journal
https://read.qxmd.com/read/38716287/a-comprehensive-study-on-the-diagnostic-value-of-multi-slice-computed-tomography-for-peripancreatic-infection-in-elderly-with-severe-acute-pancreatitis
#1
JOURNAL ARTICLE
Rui Hao, Yu Sun, Yang Hu
BACKGROUND: This study investigated the diagnostic efficacy of multi-slice spiral computed tomography (MSCT) perfusion imaging in evaluating peripancreatic infection in elderly patients with severe acute pancreatitis (SAP). METHODS: A retrospective analysis was conducted on the clinical data of 110 elderly SAP patients treated at our hospital from March 2018 to August 2019. The study correlated MSCT perfusion imaging characteristics with peripancreatic infection in elderly SAP patients...
April 2024: Gastroenterology Research
https://read.qxmd.com/read/38716286/mucosa-associated-lymphoid-tissue-surgeries-as-a-possible-risk-for-inflammatory-bowel-disease-a-systematic-review-and-meta-analysis
#2
JOURNAL ARTICLE
Rutvi Amin, Aditya Mansabdar, Hyundam Gu, Bhavani Gangineni, Neev Mehta, Harini Patel, Neel Patel, Srishti Laller, Suprada Vinayak, Mohammed Ali Abdulqader, Hardik Jain, Amitjeet Singh Rekhraj, Harshini Adimoulame, Gurinder Singh, Jose Moonjely Davis, Urvish Patel, Harmeet Gill
BACKGROUND: Inflammatory bowel disease (IBD) is a group of chronic inflammatory gastrointestinal disorders that are caused by genetic susceptibility and environmental factors and affects a significant portion of the global population. The gut-associated lymphoid tissue (GALT) is known to play a crucial role in immune modulation and maintaining gut microbiota balance. Dysbiosis in the latter has a known link to IBD. Therefore, the increasing prevalence of adenoidectomy in children should be explored for its potential association with IBD...
April 2024: Gastroenterology Research
https://read.qxmd.com/read/38716285/the-potential-of-narrow-band-imaging-as-a-novel-light-source-for-photodynamic-therapy-for-superficial-cancers-via-endoscopes
#3
JOURNAL ARTICLE
Yusuke Nakada, Takaaki Sugihara, Maria Tanaka, Wataru Hamamoto, Tsutomu Kanda, Takuki Sakaguchi, Hiroki Kurumi, Takumi Onoyama, Yuichiro Ikebuchi, Tomoaki Takata, Hajime Isomoto, Naoyuki Yamaguchi
BACKGROUND: Photodynamic therapy (PDT) has advanced through the utilization of photosensitizers and specific-wavelength light (≥ 600 nm). However, the widespread adoption of PDT is still impeded by high equipment costs and stringent laser safety requirements. Porphyrins, crucial in PDT, have another absorbance peak of blue light (λ = 380 - 500 nm). This peak corresponds to the wavelength of narrow-band imaging (NBI) (λ = 390 - 445 nm), an image-enhancement technology integrated into endoscopes by Olympus Medical Systems...
April 2024: Gastroenterology Research
https://read.qxmd.com/read/38716284/predictive-factors-of-non-inflammatory-small-bowel-obstruction-after-bowel-resection-in-crohn-s-patients
#4
JOURNAL ARTICLE
Mir Zulqarnain, Fouad Jaber, Vinay Jahagirdar, Saqr Alsakarneh, Jose Gomez, Aditi Stanton, Nedhi Patel, Poonam Beniwal-Patel, Daniel Stein, Mary Otterson, Andres J Yarur
BACKGROUND: The aim of the study was to investigate the risk factors associated with the development of small bowel obstruction (SBO) in Crohn's disease (CD) after small bowel resection (SBR) that are not due to active/recurrent inflammation. METHODS: We conducted a retrospective cohort study of patients who had SBR for active or complicated CD. Abstracted data included demographics, phenotype, therapies for CD, endoscopic disease recurrence, and several surgical variables...
April 2024: Gastroenterology Research
https://read.qxmd.com/read/38716283/clinical-overview-of-sarcopenia-frailty-and-malnutrition-in-patients-with-liver-cirrhosis
#5
REVIEW
Alexander Kusnik, Amulya Penmetsa, Farooq Chaudhary, Keerthi Renjith, Gopal Ramaraju, Marie Laryea, Johane P Allard
Sarcopenia, frailty, and malnutrition in patients with liver cirrhosis are commonly observed and are associated with higher long-term mortality. Therefore, recognizing patients with increased nutritional risk and providing recommended interventions are essential in the long- and short-term management of cirrhosis, especially as alcoholic and non-alcoholic fatty liver disease continues to rise. Various assessment tools are available to gauge frailty and malnutrition but are infrequently used. Given the global burden of liver cirrhosis, periodic screening for malnutrition, sarcopenia, and frailty is desperately needed as it improves liver transplantation outcomes...
