journal
https://read.qxmd.com/read/37771504/snasp-mutation-aggravates-to-the-tlr4-mediated-inflammation-in-sle-by-tak1-pathway
#41
JOURNAL ARTICLE
Yatao Bao, Meng Lian, Yong Chen, Xiaotian Gu, Kunyu Cao, Xiaoping Du, Jiyu Ju
Genetic factors play an important role in the pathogenesis of systemic lupus erythematosus (SLE), and abnormal Toll-like receptor (TLR) signaling pathways are closely related to the onset of SLE. In previous studies, we found that the mutant somatic nuclear autoantigenic sperm protein (sNASP) gene in the mouse lupus susceptibility locus Sle2 can promote the development of lupus model mice, but the mechanism is still unclear. Here, we stimulated mouse peritoneal macrophages with different concentrations of lipopolysaccharide...
2023: Journal of Immunology Research
https://read.qxmd.com/read/37767202/super-enhancer-regulatory-gene-fyb1-promotes-the-progression-of-t-cell-acute-lymphoblastic-leukemia-by-activating-igll1
#42
JOURNAL ARTICLE
Kunlong Zhang, Jun Lu, Fang Fang, Yongping Zhang, Juanjuan Yu, Yanfang Tao, Wenyuan Liu, Lihui Lu, Zimu Zhang, Xinran Chu, Jianwei Wang, Xiaolu Li, Yuanyuan Tian, Zhiheng Li, Qian Li, Xu Sang, Li Ma, Ningling Wang, Jian Pan, Shaoyan Hu
BACKGROUND: Arising from T progenitor cells, T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic malignant tumor, accounting for 15% of childhood ALL and 25% of adult ALL. Composing of putative enhancers in close genomic proximity, super enhancer (SE) is critical for cell identity and the pathogenesis of multiple cancers. Belonging to the cytosolute linker protein group, FYB1 is essential for TCR signaling and extensively studied in terms of tumor pathogenesis and metastasis...
2023: Journal of Immunology Research
https://read.qxmd.com/read/37745203/dupilumab-s-impact-on-blood-parameters-in-nasal-polyposis-18-month-follow-up-in-real-life
#43
JOURNAL ARTICLE
Antonella Loperfido, Andrea Ciofalo, Carlo Cavaliere, Elona Begvarfaj, Francesca Cascone, Giacomo Alfonzo, Rosalba Cadeddu, Stefano Millarelli, Gianluca Bellocchi, Antonio Greco, Marco de Vincentiis, Simonetta Masieri
BACKGROUND: Dupilumab represents the first approved biological for severe uncontrolled chronic rhinosinusitis with nasal polyps (CRSwNP). OBJECTIVE: Aim of this paper is to provide a multicentric real-life study about treatment with dupilumab for CRSwNP with a special focus on blood parameters and IgE, IgG, and IgA. METHOD: A retrospective data collection was jointly conducted at the Otolaryngology departments of San Camillo Forlanini Hospital and University of Rome "La Sapienza" from December 2020 to January 2023...
2023: Journal of Immunology Research
https://read.qxmd.com/read/37719086/evaluation-of-cd47-in-the-suppressive-tumor-microenvironment-and-immunotherapy-in-prostate-cancer
#44
JOURNAL ARTICLE
Qianqian Wang, Chunxaing Feng, Yuchun Chen, Tianming Peng, Yong Li, Kunlin Wu, Xiaoyong Pu, Hanzhong Chen, Jiumin Liu
BACKGROUND: CD47 has high levels of expression in malignant cancer cells, which binds to SIRP- α to release the "don't eat me" signal and prevents mononuclear macrophages from phagocytosing the cells. Resistance to drugs and metastases are potential barriers for prostate cancer endocrine therapy. Although immunotherapy for tumors has developed rapidly in the last few decades, its effectiveness in treating prostate cancer is unsatisfactory. Prostate cancer has a high-expression level of CD47...
