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Chihua Fang, Peng Zhang, Xiaolong Qi
Despite tremendous advances in traditional imaging technology over the past few decades, the intraoperative identification of lesions is still based on naked eye observation or pre-operative image evaluation. However, these two-dimensional image data cannot objectively reflect the complex anatomical structure of the liver and the detailed morphological features of the lesion, which directly limits the clinical application value of these imaging data in surgery in that it cannot improve the curative efficacy of surgery and the prognosis of the patient...
February 14, 2019: EBioMedicine
Xiangqi Meng, Chunbin Duan, Hengyuan Pang, Qun Chen, Bo Han, Caijun Zha, Magafurov Dinislam, Pengfei Wu, Ziwei Li, Shihong Zhao, Ruijia Wang, Lin Lin, Chuanlu Jiang, Jinquan Cai
BACKGROUND: DNA damage repair (DDR) alterations are important events in cancer initiation, progression, and therapeutic resistance. However, the involvement of DDR alterations in glioma malignancy needs further investigation. This study aims to characterize the clinical and molecular features of gliomas with DDR alterations and elucidate the biological process of DDR alterations that regulate the cross talk between gliomas and the tumor microenvironment. METHODS: Integrated transcriptomic and genomic analyses were undertaken to conduct a comprehensive investigation of the role of DDR alterations in glioma...
February 14, 2019: EBioMedicine
Oren Rom, Guan Xu, Yanhong Guo, Yunhao Zhu, Huilun Wang, Jifeng Zhang, Yanbo Fan, Wenying Liang, Haocheng Lu, Yuhao Liu, Michael Aviram, Zhipeng Liu, Seongho Kim, Wanqing Liu, Xueding Wang, Y Eugene Chen, Luis Villacorta
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) and resulting nonalcoholic steatohepatitis (NASH) are reaching global epidemic proportions. Lack of non-invasive diagnostic tools and effective therapies constitute two of the major hurdles for a bona fide treatment and a reversal of NASH progression and/or regression of the disease. Nitro-oleic acid (OA-NO2 ) has been proven effective in multiple experimental models of inflammation and fibrosis. Thus, the potential benefit of in vivo administration of OA-NO2 to treat advanced NAFLD was tested herein in a model of long-term NASH diet-induced liver damage...
February 13, 2019: EBioMedicine
Pasqualino de Antonellis
No abstract text is available yet for this article.
February 13, 2019: EBioMedicine
Rintaro Ono, Takashi Watanabe, Eiryo Kawakami, Makoto Iwasaki, Mariko Tomizawa-Murasawa, Masashi Matsuda, Yuho Najima, Shinsuke Takagi, Saera Fujiki, Rumi Sato, Yoshiki Mochizuki, Hisahiro Yoshida, Kaoru Sato, Hiromasa Yabe, Shunichi Kato, Yoriko Saito, Shuichi Taniguchi, Leonard D Shultz, Osamu Ohara, Masayuki Amagai, Haruhiko Koseki, Fumihiko Ishikawa
BACKGROUND: Graft-versus host disease (GVHD) is a complication of stem cell transplantation associated with significant morbidity and mortality. Non-specific immune-suppression, the mainstay of treatment, may result in immune-surveillance dysfunction and disease recurrence. METHODS: We created humanised mice model for chronic GVHD (cGVHD) by injecting cord blood (CB)-derived human CD34+ CD38- CD45RA- haematopoietic stem/progenitor cells (HSPCs) into hIL-6 transgenic NOD/SCID/Il2rgKO (NSG) newborns, and compared GVHD progression with NSG newborns receiving CB CD34- cells mimicking acute GVHD...
February 13, 2019: EBioMedicine
Ching-Lung Cheung, Kathryn C B Tan, Philip C M Au, Gloria H Y Li, Bernard M Y Cheung
BACKGROUND: Growth differentiation factor 15 (GDF15) is a key regulator of body weight in animals by regulating food intake. Its receptor, glial cell-derived neurotrophic factor receptor alpha-like (GFRAL), was identified recently. Pre-clinical studies showed that it is a promising therapeutic target for cardiometabolic diseases and anorexia/cachexia. Although many pharmaceutical companies are developing drugs targeting GFRAL, whether the findings from animal studies can be extrapolated to man is unknown...
