journal
Journals Canadian Journal of Gastroente...

Canadian Journal of Gastroenterology & Hepatology

https://read.qxmd.com/read/38550348/clinical-outcomes-of-ileostomy-closure-during-versus-after-adjuvant-chemotherapy-in-patients-with-rectal-cancer
#1
JOURNAL ARTICLE
Fan He, Fuyu Yang, Chenglin Tang, Defei Chen, Dongqin Zhao, Junjie Xiong, Yu Zou, Guoquan Huang, Kun Qian
BACKGROUND: Protective ileostomy can effectively prevent severe anastomotic leakage after rectal cancer surgery; however, the optimal timing for ileostomy closure during adjuvant chemotherapy remains unclear. This study aimed to explore the safety and long-term outcomes of early ileostomy closure during adjuvant chemotherapy. METHOD: Patients who underwent laparoscopic rectal cancer surgery combined with protective ileostomy and adjuvant chemotherapy between April 2017 and April 2021 were retrospectively evaluated...
2024: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38529202/a-meta-analysis-of-mirna-497-and-prognosis-of-hepatocellular-carcinoma
#2
REVIEW
Zhiqiang Xie, Qingzhi Hao, Rongrong Zhu, Ruiping Ma
BACKGROUND: Recently, microRNA-497 (miR-497) has been reported as a prognostic marker for hepatocellular carcinoma (HCC). However, there is no systematic study summarizing these data. Herein, we elucidated the prognostic role of miR497 in HCC by using meta-analysis. METHODS: We systematically searched Embase, PubMed, Web of Science, and, China National Knowledge Infrastructure for relevant studies. The two researchers conducted data extraction and quality evaluation independently...
2024: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38529201/the-role-of-inflammatory-biomarkers-in-mediating-the-effect-of-inflammatory-bowel-disease-on-nonmalignant-digestive-system-diseases-a-multivariable-mendelian-randomized-study
#3
JOURNAL ARTICLE
Shu Zhou, Qi Sun, Ning Gao, Zekai Hu, Junjun Jia, Jiangwei Song, Guocong Xu, Aiqiang Dong, Weiliang Xia, Jiafeng Wu
BACKGROUND: While observation studies have shown a positive correlation between inflammatory bowel disease (IBD) and the risk of nonmalignant digestive system diseases, a definitive causal relationship has not yet been clearly established. METHODS: Mendelian randomization (MR) was employed to investigate the potential causal association between genetic susceptibility to IBD and nonmalignant gastrointestinal diseases. Genetic variants were extracted as instrumental variables (IVs) from a genome-wide association study (GWAS) meta-analysis, which included 12,194 cases of Crohn's disease (CD) and 28,072 control cases of European ancestry...
2024: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38487594/hepatitis-c-virus-infection-and-hospital-related-outcomes-a-systematic-review
#4
REVIEW
Michelle Ng, Patrizia Maria Carrieri, Lindila Awendila, Maria Eugenia Socías, Rod Knight, Lianping Ti
BACKGROUND: People living with hepatitis C infection (HCV) have a significant impact on the global healthcare system, with high rates of inpatient service use. Direct-acting antivirals (DAAs) have the potential to alleviate this burden; however, the evidence on the impact of HCV infection and hospital outcomes is undetermined. This systematic review aims to assess this research gap, including how DAAs may modify the relationship between HCV infection and hospital-related outcomes. METHODS: We searched five databases up to August 2022 to identify relevant studies evaluating the impact of HCV infection on hospital-related outcomes...
2024: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38434933/hepatitis-c-attributable-healthcare-costs-and-mortality-among-immigrants-a-population-based-matched-cohort-study
#5
JOURNAL ARTICLE
Aysegul Erman, Yeva Sahakyan, Karl Everett, Christina Greenaway, Naveed Janjua, Jeffrey C Kwong, William W L Wong, Hong Lu, Beate Sander
BACKGROUND: Data on the economic burden of chronic hepatitis C (CHC) among immigrants are limited. Our objective was to estimate the CHC-attributable mortality and healthcare costs among immigrants in Ontario, Canada. METHODS: We conducted a population-based matched cohort study among immigrants diagnosed with CHC between May 31, 2003, and December 31, 2018, using linked health administrative data. Immigrants with CHC (exposed) were matched 1 : 1 to immigrants without CHC (unexposed) using a combination of hard (index date, sex, and age) and propensity-score matching...