2023: Journal of Immunology Research
https://read.qxmd.com/read/37692838/endoplasmic-reticulum-stress-in-systemic-lupus-erythematosus-and-lupus-nephritis-potential-therapeutic-target
#45
REVIEW
Hui-Yuan Li, Li-Feng Huang, Xiao-Rong Huang, Dan Wu, Xiao-Cui Chen, Ji-Xin Tang, Ning An, Hua-Feng Liu, Chen Yang
Systemic lupus erythematosus (SLE) is a complex autoimmune disease. Approximately one-third to two-thirds of the patients with SLE progress to lupus nephritis (LN). The pathogenesis of SLE and LN has not yet been fully elucidated, and effective treatment for both conditions is lacking. The endoplasmic reticulum (ER) is the largest intracellular organelle and is a site of protein synthesis, lipid metabolism, and calcium storage. Under stress, the function of ER is disrupted, and the accumulation of unfolded or misfolded proteins occurs in ER, resulting in an ER stress (ERS) response...
2023: Journal of Immunology Research
https://read.qxmd.com/read/37692837/effect-of-differently-polarized-human-macrophages-on-the-sh-sy5y-cells-damaged-by-ischemia-and-hypoxia-in-vitro
#46
JOURNAL ARTICLE
Ivan Mikhailovich Rashchupkin, Ekaterina Yakovlevna Shevela, Aleksandra Aleksandrovna Maksimova, Marina Aleksandrovna Tikhonova, Aleksandr Anatolevich Ostanin, Elena Removna Chernykh
Macrophages are the major cells of innate immunity with a wide range of biological effects due to their great plasticity and heterogeneity. Macrophages play a key role in neuroregeneration following nervous tissue injury. However, the neuroregenerative potential of various macrophage phenotypes, including those polarized by efferocytosis, remains unexplored. The aim of this study was to compare the neuroregenerative and neuroprotective activity of soluble factors secreted by variously activated human macrophages on the functions of neural progenitors in an in vitro model of ischemia or ischemia/hypoxia...
2023: Journal of Immunology Research
https://read.qxmd.com/read/37663051/sesamin-protects-against-apap-induced-acute-liver-injury-by-inhibiting-oxidative-stress-and-inflammatory-response-via-deactivation-of-hmgb1-tlr4-nf-%C3%AE%C2%BA-b-signal-in-mice
#47
JOURNAL ARTICLE
Hui Du, Shiwen Tong, Ge Kuang, Xia Gong, Ningman Jiang, Xian Yang, Hao Liu, Nana Li, Yao Xie, Yang Xiang, Jiashi Guo, Zhenhan Li, Yinglin Yuan, Shengwang Wu, Jingyuan Wan
Acetaminophen (APAP) overdose would lead to liver toxicity and even acute liver failure in severe cases by triggering an inflammatory response and oxidative stress. Sesamin has been reported to possess anti-inflammatory and antioxidant actions in several animal disease models. In the present study, the effects and mechanisms of sesamin on APAP-induced acute liver injury (ALI) were explored. The results showed that pretreatment with sesamin significantly alleviated APAP-induced ALI, as indicated by decreased serum aminotransferase activities, hepatic pathological damages, and hepatic cellular apoptosis...
2023: Journal of Immunology Research
https://read.qxmd.com/read/37663050/physiological-changes-in-the-levels-of-anti-cytokine-autoantibodies-in-early-pregnancy-are-missing-in-pregnant-women-with-hashimoto-s-thyroiditis
#48
JOURNAL ARTICLE
Szabina Erdő-Bonyár, Diána Simon, Anna Bajnok, Jasper Nörenberg, Tímea Serény-Litvai, Ákos Várnagy, Kálmán Kovács, Eszter Hantosi, Emese Mezősi, Tímea Berki
T helper type 1 (Th1) and inflammatory cytokines play essential roles in early pregnancy and also in the pathogenesis of Hashimoto's thyroiditis (HT). Changes in the serum level of autoantibodies to cytokines, which may be able to modulate their availability and actions have been described in several autoimmune disorders. Yet, no data are available on anti-cytokine autoantibodies either during early pregnancy or in patients with HT. The aim of the study was to measure autoantibodies to inflammatory-, Th1- and Th22-cytokines in serum samples in healthy pregnancy (HP) and in pregnant women with HT (HTP)...
2023: Journal of Immunology Research
https://read.qxmd.com/read/37649897/the-important-role-of-interleukin-2-in-covid-19
#49
REVIEW
Leila Ghanbari Naeini, Laleh Abbasi, Farzaneh Karimi, Pajman Kokabian, Fahimeh Abdi Abyaneh, Delaram Naderi
There is controversial literature about the effects of the interleukin-2 (IL-2) cytokine family in COVID-19 pathogenesis and immunity. So we aimed to identify the potential in the role of the IL-2 family in COVID-19. A narrative review search was done through online databases, including PubMed, Scopus, and Web of Science. The search deadline was up to December 2022. We applied no time limits for the searching strategy. After retrieving articles from the databases, the authors summarized the data into two data extraction tables...
