journal
https://read.qxmd.com/read/38835407/combined-genetic-association-and-differed-expression-analysis-of-ube2l3-uncovers-a-genetic-regulatory-role-of-immuno-proteasome-in-iga-nephropathy
#1
JOURNAL ARTICLE
Lin-Lin Xu, Ting Gan, Yang Li, Pei Chen, Su-Fang Shi, Li-Jun Liu, Ji-Cheng Lv, Hong Zhang, Xu-Jie Zhou
INTRODUCTION: IgA nephropathy (IgAN) is a leading cause of end-stage renal disease. The exact pathogenesis of IgAN is not well defined, but some genetic studies have led to a novel discovery that the (immuno)proteasome probably plays an important role in IgAN. METHODS: We firstly analyzed the association of variants in the UBE2L3 region with susceptibility to IgAN in 3,495 patients and 9,101 controls, and then analyzed the association between lead variant and clinical phenotypes in 1,803 patients with regular follow-up data...
June 2024: Kidney Diseases
https://read.qxmd.com/read/38835406/a-deep-insight-into-ferroptosis-in-renal-disease-facts-and-perspectives
#2
REVIEW
Zhongyu Han, Yuanke Luo, Haoran Chen, Guochen Zhang, Luling You, Meiqi Zhang, Yumeng Lin, Lan Yuan, Shiyi Zhou
BACKGROUND: Ferroptosis, a newly recognized form of programmed cell death, is distinguished by its reliance on reactive oxygen species and iron-mediated lipid peroxidation, setting it apart from established types like apoptosis, cell necrosis, and autophagy. Recent studies suggest its role in exacerbating or mitigating diseases by influencing metabolic and signaling pathways in conditions such as tumors and ischemic organ damage. Evidence also links ferroptosis to various kidney diseases, prompting a review of its research status and potential breakthroughs in understanding and treating these conditions...
June 2024: Kidney Diseases
https://read.qxmd.com/read/38835405/roxadustat-on-renal-anemia-with-macroinflammation-a-retrospective-cohort-study
#3
JOURNAL ARTICLE
Yan Tu, Zuo-Lin Li, Hong Liu, Ri-Ning Tang, Gui-Hua Wang, Lin-Li Lv, Bin Wang, Bi-Cheng Liu
INTRODUCTION: Roxadustat, the first-in-class drug for the treatment of renal anemia, has demonstrated efficacy in renal anemia with microinflammation. Additional data are needed regarding the efficacy of roxadustat on renal anemia with systemic macroinflammation. METHODS: Three cohorts of renal anemia based on the basic level of high-sensitivity CRP were included. Patients with hsCRP ≤2 mg/L were selected as non-inflammation (NI) group; 2< hsCRP ≤10 mg/L as microinflammation (MI) group; hsCRP≥10 mg/L as macroinflammation (MA) group...
June 2024: Kidney Diseases
https://read.qxmd.com/read/38835404/a-klotho-based-machine-learning-model-for-prediction-of-both-kidney-and-cardiovascular-outcomes-in-chronic-kidney-disease
#4
JOURNAL ARTICLE
Yating Wang, Yu Shi, Tangli Xiao, Xianjin Bi, Qingyu Huo, Shaobo Wang, Jiachuan Xiong, Jinghong Zhao
INTRODUCTION: This study aimed to develop and validate machine learning (ML) models based on serum Klotho for predicting end-stage kidney disease (ESKD) and cardiovascular disease (CVD) in patients with chronic kidney disease (CKD). METHODS: Five different ML models were trained to predict the risk of ESKD and CVD at three different time points (3, 5, and 8 years) using a cohort of 400 non-dialysis CKD patients. The dataset was divided into a training set (70%) and an internal validation set (30%)...
June 2024: Kidney Diseases
https://read.qxmd.com/read/38835403/chronic-kidney-disease-in-brazil-current-status-and-recommended-improvements
#5
REVIEW
Andrea Carla Bauer, Rosilene M Elias, Hugo Abensur, Marcelo Costa Batista, Angela Marie Jansen, Miguel Carlos Riella
BACKGROUND: Over the last 3 decades, over 700 million individuals worldwide have been diagnosed with chronic kidney disease (CKD). In a 2017 survey in southern Brazil, 11.4% of those surveyed had CKD. Early identification and effective therapy in Brazil may reduce CKD's impact. This panel discusses the early diagnosis and treatment of CKD and the barriers and actions needed to improve the management of CKD in Brazil. A panel of Brazilian nephrologists was provided with relevant questions to address before a multiday conference...
