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Journal of Clinical & Translational Endocrinology

Lynnsay M Dickson, Eckhart J Buchmann, Charl Janse van Rensburg, Shane A Norris
Aims: We investigated the clinical and analytic accuracy of five plasma calibrated glucometers, the use of which is advocated by the World Health Organisation and the International Federation of Gynaecology and Obstetrics, to screen for and diagnose gestational diabetes mellitus (GDM) in low resource settings. Methods: 592 consecutive black African women underwent a 75 g oral glucose tolerance test (OGTT) at 24-28 weeks gestation at an urban South African community health clinic...
June 2019: Journal of Clinical & Translational Endocrinology
Tinashe Chikowore, Venesa Sahibdeen, Liesl M Hendry, Shane A Norris, Julia H Goedecke, Lisa K Micklesfield, Zané Lombard
Aim: To evaluate the association between loss-of-function (LOF) PCSK9 variants (A433T/rs28362263 and C679X/rs28362286) and biomarkers of cardiometabolic risk, specifically fasting glucose and low density lipoprotein cholesterol (LDL-C) concentrations. Methods: Our study comprised 757 male and female black South African adolescents (mean age 18.0 ± 0.5 years) who are part of the Birth to Twenty Plus Cohort and had been genotyped for the two above-mentioned variants...
June 2019: Journal of Clinical & Translational Endocrinology
Michella Ghassibe-Sabbagh, Zeina Mehanna, Layal Abi Farraj, Angelique K Salloum, Pierre A Zalloua
Aims: The Middle East has the fastest rising rate of Type 2 Diabetes Mellitus (T2DM) worldwide, with Lebanon having 15.8% of its population affected. This study aims at studying Polycystic Ovarian Syndrome (PCOS), Gestational Diabetes Mellitus (GDM), and macrosomia as risk factors of T2DM in Lebanon. Such epidemiological and statistical study has never been conducted before in the Middle East region and would be useful for clinical diagnosis. Methods: Our cohort is comprised of 1453 Lebanese individuals, with 897 controls and 556 patients...
June 2019: Journal of Clinical & Translational Endocrinology
Emmelien E M Schillern, Andreas Pasch, Martin Feelisch, Femke Waanders, Steven H Hendriks, Rik Mencke, Geert Harms, Klaas H Groenier, Henk J G Bilo, Jan-Luuk Hillebrands, Harry van Goor, Peter R van Dijk
Aims: Oxidative stress is a driver in the development of type 2 diabetes (T2DM) complications. As thiols (R-SH) are oxidized by reactive oxygen and sulfur species, circulating concentrations may directly reflect systemic redox status. We hypothesized that high serum R-SH concentrations are a reflection of a favourable redox status and may therefore positively associate with disease status. Methods: R-SH were measured in serum of 943 T2DM outpatients (55% males, 65 years and HbA1c of 6...
June 2019: Journal of Clinical & Translational Endocrinology
Ryan G Chiu, Yinglin Xia, Lisa K Sharp, Ben S Gerber
Community health workers (CHWs) can reduce emergent care among low-income, ethnic minority patients with type 2 diabetes. A secondary analysis of a randomized controlled trial evaluated the effect of CHWs on non-urgent, ambulatory healthcare utilization. Within this trial, no effect on ambulatory care was found.
June 2019: Journal of Clinical & Translational Endocrinology
Calogero Cipolla, Giuseppa Graceffa, Sergio Calamia, Eugenio Fiorentino, Gianni Pantuso, Salvatore Vieni, Mario Latteri
Purpose: Thyroidectomy is the preferred approach as the definitive treatment for Graves' disease. The outcomes for total thyroidectomy in a large series of 594 patients, who were observed in the last decade, will be presented in this study. Methods: The study concerned a retrospective review of 594 patients, undergoing a total thyroidectomy for Graves' disease. The incidence of complications and outcomes on hyperthyroidism and correlated symptoms resolution were also evaluated...
June 2019: Journal of Clinical & Translational Endocrinology
Yotsapon Thewjitcharoen, Siriwan Butadej, Soontaree Nakasatien, Phawinpon Chotwanvirat, Sriurai Porramatikul, Sirinate Krittiyawong, Nampetch Lekpittaya, Thep Himathongkam
Incidence and Malignancy Rates Classified by The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) - An 8-year Tertiary Center experience in Thailand. Background: Fine-needle aspiration (FNA) of the thyroid is considered the best diagnostic tool for preoperative evaluation of thyroid nodules. The introduction of T he B ethesda S ystem for R eporting T hyroid C ytopathology (TBSRTC) in 2010 provided the opportunity to establish worldwide standard for reporting and terminology guidelines for diagnostic categories...
