journal
https://read.qxmd.com/read/38322626/magnetic-resonance-imaging-in-atherosclerotic-renal-artery-stenosis-the-update-and-future-directions-from-interventional-perspective
#21
REVIEW
Jia Fu, Zhiyong Lin, Bihui Zhang, Li Song, Naishan Qin, Jianxing Qiu, Min Yang, Yinghua Zou
BACKGROUND: Atherosclerotic renal artery stenosis (ARAS) is a condition where the renal arteries become narrowed due to atherosclerosis, leading to reduced blood flow to the kidneys and various renal complications. The effectiveness of interventional treatments, such as renal artery angioplasty and stenting, remains debated, making patient selection for these procedures challenging. SUMMARY: This review focuses on the diagnosis and management of ARAS, with a particular emphasis on the potential role of functional magnetic resonance imaging (MRI) in evaluating renal function and mechanisms...
February 2024: Kidney Diseases
https://read.qxmd.com/read/38322625/association-between-the-triglyceride-glucose-index-and-all-cause-mortality-in-critically-ill-patients-with-acute-kidney-injury
#22
JOURNAL ARTICLE
Liangjing Lv, Jiachuan Xiong, Yinghui Huang, Ting He, Jinghong Zhao
INTRODUCTION: The triglyceride glucose (TyG) index is a reliable alternative biomarker of insulin resistance, but the association between the TyG index and acute kidney injury (AKI) in critically ill patients remains unclear. METHODS: The data for the study were extracted from the Medical Information Mart for Intensive Care IV (MIMIC-IV) database. Cox regression and restricted cubic spline (RCS) analysis were performed to analyze the association between the TyG index and all-cause mortality...
February 2024: Kidney Diseases
https://read.qxmd.com/read/38322624/trna-derived-small-rnas-a-novel-regulatory-small-noncoding-rna-in-renal-diseases
#23
JOURNAL ARTICLE
Dan Li, Xian Xie, Ni Yin, Xueqin Wu, Bin Yi, Hao Zhang, Wei Zhang
BACKGROUND: tRNA-derived small RNAs (tsRNAs) are an emerging class of small noncoding RNAs derived from tRNA cleavage. SUMMARY: With the development of high-throughput sequencing, various biological roles of tsRNAs have been gradually revealed, including regulation of mRNA stability, transcription, translation, direct interaction with proteins and as epigenetic factors, etc. Recent studies have shown that tsRNAs are also closely related to renal disease. In clinical acute kidney injury (AKI) patients and preclinical AKI models, the production and differential expression of tsRNAs in renal tissue and plasma were observed...
February 2024: Kidney Diseases
https://read.qxmd.com/read/38098876/iron-supplements-concomitant-within-hypoxia-inducible-factor-prolyl-hydroxylase-domain-inhibitors-in-the-treatment-of-chronic-kidney-disease-anemia
#24
REVIEW
Xue Wang, Cuiting Wei, Delong Zhao, Xuefeng Sun, Fengge Zhu, Yan Mei, Qian Ma, Guangyan Cai, Xiangmei Chen, Ping Li
BACKGROUND: Anemia is a common and important complication in patients with chronic kidney disease (CKD). Accordingly, the current treatment is based on erythropoiesis-stimulating agents (ESAs) and iron. Hypoxia-inducible factor (HIF) prolyl hydroxylase domain inhibitors (HIF-PHIs) have been developed to treat renal anemia through a novel mechanism. HIF-PHIs increase erythropoietin at physiologic blood concentrations and also improve the supply of hematopoietic iron. Iron is the main component of hemoglobin, and ensuring efficient iron metabolism is essential in the treatment of anemia...
December 2023: Kidney Diseases
https://read.qxmd.com/read/38089444/risk-of-hospital-acquired-acute-kidney-injury-among-adult-opioid-analgesic-users-a-multicenter-real-world-data-analysis
#25
JOURNAL ARTICLE
Mingjing Pi, Sheng Nie, Licong Su, Yanqin Li, Yue Cao, Peiyan Gao, Yuxin Lin, Yan Zha, Yongjun Shi, Hua Li, Jiajun Zhao, Yaozhong Kong, Guisen Li, Ying Hu, Huafeng Liu, Qijun Wan, Chunbo Chen, Bicheng Liu, Qiongqiong Yang, Guobin Su, Yilun Zhou, Jianping Weng, Gang Xu, Hong Xu, Ying Tang, Mengchun Gong, Fan Fan Hou, Xin Xu
INTRODUCTION: Comprehensive data on the risk of hospital-acquired (HA) acute kidney injury (AKI) among adult users of opioid analgesics are lacking. This study aimed to systematically compare the risk of HA-AKI among the users of various opioid analgesics. METHODS: This multicenter, retrospective real-world study analyzed 255,265 adult hospitalized patients who received at least one prescription of opioid analgesic during the first 30 days of hospitalization. The primary outcome was the time from the first opioid analgesic prescription to HA-AKI occurrence...