June 2024: Kidney Diseases
https://read.qxmd.com/read/38835402/activation-of-tgr5-increases-urine-concentration-by-inducing-aqp2-and-aqp3-expression-in-renal-medullary-collecting-ducts
#6
JOURNAL ARTICLE
Yanlin Guo, Rongfang Qiao, Guixiang Xie, Yao Yao, Chunxiu Du, Yunxia Shao, Youfei Guan, Xiaoyan Zhang
INTRODUCTION: G protein-coupled bile acid receptor (TGR5), the first G protein-coupled receptor for bile acids identified, is capable of activating a variety of intracellular signaling pathways after interacting with bile acids. TGR5 plays an important role in multiple physiological processes and is considered to be a potential target for the treatment of various metabolic diseases, including type 2 diabetes. Evidence has emerged that genetic deletion of TGR5 results in an increase in basal urine output, suggesting that it may play a critical role in renal water and salt reabsorption...
June 2024: Kidney Diseases
https://read.qxmd.com/read/38799248/lrg1-contributes-to-the-pathogenesis-of-multiple-kidney-diseases-a-comprehensive-review
#7
REVIEW
Chunyan Chen, Jingwei Zhang, Tao Yu, Haiya Feng, Jian Liao, Yifei Jia
BACKGROUND: The increasing prevalence of kidney diseases has become a significant public health issue, with a global prevalence exceeding 10%. In order to accurately identify biochemical changes and treatment outcomes associated with kidney diseases, novel methods targeting specific genes have been discovered. Among these genes, leucine-rich α-2 glycoprotein 1 (LRG1) has been identified to function as a multifunctional pathogenic signaling molecule in multiple diseases, including kidney diseases...
June 2024: Kidney Diseases
https://read.qxmd.com/read/38751798/pyroptosis-the-determinator-of-cell-death-and-fate-in-acute-kidney-injury
#8
REVIEW
Jiachuan Xiong, Jinghong Zhao
BACKGROUND: Acute kidney injury (AKI) is kidney damage that leads to a rapid decline in function. AKI primarily occurs when the tubular epithelium is damaged, causing swelling, loss of brush margin, and eventual apoptosis. Research has shown that tubular epithelial cell damage in AKI is linked to cell cycle arrest, autophagy, and regulation of cell death. SUMMARY: Pyroptosis, a type of programmed cell death triggered by inflammation, is believed to play a role in the pathophysiology of AKI...
April 2024: Kidney Diseases
https://read.qxmd.com/read/38751797/long-term-efficacy-of-ultrasound-guided-percutaneous-transluminal-angioplasty-for-arteriovenous-fistula-outflow-stenosis-caused-by-venous-valve
#9
JOURNAL ARTICLE
Bo Chen, Ling Chen, Qiao Yang, Xuejing Gao, Qiquan Lai, Bo Tu, Ziming Wan
INTRODUCTION: Venous valve-related stenosis (VVRS) is an uncommon type of failure of arteriovenous fistula among patients with end-stage renal disease (ESRD). There is a paucity of data on the long-term efficacy of ultrasound-guided percutaneous transluminal angioplasty (PTA) for VVRS. METHODS: ESRD patients who underwent PTA because of VVRS between January 2017 and December 2021 at the First Affiliated Hospital of Chongqing Medical University were enrolled. Patients were classified into three cohorts (cohort1, VVRS located within 3 cm of the vein adjacent to the anastomosis; cohort2, VVRS located over 3 cm away from the anastomosis; cohort3, multiple stenoses)...
April 2024: Kidney Diseases
https://read.qxmd.com/read/38751796/from-rare-disorders-of-kidney-tubules-to-acute-renal-injury-progress-and-prospective
#10
REVIEW
Jiaying Li, Fangxing Hou, Ning Lv, Ruohuan Zhao, Lei Zhang, Cai Yue, Min Nie, Limeng Chen
BACKGROUND: Acute kidney injury (AKI) is a severe condition marked by rapid renal function deterioration and elevated mortality, with traditional biomarkers lacking sensitivity and specificity. Rare tubulointerstitial diseases encompass a spectrum of disorders, primarily including monogenic diseases, immune-related conditions, and drug-induced tubulointerstitial diseases. The clinical manifestations vary from electrolyte and acid-base imbalances to kidney function insufficiency, which is associated with AKI in up to 20% of cases...
