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Gastroenterology Research

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https://read.qxmd.com/read/30834036/malignant-peritoneal-mesothelioma-without-asbestos-exposure
#1
Hafsa Abbas, Julio C Rodriguez, Hassan Tariq, Masooma Niazi, Ahmed Alemam, Suresh Kumar Nayudu
Malignant mesothelioma is a rare neoplasm of the serosal linings. Mesothelioma has been linked to asbestos exposure, with prior asbestos exposure linked to 33-50% of malignant peritoneal mesotheliomas. We describe a case of malignant peritoneal mesothelioma (MPM) without any prior exposure to asbestos in a 40-year-old Hispanic female who presented to the emergency department with worsening abdominal pain and distension. She had a history of beta thalassemia trait and iron deficiency anemia. Examination revealed a distended abdomen with protruding umbilicus and positive shifting dullness...
February 2019: Gastroenterology Research
https://read.qxmd.com/read/30834035/formation-of-pancreatoduodenal-fistula-in-intraductal-papillary-mucinous-neoplasm-of-the-pancreas-decreased-the-frequency-of-recurrent-pancreatitis
#2
Gebran Khneizer, Kavya M Reddy, Muhammad B Hammami, Samer Alkaade
Intraductal papillary mucinous neoplasms (IPMN) of the pancreas are characterized by proliferation of mucin-secreting cells in the main pancreatic duct (PD) or its branches. The secreted thick mucin usually leads to PD obstruction and dilation. A common complication of IPMN is recurrent acute pancreatitis secondary to poor pancreatic fluid drainage, and rarely, pancreatobiliary and pancreatointestinal fistulae. We describe a unique case of IPMN in a 57-year-old male who was referred to our institution for evaluation of recurrent acute pancreatitis...
February 2019: Gastroenterology Research
https://read.qxmd.com/read/30834034/successful-endoscopic-reduction-of-an-ileocolonic-intussusception-in-an-adult-with-peutz-jeghers-syndrome
#3
Mohd Amer AlSamman, Jason D Ferreira, Abdelmoniem Moustafa, Jonathan Moveson, Paul Akerman
Peutz-Jeghers syndrome (PJS) is a rare autosomal dominant disorder characterized by hamartomatous polyps throughout the gastrointestinal tract, mostly causing gastrointestinal bleeding and recurrent intestinal obstructions. Few intussusception related to PJS occurs reportedly in adults. Unlike pediatric cases almost all reported cases end up with surgical resection. Here we present a case of PSJ-related intussusception in an adult patient treated successfully with endoscopic approach, with no surgical intervention required...
February 2019: Gastroenterology Research
https://read.qxmd.com/read/30834033/peri-ampullary-metastasis-from-endometrial-adenocarcinoma-a-rare-etiology-of-obstructive-jaundice
#4
Eimad Ahmmad, Ahmad S Abdulkarim, Ahmed Dirweesh
Endometrial cancer is the commonest gynecologic malignancy, of which adenocarcinoma is the most common histologic type. While most women who relapse present with local symptoms within 3 years of the initial diagnosis, metastatic disease usually involves the abdominal cavity and liver. Herein we present a rare case of a patient with a remote history of endometrial adenocarcinoma status-post curative surgical resection and adjuvant therapy who presented with obstructive jaundice proved to be secondary to peri-ampullary metastasis of uterine adenocarcinoma...
February 2019: Gastroenterology Research
https://read.qxmd.com/read/30834032/joint-hypermobility-syndrome-affects-response-to-a-low-fermentable-oligosaccharide-disaccharide-monosaccharide-and-polyol-diet-in-irritable-bowel-syndrome-patients-a-retrospective-study
#5
Konstantinos C Fragkos, Katie Keetarut, Anna Cox, Johanna Eady, Anton V Emmanuel, Natalia Zarate-Lopez
Background: The low fermentable oligosaccharide, disaccharide, monosaccharide and polyol (FODMAP) diet causes significant clinical improvement in patients with irritable bowel syndrome (IBS). Joint hypermobility syndrome (JHS), defined as musculoskeletal symptoms in a hypermobile individual in the absence of systemic rheumatological disease, may be associated with functional gastrointestinal symptoms, including IBS. The aim of this study is to examine whether JHS can affect the response to the low FODMAP diet in patients with IBS...
