Tong Zhao, Yue Zhang, Linhua Nan, Qing Zhu, Shukai Wang, Yutao Xie, Xinling Dong, Cui Cao, Xiaoliang Lin, Yu Lu, Yuxia Liu, Linjuan Huang, Guiping Gong, Zhongfu Wang
Understanding how dietary polysaccharides affect mucin O-glycosylation and gut microbiota could provide various nutrition-based treatments. Here, the O-glycan profile of the colonic mucosa and gut microbiome were investigated in C57BL/6J mice fed six structurally diverse dietary polysaccharides and a mixture of six fibers. Dietary polysaccharides increased total O-glycans, mainly by stimulating neutral glycans. Highly branched arabinogalactan promoted terminally fucosylated core 1 O-glycans; whereas linear polysaccharides, including pectin, konjac glucomannan, inulin, and the fiber mixture, favored terminally di-fucosylated O-glycans...
December 11, 2023: NPJ Biofilms and Microbiomes