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Iranian Journal of Pathology

Sora Yasri, Viroj Wiwanitkit
No abstract text is available yet for this article.
2018: Iranian Journal of Pathology
Gireesha Rawal, Sufian Zaheer, Amit Kumar Yadav, Indrani Dhawan
Malignant fibrous histiocytoma (MFH) is one of the most common types of soft tissue sarcomas in adults. Distant metastases are developed in 30-40% of patients with MFH, with the most common site being the lung. However, metachronous MFH has not been reported previously in literature. This report describes a case of a 30-year-old man, who had two metachronous thigh tumors, both of which were confirmed to be MFH on histopathology and immunohistochemistry evaluations. A contemporary multidisciplinary approach to therapy including surgery, radiation and chemotherapy was advocated...
2018: Iranian Journal of Pathology
Shilpa Bairwa, Bhawna Sethi, Pawan Singh, Ashok Sangwaiya, Shivani Kalhan, Satya Dutta
A choriostoma is an aggregate of microscopically normal cells or tissues which occurs in an aberrant location. It follows a benign course, rarely seen in head and neck region. A choriostoma of the palatine tonsil is very rare; less than 10 cases were reported till date. A 11-year-old male referred to ENT OPD with chronic tonsillitis and underwent tonsillectomy. The histopathological examination revealed the unexpected presence of cartilage and bone in both tonsils.
2018: Iranian Journal of Pathology
Fatemeh Nili, Azadeh Sedighi Moghadam Pour, Hedieh Moradi Tabriz, Parisa Sedighi Moghadam Pour, Hana Saffar
Peripheral primitive neuroectodermal tumor (pPNET) is a highly aggressive small round cell tumor belonging to PNET/Ewing sarcoma family. Ovarian tumors composed of primitive neuroectodermal elements are extremely rare. Herein we reported two cases of peripheral primitive neuroectodermal tumors of ovary in two patients with different clinical presentations. Definite diagnoses were made based on the histomorphology and immunohistochemistry results. With respect to different clinical behaviors, treatment modalities and prognosis of peripheral primitive neuroectodermal tumors compared to other known ovarian neoplasms, it is essential to consider this entity as a differential diagnosis in ovarian tumors especially in young patients...
2018: Iranian Journal of Pathology
Noushin Ouryazdanpanah, Shahriar Dabiri, Ali Derakhshani, Reza Vahidi, Alireza Farsinejad
Background and Objectives: The mesenchymal stem cells derived from peripheral blood (PB) have been recognized as a promising source for allogeneic cell therapy. The aim of this study was to investigate the isolation, growth and differentiation ability of peripheral blood-isolated mesenchymal stem cells. Methods: The mononuclear cells were purified from fresh peripheral blood using density gradient centrifugation then cultured in a suitable medium, expanded and characterized...
2018: Iranian Journal of Pathology
Seyedeh Mehrnaz Kouhbananinejad, Farzaneh Armin, Shahriar Dabiri, Ali Derakhshani, Maryam Iranpour, Alireza Farsinejad
Background and Objective: In recent years, due to increasing number of patients with non-healing skin ulcers, skin substitutes have been used. Skin substitutes contain living cells causing faster and more effective wound healing. Therefore, research on the use of autologous and allogeneic cells such as fibroblasts in skin substitutes has attracted attentions. However, there are discrepancies in the immune responses to allogeneic fibroblasts. Therefore, we aimed to review the immune responses to allogeneic fibroblasts...
2018: Iranian Journal of Pathology
Shadi Hosseini, Farkhondeh Behjati, Maryam Rahimi, Nazanin Taheri, Hamidreza Khoram Khorshid, Fatemeh Aghakhani Moghaddam, Saghar Ghasemi, Masoud Karimlou, Fereidoon Sirati, Elahe Keyhani
Background and Objective: The PI3K/AKT/mTOR pathway is known to play an important role in regulating angiogenesis both in normal and breast cancer (BC) tissues. PIK3CA amplification was reported in various malignancies, including approximately 10% of BC cases. The aim of this study was to identify the frequency of PIK3CA amplification in Iranian female patients suffering from BC. Additionally, possible association between PIK3CA amplification and P110α expression with microvascular density (MVD) was examined...