June 2019: Journal of Clinical & Translational Endocrinology
Daniela Chinnici, Angela Middlehurst, Nikhil Tandon, Monika Arora, Anne Belton, Denise Reis Franco, Glaucia Margonari Bechara, Fernanda Castelo Branco, Tina Rawal, Radhika Shrivastav, Els Sung, Maeva Germe, David Chaney, David Cavan
Background: The International Diabetes Federation (IDF) launched the Kids and Diabetes in School (KiDS) project in collaboration with the International Society for Paediatric and Adolescent Diabetes (ISPAD) and Sanofi Diabetes to inform and teach school staff, children and parents on the management of diabetes in school. Brazil and India were chosen as pilot countries. Methods: The evaluation was conducted using a qualitative methodology using semi-structured face to face in-depth interviews...
March 2019: Journal of Clinical & Translational Endocrinology
Roberto Vita, Flavia Di Bari, Sarah Perelli, Giovanni Capodicasa, Salvatore Benvenga
Graves' disease is characterized by two sonographic features, hypoechogenicity and increased blood flow. The aim of this study was to review retrospectively ultrasound features and biochemical data of a cohort of untreated Graves' disease patients. We reviewed charts of 42 such patients, who were referred to our Endocrinology Unit from January 2013 to May 2018. One operator performed all the thyroid sonographic scans. Serum TSH, FT3, FT4 and TSH-receptor antibodies (TRAb) levels at the time of ultrasound examination were evaluated...
March 2019: Journal of Clinical & Translational Endocrinology
Juan José Gagliardino, Rosario Arechavaleta, Freddy Goldberg Eliaschewitz, Kristy Iglay, Kimberly Brodovicz, Claudio D Gonzalez, Shengsheng Yu, R Ravi Shankar, Olaf Heisel, Paul Keown, Kaan Tunceli
Objective: To assess oral antihyperglycemic agents (OAHA) and/or statin treatment initiation in patients with type 2 diabetes (T2D) and time from diagnosis to both types of treatment initiation and intensification. Research design and methods: We reviewed 662 retrospective medical records of patients with T2D diagnosed by 31 general practitioner or specialist sites across Mexico, Argentina, and Brazil. Demographic and clinical information was abstracted from patients' medical records and summarized using descriptive statistics...
March 2019: Journal of Clinical & Translational Endocrinology
Alana Biggers, Lisa K Sharp, Hataikarn Nimitphong, Sunee Saetung, Nantaporn Siwasaranond, Areesa Manodpitipong, Stephanie J Crowley, Megan M Hood, Ben S Gerber, Sirimon Reutrakul
Objective: We analyzed two cohorts of people with type 2 diabetes to evaluate the relationships between depression, sleep quality, and history of hypoglycemia. Research design and methods: Two adult cohorts from Chicago (n = 193) and Bangkok, Thailand (n = 282) with type 2 diabetes completed questionnaires to assess sleep quality, depressive symptoms, and hypoglycemia frequency. Proportional odds logistic regression models for each cohort adjusted for duration of therapy, insulin and sulfonylurea management, and other factors...
March 2019: Journal of Clinical & Translational Endocrinology
Fausto Fama', Roberto Vita, Alessandro Sindoni, Sergio Lucio Vinci, Grazia Giorgianni, Loredana Grasso, Maria Gioffre'-Florio, Salvatore Benvenga
One-hundred four persons aged ≥ 18 years (62 males and 42 females) who were admitted for traumatic brain injury (TBI) underwent brain computed tomography (CT) scan and assay of serum cortisol, insulin-like growth factor 1 (IGF-1), thyrotropin (TSH) and free thyroxine (FT4). The main purpose was to assess any gender difference and the rate of empty sella (ES). Women were more likely to have empty sella (19/42 [45.2%] vs 19/62 [30.6%], P = 0.15, OR = 1.9), which was more frequently total ES or TES (16/19 [84...
March 2019: Journal of Clinical & Translational Endocrinology
María M Adeva-Andany, Raquel Funcasta-Calderón, Carlos Fernández-Fernández, Elvira Castro-Quintela, Natalia Carneiro-Freire
Diabetes is a common metabolic disorder that involves glucose, amino acids, and fatty acids. Either insulin deficiency or insulin resistance may cause diabetes. Insulin deficiency causes type 1 diabetes and diabetes associated with total pancreatectomy. Glucagon produces insulin resistance. Glucagon-induced insulin resistance promotes type 2 diabetes and diabetes associated with glucagonoma. Further, glucagon-induced insulin resistance aggravates the metabolic consequences of the insulin-deficient state. A major metabolic effect of insulin is the accumulation of glucose as glycogen in the liver...