February 2019: Gastroenterology Research
https://read.qxmd.com/read/30834031/acute-lower-gastrointestinal-bleeding-in-patients-treated-with-non-vitamin-k-antagonist-oral-anticoagulants-compared-with-warfarin-in-clinical-practice-characteristics-and-clinical-outcome
#6
Georgia Diamantopoulou, Christos Konstantakis, George Skroubis, George Theocharis, Vasilios Theopistos, Christos Triantos, Konstantinos Thomopoulos
Background: Acute lower gastrointestinal bleeding (ALGIB) can occur in patients on anticoagulant therapy (either warfarin or non-vitamin K oral anticoagulants (NOACs)). Use of NOACs has been increasing compared to warfarin in recent years. We analyzed patients with ALGIB on anticoagulation therapy and compared characteristics, management and clinical outcome in patients treated with NOACs versus warfarin. Methods: All patients with ALGIB on anticoagulation therapy treated in two (affiliated) centers during a 7-year period were evaluated...
February 2019: Gastroenterology Research
https://read.qxmd.com/read/30834030/sorafenib-related-adverse-events-in-predicting-the-early-radiologic-responses-of-hepatocellular-carcinoma
#7
Shou-Wu Lee, Teng-Yu Lee, Sheng-Shun Yang, Chun-Fang Tong, Hong-Zen Yeh, Chi-Sen Chang
Background: Hepatocellular carcinoma (HCC) has a poor prognosis with low chemotherapeutic efficiency to medications except to sorafenib. Previous studies showed that adverse events (AEs) of sorafenib can predict therapy efficacy to HCC. The aim of the study is to evaluate the early efficacy and AEs of sorafenib therapy. Methods: The database of HCC patients receiving sorafenib at Taichung Veterans General Hospital during the period from June 2012 to October 2016 was analyzed...
February 2019: Gastroenterology Research
https://read.qxmd.com/read/30834029/the-influence-of-hepatitis-c-viral-loads-on-natural-killer-cell-function
#8
Mark Collister, Cindy Ellison, Qian Li, Gerald Y Minuk, Julia D Rempel, Sam K Kung
Background: Hepatitis C virus (HCV) infection has a high rate of chronicity, attributable to its capacity to alter host immunity, including natural killer (NK) cell function. In this study, the interaction between NK cell activity and HCV viral load was investigated. Methods: Peripheral blood NK cells were examined for cytotoxicity and interferon (IFN)-γ expression in HCV infected low (LVL, < 800,000 IU/mL, n = 10) and high (HVL, > 800,000 IU/mL, n = 13) viral load patient cohorts...
February 2019: Gastroenterology Research
https://read.qxmd.com/read/30834028/lactic-acid-is-an-independent-predictor-of-mortality-and-improves-the-predictive-value-of-existing-risk-scores-in-patients-presenting-with-acute-gastrointestinal-bleeding
#9
Matthew Berger, Vadim Divilov, Getu Teressa
Background: There are validated clinical risk scores for risk stratifying patients presenting with acute upper gastrointestinal bleed (GIB), including Glasgow-Blatchford score (GBS), Pre-endoscopic Rockall score (RS-PE) and post-endoscopic complete Rockall Score (RS-C), and AIMS65. Several studies have explored the predictive value of lactic acid (LA) in the context of GI bleeding, but the prognostic role of LA and its incremental value in combination with existing clinical risk scores is not well defined...
February 2019: Gastroenterology Research
https://read.qxmd.com/read/30627270/anti-epileptic-medication-induced-asymptomatic-eosinophilic-colitis
#10
Yamam Al-Saadi, Mohammad Bilal, David A Pacheco, Praveen Guturu
No abstract text is available yet for this article.
