journal
Journals Therapeutic Advances in Infect...

Therapeutic Advances in Infectious Disease

https://read.qxmd.com/read/38572299/prevalence-and-predictors-of-persistent-low-level-hiv-viraemia-a-retrospective-cohort-study-among-people-receiving-dolutegravir-based-antiretroviral-therapy-in-southern-nigeria
#1
JOURNAL ARTICLE
Ogheneuzuazo Onwah, Esther Nwanja, Uduak Akpan, Otoyo Toyo, Chiagozie Nwangeneh, Babatunde Oyawola, Augustine Idemudia, Kolawole Olatunbosun, Onyeka Igboelina, Dolapo Ogundehin, Ezekiel James, Okezie Onyedinachi, Adeoye Adegboye, Andy Eyo
BACKGROUND: Persistent low-level viraemia (PLLV) is a risk factor for virologic failure among people receiving antiretroviral therapy (ART). OBJECTIVES: We assessed the prevalence and predictors of PLLV among individuals receiving Dolutegravir-based ART in southern Nigeria. DESIGN: This retrospective cohort study used routine program data from electronic medical records of persons receiving Dolutegravir-based first-line ART in 154 PEPFAR/USAID-supported health facilities in Akwa Ibom and Cross Rivers states, Nigeria...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38559699/annexin-a2-antibodies-in-post-treatment-lyme-disease
#2
JOURNAL ARTICLE
John B Miller, Alison W Rebman, Marcia Daniela Villegas de Flores, Hong Wang, Erika Darrah, John N Aucott
BACKGROUND: Anti-annexin A2 (AA2) antibodies have been described in Lyme arthritis and erythema migrans, although they have not been described in post-treatment Lyme disease (PTLD). OBJECTIVES: Determine whether anti-AA2 antibodies are present among patients with PTLD and determine the clinical relevance of these antibodies. DESIGN AND METHODS: Anti-AA2 levels were tested serially in a longitudinal cohort of 44 patients with acute Lyme disease, 22 with a return to health (EM RTH), and 22 with PTLD...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38550914/vaccine-hesitancy-under-the-lens-nigeria-s-struggle-against-the-worst-diphtheria-outbreak-in-decades
#3
REVIEW
Bashar Haruna Gulumbe, Mohammed Bashar Danlami, Abbas Bazata Yusuf, Aminu Shehu, Obi Chidiebere
The resurgence of diphtheria in Nigeria, culminating in an outbreak surpassing previous records, has spotlighted the critical imperative for robust immunization policies amidst a milieu of vaccine hesitancy. This commentary delineates the multifaceted dimensions of the current diphtheria outbreak, which started in May 2022, juxtaposed against historical outbreaks, with a focal examination of the pervasive vaccine hesitancy and its underpinning sociocultural and systemic determinants. The discourse extends to a meticulous evaluation of Nigeria's public health response, underlined by the synergy with international organizations, reflecting a global collaborative ethos in combating the diphtheria menace...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38545451/nirmatrelvir-ritonavir-and-remdesivir-against-symptomatic-treatment-in-high-risk-covid-19-outpatients-to-prevent-hospitalization-or-death-during-the-omicron-era-a-propensity-score-matched-study
#4
JOURNAL ARTICLE
Sandra Rajme-López, Bernardo A Martinez-Guerra, Carla M Román-Montes, Karla M Tamez-Torres, Andrea C Tello-Mercado, Karen M Tepo-Ponce, Zurisadai Segura-Ortíz, Abigail López-Aguirre, Orianlid Del Rocío Gutiérrez-Mazariegos, Oswaldo Lazcano-Delgadillo, Rafael Nares-López, María F González-Lara, David Kershenobich-Stalnikowitz, José Sifuentes-Osornio, Alfredo Ponce-de-León, Guillermo M Ruíz-Palacios
BACKGROUND: Even though worldwide death rates from coronavirus disease 2019 (COVID-19) have decreased, the threat of disease progression and death for high-risk groups continues. Few direct comparisons between the available severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antivirals have been made. OBJECTIVE: We aimed to compare two SARS-CoV-2 antivirals (nirmatrelvir/ritonavir and remdesivir) against all-cause hospitalization or death. DESIGN: This is a propensity score-matched cohort study...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38545450/ibrutinib-associated-cutaneous-mucormycosis-due-to-an-apophysomyces-species-report-of-a-case-and-review-of-the-literature
#5
Trung Minh Nguyen, Eva Amenta, Lynne Chapman, Sarvari Yellapragada, Bhuvaneswari Krishnan, Jonathan Lim, Richard J Hamill
