Mingwei Guo, Fei Shen, Xiaozhen Guo, Jun Zhang, Ying Ma, Xia Wu, Hui Zuo, Jing Yao, Yepeng Hu, Dongmei Wang, Yu Li, Jin Li, Jin Qiu, Jian Yu, Meiyao Meng, Ying Zheng, Xin Chen, Mingkai Gong, Kailin Liu, Ling Jin, Xiangyu Ren, Qiang Zhang, Yu Zhao, Xuejiang Gu, Feixia Shen, Dali Li, Liangcai Gao, Chang Liu, Fei Zhou, Mian Li, Jiqiu Wang, Shuzhe Ding, Xinran Ma, Jian Lu, Cen Xie, Junjie Xiao, Lingyan Xu
BACKGROUND: Resistance exercise leads to improved muscle function and metabolic homeostasis. Yet how circadian rhythm impacts exercise outcomes and its molecular transduction remains elusive. METHODS: Human volunteers were subjected to 4 weeks of resistance training protocols at different times of day to assess training outcomes and their associations with myokine irisin. Based on rhythmicity of Fibronectin type III domain containing 5 (FNDC5/irisin), we trained wild type and FNDC5 knockout mice at late active phase (high FNDC5/irisin level) or late rest phase (low FNDC5/irisin level) to analyze exercise benefits on muscle function and metabolic homeostasis...
August 24, 2024: Journal of Sport and Health Science