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Journal of Traditional and Complementary Medicine

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https://read.qxmd.com/read/30671369/mechanism-inhibition-kinetics-of-bioassay-guided-fractions-of-indian-medicinal-plants-and-foods-as-ace-inhibitors
#1
Mohammad Yaseen Khan, Vimal Kumar
Hypertension is a becoming a major threat to the world. Angiotensin converting enzyme (ACE) is a key part in the renin angiotensin aldosterone system (RAAS) which control blood pressure. Over expression of RAAS is related with vascular hypertension, ACE inhibition has turned into a noteworthy target for controlling hypertension. In the search of lead molecules from plant origin as a substitute for toxic synthetic drugs, 25 Indian medicinal plants and foods were screened for their ACE inhibitory activity. IC50 (50% inhibition of ACE) values of hydroalcoholic crude extracts and fraction were determined by a colorimetric method...
January 2019: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30671368/anti-melanogenic-effect-of-croton-roxburghii-and-croton-sublyratus-leaves-in-%C3%AE-msh-stimulated-b16f10-cells
#2
Moragot Chatatikun, Takeshi Yamauchi, Kenshi Yamasaki, Setsuya Aiba, Anchalee Chiabchalard
Croton roxburghii and Croton sublyratus have been used as skin treatments in traditional medicine. The objective of the present study was to investigate the antimelanogenic effect of ethanol extracts of Croton roxburghii (CRE) and Croton sublyratus (CSE) leaves on cellular melanin content and cellular tyrosinase activity as mediated by the action of microthalmia transcription factor (MITF) and melanogenic enzymes. Croton roxburghii and Croton sublyratus leaves were extracted by petroleum ether, dichloromethane and absolute ethanol, sequentially...
January 2019: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30671367/anti-anaphylactic-and-antiasthmatic-activity-of-euphorbia-thymifolia-l-on-experimental-animals
#3
Ghanshyam Parmar, Kilambi Pundarikakshudu, R Balaraman
In Ayurveda, Euphorbia thymifolia L. (Euphorbiaceae) prescribed in the treatment of various ailments like bronchial asthma, cough, diarrhea and bleeding piles. The present study was investigated to evaluate antianaphylactic, mast cell stabilizing and antiasthmatic activity of methanol and aqueous extract of E. thymifolia (ET) on experimental animals. Anaphylaxis was induced by administration of horse serum and triple antigen vaccine intraperitoneal (i.p.) in albino Wistar rats. Extracts of ET were administered to the rats in dose of 250 and 500 mg/kg orally for 14 days...
January 2019: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30671366/efficacy-of-topical-application-of-standardized-extract-of-tragopogon-graminifolius-in-the-healing-process-of-experimental-burn-wounds
#4
Mohammad Heidari, Roodabeh Bahramsoltani, Amir Hossein Abdolghaffari, Roja Rahimi, Mohammadamin Esfandyari, Maryam Baeeri, Gholamreza Hassanzadeh, Mohammad Abdollahi, Mohammad Hosein Farzaei
Tragopogon graminifolius DC. is a perennial plant from the family Asteraceae which grows in West parts of Iran. Several biological activities like antimicrobial, antioxidant and anti-inflammatory effects are reported for the plant. The aim of this study was to assess the wound healing activity of standardized extract from T. graminifolius (TG) aerial parts. Topical standardized TG extract with 5% and 10% concentrations in eucerine base was assessed for its healing properties on second degree burn in rats during a 14-day period...
January 2019: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30671365/antifibrotic-effects-of-gallic-acid-on-hepatic-stellate-cells-in-vitro-and-in-vivo-mechanistic-study
#5
Naglaa M El-Lakkany, Walaa H El-Maadawy, Sayed H Seif El-Din, Samira Saleh, Marwa M Safar, Shahira M Ezzat, Salwa H Mohamed, Sanaa S Botros, Zeinab Demerdash, Olfat A Hammam
Few studies reported the antifibrotic effects of gallic acid (GA) despite its known hepatoprotective and antioxidant activities. Accordingly, this study investigated the antifibrotic effects of GA through clarifying its mechanisms on hepatic stellate cells' (HSCs) activation, proliferation and/or apoptosis. In vitro effects of GA on HSC-T6 activation/proliferation, morphology and safety on hepatocytes were assessed. In vivo , hepatic fibrosis was induced via chronic thioacetamide (TAA)-intoxication. TAA-intoxicated rats were treated with silyamrin or GA...
