Aaron Wetten, Laura Ogle, George Mells, Vinod S Hegade, Laura Jopson, Margaret Corrigan, Jeremy Palmer, Maja Johansson, Torbjörn Bäckström, Magnus Doverskog, David E J Jones, Jessica K Dyson
BACKGROUND AND AIMS: A third of patients with primary biliary cholangitis (PBC) experience poorly understood cognitive symptoms, with a significant impact on quality of life (QOL), and no effective medical treatment. Allopregnanolone, a neurosteroid, is a positive allosteric modulator of gamma-aminobutyricacid-A (GABA-A) receptors, associated with disordered mood, cognition, and memory. This study explored associations between allopregnanolone and a disease-specific QOL scoring system (PBC-40) in PBC patients...
2022: Canadian Journal of Gastroenterology & Hepatology