February 13, 2019: EBioMedicine
Yong Zhuo, Lun Hua, Bin Feng, Xuemei Jiang, Jing Li, Dandan Jiang, Xiaohua Huang, Yingguo Zhu, Zhen Li, Lijun Yan, Chao Jin, Lianqiang Che, Zhengfeng Fang, Yan Lin, Shengyu Xu, Jian Li, De Wu
BACKGROUND: Global consumption of protein per capita is rising, while rates of infertility are increasing. However, a clear relationship between protein intake and reproductive health has not been demonstrated. The activation of the quiescent primordial follicles is the first step of folliculogenesis, and their activation must be tightly controlled to prevent premature exhaustion of the ovarian follicular reserve. METHODS: The primordial follicle reserve of wild-type or liver-specific ablation of fibroblast growth factor 21 (FGF21) in mice, subjected to limited or excessive protein diets or oral gavage test, were detected in vivo...
February 13, 2019: EBioMedicine
Daisuke Izumi, Feng Gao, Shusuke Toden, Fuminori Sonohara, Mitsuro Kanda, Takatsugu Ishimoto, Yasuhiro Kodera, Xin Wang, Hideo Baba, Ajay Goel
BACKGROUND: Although identification of lymph node (LN) metastasis is a well-recognized strategy for improving outcomes in patients with gastric cancer (GC), currently there is lack of availability of adequate molecular biomarkers that can identify such metastasis. Herein we have developed a robust gene-expression signature for detecting LN metastasis in early stage GC by using a transcriptome-wide biomarker discovery and subsequent validation in multiple clinical cohorts. METHODS: A total of 532 patients with pathological T1 and T2 GC from 4 different cohorts were analyzed...
February 13, 2019: EBioMedicine
Clarissa Van Hecke, Wim Trypsteen, Eva Malatinkova, Ward De Spiegelaere, Karen Vervisch, Sofie Rutsaert, Sabine Kinloch-de Loes, Magdalena Sips, Linos Vandekerckhove
No abstract text is available yet for this article.
February 12, 2019: EBioMedicine
Gabriele Capurso, Claudio Sette
No abstract text is available yet for this article.
February 11, 2019: EBioMedicine
Ashley Cornett, Harleen K Athwal, Emily Hill, George Murphy, Kenji Yeoh, Christopher A Moskaluk, Robert L Witt, Nisha J D'Silva, Seema Agarwal, Isabelle M A Lombaert
BACKGROUND: Patient-derived xenograft (PDX) models have significantly enhanced cancer research, and often serve as a robust model. However, enhanced growth rate and altered pathological phenotype with serial passages have repeatedly been shown in adenoid cystic carcinoma (ACC) PDX tumors, which is a major concern. METHODS: We evaluated the fidelity of ACCs in their natural habitat by performing ACC orthotopic xenotransplantation (PDOX) in salivary glands. FINDINGS: Our PDOX model enabled solid tumors to integrate within the local epithelial, stromal and neuronal environment...
February 11, 2019: EBioMedicine
Tuyen N M Hua, Min-Kyu Kim, Vu T A Vo, Jong-Whan Choi, Jang Hyun Choi, Hyun-Won Kim, Seung-Kuy Cha, Kyu-Sang Park, Yangsik Jeong
BACKGROUND: c-Src is a driver oncogene well-known for tumorigenic signaling, but little for metabolic function. Previous reports about c-Src regulation of glucose metabolism prompted us to investigate its function in other nutrient modulation, particularly in lipid metabolism. METHODS: Oil-red O staining, cell growth assay, and tumor volume measurement were performed to determine lipid amount and growth inhibitory effect of treatments in lung cancer cells and xenograft model...
February 9, 2019: EBioMedicine
Pablo Muriel
No abstract text is available yet for this article.
February 8, 2019: EBioMedicine
Daria V Ilatovskaya, Vladislav Levchenko, Tengis S Pavlov, Elena Isaeva, Christine A Klemens, Jessica Johnson, Pengyuan Liu, Alison J Kriegel, Alexander Staruschenko
BACKGROUND: Autosomal Recessive Polycystic Kidney Disease (ARPKD) is marked by cyst formation in the renal tubules, primarily in the collecting duct (CD) system, ultimately leading to end-stage renal disease. Patients with PKD are generally advised to restrict their dietary sodium intake. This study was aimed at testing the outcomes of dietary salt manipulation in ARPKD. METHODS: PCK/CrljCrlPkhd1pck/CRL (PCK) rats, a model of ARPKD, were fed a normal (0.4% NaCl; NS), high salt (4% NaCl; HS), and sodium-deficient (0...