January 2019: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30671364/differential-response-of-antioxidant-defense-in-hepg2-cells-on-exposure-of-livotrit-%C3%A2-in-a-concentration-dependent-manner
#6
S A Malik, S Khole, S P K Mittal, T Urmode, R Kusurkar, S S Ghaskadbi
Livotrit® , a polyherbal formulation (Zandu, India) is commonly prescribed for liver health. The present study was undertaken to elucidate possible mechanism of antioxidant potential of Livotrit® . Livotrit® exhibited concentration dependent radical scavenging activity, inhibition of lipid peroxidation as well as activation and gene expression of antioxidant enzymes. Interestingly, lower concentration of Livotrit® (0.05%) significantly increased activities and gene expression of catalase, Glutathione reductase (GR) and Gluthathione peroxidase (GPx), while higher concentration of Livotrit® (0...
January 2019: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30671363/evaluation-of-anti-urolithiatic-potential-of-ethyl-acetate-extract-of-pedalium-murex-l-on-struvite-crystal-kidney-stone
#7
B Kaleeswaran, S Ramadevi, R Murugesan, S Srigopalram, T Suman, T Balasubramanian
Pedalium murex (L.) is a traditional herb, commonly used for the treatment of kidney stone related problems. Struvite stone can swiftly grow and become 'staghorn calculi' in kidney and its associated areas, which is the most aching urological disorder. The present study investigated the anti-urolithiasis activities of ethyl acetate extract of P. murex L. (EAEP) against struvite crystal. The antibacterial activity of EAEP examined against several urease producing bacteria. It showed the minimum bactericidal concentration (MBC) against Escherichia coli and Staphylococcus aureus (>125)...
January 2019: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30671362/-ginkgo-biloba-flavonoid-glycosides-in-antimicrobial-perspective-with-reference-to-extraction-method
#8
Priyanka Sati, Praveen Dhyani, Indra Dutt Bhatt, Anita Pandey
The present study aims to investigate the effect of extraction method on the recovery of flavonoid glycosides, antimicrobials and antioxidants from Ginkgo leaves collected from six different locations in Uttarakhand, Indian Himalaya. Four extraction methods, namely maceration, reflux, shaker and soxhlet were considered, where reflux extracts showed higher antimicrobial antioxidant activity and higher content of flavonoid glycosides. The reference standards of Ginkgo flavonoid glycosides (quercetin, kaempferol and isorhamnetin) and crude extracts were tested for their antimicrobial activity against gram positive and gram negative bacteria and fungi following disc diffusion method and minimum inhibitory concentration (MIC)...
January 2019: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30671361/-in-vitro-anti-inflammatory-and-skin-protective-properties-of-virgin-coconut-oil
#9
Sandeep R Varma, Thiyagarajan O Sivaprakasam, Ilavarasu Arumugam, N Dilip, M Raghuraman, K B Pavan, Mohammed Rafiq, Rangesh Paramesh
Virgin coconut oil (VCO) has been traditionally used as moisturizer since centuries by people in the tropical region. Clinical studies have revealed that VCO improves the symptoms of skin disorders by moisturizing and soothing the skin. However, the mechanistic action of VCO and its benefits on skin has not been elucidated in vitro . The cytotoxicity (CTC50 ) of VCO was 706.53 ± 2.1 and 787.15 ± 1.1 μg/mL in THP-1 (Human monocytes) and HaCaT (Human keratinocytes) cells respectively. VCO inhibited TNF-α (62...
January 2019: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30671360/antidiabetic-potential-of-asparagus-racemosus-willd-leaf-extracts-through-inhibition-of-%C3%AE-amylase-and-%C3%AE-glucosidase
#10
R Vadivelan, R Gopala Krishnan, R Kannan
The aim of this work was to evaluate the inhibitory activities of different extracts of Asparagus racemosus Willd on α - amylase and α - glucosidase at varying concentrations. Diabetes mellitus is a clinical condition characterized by hyperglycaemia in which an elevated amount of glucose circulates in the blood plasma. α - amylase and α - glucosidase inhibitors are used to achieve greater control over hyperglycemia in type 2 diabetes mellitus. This study is to treat the diabetes using natural resources...
