Margaret H Hastings, Claire Castro, Rebecca Freeman, Azrul Abdul Kadir, Carolin Lerchenmüller, Haobo Li, James Rhee, Jason D Roh, Kangsan Roh, Anand P Singh, Chao Wu, Peng Xia, Qiulian Zhou, Junjie Xiao, Anthony Rosenzweig
Among its many cardiovascular benefits, exercise training improves heart function and protects the heart against age-related decline, pathological stress, and injury. Here, we focus on cardiac benefits with an emphasis on more recent updates to our understanding. While the cardiomyocyte continues to play a central role as both a target and effector of exercise's benefits, there is a growing recognition of the important roles of other, noncardiomyocyte lineages and pathways, including some that lie outside the heart itself...
April 2024: JACC. Basic to Translational Science