April 2024: Kidney Diseases
https://read.qxmd.com/read/38751795/car-t-cell-therapy-advances-in-kidney-related-diseases
#11
REVIEW
Longyuan Wu, Youqin Feng, Yue Huang, Jingjing Feng, Yongxian Hu, He Huang
BACKGROUND: Chimeric antigen receptor (CAR)-T cell therapy represents a significant advancement in the field of immunotherapy, providing targeted eradication of abnormal cells through the recognition between CAR and target antigens. This approach has garnered considerable attention due to its promising results in the clinical treatment of hematological malignancies and autoimmune diseases. As the focus shifts toward exploring novel targets and expanding the application of CAR-T cell therapy to solid tumors, including renal malignancies, researchers are pushing the boundaries of this innovative treatment...
April 2024: Kidney Diseases
https://read.qxmd.com/read/38751794/association-of-serum-unsaturated-fatty-acid-patterns-with-the-risk-of-diabetic-nephropathy
#12
JOURNAL ARTICLE
Shuang Xu, Xinyuan Li, Qing Hou, Ning Xu, Qingmiao Lu, Sudan Wang, Chunsun Dai
INTRODUCTION: Unsaturated fatty acids play an essential role in the progression of diabetic nephropathy (DN). However, previous studies were mainly focused on the role of individual unsaturated fatty acid. The serum unsaturated fatty acid patterns (FAPs) in patients with DN remain to be determined. METHODS: A total of 135 patients with DN (DN group) and 322 patients with type II diabetes without nephropathy (non-DN group) were included in this study. Clinical data, serum levels of unsaturated fatty acids, and other laboratory indicators were collected...
April 2024: Kidney Diseases
https://read.qxmd.com/read/38751793/immunogenicity-and-safety-of-the-three-dose-covid-19-vaccine-regimen-in-patients-receiving-renal-replacement-therapy-a-systematic-review-and-meta-analysis
#13
REVIEW
Becky Mingyao Ma, Anthony Raymond Tam, Kam Wa Chan, Ivan Fan Ngai Hung, Sydney Chi Wai Tang, Tak Mao Chan, Desmond Yat-Hin Yap
BACKGROUND: A three-dose regimen is the current standard for COVID-19 vaccination, but systematic data on immunogenicity and safety in chronic kidney disease patients remains limited. OBJECTIVES: We conducted a meta-analysis on the immunogenicity and safety of three-dose COVID-19 vaccination in patients on renal replacement therapy (RRT). METHODS: Systematic literature search in four electronic databases yielded twenty eligible studies (2,117 patients, 94% of whom received mRNA vaccines) for meta-analysis...
April 2024: Kidney Diseases
https://read.qxmd.com/read/38751792/peripheral-neuropathy-associated-with-higher-mortality-in-population-with-chronic-kidney-disease-national-health-and-nutrition-examination-surveys
#14
JOURNAL ARTICLE
Xiao-Yu Cai, Wei-Lan Li, Shu-Wang Ge, Gang Xu
INTRODUCTION: Peripheral neuropathy (PN), one of the commonest neurological complications of chronic kidney disease (CKD), was associated with physical limitation. Studies showed that a decrease in physical capability in patients with CKD is related with an increased risk of mortality. The objective of our research was to directly explore the relationship between PN and risk of mortality in patients with CKD. METHOD: 1,836 participants with CKD and 6,036 participants without CKD, which were classified by PN based on monofilament examination in National Health and Nutrition Examination Survey (NHANES), were collected from the 1999 to 2004 National Health and Nutrition Examination Surveys...
April 2024: Kidney Diseases
https://read.qxmd.com/read/38659701/stabilizing-hypoxia-inducible-factor-to-manage-anemia-in-chronic-kidney-disease-from-basic-theory-to-clinical-study
#15
REVIEW
Yudian Wang, Xiaoyong Yu
BACKGROUND: Anemia is one of the common complications of chronic kidney disease (CKD), and its prevalence has been arising globally. The key cause of anemia in CKD patients is the diseased kidney's reduced ability to synthesize endogenous erythropoietin (EPO), yet this is not the sole reason. Inflammatory elements, functional iron deficiency, and uremic toxins together participate in the development of anemia. According to research data, anemia is an independent risk factor for cardiovascular events, all-cause mortality, and worsening renal function and affects the clinical prognosis and quality of life of CKD patients...