2018: Iranian Journal of Pathology
Akbar Safaei, Ahmad Monabati, Maral Mokhtari, Moeinadin Safavi, Freidoon Solhjoo
Background and Objective: Identification of cytogenetic and molecular changes plays an important role in acute myeloid leukemia (AML) patients. Thus, they are used in classification, prognosis and treatment of the disease. The CD123 expression and FLT3 gene mutations are also the variations that may assist in prognosis and treatment of patients with AML. Methods: This study was performed on 76 patients as new cases of AML. The correlation between CD123 immunohistochemical (IHC) expression and FLT3 gene mutations with each other as well as morphological, immunophenotypical and cytogenetic factors was studied...
2018: Iranian Journal of Pathology
Amir Tajbakhsh, Faezeh Ghasemi, Seyedeh Zohre Mirbagheri, Mastoureh Momen Heravi, Mehdi Rezaee, Zahra Meshkat
Background and Objectives: The incidence of rifampin-resistant strains of Mycobacterium tuberculosis has attracted more attention than the tuberculosis infection due to laborious treatment and control. Recognizing the Mycobacterium tuberculosis genotypes involving in drug resistance via multiplex PCR, a simple and rapid genotyping method, is an emergency for better treatment and control of tuberculosis. This study was designed to specify the frequency of rifampin-resistant strains of Mycobacterium tuberculosis isolated from patients by multiplex allele-specific Polymerase Chain Reaction assay (MAS-PCR)...
2018: Iranian Journal of Pathology
Navid Bazzaz, Nazila Nouraee, Ali Zare-Mirzaie, Maryam Shahali, Syed Jawad Mowla, Mohammad Vasei
Background and Objective: Wilms' tumor (WT) is the most common genitourinary tract tumor in children. MicroRNAs (miRNAs) are small non-coding RNAs; their role in the pathogenesis of many types of human cancers has been identified. We aimed to evaluate the expression of miR-21, a well-known oncomir, in WT tissue samples which is a very common urinary tract malignancy in children. Methods: We performed chromogenic in situ hybridization (CISH) to detect the sub-cellular localization of miR-21 in 25 formalin-fixed, paraffin-embedded (FFPE) samples of WT...
2018: Iranian Journal of Pathology
Amir Hossein Jafarian, Khatoone Mirshekar Nasirabadi, Sare Etemad, Masoumeh Jafaripour, Mansoore Darijani, Maryam Sheikhi, Hossein Ayatollahi, Sepideh Shakeri, Seyyede Fatemeh Shams, Saeed Davari
Background and Objective: BRAF mutations were studied in various populations for prostate carcinoma (PC); however, mutations in BRAF gene are unusual compared to KRAS . Oncogenic activating of BRAF mutations were studied lately in almost 0%10% of prostate cancer cases. Methods: In this retrospective study, we gathered 100 formalin-fixed paraffin-embedded samples of prostate adenocarcinoma. A hundred archived samples of adjacent benign prostatic hyperplasia were chosen as normal control...
2018: Iranian Journal of Pathology
Narjes Seid Alian, Parvin Khodarahmi, Vahid Naseh
Background & Objective: Cadmium is a potent toxicant and carcinogenic substance for human and experimental animals. The evidences indicate that cadmium induces aberrant gene expression, inhibition of DNA damage repair, and apoptosis. In this study, we investigated the effects of IP (intraperitoneal) injection of cadmium on mRNA levels expression of Bcl-2 and Bax genes in rat small intestine. Methods: 28 male Wistar rats weighing 200 to 250 grams were randomly assigned into 4 groups...
2018: Iranian Journal of Pathology
Faria Hasanzadeh Haghighi, Ehsan Aryan, Mohammad Derakhshan, Aida Gholoobi, Zahra Meshkat
Background & Objective: Tuberculosis (TB) remains a major cause of death around the world. Bacillus Calmette Guérin (BCG) is the only vaccine used in TB prevention that has a protective effect in children, but its effectiveness declines in adults. Design and development of new vaccines is the most effective way against TB.The aim of this study was to design and construct a DNA vaccine encoding mtb32C and mpt51 fusion genes of Mycobacterium tuberculosis . Methods: First, mpt51 fragment was amplified by PCR method...
