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Canadian Journal of Gastroenterology & Hepatology

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https://read.qxmd.com/read/30775356/hcv-eradication-with-direct-acting-antivirals-does-not-impact-hcc-progression-on-the-waiting-list-or-hcc-recurrence-after-liver-transplantation
#1
Juliet A Emamaullee, Mariusz Bral, Glenda Meeberg, Aldo J Montano-Loza, Vincent G Bain, Kelly Warren Burak, David Bigam, A M James Shapiro, Norman Kneteman
Background: The introduction of direct-acting antivirals (DAA) for HCV has led to high rates of HCV eradication. Treatment of patients awaiting liver transplantation (LT) has been controversial. Recent data suggests that DAA treatment may accelerate recurrent HCC. The impact of DAA on delisting for HCC progression or recurrent HCC post-LT has not been well characterized. Methods: A retrospective review of both waitlist patients and LT recipients at a single institution was performed...
2019: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30733935/prophylactic-therapy-of-silymarin-milk-thistle-on-antituberculosis-drug-induced-liver-injury-a-meta-analysis-of-randomized-controlled-trials
#2
REVIEW
Lina Tao, Xiaoyu Qu, Yue Zhang, Yanqing Song, Si-Xi Zhang
Background: Prophylactic therapy with silymarin to prevent the development of antituberculosis drug-induced liver injury (anti-TB DILI) has been under debate. We aimed to evaluate the effect of silymarin in the prevention of anti-TB DILI. Methods: We searched MEDLINE, PubMed, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) up to 30th November 2018. Randomized controlled trials (RCTs) that compared silymarin and placebo to prevent anti-TB DILI were included...
2019: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30729100/investigation-of-the-local-recurrence-rate-after-colorectal-endoscopic-mucosal-resection-is-incomplete-polyp-resection-really-a-clinically-important-problem-analysis-of-the-rationale-for-the-resect-and-discard-strategy
#3
Jun Arimoto, Takuma Higurashi, Hideyuki Chiba, Noboru Misawa, Tsutomu Yoshihara, Takayuki Kato, Kenji Kanoshima, Akiko Fuyuki, Hidenori Ohkubo, Takashi Nonaka, Takamitsu Sato, Eiji Sakai, Hiroshi Iida, Tohru Goto, Atsushi Nakajima
Background/Aims: The "Resect and Discard" strategy is a potentially useful strategy. At present, only the lesion size and accuracy of diagnosis are cited as considerations for clinical adoption of this strategy. On the other hand, histopathology of the resected specimens after Endoscopic Mucosal Resection (EMR) reveals often an unclear or positive-margin status, implying Incomplete Polyp Resection (IPR). If IPR indeed increased the risk of local recurrence, histopathological evaluation of the margin would be indispensable and clinical adoption of this strategy is difficult...
2019: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30729099/achieving-complete-remission-of-hepatocellular-carcinoma-a-significant-predictor-for-recurrence-free-survival-after-liver-transplantation
#4
Christin Bürger, Miriam Maschmeier, Anna Hüsing-Kabar, Christian Wilms, Michael Köhler, Martina Schmidt, Hartmut H Schmidt, Iyad Kabar
Background: Liver transplantation (LT) is a curative treatment for hepatocellular carcinoma (HCC) and the underlying primary liver disease; however, tumor recurrence is still a major issue. Therefore, the aim of this study was to assess predictors and risk factors for HCC recurrence after LT in patients within and outside the Milan criteria with a special focus on the impact of different bridging strategies. Methods: All patients who underwent LT for HCC between 07/2002 and 09/2016 at the University Hospital of Muenster were consecutively included in this retrospective study...
2019: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30719429/liver-and-spleen-stiffness-measurements-for-assessment-of-portal-hypertension-severity-in-patients-with-budd-chiari-syndrome
#5
Elton Dajti, Federico Ravaioli, Antonio Colecchia, Giovanni Marasco, Amanda Vestito, Davide Festi
Aims: Budd-Chiari Syndrome (BCS) is a rare vascular disease of the liver caused by the obstruction of the hepatic venous outflow located from the small hepatic venules up to the entrance of the inferior vena cava (IVC) into the right atrium. Current prognostic indexes are suboptimal for an individual prognostic assessment and subsequent management of patients with BCS. Liver (LSM) and spleen (SSM) stiffness measurements are widely validated prognostic tools in hepatology, but the evidence in patients with BCS is limited...
2019: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30713836/comment-on-48-week-outcome-after-cessation-of-nucleos-t-ide-analogue-treatment-in-chronic-hepatitis-b-patient-and-the-associated-factors-with-relapse
#6
COMMENT
Yafei Guo, Lingan Wang
No abstract text is available yet for this article.