2023: Journal of Immunology Research
https://read.qxmd.com/read/37636861/periventricular-microglia-polarization-and-morphological-changes-accompany-nlrp3-inflammasome-mediated-neuroinflammation-after-hypoxic-ischemic-white-matter-damage-in-premature-rats
#50
JOURNAL ARTICLE
Liu Yang, Yajun Zhang, Xuefei Yu, Danni Li, Na Liu, Xindong Xue, Jianhua Fu
White matter damage (WMD) is a primary cause of cerebral palsy and cognitive impairment in preterm infants, and no effective treatments are available. Microglia are a major component of the innate immune system. When activated, they form typical pro-inflammatory (M1) and anti-inflammatory (M2) phenotypes and regulate myelin development and synapse formation. Therefore, they may play a pivotal role in hypoxic-ischemic (HI) WMD. Herein, we investigated neural inflammation and long-term microglia phenotypic polarization in a neonatal rat model of hypoxia-ischemia-induced WMD and elucidated the underlying pathophysiological processes...
2023: Journal of Immunology Research
https://read.qxmd.com/read/37621926/retracted-comparison-of-outcomes-between-two-surgical-techniques-for-patients-with-intestinal-neuronal-dysplasia
#51
Journal Of Immunology Research
[This retracts the article DOI: 10.1155/2022/9165651.].
2023: Journal of Immunology Research
https://read.qxmd.com/read/37621925/retracted-relationship-between-platelet-to-lymphocyte-ratio-and-lymphocyte-to-monocyte-ratio-with-spontaneous-preterm-birth-a-systematic-review-and-meta-analysis
#52
Journal Of Immunology Research
[This retracts the article DOI: 10.1155/2023/6841344.].
2023: Journal of Immunology Research
https://read.qxmd.com/read/37621924/the-immunomodulatory-activity-of-punica-granatum-l-peel-extract-increases-the-lifespan-of-mice-with-lethal-sepsis
#53
JOURNAL ARTICLE
Liana de O Trovão, Liliane Dos S Rodrigues, Priscila M Mendes, Patrícia C S Alves, Aluísio da S Oliveira, Jefferson M Brito, André A M Vale, Dimitrius V de O Garbis, Gisele Simão, Ana Paula S A Dos Santos, Paulo V S Pereira, Lucilene A Silva, Andresa A Berretta, Flávia R F Nascimento, Rosane N M Guerra, Valério Monteiro-Neto, Elizabeth S Fernandes, Márcia C G Maciel
Sepsis is an organ dysfunction syndrome associated with high mortality. To date, no effective treatment is available to combat this disease. Punica granatum L. is a potential alternative treatment due to its anti-inflammatory, antimicrobial, and antioxidant properties. Thus, this study aimed to evaluate the effects of a hydroalcoholic crude extract from the peels of P. granatum (HCEPg) in mice with lethal sepsis. Lethal polymicrobial sepsis was induced in female Swiss mice via cecal ligation and puncture (CLP)...
2023: Journal of Immunology Research
https://read.qxmd.com/read/37621923/retracted-ameliorative-impact-of-liraglutide-on-chronic-intermittent-hypoxia-induced-atrial-remodeling
#54
Journal Of Immunology Research
[This retracts the article DOI: 10.1155/2022/8181474.].
2023: Journal of Immunology Research
https://read.qxmd.com/read/37621922/retracted-mutational-screening-of-skeletal-genes-in-14-chinese-children-with-osteogenesis-imperfecta-using-targeted-sequencing
#55
Journal Of Immunology Research
[This retracts the article DOI: 10.1155/2022/5068523.].