2024: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38234411/prevalence-of-esophageal-eosinophilia-eosinophilic-esophagitis-and-lymphocytic-gastritis-in-children-with-celiac-disease-a-saudi-tertiary-center-experience
#6
JOURNAL ARTICLE
Meshari A Alaifan, Ammar Khayat, Rana Y Bokhary, Abdulhameed Ibrahim, Yagoub Bin-Taleb, Bakr H Alhussaini, Omar I Saadah
BACKGROUND: Celiac disease (CD) is an immune-mediated enteropathy that has been associated with other immune-related gastrointestinal disorders, such as eosinophilic esophagitis (EoE) and lymphocytic gastritis (LG). To our knowledge, this is the first study in Saudi Arabia that has described such an association. AIM: To evaluate the prevalence of EoE and LG in children and adolescents with CD. METHODS: This was a retrospective cross-sectional study of all pediatric patients (aged 0-18 years) with CD following up at King Abdulaziz University Hospital, between January, 2014, and December, 2021...
2024: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38187112/ghrelin-ghsr-axis-induced-m2-macrophage-and-alleviated-intestinal-barrier-dysfunction-in-a-sepsis-rat-model-by-inactivating-e2f1-nf-%C3%AE%C2%BA-b-signaling
#7
JOURNAL ARTICLE
Lei Zhu, Zhimin Dou, Wei Wu, Qiliang Hou, Sen Wang, Ziqian Yuan, Bin Li, Jian Liu
Sepsis is an inflammatory reaction disorder state that is induced by infection. The activation and regulation of the immune system play an essential role in the development of sepsis. Our previous studies have shown that ghrelin ameliorates intestinal dysfunction in sepsis. Very little is known about the mechanism of ghrelin and its receptor (GHSR) on the intestinal barrier and the immune function of macrophage regulation. Our research is to investigate the regulatory effect and molecular mechanism of the ghrelin/GHSR axis on intestinal dysfunction and macrophage polarization in septic rats...
2023: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38021269/combined-age-with-mean-decrease-rates-of-total-bilirubin-and-meld-score-as-a-novel-and-simple-clinical-predictor-on-90-day-transplant-free-mortality-in-adult-patients-with-acute-liver-failure-undergoing-plasma-exchange-a-single-center-retrospective-study
#8
JOURNAL ARTICLE
Di Jin, Kai Kang, Bing-Zhu Yan, Jian-Nan Zhang, Jun-Bo Zheng, Zhi-Hui Wang, Di Wu, Yu-Jia Tang, Xin-Tong Wang, Qi-Qi Lai, Yang Cao, Hong-Liang Wang, Yang Gao
BACKGROUND: Acute liver failure (ALF), previously known as fulminant hepatic failure, has become a common, rapidly progressive, and life-threatening catastrophic hepatic disease in intensive care unit (ICU) due to the continuous increase in drug abuse, viral infection, metabolic insult, and auto-immune cause. At present, plasma exchange (PE) is the main effective alternative treatment for ALF in ICU clinical practice, and high-volume plasma exchange (HVP) has been listed as a grade I recommendation for ALF management in the American Society for Apheresis (ASFA) guidelines...
2023: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/38021268/prevalence-of-hepatitis-b-and-hepatitis-c-viral-infections-and-their-associated-factors-among-diabetic-patients-visiting-debre-tabor-referral-hospital-northwest-ethiopia-2021-a-cross-sectional-study
#9
JOURNAL ARTICLE
Debaka Belete, Dessie Kassaw, Tesfaye Andualem
BACKGROUND: Viral hepatitis is a global public health problem that affects millions of people each year, causing disability and death. Hepatitis B and C viruses are the most common causes of viral hepatitis and are associated with chronic liver disease, cirrhosis, and hepatocellular carcinoma. The primary site of infection for these viruses is the liver, the primary site of hormone and glucose metabolism closely linked to diabetes mellitus (DM), which is associated with increased morbidity and mortality worldwide...
2023: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37954860/a2ml1-inhibits-esophageal-squamous-cell-carcinoma-progression-and-serves-as-a-novel-prognostic-biomarker
#10
JOURNAL ARTICLE
Xiaoyun Zhang, Chaogui Tang, Jianchun Lian, Yuzhang Jiang
Studies have established a correlation between α 2-macroglobulin-like 1 (A2ML1) and the prognosis of lung, pancreatic, and breast cancers; however, research on its involvement in the pathogenesis of esophageal carcinoma remains limited. Therefore, in this study, we aimed to investigate the role of A2ML1 in the progression of esophageal squamous cell carcinoma (ESCC). Immunohistochemical staining was employed to assess the expression level of A2ML1 protein in both tumor and adjacent normal tissues of patients with ESCC...