2019: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30675469/high-seroprevalence-of-autoantibodies-typical-of-autoimmune-liver-disease-in-eastern-ethiopia-is-chewing-of-khat-catha-edulis-a-triggering-factor
#7
Stian Magnus Staurung Orlien, Tekabe Abdosh Ahmed, Nejib Yusuf Ismael, Nega Berhe, Trine Lauritzen, Svein Gunnar Gundersen, Asgeir Johannessen
Background: Recent studies have identified chewing of khat ( Catha edulis ) as an independent risk factor for liver injury; however, the pathogenetic mechanism remains poorly understood. Case series have found markers of autoimmune hepatitis in patients with khat-related liver disease, suggesting that khat chewing might trigger an autoimmune response. The aims of the present study were (i) to assess the prevalence of autoantibodies typical for autoimmune liver diseases in a healthy population in Ethiopia and (ii) to explore the hypothesis that khat usage triggers autoimmunity...
2018: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30662889/aicar-induced-ampk-activation-inhibits-the-noncanonical-nf-%C3%AE%C2%BAb-pathway-to-attenuate-liver-injury-and-fibrosis-in-bdl-rats
#8
Haoyang Zhu, Yichao Chai, Dinghui Dong, Nana Zhang, Wenyan Liu, Tao Ma, Rongqian Wu, Yi Lv, Liangshuo Hu
Background: To evaluate the AMP-activated protein kinase- (AMPK-) mediated signaling and NF- κ B-related inflammatory pathways that contribute to cholestatic diseases in the bile duct ligation (BDL) rat model of chronic cholestasis and verify the protective role of 5-Aminoimidazole-4-carboxamide1- β -D-ribofuranoside (AICAR) against hepatic injury and fibrosis triggered by cholestasis-related inflammation. Methods: Animals were randomly divided into three groups: sham-operated group, BDL group, and BDL+ AICAR group...
2018: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30643761/usefulness-of-a-cannula-with-a-flexible-tip-swing-tip-for-managing-severe-biliary-stricture
#9
Daisuke Uchida, Hironari Kato, Yosuke Saragai, Saimon Takada, Shinichiro Muro, Takeshi Tomoda, Kazuyuki Matsumoto, Shigeru Horiguchi, Hiroyuki Okada
Background and Aims: Biliary stenting for the treatment of biliary stricture is the most common indication of ERCP, but the procedure is sometimes unsuccessful because of severe strictures. The Swing Tip is useful for passing through severe strictures because it has a manually operable tip. The efficacy of using a Swing Tip was retrospectively evaluated. Methods: The 2353 patients who underwent ERCP for biliary stenting at our facility between January 2012 and July 2018 were enrolled...
2018: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30643760/comment-on-prevalence-of-anxiety-and-depression-in-patients-with-inflammatory-bowel-disease
#10
COMMENT
Wenwen Lai, Shaohang Cai
No abstract text is available yet for this article.
2018: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30631760/changes-of-the-fatty-acid-profile-in-erythrocyte-membranes-of-patients-following-6-month-dietary-intervention-aimed-at-the-regression-of-nonalcoholic-fatty-liver-disease-nafld
#11
Dominika Maciejewska, Wojciech Marlicz, Karina Ryterska, Marcin Banaszczak, Dominika Jamioł-Milc, Ewa Stachowska
Background: Nonalcoholic fatty liver disease (NAFLD) is closely related to the metabolism disorders of fatty acids. The pathogenesis of the disease includes an increased concentration of FFA in blood, an increase in the biosynthesis of fatty acids, and disorders in the process of β -oxidation. Objective: The aim of the study was to analyze the fatty acids in erythrocyte membranes among 55 patients with NAFLD who were subjected to a 6-month dietary intervention in order to reduce fatty liver...
2018: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30631759/fecal-elastase-levels-predict-honeycombing-in-pancreas-detected-with-endoscopic-ultrasound
#12
Sinan Akay, Burcu Şirin, Belkıs Ünsal
Background and Study Aims: We aimed to demonstrate the association between fecal elastase levels and Rosemont categories in patients with chronic changes in pancreas detected with endoscopic ultrasound. Patients and Methods: Patients were selected consecutively from endosonography examinations performed for upper gastrointestinal subepithelial lesions and for pancreas evaluation. Pancreas imaging findings were categorized according to the Rosemont criteria using echoendoscope...
2018: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30631758/entamoeba-histolytica-updates-in-clinical-manifestation-pathogenesis-and-vaccine-development
#13
REVIEW
Micaella Kantor, Anarella Abrantes, Andrea Estevez, Alan Schiller, Jose Torrent, Jose Gascon, Robert Hernandez, Christopher Ochner
Entamoeba histolytica is the responsible parasite of amoebiasis and remains one of the top three parasitic causes of mortality worldwide. With increased travel and emigration to developed countries, infection is becoming more common in nonendemic areas. Although the majority of individuals infected with E. histolytica remain asymptomatic, some present with amoebic colitis and disseminated disease. As more is learned about its pathogenesis and the host's immune response, the potential for developing a vaccine holds promise...