The use of ibrutinib, a Bruton tyrosine kinase inhibitor, has been associated with invasive fungal infections (IFIs). We describe a case of Apophysomyces infection associated with long-term use of ibrutinib for the treatment of chronic lymphocytic leukemia as well as perform a literature review of Mucormycosis infections in patients on ibrutinib. Our review found that the onset of IFI can occur within months to years of starting tyrosine kinase inhibitors. These reports provide a more complete picture of the risk of IFI while patients are on ibrutinib...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38545449/invasive-fungal-infections-in-patients-with-multiple-myeloma-a-possible-growing-problem-in-hematology-and-infectious-diseases
#6
REVIEW
Toni Valkovic, Lucija Marcelic, Frane Valkovic
Multiple myeloma is among the most common hematological malignancies and is characterized by a strong susceptibility to infections primarily bacterial and viral and, to a much lesser extent, fungal. There appears to be a slightly increasing frequency of invasive fungal infections. This is attributed to the use of different combinations of newer drugs and patients' exposure to increasing therapeutic lines, and thus to risk factors for invasive fungal infections, especially severe and long-term neutropenia. Novel immunotherapy modalities including bispecific antibodies and chimeric antigen receptor T-cell therapy are being introduced for the treatment of relapsing-refractory forms of the disease...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38510990/fournier-s-gangrene-a-review-of-predictive-scoring-systems-and-practical-guide-for-patient-management
#7
REVIEW
Daniel Bowen, Thomas Hughes, Patrick Juliebø-Jones, Bhaskar Somani
This article aims to provide a practical guide for patient management and an overview of the predictive scorings for Fournier's gangrene (FG) that are available to aid clinicians. A literature was performed reviewing currently used scoring systems for FG and presenting a practical guide for its management based on the available evidence. There are four specific scoring systems available for the assessment of FG although few other non-specific and generic tools also exist. These specific tools include Laboratory Risk Indicator for Necrotizing Fasciitis, Fournier's Gangrene Severity Index, Uludag Fournier's Gangrene Severity Index, and Simplified Fournier's Gangrene Severity Index and help calculate expected mortality...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38476737/short-term-versus-usual-term-antibiotic-treatment-for-uncomplicated-staphylococcus-aureus-bacteremia-a-systematic-review-and-meta-analysis
#8
REVIEW
Santiago Grillo Perez, Candida Diaz-Brochero, Javier Ricardo Garzon Herazo, Oscar Mauricio Muñoz Velandia
INTRODUCTION: Uncomplicated Staphylococcus aureus bacteremia remains a leading cause of morbidity and mortality in hospitalized patients. Current guidelines recommend a minimum of 14 days of treatment. OBJECTIVE: To evaluate the efficacy and safety of short versus usual antibiotic therapy in adults with uncomplicated S . aureus bacteremia (SAB). METHODS: We developed a search strategy to identify systematic review and meta-analysis of non-randomized studies (NRS), comparing short versus usual or long antibiotic regimens for uncomplicated SAB in MEDLINE, Embase, and the Cochrane Register up to June 2023...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38476736/infective-endocarditis-due-to-citrobacter-koseri-following-testicular-trauma-case-report-and-literature-review
#9
Julian Orlando Casallas-Barrera, Claudia Marcela Poveda-Henao, Karen Andrea Mantilla-Viviescas, Edwin Silva-Monsalve
Infective endocarditis (IE) is a condition with low prevalence but high mortality rates within intensive care units. Microbiologically, most cases are attributed to Gram-positive cocci, while Gram-negative bacilli are less commonly involved. This case report describes a patient with IE caused by Citrobacter koseri (C. koseri) with secondary bacteremia due to blunt testicular trauma and epididymitis. We conducted a review of the literature to assess the clinical and associated risk factors of this underreported condition...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38434592/corrigendum-to-gram-negative-bacteria-related-urinary-tract-infections-spectrum-of-antimicrobial-resistance-over-9-years-in-a-university-tertiary-referral-hospital
#10
(no author information available yet)
[This corrects the article DOI: 10.1177/20499361241228342.].