2018: Iranian Journal of Pathology
Seyyede Fatemeh Shams, Hossein Ayatollahi, Mohammad Hadi Sadeghian, Monavar Afzalaghaee, Sepideh Shakeri, Ehsan Yazdandoust, Maryam Sheikhi, Nafiseh Amini, Samane Bakhshi, Afsane Bahrami
Background and Objective: Janus kinase 2 (JAK2) and Myeloproliferative Leukemia (MPL) mutations are confirmatory indicators for Myeloproliferative Neoplasm (MPN). The current study was performed to determine the frequency of MPL mutation in MPN patients without JAK2 mutation, in order to assign MPL mutation frequency in North-East of Iran. Methods: Total of 105 negative JAK2 cases including 5 Myeloproliferative Disorders (MPD), 15 Polycytemia Vera (PV) and 15 Essential Thrombocytosis (ET) who referred to Qaem Medical Center were assigned to this study...
2018: Iranian Journal of Pathology
Farid Kosari, Fatemeh Ghaffari
Background and Objective: Hodgkin's lymphoma is a potentially curable hematologic malignancy with difficulty in its diagnosis especially in atypical cases even in expert hands. Today, immunohistochemistry plays a significant role in the diagnosis of it especially applying the anti-CD15 and anti-CD30 antibodies. The negativity of CD15 can be reduced by antigen retrieval for methods. In this study, the effect of autoclave was compared with microwave as heating sources of antigen retrieval in immunohistochemical staining...
2018: Iranian Journal of Pathology
Massoud Hajia, Amir Sohrabi
No abstract text is available yet for this article.
2018: Iranian Journal of Pathology
Srilatha Parampalli Srinivas, Archana Shivamurthy, Lakshmi Rao, Rajeshwari Gurumoorthy Bhat
Hepatoid variant of yolk sac tumor of ovary is an unusual tumor with an aggressive behavior. It is usually observed in young females, presents with abdominal complaints and is associated with raised α-fetoprotein (AFP) levels. It should be differentiated from other hepatoid tumors involving the ovary. A complete patient evaluation with gross, microscopy, and immunohistochemistry can identify the site of origin to administer appropriate treatment. The current study reported the case of a 30-year-old married parous female presenting with abdominal distention and pain of two months duration...
2018: Iranian Journal of Pathology
Ali Yaghobi Joybari, Payam Azadeh, Behzad Nemati Honar
Verrucous carcinoma (VC) is a rare variant of well differentiated squamous cell carcinoma (SCC) which is usually found in oral cavity mucosa. Cutaneous verrucous carcinoma is a rare entity and in this paper we report a 43 years old man with VCsuperimposed on chronically inflamed skin of ileostomy site. Previously, he was operated to treat rectal adenocarcinoma and has had ileostomy for six months. The skin lesion was resected totally during surgical operation for ileostomy closure. Histopathologic examination confirmed the diagnosis of cutaneous verrucous carcinoma...
2018: Iranian Journal of Pathology
Arun Puri, Heena Wadhwa, Navtej Singh
Multiple Myeloma is a neoplasm of B cell lineage characterized by excessive proliferation of abnormal plasma cells. It is characterized by a clinical pentad of 1) anemia, 2) a monoclonal protein in the serum or the urine or both, 3) bone leisons and or bone pain, 4) hypercalcemia>11.5g/dl and 5) renal insufficiency. Non secretory multiple myeloma is a rare variant of the classic form of multiple myeloma and accounts for 1% to 5 % of all cases of multiple myeloma. The clinical presentation and radiographic findings of non-secretory multiple myeloma and multiple myeloma are the same...
2018: Iranian Journal of Pathology
Adriana Handra-Luca
Squamous cell differentiation (SCD) may occur in papillary thyroid carcinoma (PTC) only at metastatic sites. We have studied cytokeratin CK5/6 and P63 along with TTF1 (thyroid transcription factor 1) and B-Raf (V-Raf murine sarcoma viral oncogene homolog B1) immunohistochemical expression in neck lymph node metastases of thyroid PTC showing SCD. The patient (21-years) presented with a neck mass. The check-up revealed bilateral thyroid nodules. Total thyroidectomy and neck lymph node dissection were performed...
2018: Iranian Journal of Pathology
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