February 7, 2019: EBioMedicine
Rona J Strawbridge, Joey Ward, Amy Ferguson, Nicholas Graham, Richard J Shaw, Breda Cullen, Robert Pearsall, Laura M Lyall, Keira J A Johnston, Claire L Niedzwiedz, Jill P Pell, Daniel Mackay, Julie Langan Martin, Donald M Lyall, Mark E S Bailey, Daniel J Smith
BACKGROUND: Suicide is a major issue for global public health. Suicidality describes a broad spectrum of thoughts and behaviours, some of which are common in the general population. Although suicide results from a complex interaction of multiple social and psychological factors, predisposition to suicidality is at least partly genetic. METHODS: Ordinal genome-wide association study of suicidality in the UK Biobank cohort comparing: 'no suicidality' controls (N = 83,557); 'thoughts that life was not worth living' (N = 21,063); 'ever contemplated self-harm' (N = 13,038); 'act of deliberate self-harm in the past' (N = 2498); and 'previous suicide attempt' (N = 2666)...
February 7, 2019: EBioMedicine
Xuejiao Hu, Shun Liao, Hao Bai, Lijuan Wu, Minjin Wang, Qian Wu, Juan Zhou, Lin Jiao, Xuerong Chen, Yanhong Zhou, Xiaojun Lu, Binwu Ying, Zhaolei Zhang, Weimin Li
Background Tuberculosis (TB) is difficult to diagnose under complex clinical conditions as electronic health records (EHRs) are often inadequate in making an affirmative diagnosis. As exosomal miRNAs emerged as promising biomarkers, we investigated the potential of using exosomal miRNAs and EHRs in TB diagnosis. METHODS: A total of 370 individuals, including pulmonary tuberculosis (PTB), tuberculous meningitis (TBM), non-TB disease controls and healthy state controls, were enrolled. Exosomal miRNAs were profiled in the exploratory cohort using microarray and miRNA candidates were selected in the selection cohort using qRT-PCR...
February 7, 2019: EBioMedicine
Boshi Wang, Xiaoli Xu, Zhaojuan Yang, Li Zhang, Yun Liu, Aihui Ma, Guiqin Xu, Ming Tang, Tiantian Jing, Lin Wu, Yongzhong Liu
BACKGROUND: Hyper-activation of TGF-β signaling is critically involved in progression of hepatocellular carcinoma (HCC). However, the events that contribute to the dysregulation of TGF-β pathway in HCC, especially at the post-translational level, are not well understood. METHODS: Associations of deubiquitinase POH1 with TGF-β signaling activity and the outcomes of HCC patients were examined by data mining of online HCC datasets, immunohistochemistry analyses using human HCC specimens, spearman correlation and survival analyses...
February 7, 2019: EBioMedicine
Xiaoquan Rao, Shi Zhao, Zachary Braunstein, Hong Mao, Michael Razavi, Lihua Duan, Yingying Wei, Amelia C Toomey, Sanjay Rajagopalan, Jixin Zhong
BACKGROUND: We and others have shown that dipeptidyl peptidase-IV (DPP4) expression is increased in obesity/atherosclerosis and is positively correlated with atherosclerotic burden. However, the mechanism by which DPP4 expression is regulated in obesity remains unclear. In this study, we investigated the pathways regulating the expression of DPP4 on macrophages. METHODS: Flowsight® Imaging Flow Cytometry was employed for the detection of DPP4 and immunophenotyping...
February 6, 2019: EBioMedicine
Sinno H P Simons
No abstract text is available yet for this article.
February 6, 2019: EBioMedicine
Qiang Wen, Xinwei Jiao, Fei Kuang, Beibei Hou, Yajing Zhu, Wenyu Guo, Guangxin Sun, Yufeng Ba, Dandan Yu, David Wang, Faya Zhang, Hui Chao Qiao, Shuolin Wang, Shu Tang, Hailing Qiao
BACKGROUND: The resistance to EGF receptor (EGFR) tyrosine kinase inhibitors (TKI) is a major challenge in the treatment of non-small cell lung cancer (NSCLC). Understanding the molecular mechanisms behind resistance is therefore an important issue. Here we assessed the role of EGFR pathway substrate 8 (EPS8) and Forkhead box O 3a (FoxO3a) as potentially valuable targets in the resistance of NSCLC . METHODS: The expression levels of EPS8 and FoxO3a in patients with NSCLC (n = 75) were examined by immunohistochemistry staining, while in cells were detected by qPCR and western blot...
February 6, 2019: EBioMedicine
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