April 2024: Gastroenterology Research
https://read.qxmd.com/read/38463150/a-real-world-experience-on-a-chinese-population-of-patients-with-unresectable-hepatocellular-carcinoma-treated-with-nivolumab
#6
JOURNAL ARTICLE
Shou-Wu Lee, Sheng-Shun Yang, Teng-Yu Lee
BACKGROUND: For unresectable hepatocellular carcinoma (HCC), nivolumab (anti-programmed death receptor-1 (PD-1)) is used as non-curative interventions. The aim of the study was to focus on the real-world experience of nivolumab applied to patients with HCC. METHODS: Unresectable HCC patients receiving nivolumab treatments at Taichung Veterans General Hospital, from June 2018 to May 2020, were recruited. Exclusion criteria were Child-Pugh stage C, poor performance status, a lack of compliance or intolerable to drug treatments...
February 2024: Gastroenterology Research
https://read.qxmd.com/read/38463149/primary-non-function-of-hepatic-allograft-with-preexisting-microvesicular-steatosis-foamy-degeneration-and-mild-large-droplet-macrovesicular-steatosis
#7
Melissa E Limia, Xiu Li Liu, Jennifer Yu, Kathleen Byrnes
It has been established that more than mild large-droplet macrovesicular steatosis (LD-MAS) is associated with increased risk of graft non-function. In contrast, even severe small-droplet macrovesicular steatosis (SD-MAS) has been found to be less prognostically significant. It remains unclear if a donor liver with diffuse microvesicular steatosis is associated with an increased risk of graft dysfunction. A 56-year-old male with alcoholic cirrhosis was transplanted with a liver from a 42-year-old overweight male donor after brain death...
February 2024: Gastroenterology Research
https://read.qxmd.com/read/38463148/pre-and-post-implant-endoscopy-in-left-ventricular-assist-device-recipients-a-single-center-experience
#8
JOURNAL ARTICLE
Wael T Mohamed, Vinay Jahagirdar, Fouad Jaber, Mohamed K Ahmed, Hassan M Ghoz, Brett W Sperry, Wendell K Clarkston
BACKGROUND: Gastrointestinal bleeding (GIB) is common in left ventricular assist devices (LVADs) patients, but the optimal screening approach before LVAD implantation is still unclear. The aim of the study was to describe our experience with pre- and post-LVAD implantation endoscopic screening and subsequent GI bleeding in this cohort. METHODS: A retrospective review was conducted among all patients who underwent LVAD implantation at Saint Luke's Hospital, between 2010 and 2020...
February 2024: Gastroenterology Research
https://read.qxmd.com/read/38463147/fulminant-emphysematous-pancreatitis-diagnosis-time-counts
#9
Basel Darawsha, Subhi Mansour, Tawfik Fahoum, Naseem Azzam, Yoram Kluger, Ahmad Assalia, Safi Khuri
Emphysematous pancreatitis (EP), a severe form of necrotizing infection of the pancreas, is an extremely rare medical emergency with high rates of mortality. It is characterized by intraparenchymal pancreatic or peri-pancreatic air due to either monomicrobial or polymicrobial infection with gas-forming bacteria or due to entero-pancreatic fistula. EP is classified according to timing from disease onset when air bubble signs were detected on computed tomography (CT) scan, as early onset (within 2 weeks from disease onset) or late (more than 2 weeks from disease onset)...
February 2024: Gastroenterology Research
https://read.qxmd.com/read/38463146/clinicopathological-aspects-and-inflammation-immune-markers-in-alcohol-and-or-hepatitis-c-virus-induced-hepatocellular-carcinoma-patients-treated-with-sorafenib
#10
JOURNAL ARTICLE
Thiago Alexandre Martins Pinto, Helena Paes Almeida Saito, Carolina Lopes Nourani, Elaine Cristina Ataide, Ilka Fatima Santana Ferreira Boin, Gustavo Jacob Lourenco, Carmen Silvia Passos Lima
BACKGROUND: Tyrosine kinase inhibitors have been used to treat hepatocellular carcinoma (HCC), but the outcomes of patients under treatment vary. Since the roles of clinicopathological aspects and markers of chronic inflammation/immune homeostasis in the outcome of HCC patients treated with sorafenib are still unclear, these were the aims of this study. METHODS: Patients with alcohol-induced and/or hepatitis C virus (HCV)-induced HCC (n = 182) uniformly treated with sorafenib were included in the study...