December 2018: Gastroenterology Research
https://read.qxmd.com/read/30627269/crohn-s-disease-manifesting-as-a-duodenal-obstruction-an-unusual-case
#11
Jamil Shah, Denzil Etienne, Madhavi Reddy, Jiten P Kothadia, Abul Shahidullah, A A M Abdullahel Baqui
We describe a case of a 31-year-old man who presented with a 3-year history of worsening upper abdominal pain, nausea, and vomiting: symptoms that were resistant to medical treatment and unexplained despite a thorough diagnostic evaluation. Then, an upper gastrointestinal series with small bowel follow-through showed proximal duodenal dilation and distal decompression of the duodenum, suggestive of a partial duodenal obstruction. An abdominal computed tomography (CT) scan revealed a transition point in the distal duodenum...
December 2018: Gastroenterology Research
https://read.qxmd.com/read/30627268/liver-metastasis-of-hepatoid-colonic-adenocarcinoma-a-rare-and-unusual-entity-with-poor-prognosis-and-review-of-the-literature
#12
Ming Hu, Weidong Liu, Feng Yin, Dongwei Zhang, Xiuli Liu, Jinping Lai
Hepatoid adenocarcinoma (HAC) is rare and was first reported as α-fetoprotein (AFP)-producing tumor. It is an important variant of extrahepatic adenocarcinoma with clinicopathological presentation mimicking hepatocellular carcinoma and carries exceedingly poor prognosis. HAC most commonly originates in the stomach, and less commonly in the ovary, esophagus, lung, among other organs. HAC originating in the colon is exceedingly rare. Here we report such a case of a 63-year-old man presented as decompensated liver failure with jaundice and weakness...
December 2018: Gastroenterology Research
https://read.qxmd.com/read/30627267/klippel-trenaunay-syndrome-a-rare-cause-of-hematochezia
#13
Eric Omar Then, Andrew Ofosu, Prashanth Rawla, Tagore Sunkara, Vinaya Gaduputi
Klippel-Trenaunay syndrome (KTS) is a rare disorder with a wide array of clinical manifestations. It is primarily a disorder of vascular malformations that is classically associated with the development of hemangiomas and venous malformations. Rarely will KTS present with visceral involvement. Venous malformations of the gastrointestinal tract in specific are an exceedingly rare manifestation of KTS. When present, it can result in life-threatening bleeding that is oftentimes difficult to manage. Our case highlights a 53-year-old woman who presented to our clinic with chronic rectal bleeding secondary to KTS...
December 2018: Gastroenterology Research
https://read.qxmd.com/read/30627266/isolated-gastric-metastasis-of-endometrial-adenocarcinoma-first-case-report-and-review-of-pertinent-literature
#14
Min Cui, Xiaofei Zhang, Noam Harpaz
Upper gastrointestinal metastasis of endometrial carcinoma rarely occurs in the absence of locoregional disease and other distant metastases. We describe herein the unique case of an isolated gastric metastasis of a stage I endometrial adenocarcinoma. Because the metastatic tumor was initially misdiagnosed clinically and pathologically as a primary gastric carcinoma, we illustrate the histopathology and review the pertinent literature. A 42-year-old woman with Lynch syndrome underwent treatment of endometrial adenocarcinoma at an outside hospital comprising clinical and radiological staging including a positron emission tomography-computed tomography (PET-CT) scan followed by a total intra-abdominal hysterectomy, bilateral salpingoophorectomy and pelvic and paraaortic lymphadenectomy...
December 2018: Gastroenterology Research
https://read.qxmd.com/read/30627265/factors-influencing-the-adequacy-of-bowel-preparation-in-patients-with-developmental-disabilities
#15
Jose Mari Parungao, Charina Reyes, Nancy Jackson, Nancy Roizen, Michael Piper
Background: The rate of inadequate bowel preparation in the general population is approximately 23%. As more individuals with developmental disabilities enter late adulthood, a concomitant rise in endoscopic procedures for this population, including screening colonoscopies, is anticipated. However, there are sparse data on the adequacy of bowel preparation in patients with developmental disabilities. Methods: A retrospective analysis of 91 patients with developmental disabilities who underwent colonoscopy from 2006 to 2014 was performed...