January 2019: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30302332/relaxant-effects-of-azadirachta-indica-a-juss-var-siamensis-valeton-flower-extract-on-isolated-rat-ileum-contractions-and-the-mechanisms-of-action
#11
Acharaporn Duangjai, Bey-Hing Goh, Learn-Han Lee, Surasak Saokaew
Azadirachta indica A. Juss var. siamensis Valeton or commonly known as Siamese neem is one of the most well-known plant in traditional Ayurvedic medicine. The aim of the present study was to investigate the relaxant effects of A. indica on isolated rat ileum contractions and its potential underlying mechanisms involved. The isometric contractions of ileum segments were investigated in organ baths for spontaneous activity and response to aqueous extract of Siamese neem flower (SNF). The spasmolytic action of the extract was also assessed on contraction induced by acetylcholine and high potassium...
October 2018: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30302331/preliminary-clinical-assessment-and-non-toxicity-evaluation-of-an-ayurvedic-formulation-bgr-34-in-niddm
#12
B P Gupta, I Sharma, N Kohli, S Sharma, A Rathi, A K Sharma
In view of the overall health impact of NIDDM, inventers understand the necessity of improving glycemic control in adults with type 2 diabetes. BGR-34 provides an effective treatment option for adults with type 2 diabetes who have been inadequately controlled on lifestyle with or without other oral hypoglycemic agents (OHGAs) such as metformin, sulfonylurea, or a glitazones. BGR-34 is an appropriate option to consider for addition to a managed care drug formulary. Treatment with BGR-34 produced clinically relevant and statistically significant reductions in all three key measures of glucose control studied -FPG, PPBG and HbA1c- when compared with placebo...
October 2018: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30302330/anti-inflammatory-and-preventive-activity-of-white-mulberry-root-bark-extract-in-an-experimental-model-of-pancreatitis
#13
Yuvaraj Kavitha, Arumugam Geetha
Pancreatitis is characterized by highly morbid inflammation in the pancreas. Currently, there is no specific drug available for pancreatitis except supportive medicines. The present study assessed the pancreato-protective effect of Morus alba root bark extract by using alcohol and cerulein-induced model of pancreatitis. The study also investigated the phytochemical profile through GC-MS and HPLC. Methanolic extract of Morus alba root bark extract (MEMARB) was subjected to GC-MS and HPLC studies. Male albino Wistar rats were administered ethanol (0%-36%) and cerulein (20 μg/kg b...
October 2018: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30302329/chemical-composition-antioxidant-potential-macromolecule-damage-and-neuroprotective-activity-of-convolvulus-pluricaulis
#14
P Rachitha, K Krupashree, G V Jayashree, Hemanth Kumar Kandikattu, Narayanappa Amruta, Natarajan Gopalan, M K Rao, Farhath Khanum
Herbal medicines are known to mitigate radical induced cell damage. Hence identification and scientific validation of herbal medicines contribute to better use in Ayurvedic/Unani research. In the present study, we investigated antioxidant and anti-apoptotic properties of Convolvulus pluricaulis ( C. pluricaulis ). C. pluricaulis exhibited antioxidant potential evident by free radical scavenging activities. C. pluricaulis pretreatment inhibited H2 O2 induced macromolecule damage such as plasmid DNA damage and AAPH induced oxidation of bovine serum albumin and lipid peroxidation of rat hepatic tissues...
October 2018: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30302328/extraction-isolation-and-identification-of-flavonoid-from-chenopodium-album-aerial-parts
#15
Sumit Arora, Prakash Itankar
Chenopodium album L., ( C. album ) (family: Chenopodiaceae) is an annual shrub widely grown in Asia, Africa, Europe and North America. It is commonly known as Bathua (in Hindi), pigweed, fat hen or lamb-quarters. The leaves of C. album are applied as a poultice to bug bites, sunstroke, rheumatic joints and as mild laxative. The flavonoids contained in C. album aerial parts were extracted, identified and characterized. Sequential soxhlet extraction was subjected to preliminary phytochemical screening and flavonoid quantification...