February 2024: Gastroenterology Research
https://read.qxmd.com/read/38463145/alcohol-relapse-after-early-liver-transplantation-in-patients-with-alcoholic-liver-disease-a-meta-analysis
#11
JOURNAL ARTICLE
Yousaf Zafar, Ahmed Kamal Siddiqi, Nafhat Shaikh, Maria Imran, Syed Sarmad Javaid, Laila Manzoor, Arsalan Zafar Iqbal, Jan Petrasek
BACKGROUND: Alcohol use disorder (AUD) is a significant source of end-stage liver disease and liver failure and an indication for liver transplant (LT). Historically, LT for alcoholic liver disease (ALD) required 6 months of alcohol abstinence. Recently, it has been demonstrated that early LT (< 6 months of abstinence) in strictly selected group of patients provides survival benefit while keeping the relapse to harmful drinking at acceptable levels. This practice has been reflected in the Dallas consensus, but more data are needed to appropriately risk stratify the patient from the perspective of return to harmful alcohol drinking post-transplant...
February 2024: Gastroenterology Research
https://read.qxmd.com/read/38463144/delays-in-colorectal-cancer-screening-for-latino-patients-the-role-of-immigrant-healthcare-in-stemming-the-rising-global-incidence-of-colorectal-cancer
#12
Eleazar E Montalvan-Sanchez, Renato Beas, Ahmad Karkash, Ambar Godoy, Dalton Argean Norwood, Michael Dougherty
The significant global burden of colorectal cancer accentuates disparities in access to preventive healthcare in most low- and middle-income countries (LMICs) as well as large sections of underserved populations within high-income countries. The barriers to colorectal cancer screening in economically transitioning Latin America are multiple. At the same time, immigration from these countries to the USA continues to increase. This case highlights the delays in diagnosis experienced by a recent immigrant from a country with no established colorectal cancer screening program, to an immigrant population in the USA with similar poor screening coverage...
February 2024: Gastroenterology Research
https://read.qxmd.com/read/38186587/marital-status-is-a-prognostic-factor-for-cardiovascular-mortality-but-not-a-prognostic-factor-for-cancer-mortality-in-siewert-type-ii-adenocarcinoma-of-the-esophagogastric-junction
#13
JOURNAL ARTICLE
Zhong Qiang Zheng, Xuan Zi Sun
BACKGROUND: The impact of marital status on the prognosis of patients with Siewert type II adenocarcinoma of the esophagogatric junction (AEG) remained unclear. This study aimed to investigate the associations of marital status with cancer-specific death risk and cardiovascular death risk in Siewert type II AEG patients. METHODS: Data for Siewert type II AEG patients were obtained from the Surveillance, Epidemiology, and End Results database from 2010 to 2015. A 1:1 propensity score matching (PSM) was applied to reduce inter-group bias between the married and unmarried groups...
December 2023: Gastroenterology Research
https://read.qxmd.com/read/38186586/timing-and-outcomes-of-percutaneous-endoscopic-gastrostomy-after-ischemic-stroke
#14
JOURNAL ARTICLE
Shoma Bommena, Pooja Rangan, Joyce Lee-Iannotti, Wahid Wassef, Rakesh Nanda
BACKGROUND: Guidelines recommend using percutaneous endoscopic gastrostomy (PEG) for dysphagia after 2 weeks of stroke onset. We aimed to study the impact of PEG timing on outcomes in patients with ischemic stroke. METHODS: In this retrospective study of patients with ischemic stroke and PEG between 2014 and 2019, early PEG was defined as PEG tube placed within 14 days of stroke and late PEG after 14 days. Outcomes of 30-day mortality, PEG-related complications, and functional swallow recovery were compared between early and late PEG...
December 2023: Gastroenterology Research
https://read.qxmd.com/read/38186585/identifying-key-genes-to-the-early-diagnosis-of-inflammatory-bowel-disease-by-integrating-analysis-at-the-blood-and-tissue-levels
#15
JOURNAL ARTICLE
Xin Yu Wang, Dan Zhang
BACKGROUND: Inflammatory bowel disease (IBD) encompasses Crohn's disease (CD) and ulcerative colitis (UC), is challenging to diagnose, and frequently relapses, significantly affecting patients' quality of life. Despite extensive efforts, the pathogenesis of IBD remains unclear. METHODS: In this study, we integrated bioinformatics analysis and animal disease model to investigate IBD from two dimensions to identify potential diagnostic biomarkers and explore the pathogenesis of distinct conditions at tissue-specific levels...