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38434591/implementing-health-worker-training-on-sepsis-in-south-eastern-nigeria-using-innovative-digital-strategies-an-interventional-study
#11
JOURNAL ARTICLE
Akaninyene Otu, Obiageli Onwusaka, Daniel E Otokpa, Ukam Edadi, Ubong Udoh, Peter Yougha, Chinelo Oduche, Okey Okuzu, Shevin T Jacob, Jamie Rylance, Emmanuel Effa
BACKGROUND: Sepsis is a leading cause of morbidity and mortality especially in low- and middle-income countries such as Nigeria. Training of health workers using digital platforms may improve knowledge and lead to better patient outcomes. OBJECTIVES: To assess the effectiveness of a digital health educational module on sepsis in improving the knowledge of medical doctors in Cross River State Nigeria on the diagnosis and management of patients presenting with sepsis...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38410828/acute-kidney-injury-should-not-be-neglected-optimization-of-quick-pitt-bacteremia-score-for-predicting-mortality-in-critically-ill-patients-with-bloodstream-infection-a-retrospective-cohort-study
#12
JOURNAL ARTICLE
Jiaqi Cai, Ming Yang, Han Deng, Hao Bai, Guanhao Zheng, Juan He
BACKGROUND: Considering the therapeutic difficulties and mortality associated with bloodstream infection (BSI), it is essential to investigate other potential factors affecting mortality in critically ill patients with BSI and examine the utility of the quick Pitt bacteremia (qPitt) score to improve the survival rate. OBJECTIVES: To improve the predictive accuracy of the qPitt scoring system by evaluating the five current components of qPitt and including other potential factors influencing mortality in critically ill patients with BSI...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38404751/evaluation-of-the-diagnostic-utility-of-metagenomic-next-generation-sequencing-testing-for-pathogen-identification-in-infected-hosts-a-retrospective-cohort-study
#13
JOURNAL ARTICLE
Austin Williams, William Zach Webster, Chao Cai, Alexander Milgrom, Majdi Al-Hasan, P Brandon Bookstaver
BACKGROUND: Metagenomic next-generation sequencing (mNGS) testing identifies thousands of potential pathogens in a single blood test, though data on its real-world diagnostic utility are lacking. OBJECTIVES: Determine the diagnostic utility of mNGS testing in practice and factors associated with high clinical utility. DESIGN: Retrospective cohort study of mNGS tests ordered from June 2018 through May 2020 at a community teaching hospital. METHODS: Tests were included if ordered for diagnostic purposes in patients with probable or high clinical suspicion of infection...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38380160/preference-for-long-acting-injectable-for-art-and-prep-among-people-with-and-without-hiv-a-cross-sectional-study-in-argentina
#14
JOURNAL ARTICLE
Sergio Sciannameo, Virginia Zalazar, Luciana Spadaccini, Mariana Duarte, Pedro Cahn, Ines Aristegui, Omar Sued
BACKGROUND: Little is known about the preferences for antiretroviral therapy (ART) administration methods, such as oral daily pills or long-acting injectable (LAI) options, as well as preferences for pre-exposure prophylaxis (PrEP) administration methods among people without HIV in Latin America. OBJECTIVES: This study aimed to assess the preferences for ART administration methods among people with HIV and PrEP methods among those without HIV, as well as to examine the correlations and reasons for these preferences...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38361916/-aspergillus-granulosus-femoral-osteomyelitis-in-a-cardiac-transplant-patient-first-reported-case-and-literature-review
#15
Alessandro Giacinta, Zorba Blázquez, Paloma García Clemente, Álvaro Pedraz, Pilar Escribano, Jesús Guinea, Patricia Muñoz, Maricela Valerio
Aspergillus osteomyelitis is a rare complication of extrapulmonary invasive aspergillosis, which usually presents as spondylodiscitis. The clinical picture is usually paucisymptomatic and of long evolution, which leads to diagnostic difficulties, especially in immunosuppressed patients presenting a delayed systemic host response. We report a case of femoral osteomyelitis caused by Aspergillus granulosus in a heart transplant recipient successfully treated with a combined surgical and antifungal approach. A 65-year-old heart transplant male presented with left knee pain lasting 3 months...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38361915/covid-19-associated-with-cryptococcosis-a-scoping-review