2018: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30631757/the-natural-history-of-incidental-colonic-diverticulosis-on-screening-colonoscopy
#14
Ala I Sharara, Nathalie Ziade, Rani H Shayto, Luma Basma O Rustom, Hamed Chehab, Hussein H Rimmani, Krystelle Hanna, Jean M Chalhoub, Fayez S Sarkis, Mahmoud A Rahal, Assaad Soweid, Fadi H Mourad, Kassem Barada, Ali H Harb
Background: The natural history of colonic diverticulosis is unclear. Methods: Patients with incidental diverticulosis identified in a previous prospective cross-sectional screening colonoscopy study were evaluated retrospectively for clinic or hospital visit(s) for diverticular disease (DD= acute diverticulitis or diverticular bleeding) using review of electronic health records and patient phone interview. Results: 826 patients were included in the screening colonoscopy study...
2018: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30631756/effect-of-admission-time-on-the-outcomes-of-liver-cirrhosis-with-acute-upper-gastrointestinal-bleeding-regular-hours-versus-off-hours-admission
#15
Yingying Li, Bing Han, Hongyu Li, Tingxue Song, Wenchun Bao, Ran Wang, Zhaohui Bai, Kexin Zheng, Qianqian Li, Xiaozhong Guo, Xingshun Qi
Background and Aims: Acute upper gastrointestinal bleeding (AUGIB) is a lethal complication of liver cirrhosis. We aimed to compare the outcomes of patients with liver cirrhosis and AUGIB who were admitted to hospital on regular hours and off-hours. Methods: This retrospective study screened all cirrhotic patients with AUGIB who were admitted to our hospital from January 2010 to June 2014 for the test cohort and from December 2014 to March 2018 for the validation cohort...
2018: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30538973/sofosbuvir-based-therapies-for-patients-with-hepatitis-c-virus-infection-real-world-experience-in-china
#16
Chengguang Hu, Guosheng Yuan, Junwei Liu, Huaping Huang, Yanyu Ren, Yinping Li, Xuefu Chen, Wei Li, Tao Wu, Hong Deng, Yanzhong Peng, Yong-Yuan Zhang, Yuanping Zhou
Background and Aims: There is scarcity of data in literature regarding the treatment response to sofosbuvir- (SOF-) based therapies in Chinese patients with chronic Hepatitis C Virus (HCV) infection. The aim of this study was to evaluate the efficacy and safety of SOF-based regimens for chronic hepatitis C (CHC) patients without cirrhosis in a real-world setting in mainland China. Methods: A total of 226 patients receiving SOF plus daclatasvir (DCV), ledipasvir (LDV), or velpatasvir (VEL) were enrolled from December 2014 to June 2017...
2018: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30533404/the-dynamic-roles-of-mesenchymal-stem-cells-in-colon-cancer
#17
REVIEW
Shan Wang, Zhiguo Miao, Qiyuan Yang, Yimin Wang, Jinzhou Zhang
Colon cancer is still one of the most common causes of cancer in human and is characterized by lymphocyte infiltrates and originates from the epithelial cells found in the lining of colon or rectum of the gastrointestinal tract. Mesenchymal stem cells (MSCs) are composed of the multipotent stem cell group of stroma and can be differentiated as various cell lineages, such as fibroblasts, osteoblasts, and adipocytes. MSCs provide mechanical and structural support and have potential functions during tumor growth and metastasis...
2018: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30533403/model-for-end-stage-liver-disease-and-sodium-velocity-predicts-overall-survival-in-nonmetastatic-hepatocellular-carcinoma-patients
#18
Justin Y Tang, Nitin Ohri, Rafi Kabarriti, Santiago Aparo, Jennifer Chuy, Sanjay Goel, Jonathan M Schwartz, Milan Kinkhabwala, Andreas Kaubisch, Chandan Guha
Background & Aims: The significance of short-term changes in model for end-stage liver disease and Sodium (MELD-Na) following hepatocellular carcinoma (HCC) diagnosis is unknown. In this report, we explore the value of the rate of short-term changes in MELD-Na as an independent predictor of mortality in patients with nonmetastatic HCC. Methods: We reviewed a cohort of patients diagnosed with nonmetastatic HCC at our institution between 2001 and 2011. We evaluated potential predictors of overall survival, including baseline MELD-Na and the change in MELD-Na over 90 days...
2018: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30519549/metastatic-colorectal-cancer-in-the-era-of-personalized-medicine-a-more-tailored-approach-to-systemic-therapy
#19
REVIEW
Irene S Yu, Winson Y Cheung
Colorectal cancer is the second most common malignancy diagnosed in Canada. Despite declining incidence and mortality rates in recent years, there is still a significant number of cases that are metastatic at presentation. Fluoropyrimidine-based chemotherapy was the backbone of colorectal cancer treatment, but the addition of irinotecan and oxaliplatin to form combination regimens has significantly improved overall survival. In the past decade, the development of novel biologic agents including therapies directed against vascular endothelial growth factor and epidermal growth factor receptor has further altered the landscape of metastatic colorectal cancer treatment...
2018: Canadian Journal of Gastroenterology & Hepatology
https://read.qxmd.com/read/30519548/chronic-viral-hepatitis-and-metabolic-syndrome-cardiovascular-risk
#20
EDITORIAL
Peter Jarcuska, Ahmed Abdel-Razik, Robert Flisiak, Ram B Singh
No abstract text is available yet for this article.
2018: Canadian Journal of Gastroenterology & Hepatology
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