December 2023: Gastroenterology Research
https://read.qxmd.com/read/38186584/serum-activin-a-is-a-novel-biomarker-of-endoscopic-activity-in-ulcerative-colitis
#16
JOURNAL ARTICLE
Ryohei Ogihara, Hiroki Kurumi, Tsutomu Kanda, Kazuo Yashima, Hajime Isomoto, Naoyuki Yamaguchi
BACKGROUND: Endoscopic healing (EH) is the long-term therapeutic goal for ulcerative colitis (UC). Since repeated colonoscopies are inconvenient and invasive, a surrogate biomarker for endoscopic activity is needed. Activin A is one of the transforming growth factor-β superfamily of proteins and has been shown to be associated with intestinal inflammation. METHODS: This single-center observational study included 27 Japanese patients with UC in clinical remission who underwent colonoscopy and blood sampling...
December 2023: Gastroenterology Research
https://read.qxmd.com/read/38186583/comparing-the-efficacy-and-safety-of-adalimumab-and-vedolizumab-in-treating-moderate-to-severe-crohn-s-disease-and-ulcerative-colitis
#17
JOURNAL ARTICLE
Nooraldin Merza, Yusuf Nawras, Omar Saab, Dushyant Singh Dahiya, Zohaib Ahmed, Meghana Ranabothu, Safa Boujemaa, Mona Hassan, Abdallah Kobeissy, Kirthi Lilley
BACKGROUND: Numerous patients with inflammatory bowel disease (IBD) do not respond to conventional or biological therapy. Adalimumab (ADA) and vedolizumab (VDZ), according to certain research, may be a useful alternative treatment for these people. The purpose of this study was to assess the effectiveness and safety of using ADA and VDZ to treat moderate to severe IBD: Crohn's disease (CD) and ulcerative colitis (UC). METHODS: We searched PubMed, Medline, Web of Science, Scopus, the Cochrane Library, Embase, Google Scholar, CINAHL, Clinicaltrials...
December 2023: Gastroenterology Research
https://read.qxmd.com/read/37937229/safety-and-efficacy-of-powered-non-thermal-endoscopic-resection-device-for-removal-of-colonic-polyps-a-systematic-review-and-meta-analysis
#18
JOURNAL ARTICLE
Zohaib Ahmed, Daryl Ramai, Nooraldin Merza, Joyce Badal, Umair Iqbal, Syeda F Arif, Alsadiq Al-Hillan, Tony Varughese, Wade Lee-Smith, Ali Nawras, Yaseen Alastal, Harshit S Khara, Bradley D Confer, David L Diehl, Douglas G Adler
BACKGROUND: Endoscopic mucosal resection is a frequently employed method for removing colonic polyps. Nonetheless, the recurrence of these polyps over a healed submucosal base can complicate the extraction of leftover lesions through standard procedures. EndoRotor® , a non-thermal device specifically designed for endoscopic mucosal resection, has recently been assessed for its utility in removing colonic polyps, non-dysplastic Barrett's esophagus, and pancreatic necrosis. We conducted a systematic review and meta-analysis to ascertain the safety and efficacy of EndoRotor® in resecting scared or recurrence colonic polyps...
October 2023: Gastroenterology Research
https://read.qxmd.com/read/37937228/the-impact-of-covid-19-on-outcomes-of-ischemic-colitis-a-nationwide-retrospective-analysis
#19
JOURNAL ARTICLE
Humzah Iqbal, Rakahn Haddadin, Patrick Zhang, Hasib Haidary, Devang Prajapati
BACKGROUND: Ischemic colitis is the most common presentation of mesenteric ischemia and is associated with significant morbidity and mortality. Coagulopathy has been associated with the development of ischemic colitis. Coronavirus disease 2019 (COVID-19) infection can lead to a variety of pathology and physiological derangements, including coagulopathy. Some case reports have described severe ischemic colitis in patients with COVID-19 infection. Our study aimed to elucidate the impact of COVID-19 infection on ischemic colitis outcomes...
October 2023: Gastroenterology Research
https://read.qxmd.com/read/37937227/covid-19-outcomes-in-inflammatory-bowel-disease-hospitalized-patients-a-comprehensive-analysis-using-the-national-inpatient-sample
#20
JOURNAL ARTICLE
Justin M Joseph, Anum Akhlaq, Rehmat Ullah Awan, Saleha Aziz, Moon Ryu, Asif Farooq, Karthik Gangu, Ehizogie Edigin, Abu Baker Sheikh
BACKGROUND: There is no uniformity in the available literature concerning the effects of coronavirus disease 2019 (COVID-19) viral illness on people with inflammatory bowel disease (IBD). METHODS: We conducted an analysis using the 2020 National Inpatient Sample (NIS) database to compare the outcomes of COVID-19 hospitalized patients with and without IBD. RESULTS: Of 1,050,040 patients admitted with COVID-19, 5,750 (0.5%) also had IBD. The group with COVID-19 and IBD had higher percentages of females and White individuals and a greater prevalence of chronic lung disease, peripheral vascular disease, and liver disease...
October 2023: Gastroenterology Research
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