Yang Fu, Yong-Song Chen, Dai-Yang Xia, Xiao-Dan Luo, Hao-Tong Luo, Jie Pan, Wei-Qing Ma, Jin-Ze Li, Qian-Yuan Mo, Qiang Tu, Meng-Meng Li, Yue Zhao, Yu Li, Yi-Teng Huang, Zhi-Xian Chen, Zhen-Jun Li, Lukuyu Bernard, Michel Dione, You-Ming Zhang, Kai Miao, Jian-Ying Chen, Shan-Shan Zhu, Jie Ren, Ling-Juan Zhou, Xian-Zhi Jiang, Juan Chen, Zhen-Ping Lin, Jun-Peng Chen, Hui Ye, Qing-Yun Cao, Yong-Wen Zhu, Lin Yang, Xue Wang, Wen-Ce Wang
Hyperuricemia (HUA) is a metabolic syndrome caused by abnormal purine metabolism. Although recent studies have noted a relationship between the gut microbiota and gout, whether the microbiota could ameliorate HUA-associated systemic purine metabolism remains unclear. In this study, we constructed a novel model of HUA in geese and investigated the mechanism by which Lactobacillus rhamnosus GG (LGG) could have beneficial effects on HUA. The administration of antibiotics and fecal microbiota transplantation (FMT) experiments were used in this HUA goose model...
March 20, 2024: NPJ Biofilms and Microbiomes