#16
JOURNAL ARTICLE
Alvaro Quincho-Lopez, Nuvith Poma, Juan José Montenegro-Idrogo
BACKGROUND: There is growing evidence of fungal infections associated with COVID-19. The development of cryptococcosis in these patients has been infrequently reported. However, it can be life-threatening. OBJECTIVE: To identify cases of COVID-19 patients who developed cryptococcosis and to compare baseline characteristics and management between those who survived and those who died. METHODS: We conducted a scoping review using PubMed, Scopus, Web of Science, and Embase to identify studies that reported patients with COVID-19 and cryptococcosis...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38333229/cerebrospinal-fluid-shunting-for-the-management-of-cryptococcal-meningitis-a-scoping-review
#17
JOURNAL ARTICLE
Gonzalo Cornejo-Venegas, Xosse Carreras, Andrea S Salcedo, David R Soriano-Moreno, Jorge L Salinas, Jorge Alave
OBJECTIVE: This scoping review aimed to describe studies that evaluate the management of cryptococcal meningitis (CM) using cerebrospinal fluid (CSF) shunts, types of shunts used, and clinically relevant patient outcomes. METHODS: We searched in the following databases: PubMed, Web of Science/Core collection, Embase, the Cochrane Library, and clinicaltrials.gov on 1 April 2022. We included two-arm and one-arm cohort studies that evaluated clinically relevant patient outcomes...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38333228/isolated-cryptococcal-osteomyelitis-in-the-setting-of-immune-reconstitution-inflammatory-syndrome
#18
Pamela Horton Embrey, Alexandra Long, Rasha Alfattal, Suimin Qiu, Joseph Patrik Hornak
Cryptococcal infections, though rare, must be considered in all immunocompromised patients. Patients with HIV/AIDS on antiretrovirals may have a treatment course complicated by immune reconstitution inflammatory syndrome. Here we present a case of a 38-year-old woman with HIV/AIDS with knee pain who only began to experience severe pain after induction of antiretroviral therapy. She was found to have cryptococcal osteomyelitis without dissemination to the central nervous system, an unusual presentation for immunocompromised patients...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38328511/re-estimation-of-the-burden-of-serious-fungal-diseases-in-uganda
#19
JOURNAL ARTICLE
Felix Bongomin, Richard Kwizera, Martha Namusobya, Norman van Rhijn, Irene Andia-Biraro, Bruce J Kirenga, David B Meya, David W Denning
BACKGROUND: It is of utmost importance to monitor any change in the epidemiology of fungal diseases that may arise from a change in the number of the at-risk population or the availability of local data. OBJECTIVE: We sought to update the 2015 publication on the incidence and prevalence of serious fungal diseases in Uganda. METHODS: Using the Leading International Fungal Education methodology, we reviewed published data on fungal diseases and drivers of fungal diseases in Uganda...
2024: Therapeutic Advances in Infectious Disease
https://read.qxmd.com/read/38312850/imported-congenital-malaria-caused-by-plasmodium-ovale-a-case-report
#20
Laura K Erdman, Andrea K Boggild, Ari Bitnun
We describe a 5-week-old term infant with Plasmodium ovale severe congenital malaria in a non-endemic setting. She presented with diarrhea, poor feeding, lethargy, hepatosplenomegaly, and severe anemia. She was fortuitously diagnosed with malaria on routine blood smear, and successfully treated with intravenous artesunate. Subsequent history revealed maternal malaria diagnosis and treatment during pregnancy in Nigeria. This case underscores the importance of obtaining maternal exposure history and considering malaria testing in pregnant women and infants with unexplained illness...
2024: Therapeutic Advances in Infectious Disease
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