December 2023: Kidney Diseases
https://read.qxmd.com/read/38089443/the-role-of-pyroptosis-in-the-pathogenesis-of-kidney-diseases
#26
REVIEW
Zhuanli Zhou, Qin Li
BACKGROUND: Recently, in addition to apoptosis and necrosis, several other forms of cell death have been discovered, such as necroptosis, autophagy, pyroptosis, and ferroptosis. These cell death modalities play diverse roles in kidney diseases. Pyroptosis is a newly described type of proinflammatory programmed necrosis. Further exploring pyroptosis is helpful to slow the progression of kidney diseases and reduce their complications. SUMMARY: Pyroptosis is mainly mediated by the cleavage of gasdermin D (GSDMD) along with downstream inflammasome activation...
December 2023: Kidney Diseases
https://read.qxmd.com/read/38089442/oxalate-nephropathy-and-the-mechanism-of-oxalate-induced-kidney-injury
#27
REVIEW
Daorina Bao, Yu Wang, Ming-Hui Zhao
BACKGROUND: Hyperoxaluria is a major cause of oxalate nephropathy, which can lead to impaired renal function presenting as acute kidney injury, acute on chronic kidney disease, or chronic kidney disease. The Chronic Renal Insufficiency Cohort study showed that higher urinary oxalate is associated with renal outcome in patients with chronic kidney disease, supporting the nephrotoxicity of oxalate. Therefore, a better understanding of the role of oxalate in kidney injury is needed. This review describes the metabolism of oxalate and the clinical and pathology presentation of oxalate nephropathy...
December 2023: Kidney Diseases
https://read.qxmd.com/read/38089441/segmental-membranous-glomerulopathy-in-adults
#28
JOURNAL ARTICLE
Shuangshuang Zhu, Xiaoting Liu, Shuling Yue, Bei Luo, Zhen Song, Xiaomeng Xu, Lin Wang, Xiaotao Hou, Kongshan Li, Qiming Liang, Zheya Zhou, Wenfang Chen, Lei Zheng
INTRODUCTION: The clinicopathological features of segmental membranous glomerulopathy (SMGN) have not been well characterized. The aim of this study was to investigate the prevalence and clinicopathological features of SMGN in adults. METHODS: Adult patients with biopsy-confirmed SMGN in the native kidney at our center between January 2017 to September 2020 were identified. The clinicopathological features of SMGN were collected. The glomerular deposition of IgG subclasses, M-type phospholipase A2 receptor 1 (PLA2R), thrombospondin type 1 domain-containing 7A (THSD7A), and neural epidermal growth factor-like 1 protein (NELL1) were tested...
December 2023: Kidney Diseases
https://read.qxmd.com/read/38089440/metabolism-of-polyamines-and-kidney-disease-a-promising-therapeutic-target
#29
REVIEW
Dan Luo, Xiaohui Lu, Yi Li, Yiping Xu, Yi Zhou, Haiping Mao
BACKGROUND: More than 850 million people worldwide suffer from acute and chronic kidney diseases (CKD) which are tremendous socioeconomic burdens for society. Currently, the treatment choices for CKD are limited. There is a great need to understand the underlying mechanisms of the development of CKD in order to develop potential therapeutic strategies. SUMMARY: The alteration in cellular metabolism has emerged as an important common pathological mechanism in different kidney diseases...
December 2023: Kidney Diseases
https://read.qxmd.com/read/38089439/acknowledgement-to-reviewers
#30
JOURNAL ARTICLE
(no author information available yet)
No abstract text is available yet for this article.