October 2018: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30302327/rosemary-leaves-extract-anti-snake-action-against-egyptian-cerastes-cerastes-venom
#16
Walaa H Salama, Azza M Abdel-Aty, Afaf S Fahmy
The morbidity caused by viper bites is very dangerous and the anti-venom therapy couldn't treat the local injures such as hemorrhage, edema, necrosis and inflammation of bitten tissues. Searching for safe and effective anti-venom compounds from natural sources is very important. This study was designed to explore the neutralizing ability of Rosmarinus officinalis L. leaves aqueous extract (RMAE) against Egyptian Cerastes cerastes (Cc) viper venom toxicity. The RMAE contained a considerable amount of phenolic and flavonoid contents with 3,300 and 800 mg/100 g dry weight, respectively...
October 2018: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30302326/in-vitro-studies-of-the-anticancer-action-of-tectaria-cicutaria-in-human-cancer-cell-lines-g-0-g-1-p53-associated-cell-cycle-arrest-part-i
#17
Preeti Gajendra Karade, Namdeo Ramhari Jadhav
Objective: The rhizome of Tectaria cicutaria has been used in Indian traditional medicine for the treatment of various disorders. The objective of present investigation is to screen various extracts of the rhizomes of Tectaria cicutaria for anti-cancer activity and to investigate the mechanism involved. Materials and methods: The rhizomes of Tectaria cicutaria were extracted with different solvents. In vitro anti-cancer activity of different rhizome extracts were studied in Human cancer Cell Lines using Sulphorodamine B (SRB) colorimetric cytotoxicity assay...
October 2018: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30302325/herbal-beverages-bioactive-compounds-and-their-role-in-disease-risk-reduction-a-review
#18
REVIEW
Anoma Chandrasekara, Fereidoon Shahidi
There is a renewed interest in non-nutritive bioactive compounds of foods and beverages as 'lifespan nutrients' in the risk reduction of non-communicable diseases. Herbal beverages, consumed as part of a balanced diet, may improve the antioxidant status and enhance the overall health status. Herbal teas/beverages are rich sources of natural bioactive compounds such as carotenoids, phenolic acids, flavonoids, coumarins, alkaloids, polyacetylenes, saponins and terpenoids, among others. A wealth of available scientific evidence demonstrates that natural bioactive compounds render a number of diversified biological effects, such as antioxidant, antibacterial, antiviral, antiinflammatory, antiallergic, antithrombotic and vasodilatory actions, as well as antimutagenicity, anticarcinogenicity and antiaging effects...
October 2018: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30302324/a-review-of-antioxidant-and-pharmacological-properties-of-phenolic-compounds-in-acacia-confusa
#19
REVIEW
Huan-You Lin, Tzu-Cheng Chang, Shang-Tzen Chang
In the present review article, the phytochemical, antioxidant and pharmacological studies are congregated and summarized concerning the current knowledge of the phenolic compounds of a traditional medical plant Acacia confusa in Taiwan. This plant is native to Taiwan and South-East Asia. It possesses major pharmacological activities, including antioxidant and radical scavenging activity, hepatoprotective effect, xanthine oxidase inhibition, semicarbazide-sensitive amine oxidase inhibition, angiotensin I converting enzyme inhibition, antihyperuricemic effect and anti-inflammatory activity...
October 2018: Journal of Traditional and Complementary Medicine
https://read.qxmd.com/read/30302323/various-stem-cells-in-acupuncture-meridians-and-points-and-their-putative-roles
#20
REVIEW
Jeanne Adiwinata Pawitan
Traditional Chinese and Korean medicine uses various manipulations on acupuncture points/acupoints that are located along imaginary lines on the surface of a human body, which are called 'meridians'. Acupuncture has been used from the ancient time till now to cure various diseases, including for the purpose of regenerative medicine. In various studies, meridians are alternatively called as Bong-Han ducts, primo vessels, or hyaluronic-acid rich ducts, while acupoints are called Bong-Han corpuscles, primo nodes, or hyaluronic-acid rich nodes...
October 2018: Journal of Traditional and Complementary Medicine
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