sandro C Esteves, Dolores J Lamb, James M Hotaling, Aleksander Giwercman, Kathleen Hwang, Yu-Sheng Cheng
Clinical infertility is the inability of a couple to conceive after 12 months of trying. Male factors are estimated to contribute to 30-50% of cases of infertility. Infertility or reduced fertility can result from testicular dysfunction, endocrinopathies, lifestyle factors (such as tobacco and obesity), congenital anatomical factors, gonadotoxic exposures and ageing, among others. The evaluation of male infertility includes detailed history taking, focused physical examination and selective laboratory testing, including semen analysis...
September 14, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37709809/male-infertility
#4
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
September 14, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37696843/author-correction-hiv-infection
#5
Linda-Gail Bekker, Chris Beyrer, Nyaradzo Mgodi, Sharon R Lewin, Sinead Delany-Moretlwe, Babafemi Taiwo, Mary Clare Masters, Jeffrey V Lazarus
No abstract text is available yet for this article.
September 11, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37679331/glycogen-storage-diseases
#6
REVIEW
William B Hannah, Terry G J Derks, Mitchell L Drumm, Sarah C Grünert, Priya S Kishnani, John Vissing
Glycogen storage diseases (GSDs) are a group of rare, monogenic disorders that share a defect in the synthesis or breakdown of glycogen. This Primer describes the multi-organ clinical features of hepatic GSDs and muscle GSDs, in addition to their epidemiology, biochemistry and mechanisms of disease, diagnosis, management, quality of life and future research directions. Some GSDs have available guidelines for diagnosis and management. Diagnostic considerations include phenotypic characterization, biomarkers, imaging, genetic testing, enzyme activity analysis and histology...
September 7, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37620379/major-depressive-disorder
#7
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
August 24, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37620370/major-depressive-disorder
#8
REVIEW
Wolfgang Marx, Brenda W J H Penninx, Marco Solmi, Toshi A Furukawa, Joseph Firth, Andre F Carvalho, Michael Berk
Major depressive disorder (MDD) is characterized by persistent depressed mood, loss of interest or pleasure in previously enjoyable activities, recurrent thoughts of death, and physical and cognitive symptoms. People with MDD can have reduced quality of life owing to the disorder itself as well as related medical comorbidities, social factors, and impaired functional outcomes. MDD is a complex disorder that cannot be fully explained by any one single established biological or environmental pathway. Instead, MDD seems to be caused by a combination of genetic, environmental, psychological and biological factors...
August 24, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37592000/hiv-infection
#9
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
August 17, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37591865/hiv-infection
#10
REVIEW
Linda-Gail Bekker, Chris Beyrer, Nyaradzo Mgodi, Sharon R Lewin, Sinead Delany-Moretlwe, Babafemi Taiwo, Mary Clare Masters, Jeffrey V Lazarus
The AIDS epidemic has been a global public health issue for more than 40 years and has resulted in ~40 million deaths. AIDS is caused by the retrovirus, HIV-1, which is transmitted via body fluids and secretions. After infection, the virus invades host cells by attaching to CD4 receptors and thereafter one of two major chemokine coreceptors, CCR5 or CXCR4, destroying the host cell, most often a T lymphocyte, as it replicates. If unchecked this can lead to an immune-deficient state and demise over a period of ~2-10 years...
August 17, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37563181/frontotemporal-lobar-degeneration
#11
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
August 10, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37563165/frontotemporal-lobar-degeneration
#12
REVIEW
Murray Grossman, William W Seeley, Adam L Boxer, Argye E Hillis, David S Knopman, Peter A Ljubenov, Bruce Miller, Olivier Piguet, Rosa Rademakers, Jennifer L Whitwell, Henrik Zetterberg, John C van Swieten
Frontotemporal lobar degeneration (FTLD) is one of the most common causes of early-onset dementia and presents with early social-emotional-behavioural and/or language changes that can be accompanied by a pyramidal or extrapyramidal motor disorder. About 20-25% of individuals with FTLD are estimated to carry a mutation associated with a specific FTLD pathology. The discovery of these mutations has led to important advances in potentially disease-modifying treatments that aim to slow progression or delay disease onset and has improved understanding of brain functioning...
August 10, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37500684/hiv-associated-lung-disease
#13
REVIEW
Ioannis Konstantinidis, Kristina Crothers, Ken M Kunisaki, M Bradley Drummond, Thomas Benfield, Heather J Zar, Laurence Huang, Alison Morris
Lung disease encompasses acute, infectious processes and chronic, non-infectious processes such as chronic obstructive pulmonary disease, asthma and lung cancer. People living with HIV are at increased risk of both acute and chronic lung diseases. Although the use of effective antiretroviral therapy has diminished the burden of infectious lung disease, people living with HIV experience growing morbidity and mortality from chronic lung diseases. A key risk factor for HIV-associated lung disease is cigarette smoking, which is more prevalent in people living with HIV than in uninfected people...
July 27, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37500676/hiv-associated-lung-disease
#14
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
July 27, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37474606/cardiac-tamponade
#15
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
July 20, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37474539/cardiac-tamponade
#16
REVIEW
Yehuda Adler, Arsen D Ristić, Massimo Imazio, Antonio Brucato, Sabine Pankuweit, Ivana Burazor, Petar M Seferović, Jae K Oh
Cardiac tamponade is a medical emergency caused by the progressive accumulation of pericardial fluid (effusion), blood, pus or air in the pericardium, compressing the heart chambers and leading to haemodynamic compromise, circulatory shock, cardiac arrest and death. Pericardial diseases of any aetiology as well as complications of interventional and surgical procedures or chest trauma can cause cardiac tamponade. Tamponade can be precipitated in patients with pericardial effusion by dehydration or exposure to certain medications, particularly vasodilators or intravenous diuretics...
July 20, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37400556/author-correction-pre-eclampsia
#17
Evdokia Dimitriadis, Daniel L Rolnik, Wei Zhou, Guadalupe Estrada-Gutierrez, Kaori Koga, Rossana P V Francisco, Clare Whitehead, Jon Hyett, Fabricio da Silva Costa, Kypros Nicolaides, Ellen Menkhorst
No abstract text is available yet for this article.
July 3, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37386029/imprinting-disorders
#18
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
June 29, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37386011/imprinting-disorders
#19
REVIEW
Thomas Eggermann, David Monk, Guiomar Perez de Nanclares, Masayo Kagami, Eloïse Giabicani, Andrea Riccio, Zeynep Tümer, Jennifer M Kalish, Maithé Tauber, Jessica Duis, Rosanna Weksberg, Eamonn R Maher, Matthias Begemann, Miriam Elbracht
Imprinting disorders (ImpDis) are congenital conditions that are characterized by disturbances of genomic imprinting. The most common individual ImpDis are Prader-Willi syndrome, Angelman syndrome and Beckwith-Wiedemann syndrome. Individual ImpDis have similar clinical features, such as growth disturbances and developmental delay, but the disorders are heterogeneous and the key clinical manifestations are often non-specific, rendering diagnosis difficult. Four types of genomic and imprinting defect (ImpDef) affecting differentially methylated regions (DMRs) can cause ImpDis...
June 29, 2023: Nature Reviews. Disease Primers
https://read.qxmd.com/read/37349500/oppositional-defiant-disorder
#20
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
June 22, 2023: Nature Reviews. Disease Primers
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