April 2024: Kidney Diseases
https://read.qxmd.com/read/38322631/thickened-perirenal-fat-predicts-poor-renal-outcome-in-patients-with-immunoglobulin-a-nephropathy-a-population-based-retrospective-cohort-study
#16
JOURNAL ARTICLE
Hongtu Hu, Zongwei Zhang, Zikang Liu, Fan Chu, Jialu Ran, Wei Liang
INTRODUCTION: Perirenal fat is a pad that fills the retroperitoneal space outside the kidney, which affects kidney function in various ways. However, the association between perirenal fat and IgA nephropathy (IgAN) has not yet been elucidated. This study aimed to investigate the role of perirenal fat in predicting IgAN progression. METHODS: A total of 473 patients with biopsy-proven IgAN and follow-up information were recruited, and perirenal fat thickness (PFT) was measured using color Doppler ultrasonography at renal biopsy...
February 2024: Kidney Diseases
https://read.qxmd.com/read/38322630/the-treatment-of-coronary-artery-disease-in-patients-with-chronic-kidney-disease-gaps-challenges-and-solutions
#17
REVIEW
Ilya Losin, Keren-Cohen Hagai, David Pereg
BACKGROUND: Chronic kidney disease (CKD) is associated with a high burden of coronary artery disease (CAD), which remains the leading cause of death in CKD patients. Despite the high cardiovascular risk, ACS patients with renal dysfunction are less commonly treated with guideline-based medical therapy and are less frequently referred for coronary revascularization. SUMMARY: The management of CAD is more challenging in patients with CKD than in the general population due to concerns regarding side effects and renal toxicity, as well as uncertainty regarding clinical benefit of guideline-based medical therapy and interventions...
February 2024: Kidney Diseases
https://read.qxmd.com/read/38322629/monogenic-causes-identified-in-23-68-of-children-with-steroid-resistant-nephrotic-syndrome-a-single-centre-study
#18
JOURNAL ARTICLE
Luyan Zhang, Fei Zhao, Guixia Ding, Ying Chen, Sanlong Zhao, Qiuxia Chen, Yugen Sha, Ruochen Che, Songming Huang, Bixia Zheng, Aihua Zhang
INTRODUCTION: Steroid-resistant nephrotic syndrome (SRNS) is the second most common cause of end-stage kidney disease in children, mostly associated with focal segmental glomerulosclerosis (FSGS). Advances in genomic science have enabled the identification of causative variants in 20-30% of SRNS patients. METHODS: We used whole exome sequencing to explore the genetic causes of SRNS in children. Totally, 101 patients with SRNS and 13 patients with nephrotic proteinuria and FSGS were retrospectively enrolled in our hospital between 2018 and 2022...
February 2024: Kidney Diseases
https://read.qxmd.com/read/38322628/roxadustat-for-patients-with-posttransplant-anemia-a-narrative-review
#19
REVIEW
Xiaoxiao Tang, Fei Liu, Qiuyu Li, Jianhua Mao
BACKGROUND: Hypoxia-inducible factor-prolyl hydroxylase inhibitors (HIF-PHIs) are novel oral agents used for renal anemia treatment. Roxadustat, a first-in-class HIF-PHI used for treating anemia in chronic kidney disease patients, has been approved in China, Japan, South Korea, Chile, and Europe. Roxadustat is involved in HIF degradation, which can stimulate endogenous erythropoietin (EPO) production and improve iron utilization. Besides, roxadustat can promote dietary iron uptake and transport...
February 2024: Kidney Diseases
https://read.qxmd.com/read/38322627/long-term-impact-of-renin-angiotensin-system-inhibitors-for-secondary-prevention-in-patients-with-chronic-kidney-disease-who-underwent-percutaneous-coronary-intervention
#20
JOURNAL ARTICLE
Tatsuya Fukase, Tomotaka Dohi, Ryota Nishio, Mitsuhiro Takeuchi, Norihito Takahashi, Yuichi Chikata, Hirohisa Endo, Shinichiro Doi, Hiroki Nishiyama, Iwao Okai, Hiroshi Iwata, Shinya Okazaki, Katsumi Miyauchi, Hiroyuki Daida, Tohru Minamino
INTRODUCTION: The long-term impact of renin-angiotensin system (RAS) inhibitors for secondary prevention in patients with chronic kidney disease (CKD) and coexisting coronary artery disease remains unclear. METHODS: Altogether, 1,160 consecutive patients with CKD (mean age, 70 ± 9 years; 78% men) who underwent their first percutaneous coronary intervention (PCI) between 2000 and 2018 were included and analyzed. Based on their RAS inhibitor use, 674 patients (58%) were allocated to the RAS inhibitor group, and 486 patients (42%) were allocated to the non-RAS inhibitor group...
February 2024: Kidney Diseases
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