2023: Journal of Immunology Research
https://read.qxmd.com/read/37600067/analyzation-of-the-peripheral-blood-mononuclear-cells-atlas-and-cell-communication-of-rheumatoid-arthritis-patients-based-on-single-cell-rna-seq
#56
JOURNAL ARTICLE
Xinqiang Song, Yu Zhang, Lijun Zhao, Jinke Fan, Tao Peng, Ying Ma, Nailiang Guo, Xiaotong Wang, Xudong Liu, Zhe Liu, Lei Wang
BACKGROUND: Rheumatoid arthritis (RA) is a common chronic inflammatory autoimmune disease with a multifactorial etiology. Peripheral blood is the main channel of the immune system, and peripheral blood mononuclear cells (PBMCs) are the immune cells that initiate the autoimmune inflammatory process. However, there are few reports on the mechanisms of peripheral blood immunity in RA. METHODS: ScRNA-seq was performed on four RA samples and integrated with single-cell transcriptome data from four healthy control samples downloaded from publicly available databases for analysis...
2023: Journal of Immunology Research
https://read.qxmd.com/read/37600066/il-17-balancing-protective-immunity-and-pathogenesis
#57
REVIEW
Lu Sun, Lufei Wang, Bethany B Moore, Shaoping Zhang, Peng Xiao, Ann M Decker, Hom-Lay Wang
The biological role of interleukin 17 (IL-17) has been explored during recent decades and identified as a pivotal player in coordinating innate and adaptive immune responses. Notably, IL-17 functions as a double-edged sword with both destructive and protective immunological roles. While substantial progress has implicated unrestrained IL-17 in a variety of infectious diseases or autoimmune conditions, IL-17 plays an important role in protecting the host against pathogens and maintaining physiological homeostasis...
2023: Journal of Immunology Research
https://read.qxmd.com/read/37592925/novel-predictive-scoring-system-for-intravenous-immunoglobulin-resistance-helps-timely-intervention-in-kawasaki-disease-the-chinese-experience
#58
JOURNAL ARTICLE
Yan Wang, Shuoyin Huang, Panpan Wang, Yan Wu, Yingying Liu, Yuting Pan, Jinyuan Dong, Zhidan Fan, Haiguo Yu
BACKGROUND: Approximately 10%-20% of patients with Kawasaki disease (KD) are nonresponsive to intravenous immunoglobulin (IVIG) treatment, placing them at higher risk of developing coronary heart lesions. Early detection of nonresponsiveness is crucial to curtail this risk; however, the applicability of existing predictive scoring systems is limited to the Japanese population. Our study aimed to identify a predictive scoring system for IVIG resistance in KD specific to the Chinese population...
2023: Journal of Immunology Research
https://read.qxmd.com/read/37577033/insights-regarding-the-role-of-inflammasomes-in-leukemia-what-do-we-know
#59
REVIEW
Fabíola Silva Alves-Hanna, Juniel Assis Crespo-Neto, Glenda Menezes Nogueira, Daniele Sá Pereira, Amanda Barros Lima, Thaís Lohana Pereira Ribeiro, Vitória Giovanna Rodrigues Santos, Joey Ramone Ferreira Fonseca, Fábio Magalhães-Gama, Aya Sadahiro, Allyson Guimarães Costa
Inflammation is a physiological mechanism of the immune response and has an important role in maintaining the hematopoietic cell niche in the bone marrow. During this process, the participation of molecules produced by innate immunity cells in response to a variety of pathogen-associated molecular patterns and damage-associated molecular patterns is observed. However, chronic inflammation is intrinsically associated with leukemogenesis, as it induces DNA damage in hematopoietic stem cells and contributes to the creation of the preleukemic clone...
2023: Journal of Immunology Research
https://read.qxmd.com/read/37545544/early-life-exposure-to-human-milk-oligosaccharides-reduces-allergic-response-in-a-murine-asthma-model
#60
JOURNAL ARTICLE
Tahereh Bozorgmehr, Rozlyn C T Boutin, Sarah E Woodward, Katherine Donald, Jo May Chow, Rachael H Buck, B Brett Finlay
BACKGROUND: Studies suggest that early-life gut microbiota composition and intestinal short-chain fatty acids (SCFAs) are linked to future asthma susceptibility. Furthermore, infancy offers a critical time window to modulate the microbiota and associated metabolites through diet-microbe interactions to promote infant health. Human milk oligosaccharides (HMOs), nondigestible carbohydrates abundant in breast milk, are prebiotics selectively metabolized by gut microbiota that consequently modify microbiome composition and SCFA production...
2023: Journal of Immunology Research
journal
journal
48345
3
4
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.