December 2023: Kidney Diseases
https://read.qxmd.com/read/38089438/rapid-initiation-of-peritoneal-dialysis-by-automated-peritoneal-dialysis-or-hemodialysis-a-randomized-clinical-trial
#31
JOURNAL ARTICLE
Qianying Zhang, Pei Wu, Jingyuan Xie, Xiao Li, Tian Xu, Xiaomin Huang, Chunyan Zhang, Nan Chen, Hong Ren
INTRODUCTION: It is still controversial whether automated peritoneal dialysis (APD) or hemodialysis (HD) is a more favorable choice for the rapid initiation of peritoneal dialysis (PD). METHODS: A pilot randomized prospective controlled trial was carried out in Shanghai Ruijin Hospital. Sixty-seven patients who chose long-term PD treatment and needed unplanned dialysis were enrolled and randomized into HD-CAPD group (33 cases) or APD-CAPD group (34 cases) based on the dialysis modality during the transition period (within 14 days from the day PD catheter was implanted)...
December 2023: Kidney Diseases
https://read.qxmd.com/read/38089437/finerenone-in-patients-with-chronic-kidney-disease-and-type-2-diabetes-the-fidelio-dkd-subgroup-from-china
#32
JOURNAL ARTICLE
Haitao Zhang, Jingyuan Xie, Chuanming Hao, Xuemei Li, Dalong Zhu, Hongguang Zheng, Xudong Xu, Zhaohui Mo, Weiping Lu, Yibing Lu, Chaoqing Wu, Nanwei Tong, Li Wang, Zhihong Liu
BACKGROUND: This prespecified subgroup analysis of the FIDELIO-DKD trial aimed to evaluate the efficacy and safety of finerenone in patients with chronic kidney disease (CKD) and type 2 diabetes mellitus (T2DM) in China. METHODS: 372 participants were recruited from 67 centers in China and randomized 1:1 to oral finerenone or placebo with standard therapy for T2DM. The primary composite outcome included kidney failure, sustained decrease of estimated glomerular filtration rate ≥40% from baseline over at least 4 weeks, or renal death...
December 2023: Kidney Diseases
https://read.qxmd.com/read/37927402/nephropathy-is-aggravated-by-fatty-acids-in-diabetic-kidney-disease-through-tubular-epithelial-cell-necroptosis-and-is-alleviated-by-an-ripk-1-inhibitor
#33
JOURNAL ARTICLE
Qi Yu, Ying Chen, Youlu Zhao, Shuo Huang, Xiaohong Xin, Lei Jiang, Hui Wang, Wenyan Wu, Lei Qu, Chengang Xiang, Suxia Wang, Gang Liu, Li Yang
INTRODUCTION: Diabetic kidney disease (DKD), one of the leading causes of end-stage renal disease, has complex pathogenic mechanisms and few effective clinical therapies. DKD progression is accompanied by the loss of renal resident cells, followed by chronic inflammation and extracellular matrix deposition. Necroptosis is a newly discovered form of regulated cell death and is a major form of intrinsic cell loss in certain diabetic complications such as cardiomyopathy, intestinal disease, and retinal neuropathy; however, its significance in DKD is largely unknown...
October 2023: Kidney Diseases
https://read.qxmd.com/read/37901714/development-and-validation-of-a-nomogram-for-renal-survival-prediction-in-patients-with-autosomal-dominant-polycystic-kidney-disease
#34
JOURNAL ARTICLE
Xiaomei Wang, Rui Zheng, Zhende Liu, Ling Qi, Liang Gu, Xiaoping Wang, Shan Zhu, Mingyue Zhang, Danya Jia, Zhen Su
INTRODUCTION: Due to the wide variation in the prognosis of autosomal dominant polycystic kidney disease (ADPKD), prediction of risk of renal survival in ADPKD patients is a tough challenge. We aimed to establish a nomogram for the prediction of renal survival in ADPKD patients. METHODS: We conducted a retrospective observational cohort study in 263 patients with ADPKD. The patients were randomly assigned to a training set ( N = 198) and a validation set ( N = 65), and demographic and statistical data at baseline were collected...
October 2023: Kidney Diseases
https://read.qxmd.com/read/37901713/impact-of-angiotensin-receptor-blockers-use-on-in-hospital-mortality-in-community-acquired-pneumonia-patients-with-hypertension
#35
JOURNAL ARTICLE
Dawei Chen, Yan Tan, Xin Wan
INTRODUCTION: This study aimed to explore the association of angiotensin receptor blockers (ARBs) use with in-hospital mortality among Chinese patients with hypertension hospitalized with community-acquired pneumonia (CAP). METHODS: This study was conducted from January 2014 to January 2017, and data from patients with hypertension hospitalized with CAP were analyzed retrospectively. Multivariable logistic regression and propensity score matching (PSM) were used to investigate any association...