December 2018: Gastroenterology Research
https://read.qxmd.com/read/30627264/influence-of-body-height-on-oral-and-pharyngeal-transit-time-of-a-liquid-bolus-in-healthy-volunteers
#16
Marcia R K Bernardi Regueiro, Luana Casari Parreira, Weslania Viviane Nascimento, Roberto Oliveira Dantas
Background: Swallowing duration may be influenced by several factors. The effect of body height on oral-pharyngeal bolus transit has not been clearly elucidated. The hypothesis of this investigation was that height has influence on oral-pharyngeal transit time of a liquid bolus. Methods: Videofluoroscopic assessment of swallowing was performed on 40 healthy volunteers: 20 "tall" (171 cm to 207 cm) and 20 "short" (152 cm to 170 cm) subjects, 10 men and 10 women in each group...
December 2018: Gastroenterology Research
https://read.qxmd.com/read/30627263/autophagy-related-protein-16-1-up-regulated-in-hepatitis-b-virus-related-hepatocellular-carcinoma-and-impaired-apoptosis
#17
Jiaranai Peantum, Areerat Kunanopparat, Nattiya Hirankarn, Pisit Tangkijvanich, Ingorn Kimkong
Background: Hepatocellular carcinoma (HCC) as primary malignancy of the liver has become the most common type of cancer worldwide. HCC development is mainly caused by viruses, especially the hepatitis B virus (HBV). Autophagy is an important defense mechanism against virus infection; however, HBV promotes autophagy mediated by the HBx protein which stimulates its replication. The autophagy-related protein 16-1 (ATG16L1) binds to the ATG12-ATG5 conjugate and forms a large protein autophagosome complex...
December 2018: Gastroenterology Research
https://read.qxmd.com/read/30627262/long-term-safety-and-efficacy-of-fecal-microbiota-transplantation-in-the-treatment-of-clostridium-difficile-infection-in-patients-with-and-without-inflammatory-bowel-disease-a-tertiary-care-center-s-experience
#18
Obada M Tabbaa, Mohammed M Aboelsoud, Mark C Mattar
Background: Clostridium difficile infection (CDI) carries a large burden on the national public health with its high morbidity and mortality rates. Patients with inflammatory bowel disease (IBD) are generally at higher risk of infection, recurrence and complications. Therefore, the need for more reliable and safe therapy is necessary. Our study aims to evaluate long-term fecal microbiota transplant (FMT) outcomes in the general population compared to patients with IBD. Methods: A single center long-term follow-up study was conducted to evaluate the outcomes of FMT in patients with and without IBD...
December 2018: Gastroenterology Research
https://read.qxmd.com/read/30627261/steatohepatitic-variant-of-hepatocellular-carcinoma-a-focused-review
#19
REVIEW
Andrea Morgan Olofson, David Hernandez Gonzalo, Michael Chang, Xiuli Liu
The incidence of hepatocellular carcinoma (HCC) has steadily increased over the past three decades and currently ranks as the fifth most common cancer worldwide. Likewise, non-alcoholic fatty liver disease (NAFLD), a known risk factor for the development of HCC, has emerged as the most common liver disease in Western countries. The underlying pathogenesis of NAFLD-related HCC remains unclear. The steatohepatitic variant of HCC (SH-HCC) typically presents in patients with metabolic risk factors and either cirrhotic or non-cirrhotic NAFLD and shares many of the histological features found in non-alcoholic steatohepatitis (NASH)...
December 2018: Gastroenterology Research
https://read.qxmd.com/read/30344813/esophageal-ulcers-in-primary-biliary-cholangitis-a-rare-cause-of-hematemesis-in-the-setting-of-portal-hypertension-and-esophageal-varices
#20
Sindhura Kolli, Amit Mori, Isaac Moshenyat
Our patient with primary biliary cholangitis, previously termed as primary biliary cirrhosis, presented with an unexpected and unusual cause of hematemesis in the form of multiple esophageal ulcers in-between variceal columns. Given that upon endoscopic examination, the esophageal ulcers were found to bleeding instead of the varices; they should be considered in the differential in the etiology of hematemesis in primary biliary cholangitis and thoroughly searched for during an endoscopic procedure for early treatment and subsequent secondary prevention...
October 2018: Gastroenterology Research
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