Damla Raimoglou, Cemil İzgi, Rasim Enar, M Hakan Karpuz, Bilgehan Karadağ, Barış İktimur, Utku Raimoğlu, Ali Uğur Soysal, Osman Aykan Kargın, Mehmet Güven, Namina Malikova, Elif Çıtak, Ece Yurtseven, Eser Durmaz
BACKGROUND: Hypertrophic cardiomyopathy (HCM) is a genetically inherited cardiac disorder with diverse clinical presentations. Adrenergic activity, primarily mediated through beta-adrenoceptors, plays a central role in the clinical course of HCM. Adrenergic stimulation increases cardiac contractility and heart rate through beta-1 adrenoceptor activation. Beta-blocker drugs are recommended as the primary treatment for symptomatic HCM patients to mitigate these effects. METHODS: This prospective study aimed to investigate the impact of common ADRB-1 gene polymorphisms, specifically serine-glycine at position 49 and arginine-glycine at position 389, on the clinical and structural aspects of HCM...
March 2024: Anatolian Journal of Cardiology