October 2023: Kidney Diseases
https://read.qxmd.com/read/37901712/efficacy-and-safety-of-sodium-glucose-cotransporter-2-inhibitors-in-nondiabetic-patients-with-chronic-kidney-disease-a-review-of-recent-evidence
#36
REVIEW
Junhao Lv, Luying Guo, Rending Wang, Jianghua Chen
BACKGROUND: Sodium-glucose cotransporter-2 inhibitors (SGLT2i) were initially developed as glucose-lowering agents in patients with type-2 diabetes. However, available data from clinical trials and meta-analyses suggest that SGLT2i have pleiotropic benefits in reducing mortality and delaying the progression of chronic kidney disease (CKD) in both diabetic and nondiabetic patients. Thus, we herein review the current evidence regarding the efficacy and safety of SGLT2i in patients with nondiabetic CKD and appraise the recently reported clinical trials that might facilitate the management of CKD in routine clinical practice...
October 2023: Kidney Diseases
https://read.qxmd.com/read/37901711/cognitive-impairment-in-chronic-kidney-disease-is-associated-with-glymphatic-system-dysfunction
#37
JOURNAL ARTICLE
Shuqin Xu, Jiuqi Wang, Kedi Sun, Lin Meng, Chi Qin, Renyi Feng, Yiming Tian, Yanping Zhai, Dongxiao Liang, Rui Zhang, Haiyan Tian, Han Liu, Yongkang Chen, Yu Fu, Pei Chen, Qingyong Zhu, Junfang Teng, Xuejing Wang
INTRODUCTION: This study was designed to explore the associations between impaired cognition in chronic kidney disease (CKD) patients and the dysfunction of the glymphatic system. METHOD: Data were obtained from 77 CKD patients and 50 age-matched healthy control individuals from the First Affiliated Hospital of Zhengzhou University. CKD patients were stratified into with and without impaired cognitive function. T2-weighted magnetic resonance imaging results were used to assess area ratios for the perivascular space and ventricles in participants, while the Montreal Cognitive Assessment and the Mini-Mental State Examination were employed to measure cognitive function...
October 2023: Kidney Diseases
https://read.qxmd.com/read/37901710/genetic-diagnosis-and-treatment-of-inherited-renal-tubular-acidosis
#38
REVIEW
Wenkai Guo, Pengcheng Ji, Yuansheng Xie
BACKGROUND: Renal tubular acidosis (RTA) is caused by various disruptions to the secretion of H+ by distal renal tubules and/or dysfunctional reabsorption of HCO3 - by proximal renal tubules, which causes renal acidification dysfunction, ultimately leading to a clinical syndrome characterized by hyperchloremic metabolic acidosis with a normal anion gap. With the development of molecular genetics and gene sequencing technology, inherited RTA has also attracted attention, and an increasing number of RTA-related pathogenic genes have been discovered and reported...
October 2023: Kidney Diseases
https://read.qxmd.com/read/37901709/delivering-personalized-goal-directed-care-to-older-patients-receiving-peritoneal-dialysis
#39
REVIEW
Henry H L Wu, Dimitrios Poulikakos, Helen Hurst, David Lewis, Rajkumar Chinnadurai
BACKGROUND: An aging population living with chronic kidney disease and progressing to kidney failure, subsequently receiving peritoneal dialysis (PD) is growing. A significant proportion of these patients are also living with multi-morbidities and some degree of frailty. Recent practice recommendations from the International Society of Peritoneal Dialysis advocate for high-quality, goal-directed PD prescription, and the Standardized Outcomes of Nephrology-PD initiative emphasized the need for an individualized, goal-based care approach in all patients receiving PD treatment...
October 2023: Kidney Diseases
https://read.qxmd.com/read/37901708/construction-of-an-early-alert-system-for-intradialytic-hypotension-before-initiating-hemodialysis-based-on-machine-learning
#40
JOURNAL ARTICLE
Daqing Hong, Huan Chang, Xin He, Ya Zhan, Rongsheng Tong, Xingwei Wu, Guisen Li
INTRODUCTION: Intradialytic hypotension (IDH) is prevalent and associated with high hospitalization and mortality rates. The purpose of this study was to explore the risk factors for IDH and use artificial intelligence to establish an early alert system before hemodialysis sessions to identify patients at high risk of IDH. MATERIALS AND METHODS: We obtained data on 314,534 hemodialysis sessions conducted at Sichuan Provincial People's Hospital from the renal disease treatment information system...
October 2023: Kidney Diseases
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