March 2019: Journal of Clinical & Translational Endocrinology
Norikazu Toi, Masaaki Inaba, Masafumi Kurajoh, Tomoaki Morioka, Noriyuki Hayashi, Tomoe Hirota, Daichi Miyaoka, Masanori Emoto, Shinsuke Yamada
Introduction: Acute and chronic insomnia can exacerbate type 2 diabetes mellitus (T2DM). We investigated suvorexant (an anti-insomnia drug that targets the orexin system) effects on sleep architecture and glucose metabolism in T2DM patients with insomnia. Materials and methods: This 7 day open-label, single-arm, intervention trial included 18 subjects with T2DM and insomnia. After 1 day acclimatization, daily glucose levels, sleep architecture, and autonomic nervous function were evaluated by continuous glucose monitoring (CGM), single-channel electroencephalography, and accelerometry, respectively...
March 2019: Journal of Clinical & Translational Endocrinology
Mohsen Eledrisi, Noor Nabeel Suleiman, Obada Salameh, Mohammad Khair Hamad, Omar Rabadi, Ahmed Mohamed, Rana Al Adawi, Abdul Salam
No abstract text is available yet for this article.
March 2019: Journal of Clinical & Translational Endocrinology
Hala Ibrahim El Gendy, Noha Adly Sadik, Mona Youssry Helmy, Laila Ahmed Rashed
Background: Vitamin D deficiency and vitamin D receptor (VDR) gene polymorphisms have been linked to type 2 diabetes mellitus (T2DM) and its metabolic parameters, however there are conflicting results therefore we aimed to evaluate VDR gene polymorphisms (Fok1, Bsm1 and Taq1) and vitamin D status in Egyptian patients with T2DM and to detect the associations of these polymorphisms to their metabolic parameters and glycemic control. Methods: 50 patients with T2DM and 50 healthy age matched control subjects were enrolled...
March 2019: Journal of Clinical & Translational Endocrinology
Rahul Peravali, Lucas Gunnels, Satyanarayana Alleboina, Ivan C Gerling, Ayotunde O Dokun
Peripheral Artery Disease (PAD) is a chronic, activity-limiting disease that is caused by atherosclerotic occlusion of blood vessels outside the heart. Type 1 Diabetes (T1D) not only increases an individual's likelihood of developing PAD, but also contributes to poor clinical outcomes after PAD manifestation. Although there is some evidence suggesting that hyperglycemia might alter expression of genes involved in regulating PAD severity or outcomes, our knowledge about the specific genes and pathways involved remains incomplete...
March 2019: Journal of Clinical & Translational Endocrinology
Salvatore Benvenga, Flavia Di Bari, Roberto Vita, Maria Le Donne, Onofrio Triolo, Roberta Granese, Irene Borrielli, Giuseppe Sole, Marco Floridia, Filippo Genovesi, Domitilla Tromba, Domenico Tromba
The prevalence of postpartum thyroiditis (PPT) averages 5%, with a range from 1% (Thailand) to 22% (Wales, UK, and Liguria, Italy), but 3.6% in another Italian region (Puglia). Evolution of PPT into permanent hypothyroidism (PH) occurs in approximately 50% of cases. Positive thyroperoxidase autoantibodies (TPOAb) in a pregnant woman is a strong predictor of PPT. Because in previous gestational cohorts we found an approximate 12% rate of TPOAb positivity, which compares with 15% in the Liguria cohort and 6% in the Puglia cohort, we hypothesized that the currently unknown prevalence of PPT in Sicily would approximate the said Liguria prevalence...
March 2019: Journal of Clinical & Translational Endocrinology
James Heath Pelham, Lynae Hanks, Stella Aslibekyan, Shima Dowla, Ambika P Ashraf
Aim: Significant knowledge gaps exist regarding lipoprotein profiles in children with type 2 diabetes mellitus (T2DM). The primary objective was to analyze the type and nature of lipoprotein abnormalities present in children with T2DM and to identify determinants of adverse lipoprotein profiles. The secondary objective was to assess associations with elevated glycated hemoglobin (HbA1C), i.e., <8% vs. ≥8.0% and pediatric dyslipidemias in the setting of T2DM. Methods: This retrospective chart review included children with T2DM who had undergone lipoprotein analysis and were not on lipid lowering medications (n = 93)...
March 2019: Journal of Clinical & Translational Endocrinology
Le Zhou, Gianlorenzo Dionigi, Alessandro Pontin, Antonella Pino, Ettore Caruso, Che-Wei Wu, Hui Sun, Ralph P Tufano, Hoon Yub Kim
We evaluate the role of intraoperative neuromonitoring (IONM) in thyroidectomy performed for Graves' disease (GD) with an emphasis on recurrent laryngeal nerve (RLN) management and completeness of resection. The study is a retrospective series comprising 55 thyroidectomy (control group) versus 82 procedures with intermittent IONM (I-IONM) and 72 by means of continuous IONM (C-IONM). In the control group the laryngeal nerves have been identified by visualization solely. In the I-IONM group both vagal nerve (VN) and RLN have been localized and monitored during thyroid resection...
March 2019: Journal of Clinical & Translational Endocrinology
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