2023: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37766807/-mir-325-3p-reduces-proliferation-and-promotes-apoptosis-of-gastric-cancer-cells-by-inhibiting-human-antigen-r
#11
JOURNAL ARTICLE
Zhengwei Huang, Yacan Luo, Congcong Chen, Chaoyang Zhou, Zhengkang Su, Chang Cai, Xi Li, Wenzhi Wu
Human antigen R (HuR), also known as ELAVL1, is a widely expressed RNA-binding protein (RBP) that has a significant impact on the development and advancement of tumors. Our previous study found that 5-fluorouracil (5-FU) may impede the proliferation and increase apoptosis in gastric cancer cells by reducing the nucleocytoplasmic shuttling of HuR. However, how posttranscriptional regulation influences HuR functions in gastric cancer remains to be elucidated. Here, we demonstrated that miR-325-3p has the potential to regulate the expression level of HuR by directly binding to its 3'UTR, which in turn led to a significant reduction in proliferation and an increase in apoptosis in gastric cancer cells...
2023: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37719132/the-potential-dual-role-of-h2-0-like-homeobox-in-the-tumorgenesis-and-development-of-colorectal-cancer-and-its-prognostic-value
#12
JOURNAL ARTICLE
Shuo Chen, Lin Zhang, Kai Wang, Jizhen Huo, Siqi Zhang, Xipeng Zhang
BACKGROUND: H2.0-like homeobox ( HLX ) is highly expressed in several hematopoietic malignancies. However, the role of HLX in the carcinogenesis and progression of colorectal cancer (CRC) patients has rarely been reported. METHODS: In this study, the data were collected from The Cancer Genome Atlas and Gene Expression Omnibus databases. The diagnostic value of HLX was analyzed by the R package "pROC." The overall survival was estimated using the "survival" and "survminer" packages...
2023: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37588664/gambogic-acid-inhibits-gastric-cancer-cell-proliferation-through-necroptosis
#13
JOURNAL ARTICLE
Shujun Wang, Yiping Wang, Hui Zhu, Miaohui Chen, Liang Zhang
Gambogic acid (GA) is a natural xanthonoid secreted by Garcinia hanburyi tree. It possesses anti-cancer activity in various types of cancers. In gastric cancer, it inhibits cell proliferation through increasing apoptosis. However, whether necroptosis is involved in the GA-induced proliferation inhibited in gastric cancer is unknown. In the present study, we found that RIPK1 specific inhibitor necrostatin-1 (Nec-1) attenuated GA-induced proliferation inhibition. GA treatment increased the phosphorylation of necroptosis-related proteins, RIPK1, RIPK3, and MLKL, and their interactions to form the necrosome complex...
2023: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37485072/platelet-to-monocyte-ratio-as-a-novel-promising-agent-for-the-prognosis-of-hepatitis-b-virus-associated-decompensated-cirrhosis
#14
JOURNAL ARTICLE
Jun Zhou, Xin Li, Min Wang, Chunrong Gu, Jingping Liu
AIM: The present study aimed at investigating associations of the platelet-to-monocyte ratio (PMR), a novel hematological indicator of inflammatory responses with 30-day outcomes in patients with HBV-associated decompensated cirrhosis (HBV-DeCi). METHODS: We recruited 329 patients with HBV-DeCi for this retrospective study and extracted baseline clinical data and laboratory characteristics from medical records. Univariate and multivariate analyses were performed to determine major factors influencing 30-day mortality...
2023: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37469934/plasma-s100a8-and-s100a9-are-strong-prognostic-factors-for-hepatitis-b-virus-related-acute-on-chronic-liver-failure
#15
JOURNAL ARTICLE
Yao Zhang, Xueyun Zhang, Jiajia Han, Yifei Guo, Jingjing He, Feifei Yang, Richeng Mao, Yuxian Huang, Jiming Zhang
OBJECTIVES: The rapidly evolving organ failure and high short-run mortality of acute-on-chronic liver failure (ACLF) are inseparable from the role of systemic inflammatory response. S100A8 and S100A9 are associated with the excessive cytokine storm and play a decisive part within the process of inflammation. We aimed to clarify the role of them in predicting prognosis of hepatitis B virus-related ACLF (HBV-ACLF). METHODS: S100A8 and S100A9 levels were analyzed in plasma of 187 transplant-free HBV-ACLF patients, 28 healthy controls and 40 chronic hepatitis B (CHB) patients...
2023: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37396501/diabetes-and-metabolic-disorders-their-impact-on-cardiovascular-events-in-liver-transplant-patients
#16
JOURNAL ARTICLE
Simone Di Cola, Giulia Cusi, Lucia Lapenna, Jakub Gazda, Stefano Fonte, Marco Mattana, Gianluca Mennini, Patrizio Pasqualetti, Manuela Merli
Cardiovascular diseases are currently one of the most important causes of morbidity and mortality in liver transplant patients over the long term. Therefore, evaluating prognostic factors for cardiovascular events (CVEs) in this population is essential for taking preventive measures. The aim of this study was to identify the impact of diabetes and other metabolic disorders on CVEs in liver transplant patients. Three hundred fifty-six liver transplant recipients who survived at least 6 months after surgery were enrolled...
2023: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37265583/prediction-of-liver-steatosis-and-fibrosis-based-on-clinical-variables-using-a-large-national-survey-database
#17
JOURNAL ARTICLE
Yanal Alnimer, Touleen Alnimer
BACKGROUND: Vibration-controlled transient elastography (VCTA) and controlled attenuation parameter (CAP) are used more frequently to diagnose liver fibrosis and steatosis among nonalcoholic fatty liver disease patients. However, limited robust data are available on the clinical variables strongly related to these disorders and who needs to be referred for screening. METHODS: We used the National Health and Nutritional Examination Survey 2017-2018 database to identify the clinical predictors strongly related to liver steatosis and advanced fibrosis...
2023: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37153689/efficacy-and-safety-of-drug-eluting-bead-tace-in-the-treatment-of-primary-or-secondary-liver-cancer
#18
JOURNAL ARTICLE
Jiabing Wang, Haoqian Xu, Ying Wang, Long Feng, Fengming Yi
BACKGROUND: The drug-eluting beads transarterial chemoembolization (DEB-TACE) has already been used in hepatic malignancies. We aim to evaluate the efficacy and safety of DEB-TACE in treating primary or secondary liver cancer. METHODS: We retrospectively evaluated 59 patients with hepatic malignancies, including 41 patients with primary liver cancer and 18 patients with secondary liver cancer, between September 2016 and February 2019. All patients were treated with DEB-TACE...
2023: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37090103/comparison-of-68-ga-ga-dota-fapi-04-and-18-f-fdg-pet-mri-in-the-preoperative-diagnosis-of-gastric-cancer
#19
JOURNAL ARTICLE
Tao Du, Shun Zhang, Xi-Mao Cui, Ren-Hao Hu, Hai-Yan Wang, Jian-Juan Jiang, Jun Zhao, Lan Zhong, Xiao-Hua Jiang
PURPOSE: Our objective was to compare the value of positron emission tomography/magnetic resonance imaging (PET/MRI) with the new imaging agent [68 Ga]Ga-DOTA-FAPI-04 and the traditional imaging agent [18 F]FDG for the preoperative diagnosis of gastric cancer. METHODS: Forty patients with gastric cancer diagnosed by gastroscopy in gastrointestinal surgery at our hospital from June 2020 to January 2021 were analyzed. All patients underwent simultaneous [68 Ga]Ga-DOTA-FAPI-04 and [18 F]FDG PET/MRI...
2023: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/37090102/effect-of-covid-19-pandemic-related-delays-in-chemoembolization-on-the-survival-of-patients-with-hepatocellular-carcinoma
#20
JOURNAL ARTICLE
Kittipitch Bannangkoon, Keerati Hongsakul, Teeravut Tubtawee, Phurich Janjindamai
BACKGROUND AND AIMS: COVID-19 has led to potential delays in liver cancer treatment, which may have undesirable effects on the prognosis of patients. We aimed to quantify the COVID-19 pandemic impact on the survival of patients with hepatocellular carcinoma (HCC) who underwent transarterial chemoembolization (TACE). METHODS: A retrospective study was conducted in patients with HCC who underwent TACE at a tertiary care center during the prelockdown (March to July 2019) and lockdown (March to July 2020) periods...
2023: Canadian Journal of Gastroenterology & Hepatology
journal
journal
48326
1
2
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read
×

Save your favorite articles in one place with a free QxMD account.

×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"

We want to hear from doctors like you!

Take a second to answer a survey question.